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IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner

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Science Bulletin 2021年第20期66卷 2115-2123,M0004页

作者： xuesen zheng Lei Liu Guangxun Meng Shu Zhu Rongbin Zhou Wei Jiang Hefei National Laboratory for Physical Sciences at Microscale The CAS Key Laboratory of Innate Immunity and Chronic DiseaseSchool of Basic Medical SciencesDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China The Center for Microbes Development and HealthKey Laboratory of Molecular Virology and ImmunologyInstitut Pasteur of ShanghaiChinese Academy of SciencesShanghai 200031China CAS Center for Excellence in Cell and Molecular Biology University of Science and Technology of ChinaHefei 230027China

Inflammasomes and their product interleukin 18(IL-18)play important roles in gut microbiota monitoring and homeostasis,and their loss of function could lead to microbiota dysbiosis and accelerate disease ***,the impacts of the resulting microbiota dysbiosis on the mucosal immune system are largely ***,we show that dysbiotic microbiota from Il18^(-/-)mice induced immune cell loss in the small intestine(SI)in an inflammasome-independent *** experiments revealed that the immunotoxic phenotype of these microbiota was transferable to wild type(WT)mice and induced immune cell death through the receptor-interacting protein kinase 3(RIP3)-mixed lineage kinase domain like pseudokinase(MLKL)*** of microbiota composition identified two types of bacteria at the genus level,Ureaplasma and Parasutterella,that accumulated in Il18^(-/-)mice and negatively mediated changes in immune cells in the ***,dysbiosis in Il18^(-/-)mice also contributed to increased susceptibility to Listeria ***,our results demonstrate that IL-18 is essential to microbiota homeostasis and that dysbiotic microbiota could significantly shape the landscape of the immune system.

关键词： Dysbiosis Immune system IL-18 Inflammasome

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Afforestation increases microbial diversity in low-carbon soils

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Journal of Forestry Research 2024年第2期35卷 14-22页

作者： xuesen Pang Chuankuan Wang Chengjie Ren zhenghu Zhou Center for Ecological Research Key Laboratory of Sustainable Forest Ecosystem Management‑Ministry of EducationNortheast Forestry UniversityHarbin 150040People’s Republic of China Northeast Asia Biodiversity Research Center Northeast Forestry UniversityHarbin 150040People’s Republic of China State Key Laboratory of Soil Erosion and Dryland Farming on the Loess Plateau Northwest A&F UniversityYangling 712100People’s Republic of China

Afforestation has an important role in biodiversity conservation and ecosystem function improvement.A meta-analysis was carried out in China,which has the largest plantation area globally,to quantify the effects of plantings on soil microbial *** results showed that the overall effect of afforestation on soil microbial diversity was positive across the *** forest algorithm suggested that soil carbon was the most important factor regulating microbial diversity and the positive response was only found with new plantings on low-carbon bare lands but not on high-carbon farmlands and *** addition,afforestation with broadleaved species increased microbial diversity,whereas planting with conifers had no effect on microbial *** study clarified the effects of plantings on soil microbial diversity,which has an important implication for establishing appropriate policies and practices to improve the multiple functionalities(e.g.,biodiversity conservation and climate change mitigation)during plantation establishment.

关键词： Afforestation Microbial diversity Soil microbial communities Species-energy theory Plantations

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Cobalt-Catalyzed Switchable[4+1]and[4+1+1]Spirocyclization of Aromatic Amides with 2-Diazo-1H-indene-1,3(2H)-dione:Access to Spiro Indene-2,1'-isoindolinones and Spiro Isochroman-3,1'-isoindolinones

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Chinese Journal of Chemistry 2024年第4期42卷 363-369页

作者： Bin Li Mengmeng Xie Jingyu Li Nana Shen Xinying Zhang xuesen Fan State Key Laboratory of Antiviral Drugs Pingyuan LaboratoryKey Laboratory of Green Chemical Media and ReactionsKey Laboratory for Yellow River and Huai River Water Environmental Pollution ControlMinistry of EducationSchool of EnvironmentSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiangHenan453007 China

Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromatic amides with 2-diazo-1H-indene-1,3(2H)-*** the reaction is carried out under air in ethyl acetate,spiro indene-2,1'-isoindolinones are formed through Co(II)-catalyzed C—H/N—H[4+1]*** the reaction is run under O2 in CH3CN,on the other hand,spiro isochroman-3,1'-isoindolinones are generated through Baeyer-Villiger oxidation of the in situ formed spiro indene-2,1'-isoindolinones with O2 as a cheaper and environmental-friendly oxygen *** general,these protocols have advantages such as using non-precious and earth-abundant metal catalyst,no extra additive,high efficiency and regioselectivity.A gram-scale synthesis and the removal of the directing group further highlight its utility.

关键词： Spiro indene-2,1'-isoindolinones Spiro isochroman-3,1'-isoindolinones 3d Transition metals Cobalt-catalyzed C-H Activation Switchable[4+1]and[4+1+1]spirocyclization Aromatic amides 2-Diazo-1H-indene-1,3(2H)-dione

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Finite element analysis and experimental validation of polymer-metal contacts in block-on-ring configuration

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Friction 2024年第3期12卷 554-568页

作者： K.Y.Eayal AWWAD Khosro FALLAHNEZHAD B.F.YOUSIF Ahmad MOSTAFA Omar ALAJARMEH A.SHALWAN xuesen ZENG Mechanical Engineering Department Faculty of EngineeringTafila Technical UniversityTafila 66110Jordan Medical Device Research Institute College of Science and EngineeringFlinders UniversitySouth Australia 5042Australia Centre for Future Materials University of Southern QueenslandToowoomba 4350Australia Department of Manufacturing Engineering Technology Public Authority for Applied Education and TrainingKuwait 13092Kuwait

The wear profile analysis,obtained by different tribometers,is essential to characterise the wear ***,most of the available methods did not take the stress distribution over the wear profile in consideration,which causes inaccurate *** this study,the wear profile of polymer–metal contact,obtained by block-on-ring configuration under dry sliding conditions,was analysed using finite element modelling(FEM)and experimental ***’s wear equation was integrated into a developed FORTRAN-UMESHMOTION code linked with Abaqus software.A varying wear coefficient(k)values covering both running-in and steady state regions,and a range of applied loads involving both mild and severe wear regions were measured and implemented in the *** FEM was in good agreement with the *** model reproduced the stress distribution profiles under variable testing conditions,while their values were affected by the sliding direction and maximum wear depth(hmax).The largest area of the wear profile,exposed to the average contact stresses,is defined as the normal *** the critical zones were characterized by high stress concentrations reaching up to 10 times of that at the normal *** wear profile was mapped to identify the critical zone where the stress concentration is the key point in this *** surface features were examined in different regions using scanning electron microscope(SEM).Ultimately,SEM analysis showed severer damage features in the critical zone than that in the normal zone as proven by ***,the literature data presented and considered the wear features the same at any point of the wear *** this study,the normal zone was determined at a stress value of about 0.5 MPa,whereas the critical zone was at about 5.5 *** wear behaviour of these two zones showed totally different features from one another.

关键词： polymer-to-metal contact block-on-ring wear profile wear model

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国内汽车复合材料应用现状与未来展望

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玻璃纤维 2010年第3期 35-42页

作者：郑学森北京汽车玻璃钢有限公司北京102101

阐述了汽车复合材料的应用顺应了国际汽车的节能、环保和安全的发展方向。回顾了复合材料在我国汽车零部件开发中的发展历程。详细介绍了当今复合材料在轿车(含SUV)、载货车、客车等各种车辆及汽车工业相关领域的应用现状。展望了复合... 详细信息

阐述了汽车复合材料的应用顺应了国际汽车的节能、环保和安全的发展方向。回顾了复合材料在我国汽车零部件开发中的发展历程。详细介绍了当今复合材料在轿车(含SUV)、载货车、客车等各种车辆及汽车工业相关领域的应用现状。展望了复合材料在汽车部件中将不断开发的新应用。总结我国汽车复合材料的发展举措。

关键词：汽车复合材料回顾现状展望

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车用材料设计一致性应用实践与探讨

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汽车工艺与材料 2022年第2期 59-65页

作者：郑学森王宝昆北京福田戴姆勒汽车有限公司研发中心北京101400

材料是汽车零部件的基础,在汽车零部件一致性乃至整车一致性保障方面起到至关重要的作用。借助5M1E工作法并运用设计防错技术,通过组建材料设计一致性工作团队,优化车用工程材料体系架构和材料标准溯源研究,以一体化研究和材料数据库建... 详细信息

材料是汽车零部件的基础,在汽车零部件一致性乃至整车一致性保障方面起到至关重要的作用。借助5M1E工作法并运用设计防错技术,通过组建材料设计一致性工作团队,优化车用工程材料体系架构和材料标准溯源研究,以一体化研究和材料数据库建设为主线实现材料信息数据的标准化、集成化、共享化目标,建立完善产品开发过程设计选材管理流程,提出材料设计一致性控制策略,为最终的零部件与整车一致性保障奠定基础。

关键词：设计选材材料一致性材料数据库

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Improving the spaceborne GNSS-R altimetric precision based on the novel multilayer feedforward neural network weighted joint prediction model

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Defence Technology（防务技术） 2024年第2期32卷 271-284页

作者： Yiwen Zhang Wei zheng Zongqiang Liu Qian xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China China Academy of Aerospace Science and Innovation Beijing 100176China State Key Laboratory of Space-Ground Integrated Information Technology Beijing Institute of Satellite Information EngineeringBeijing 100194China

Global navigation satellite system-reflection(GNSS-R)sea surface altimetry based on satellite constellation platforms has become a new research direction and inevitable trend,which can meet the altimetric precision at the global scale required for underwater *** present,there are still research gaps for GNSS-R altimetry under this mode,and its altimetric capability cannot be specifically ***,GNSS-R satellite constellations that meet the global altimetry needs to be ***,the matching precision prediction model needs to be established to quantitatively predict the GNSS-R constellation altimetric ***,the GNSS-R constellations altimetric precision under different configuration parameters is calculated,and the mechanism of the influence of orbital altitude,orbital inclination,number of satellites and simulation period on the precision is analyzed,and a new multilayer feedforward neural network weighted joint prediction model is ***,the fit of the prediction model is verified and the performance capability of the model is tested by calculating the R2 value of the model as 0.9972 and the root mean square error(RMSE)as 0.0022,which indicates that the prediction capability of the model is ***,using the novel multilayer feedforward neural network weighted joint prediction model,and considering the research results and realistic costs,it is proposed that when the constellation is set to an orbital altitude of 500 km,orbital inclination of 75and the number of satellites is 6,the altimetry precision can reach 0.0732 m within one year simulation period,which can meet the requirements of underwater navigation precision,and thus can provide a reference basis for subsequent research on spaceborne GNSS-R sea surface altimetry.

关键词： GNSS-R satellite constellations Sea surface altimetric precision Underwater navigation Multilayer feedforward neural network

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STUDY OF HIGH FLAMMABLE RESISTANT AND LOW SMOKE EMISSION SMC

STUDY OF HIGH FLAMMABLE RESISTANT AND LOW SMOKE EMISSION SMC

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作者： Sun Wei, zheng xuesen , Zhai Guofang , Wang Ji-hui School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, Beijing FRP Auto Parts Corp . Ltd. , Beijing 102101, China

＜正＞The effects of different resins, low - profile additives and flame resistance reagents on the mechanical and flame resistance performances of Sheet Molding Compound （SMC） were studied by orthogonal test method in this paper. The optimal formula of high flame - resistant and low smoke emission SMC was determined by the measurement of tensile strength and oxygen index.

关键词： SMC Flame resistant agent Tensile strength Oxygen index

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国内外重型载货汽车外饰系统关键部件用材趋势研究

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汽车工艺与材料 2019年第8期 21-25页

作者：郑学森张喆马永孝北京福田戴姆勒汽车有限公司技术中心

外饰系统是重型载货车车身的重要组成部分,承担着装饰、功能、载体和安全四大作用。如何做好外饰系统关键部件的设计选材及合理应用直接影响到节能、环保、安全、舒适等整车特性指标的达成。通过对国内外重型载货车中的前面罩、保险杠... 详细信息

外饰系统是重型载货车车身的重要组成部分,承担着装饰、功能、载体和安全四大作用。如何做好外饰系统关键部件的设计选材及合理应用直接影响到节能、环保、安全、舒适等整车特性指标的达成。通过对国内外重型载货车中的前面罩、保险杠、导流系统、脚踏板等外饰系统关键部件的用材趋势研究,为车身外饰系统设计人员在设计选材及改进方面提供一定的参考和借鉴作用。

关键词：外饰件轻量化设计选材

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Improving path planning efficiency for underwater gravity-aided navigation based on a new depth sorting fast search algorithm

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Defence Technology（防务技术） 2024年第2期32卷 285-296页

作者： Xiaocong Zhou Wei zheng Zhaowei Li Panlong Wu Yongjin Sun School of Automation Nanjing University of Science and TechnologyNanjing210094China China Academy of Aerospace Science and Innovation Beijing100176China Qian xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing100094China School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin150001China

This study focuses on the improvement of path planning efficiency for underwater gravity-aided ***,a Depth Sorting Fast Search(DSFS)algorithm was proposed to improve the planning speed of the Quick Rapidly-exploring Random Trees*(Q-RRT*)algorithm.A cost inequality relationship between an ancestor and its descendants was derived,and the ancestors were filtered ***,the underwater gravity-aided navigation path planning system was designed based on the DSFS algorithm,taking into account the fitness,safety,and asymptotic optimality of the routes,according to the gravity suitability distribution of the navigation ***,experimental comparisons of the computing performance of the ChooseParent procedure,the Rewire procedure,and the combination of the two procedures for Q-RRT*and DSFS were conducted under the same planning environment and parameter conditions,*** results showed that the computational efficiency of the DSFS algorithm was improved by about 1.2 times compared with the Q-RRT*algorithm while ensuring correct computational results.

关键词： Depth Sorting Fast Search algorithm Underwater gravity-aided navigation Path planning efficiency Quick Rapidly-exploring Random Trees*(QRRT*)

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