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Virologica Sinica 2015年第3期30卷 218-220页

作者： Jin Peng Yueyue Fang xuesen zhao Yihong Peng Jiujiang Women's & Children's Hospital Department of Microbiology School of Basic Medical SciencePeking University

Dear Editor,Torque Teno virus(TTV)is a nonenveloped human DNA virus that was isolated from the serum of a patient with transfusion-transmitted hepatitis with unknown etiology in 1997(Nishizawa et al.,1997).TTV is the first human virus with a single-stranded circular DNA genome to be identified,and is recently classified as the Alphatorquevirus genus of the Anelloviridae family by the International Committee on Taxonomy of Viruses(ICTV)(King et al.,2011).TTV shows very high

关键词： prevalence DNA transfusion circular classified etiology stranded transmitted comparable serological

Highly efficient green organic light-emitting devices based on terbium complex by employing hole block material as host

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Science China(Technological Sciences) 2018年第9期61卷 1334-1339页

作者： zhao xuesen zhao ZiFeng ZHOU Liang ZHU Qi LIU ZhiWei BIAN ZuQiang HUANG ChunHui ZHANG HongJie State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changehun 130022 China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular Engineering Peking University Beijing 100871 China

In this work,efficient green electroluminescent(EL)devices with simplified device structure were prepared by doping trivalent terbium complex Tb(PMIP)_3into hole block material Tm Py *** high triplet energy of Tm Py PB helps to confine excitons within light-emitting layer,while the electron transport characteristic of Tm Py PB facilitates the balance of carriers on Tb(PMIP)_*** optimizing the doping concentration of Tb(PMIP)_3and the thickness of each functional layer,highly efficient green EL device with the structure of ITO/Mo O_3(3 nm)/TAPC(50 nm)/Tb(PMIP)_3(30 wt%):Tm Py PB(25 nm)/Tm Py PB(60 nm)/Li F(1 nm)/Al(100 nm)displayed pure Tb^(3+)characteristic emission with maximum current efficiency,power efficiency and brightness up to 47.24 cd/A(external quantum efficiency(EQE)of 14.4%),43.63 lm/W and 1694 cd/m^2,*** certain brightness of 100 cd/m^2,the device still maintained a current efficiency of 19.96 cd/A(EQE=6.1%).Such a device design strategy helps to improve the EL performances of Tb(PMIP)_3and to simplify device fabrication processes,thus reduce the fabrication cost.

关键词：设备结构建筑群材料主人器官铽运输特征 Tm

Therapeutic strategies for a functional cure of chronic hepatitis B virus infection

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Acta Pharmaceutica Sinica B 2014年第4期4卷 248-257页

作者： Jinhong Chang Fang Guo xuesen zhao Ju-Tao Guo Department of Microbiology and Immunology Drexel University College of MedicineDoylestownPA 18902USA

Treatment of chronic hepatitis B virus(HBV)infection with the viral DNA polymerase inhibitors or pegylated alpha-interferon has led to a significant retardation in HBV-related disease progression and reduction in mortality related to chronic hepatitis B associated liver decompensation and hepatocellular ***,chronic HBV infection remains not *** reasons for the failure to eradicate HBV infection by long-term antiviral therapy are not completely ***,clinical studies suggest that the intrinsic stability of the nuclear form of viral genome,the covalently closed circular(ccc)DNA,sustained low level viral replication under antiviral therapy and homeostatic proliferation of hepatocytes are the critical virological and pathophysiological factors that affect the persistence and therapeutic outcomes of HBV *** importantly,despite potent suppression of HBV replication in livers of the treated patients,the dysfunction of HBV-specific antiviral immunity *** inability of the immune system to recognize cells harboring HBV infection and to cure or eliminate cells actively producing virus is the biggest challenge to finding a *** the complex virus–host interactions that lead to persistent infection should facilitate the rational design of antivirals and immunotherapeutics to cure chronic HBV infection.

关键词： Hepatitis B virus cccDNA Antiviral agents

Surface characterization of ICF capsule by AFM-based profilometer

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High Power Laser Science and Engineering 2017年第3期5卷 55-61页

作者： Jie Meng xuesen zhao Xing Tang Yihao Xia Xiaojun Ma Dangzhong Gao Research Center of Laser Fusion CAEP Harbin Institute of Technology

Outside surface fluctuations of inertial confinement fusion(ICF) capsule greatly affect the implosion performance. An atomic force microscope(AFM)-based profilometer is developed to precisely characterize the capsule surface with nanometer resolution. With the standard nine surface profiles and the complete coverage data, 1D and 2D power spectra are obtained to quantitatively qualify the capsule. Capsule center fast aligning, orbit traces automatic recording, 3D capsule orientation have been studied to improve the accuracy and efficiency of the profilometer.

关键词： inertial confinement fusion target design and fabrication

The coupling effect of slow-rate mechanical motion on the confined etching process in electrochemical mechanical micromachining

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Science China Chemistry 2018年第6期61卷 715-724页

作者： Lianhuan Han Yuchao Jia Yongzhi Cao Zhenjiang Hu xuesen zhao Shusen Guo Yongda Yan Zhongqun Tian Dongping Zhan Key Laboratory of Micro-Systems and Micro-Structures Manufacturing of Ministry of Education Harbin Institute of Technology Center for Precision Engineering Harbin Institute of Technology State Key Laboratory of Physical Chemistry of Solid Surfaces (PCOSS) Collaborative Innovation Centre of Chemistry for Energy Materials(iChEM) and Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University

By introducing the mechanical motion into the confined etchant layer technique(CELT), we have developed a promising ultraprecision machining method, termed as electrochemical mechanical micromachining(ECMM), for producing both regular and irregular three dimensional(3 D) microstructures. It was found that there was a dramatic coupling effect between the confined etching process and the slow-rate mechanical motion because of the concentration distribution of electrogenerated etchant caused by the latter. In this article, the coupling effect was investigated systemically by comparing the etchant diffusion, etching depths and profiles in the non-confined and confined machining modes. A two-dimensional(2 D) numerical simulation model was proposed to analyze the diffusion variations during the ECMM process, which is well verified by the machining experiments. The results showed that, in the confined machining mode, both the machining resolution and the perpendicularity tolerance of side faces were improved effectively. Furthermore, the theoretical modeling and numerical simulations were proved valuable to optimize the technical parameters of the ECMM process.

关键词：机械运动电气化学蚀刻剂机器制造技术参数制造方法微观结构模拟模型

Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1555-1567页

作者： Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong xuesen zhao Hui Zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical SchoolBeijing 100050China Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical SchoolBeijing 100730China Institute of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Lady Davis Institute Jewish General HospitalMc Gill UniversityMontrealQuebec H3T 1E2Canada CAMS Key Laboratory of Antiviral Drug Research Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population *** RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of ***,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/*** modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by *** addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 *** with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics.

关键词： SARS-CoV-2 RdRp Structure-based virtual screening Viral replication Non-nucleoside inhibitor Drug combinations Corilagin

Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

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Science China(Life Sciences) 2022年第1期65卷 223-226页

作者： Junyan Han Ning Zhang Danying Chen Yuhuan Gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang xuesen zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song Yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui Zeng Yuhai Bi Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research andEarly-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Intensive Care Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Laboratory of Infectious Diseases Center of Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China The Infectious Disease Diagnostic Therapeutic and Research CentersBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Clinical Center for HIV/AIDS Clinical and Research Center of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity.

关键词： protective vaccine severity

COVID-19 reinfection in the presence of neutralizing antibodies

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National Science Review 2021年第4期8卷 42-47页

作者： Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen xuesen zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng Beijing Ditan Hospital Capital Medical University Beijing Key Laboratory of Emerging Infectious Diseases NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Advanced Innovation Center for Genomics Biomedical Pioneering Innovation Center Peking University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical School CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Center for Influenza Research and Early-Warning (CASCIRE) CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID) Chinese Academy of Sciences University of Chinese Academy of Sciences Division of Life Science and Department of Chemical and Biological Engineering Hong Kong University of Science and Technology

Due to the high transmissibility of the SARS-CoV-2 virus, it continues to infect over 300 000 people worldwide per day(WHO statistics, December 2020), even almost one year after the first COVID-19 cases were confirmed [1,2]. One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals.

关键词： COVID-19 SARS-CoV-2 reinfection neutralizing antibody

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MEMS器件圆度误差纳米级测量方法研究

中国机械工程 2005年第z1期16卷 479-481页

作者：孙涛赵学森闫永达董申哈尔滨工业大学哈尔滨150001 哈尔滨工业大学哈尔滨150001 哈尔滨工业大学哈尔滨150001 哈尔滨工业大学哈尔滨150001

为了测量毫米以下尺寸MEMS零件的圆度参数,建立了将扫描探针显微镜(SPM)系统的原子力测头作为测量传感器,配合精密回转气浮轴系实现对待测试件进行转位的测试系统;讨论了精密气浮轴系、驱动电机、装夹调心装置等关键部件的设计问题及测... 详细信息

为了测量毫米以下尺寸MEMS零件的圆度参数,建立了将扫描探针显微镜(SPM)系统的原子力测头作为测量传感器,配合精密回转气浮轴系实现对待测试件进行转位的测试系统;讨论了精密气浮轴系、驱动电机、装夹调心装置等关键部件的设计问题及测量系统的工作原理.应用测试系统测量了直径约为0.2mm的微细电极外表面形貌,对获得的表面数据进行了滤波处理,最后使用最小二乘圆度评定准则计算其圆度误差为3.210μm.这种方法可以为圆形MEMS器件的制造工艺提供可行的测量方法与手段.

关键词： MEMS 扫描探针显微镜(SPM) 圆度测量

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刷衬-篦齿密封泄漏流动特性数值模拟研究

推进技术 2024年第7期45卷 88-101页

作者：顾超马英群刘翼腾杨学森赵巍赵庆军中国科学院工程热物理研究所北京100190 中国科学院大学航空宇航学院北京100049 中国科学院轻型涡轮动力全国重点实验室北京100190 中国科学院分布式冷热电联供系统北京市重点实验室北京100190

为进一步提高空气涡轮火箭发动机(Air-Turbo Rocket Engine,ATR)在高封严压差下的密封性能,同时避免接触式刷式密封摩擦升热问题,建立了刷衬-篦齿密封结构和数值模型,在已有刷束泄漏流动实验数据验证模型准确性的基础上,计算了刷衬-篦... 详细信息

为进一步提高空气涡轮火箭发动机(Air-Turbo Rocket Engine,ATR)在高封严压差下的密封性能,同时避免接触式刷式密封摩擦升热问题,建立了刷衬-篦齿密封结构和数值模型,在已有刷束泄漏流动实验数据验证模型准确性的基础上,计算了刷衬-篦齿密封不同结构参数下的流场、压力分布和泄漏流量,分析了刷衬-篦齿密封各主要结构参数对密封性能的影响,结合参数与泄漏流量之间的关系,改进了刷衬-篦齿密封的结构。结果表明,刷衬-篦齿密封泄漏的主要来源为篦齿与刷束之间间隙的“透气效应”,减小篦齿与刷衬之间的间隙、刷丝直径、刷丝自由高度可不同程度地减小泄漏率;而减少齿数、刷束厚度、齿顶宽度、篦齿间距、刷束密度等参数则导致泄漏的增加,其中篦齿与刷衬之间零间隙泄漏率约为间隙0.3 mm时的23%;改进后的刷衬-篦齿密封泄漏率较原刷衬-篦齿密封低8.9%,密封性能得到进一步改善。

关键词： ATR发动机刷衬-篦齿密封流场分析涡流耗散密封结构改进

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