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Finite element analysis and experimental validation of polymer-metal contacts in block-on-ring configuration

Friction 2024年第3期12卷 554-568页

作者： K.Y.Eayal AWWAD Khosro FALLAHNEZHAD B.F.YOUSIF Ahmad MOSTAFA Omar ALAJARMEH A.SHALWAN xuesen zeng Mechanical Engineering Department Faculty of EngineeringTafila Technical UniversityTafila 66110Jordan Medical Device Research Institute College of Science and EngineeringFlinders UniversitySouth Australia 5042Australia Centre for Future Materials University of Southern QueenslandToowoomba 4350Australia Department of Manufacturing Engineering Technology Public Authority for Applied Education and TrainingKuwait 13092Kuwait

The wear profile analysis,obtained by different tribometers,is essential to characterise the wear mechanisms.However,most of the available methods did not take the stress distribution over the wear profile in consideration,which causes inaccurate analysis.In this study,the wear profile of polymer–metal contact,obtained by block-on-ring configuration under dry sliding conditions,was analysed using finite element modelling(FEM)and experimental investigation.Archard’s wear equation was integrated into a developed FORTRAN-UMESHMOTION code linked with Abaqus software.A varying wear coefficient(k)values covering both running-in and steady state regions,and a range of applied loads involving both mild and severe wear regions were measured and implemented in the FEM.The FEM was in good agreement with the experiments.The model reproduced the stress distribution profiles under variable testing conditions,while their values were affected by the sliding direction and maximum wear depth(hmax).The largest area of the wear profile,exposed to the average contact stresses,is defined as the normal zone.Whereas the critical zones were characterized by high stress concentrations reaching up to 10 times of that at the normal zone.The wear profile was mapped to identify the critical zone where the stress concentration is the key point in this definition.The surface features were examined in different regions using scanning electron microscope(SEM).Ultimately,SEM analysis showed severer damage features in the critical zone than that in the normal zone as proven by FEM.However,the literature data presented and considered the wear features the same at any point of the wear profile.In this study,the normal zone was determined at a stress value of about 0.5 MPa,whereas the critical zone was at about 5.5 MPa.The wear behaviour of these two zones showed totally different features from one another.

关键词： polymer-to-metal contact block-on-ring wear profile wear model

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Engineering phosphorus-containing lignin for epoxy biocomposites with enhanced thermal stability,fire retardancy and mechanical properties

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Journal of Materials Science & Technology 2023年第36期167卷 82-93页

作者： Anlin Zhang Jianzhong Zhang Lina Liu Jinfeng Dai Xinyu Lu Siqi Huo Min Hong Xiaohuan Liu Mark Lynch xuesen zeng Paulomi Burey Pingan Song College of Chemistry and Materials Science Zhejiang A&F UniversityHangzhou 311300China Centre for Future Materials University of Southern QueenslandSpringfieldQLD 4300Australia College of Life Science Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and ConservationTaizhou UniversityTaizhou 318000China School of Agriculture and Environmental Science University of Southern QueenslandSpringfieldQLD 4300Australia

Fabricating a high-performing thermoset using bio-based flame retardant is critical for the sustain-able development of engineering materials with superior fire safety and robust mechanical properties.Herein,the epoxy(EP)composites with the industrial requirements are manufactured with a novel high-efficient,lignin-based flame retardant named DAL-x,which is fabricated by grafting 9,10-dihydro-9-oxa-10-phosphaze-10-oxide(DOPO)onto lignin.The resulting DAL-x/EP composite exhibits excellent flame retardancy with a desirable UL-94 V-0 rating and a satisfactory limiting oxygen index(LOI)of 29.8%due to the appropriate phosphorus content of DAL-x with adjustable molecular chain structure.More-over,the DAL-x/EP composite shows an unexpected improvement in the elastic modulus(∼36%)and well-preserved strength and ductility compared with those of pure EP.This work offers a feasible strat-egy for creating efficient bio-based flame retardants utilizing industrial waste lignin and preparing high-performance EP composites that meet the demanding requirement of fire retardancy in industries,con-tributing to the circular economy and sustainability.

关键词： Epoxy resin Lignin Flame retardancy Thermal stability Mechanical property

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Influence of graphene nanoplatelets on mechanical properties and adhesive wear performance of epoxy-based composites

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Friction 2021年第4期9卷 856-875页

作者： K.Y.EAYAL AWWAD B.F.YOUSIF Khosro FALLAHNEZHAD Khalid SALEH xuesen zeng Faculty of Health Engineering and SciencesUniversity of Southern QueenslandToowoombaQLDAustralia Centre for Future Materials University of Southern QueenslandToowoombaQLDAustralia School of Mechanical and Mining Engineering University of QueenslandBrisbaneQLDAustralia

Epoxy resin is one of the most widely used thermoset polymers in high-performance composite materials for lightweight applications.However,epoxy has a high coefficient of friction,which limits its tribological applications.In this study,the effect was investigated of different weight fractions of solid lubricant graphene nanoplatelets(GNPs),ranging from 0 to 4.5 wt%,on mechanical and adhesive wear performance of epoxy.Adhesive wear tests covered mild and severe wear regimes.The correlation of tribological and mechanical properties was studied as well.Scanning electron microscopy(SEM)was used to observe the failure mechanisms for both tribological and mechanical samples after each test.The results revealed that the addition of GNPs to the epoxy improved its stiffness and hardness but reduced its fracture strength and toughness.Adhesive wear performance exhibited high efficiency with GNP additions and showed reductions in the specific wear rate,the coefficient of friction,and the induced interface temperature by 76%,37%,and 22%,respectively.A fatigue wear mechanism was predominant as the applied load increased.Most importantly,severe wear signs occurred when the interface temperature reached the heat distortion temperature of the epoxy.The tribological,and mechanical properties showed only a weak correlation to each other.The addition of GNPs to epoxy by less than 4.5 wt%was highly efficient to improve the wear performance while maintaining the fracture strength and toughness.Fourier transform infrared spectroscopy(FTIR)analysis shows no chemical interaction between the epoxy matrix with GNPs,which implies its physical interaction.

关键词： graphene nanoplatelets epoxy adhesive wear solid lubricants

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自动化实时监测技术在水中现浇桥梁模板支撑工程中的应用与研究

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广东建材 2024年第3期40卷 41-45页

作者：叶建新钟学森刘权罗业超曾绮琪广州广检建设工程检测中心有限公司广东省建筑物健康监测与安全预警工程技术研究中心广州市增城区公共建设项目管理服务中心

广东地区水道纵横,水中现浇桥梁模板支撑施工是跨河中、小桥梁常用的施工方法。然而受复杂环境影响,目前针对水中现浇桥梁模板支撑工程的高支模自动化实时监测方案研究较少。因此,基于广州某跨河现浇施工桥梁工程,通过多个传感器、物联... 详细信息

广东地区水道纵横,水中现浇桥梁模板支撑施工是跨河中、小桥梁常用的施工方法。然而受复杂环境影响,目前针对水中现浇桥梁模板支撑工程的高支模自动化实时监测方案研究较少。因此,基于广州某跨河现浇施工桥梁工程,通过多个传感器、物联网技术、测量机器人等,设计了针对该现浇施工桥梁的高支模自动化监测方案,以实时反馈混凝土浇筑过程中水中平台与支架组成的支撑体系的受力、变形情况,并设置参数预警值实现自动预警,为水中现浇桥梁支撑模板工程施工的提供安全保障措施。同时,提出了同类工程的测点设置原则、过程巡查要点和预警值设置思路,提高了监测技术安全预警能力及预警准确性,为同类工程的实施提供技术支持。

关键词：自动化监测测量机器人监测巡查监测预警值

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灰毡毛忍冬MADS-box基因家族鉴定与CMB1基因克隆

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湖南中医药大学学报 2024年第3期44卷 383-394页

作者：付学森刘紫璇王玲龙雨青曾娟周日宝刘湘丹湖南中医药大学药学院湖南长沙410208 湘产大宗道地药材种质资源及规范化种植重点研究室湖南长沙410208 湖南省普通高等学校中药现代化研究重点实验室湖南长沙410208 湖南省中药饮片标准化及功能工程技术研究中心湖南长沙410208

目的鉴定灰毡毛忍冬Lonicera macranthoides MADS-box家族基因并进行生物信息学分析与表达模式验证,克隆湘蕾型和野生型灰毡毛忍冬MADS-box家族成员CMB1全长。方法基于转录组数据,利用在线工具对灰毡毛忍冬MADS-box进行生物信息学分析,... 详细信息

目的鉴定灰毡毛忍冬Lonicera macranthoides MADS-box家族基因并进行生物信息学分析与表达模式验证,克隆湘蕾型和野生型灰毡毛忍冬MADS-box家族成员CMB1全长。方法基于转录组数据,利用在线工具对灰毡毛忍冬MADS-box进行生物信息学分析,并利用qRT-PCR验证MADS-box基因在不同品种中的表达模式,通过RT-PCR、RACE技术克隆湘蕾型和野生型灰毡毛忍冬CMB1基因全长。结果28个灰毡毛忍冬MADS-box蛋白长度为89~359 aa,碱性蛋白占比85.7%,不稳定蛋白占比96.4%,亲水性蛋白占比96.4%,均定位于细胞核,均为无跨膜结构的非分泌蛋白。转录组显示,与野生型比较,湘蕾型中28个MADS-box基因有17.86%表达下调,MIKCC型基因中有18.75%表达下调。克隆得到在两个品种的灰毡毛忍冬花中高度特异性表达的CMB1基因全长,均包含一个738 bp的ORF,编码245个氨基酸。CMB1基因在两个品种的花中表达量存在显著差异(P<0.01),且与茎、叶相比,在花中高度特异性表达(P<0.01)。结论基于灰毡毛忍冬转录组数据,鉴定了28个MADS-box家族基因,克隆得到湘蕾型与野生型灰毡毛忍冬CMB1基因全长,为进一步研究灰毡毛忍冬花发育、优良表型形成的分子机制提供研究基础与理论依据。

关键词：灰毡毛忍冬 MADS-box基因家族表达分析 CMB1基因基因克隆表型变异

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Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity

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Science China(Life Sciences) 2022年第1期65卷 223-226页

作者： Junyan Han Ning Zhang Danying Chen Yuhuan Gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang xuesen Zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song Yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui zeng Yuhai Bi Beijing Key Laboratory of Emerging Infectious Diseases Institute of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyCenter for Influenza Research andEarly-warning(CASCIRE)CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID)Chinese Academy of SciencesBeijing 100101China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Intensive Care Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Center of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Laboratory of Infectious Diseases Center of Beijing Ditan Hospital Capital Medical UniversityBeijing 100015China The Infectious Disease Diagnostic Therapeutic and Research CentersBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China Clinical Center for HIV/AIDS Clinical and Research Center of Infectious DiseasesBeijing Ditan HospitalCapital Medical UniversityBeijing 100015China University of Chinese Academy of Sciences Beijing 100049China

Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity.

关键词： protective vaccine severity

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Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1555-1567页

作者： Quanjie Li Dongrong Yi Xiaobo Lei Jianyuan Zhao Yongxin Zhang Xiangling Cui Xia Xiao Tao Jiao Xiaojing Dong xuesen Zhao Hui zeng Chen Liang Lili Ren Fei Guo Xiaoyu Li Jianwei Wang Shan Cen Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical SchoolBeijing 100050China Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical SchoolBeijing 100730China Institute of Infectious Disease Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Lady Davis Institute Jewish General HospitalMc Gill UniversityMontrealQuebec H3T 1E2Canada CAMS Key Laboratory of Antiviral Drug Research Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has become one major threat to human population health.The RNA-dependent RNA polymerase(RdRp) presents an ideal target of antivirals,whereas nucleoside analogs inhibitor is hindered by the proofreading activity of coronavirus.Herein,we report that corilagin(RAI-S-37) as a non-nucleoside inhibitor of SARS-CoV-2 RdRp,binds directly to RdRp,effectively inhibits the polymerase activity in both cell-free and cell-based assays,fully resists the proofreading activity and potently inhibits SARS-CoV-2 infection with a low 50% effective concentration(EC50) value of 0.13 μmol/L.Computation modeling predicts that RAI-S-37 lands at the palm domain of RdRp and prevents conformational changes required for nucleotide incorporation by RdRp.In addition,combination of RAI-S-37 with remdesivir exhibits additive activity against antiSARS-CoV-2 RdRp.Together with the current data available on the safety and pharmacokinetics of corilagin as a medicinal herbal agent,these results demonstrate the potential of being developed into one of the much-needed SARS-CoV-2 therapeutics.

关键词： SARS-CoV-2 RdRp Structure-based virtual screening Viral replication Non-nucleoside inhibitor Drug combinations Corilagin

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Chinese Medicine Meets Conventional Medicine in Targeting COVID-19 Pathophysiology,Complications and Comorbidities

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Chinese Journal of Integrative Medicine 2022年第7期28卷 627-635页

作者： WANG Shan-shan zeng Xian WANG Ya-li Zhuoma Dongzhi ZHAO Yu-fen CHEN Yu-zong Qian xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences Institute of Drug Discovery TechnologyNingbo UniversityNingboZhejiang Province 315211China Department of Biological Medicines&Shanghai Engineering Research Center of Immunotherapeutics Fudan University School of PharmacyShanghai 201203China Bioinformatics and Drug Design Group Department of PharmacyNational University of Singapore117543Singapore Medical College Tibet UniversityLhasa 850011China Department of Chemical Biology College of Chemistry and Chemical Engineeringand The Key Laboratory for Chemical Biology of Fujian ProvinceXiamen UniversityXiamenFujian Province 361005China Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing 102206China

Objective: To investigate how the National Health Commission of China(NHCC)-recommended Chinese medicines(CMs) modulate the major maladjustments of coronavirus disease 2019(COVID-19),particularly the clinically observed complications and comorbidities. Methods: By focusing on the potent targets in common with the conventional medicines, we investigated the mechanisms of 11 NHCC-recommended CMs in the modulation of the major COVID-19 pathophysiology(hyperinflammations, viral replication), complications(pain, headache) and comorbidities(hypertension, obesity, diabetes). The constituent herbs of these CMs and their chemical ingredients were from the Traditional Chinese Medicine Information Database. The experimentally-determined targets and the activity values of the chemical ingredients of these CMs were from the Natural Product Activity and Species Source Database. The approved and clinical trial drugs against these targets were searched from the Therapeutic Target Database and DrugBank Database. Pathways of the targets was obtained from Kyoto Encyclopedia of Genes and Genomes and additional literature search. Results: Overall,9 CMs modulated 6 targets discovered by the COVID-19 target discovery studies, 8 and 11 CMs modulated 8and 6 targets of the approved or clinical trial drugs for the treatment of the major COVID-19 complications and comorbidities, respectively. Conclusion: The coordinated actions of each NHCC-recommended CM against a few targets of the major COVID-19 pathophysiology, complications and comorbidities, partly have common mechanisms with the conventional medicines.

关键词： COVID-19 Chinese medicine target therapeutic mechanism pathophysiology comorbidity

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COVID-19 reinfection in the presence of neutralizing antibodies

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National Science Review 2021年第4期8卷 42-47页

作者： Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui zeng Beijing Ditan Hospital Capital Medical University Beijing Key Laboratory of Emerging Infectious Diseases NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory Institute of Pathogen BiologyChinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical College Beijing Advanced Innovation Center for Genomics Biomedical Pioneering Innovation Center Peking University Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical School CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Center for Influenza Research and Early-Warning (CASCIRE) CAS-TWAS Center of Excellence for Emerging Infectious Diseases(CEEID) Chinese Academy of Sciences University of Chinese Academy of Sciences Division of Life Science and Department of Chemical and Biological Engineering Hong Kong University of Science and Technology

Due to the high transmissibility of the SARS-CoV-2 virus, it continues to infect over 300 000 people worldwide per day(WHO statistics, December 2020), even almost one year after the first COVID-19 cases were confirmed [1,2]. One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals.

关键词： COVID-19 SARS-CoV-2 reinfection neutralizing antibody

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硬覆盖对土壤水热传输及作物生长发育影响的试验研究

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生态学杂志 2000年第2期19卷 68-71页

作者：毛学森曾江海中国科学院石家庄农业现代化研究所 050021

Effects of the concrete mulch on evaporation, transpiration, evaportranspiration, soil temperature, yield of cotton and corn,and water use efficiency were studied by field experiments. The results showed that the concrete mulch cover effectively increased transpiration, yield and water use efficiency and greatly reduced soil evaporation loss and the amplitude of daily and seasonally soil temperature, water content variations.

关键词：作物生长发育覆盖保墒水泥硬壳土壤水热传输

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