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Frontiers of Chemical Science and Engineering 2024年第4期18卷 97-106页

作者： Ying Li Lu wang Junyan Xie Yong Dai Xuehong Gu xuerui wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Quzhou Membrane Material Innovation Institute Quzhou 324000China

Membrane gas separation is considered an energy-saving technique to extract He from natural gas due to no phase change and room temperature ***,the membrane performance was strongly limited by the trade-off between permeance and ***,novel 4,4′-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)-2,2′-bis(3-amino-4-hydroxyphenyl)hexafluoropropane(APAF)-5-amino-2-(4-aminobenzene)benzimidazole(BIA)asymmetric membranes with a thickness of 300 nm were successfully prepared by the non-solvent induced phase separation *** membrane performance was modulated by regulating dope solution compositions(e.g.,tetrahydrofuran and polymer concentration).The ideal He/CH_(4) selectivity was 124 and the optimized He permeance reached 87 GPU,beyond the current upper ***/CH_(4) selectivity was 75 and He permeance was 73 GPU for the binary mixture feed containing 0.2 mol%*** membrane showed good resistance to CO_(2) and C_(2)H_(6),which are the typical impurities in natural *** 6FDA-APAF-BIA membranes have good stability(>160 h),which can provide great potential in He extraction from natural gas.

关键词： He separation membrane natural gas copolyimide

Coupled multiphysical model for investigation of influence factors in the application of microbially induced calcite precipitation

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2232-2249页

作者： xuerui wang Pavan Kumar Bhukya Dali Naidu Arnepalli Shuang Chen Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)GGmbH Braunschweig38122Germany Department of Civil Engineering Indian Institute of Technology MadrasChennai600036India Federal Institute for Geosciences and Natural Resources(BGR) Hannover30655Germany

The study presents a comprehensive coupled thermo-bio-chemo-hydraulic(T-BCH)modeling framework for stabilizing soils using microbially induced calcite precipitation(MICP).The numerical model considers relevant multiphysics involved in MICP,such as bacterial ureolytic activities,biochemical reactions,multiphase and multicomponent transport,and alteration of the porosity and *** model incorporates multiphysical coupling effects through well-established constitutive relations that connect parameters and variables from different physical *** was implemented in the open-source finite element code OpenGeoSys(OGS),and a semi-staggered solution strategy was designed to solve the couplings,allowing for flexible model ***,the developed model can be easily adapted to simulate MICP applications in different *** numerical model was employed to analyze the effect of various factors,including temperature,injection strategies,and application ***,a TBCH modeling study was conducted on the laboratory-scale domain to analyze the effects of temperature on urease activity and precipitated calcium *** understand the scale dependency of MICP treatment,a large-scale heterogeneous domain was subjected to variable biochemical injection *** simulations conducted at the field-scale guided the selection of an injection strategy to achieve the desired type and amount of ***,the study emphasized the potential of numerical models as reliable tools for optimizing future developments in field-scale MICP *** present study demonstrates the potential of this numerical framework for designing and optimizing the MICP applications in laboratory-,prototype-,and field-scale scenarios.

关键词： Multiphysics Microbially induced calcite precipitation(MICP) Coupled thermo-bio-chemo-hydraulic(TBCH) model OpenGeoSys(OGS) Influence factors

Modelling of the elastoplastic behaviour of the bio-cemented soils using an extended Modified Cam Clay model

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2184-2197页

作者： xuerui wang Christian B.Silbermann Thomas Nagel Udo Nackenhorst Institute of Mechanics and Computational Mechanics Leibniz UniversitätHannoverAppelstr.9aHannover30167Germany Gesellschaft für Anlagen-und Reaktorsicherheit(GRS)gGmbH Theodor-Heuss-Straße 4Braunschweig38122Germany Geotechnical Institute Technische Universität BergakademieFreibergGustav-Zeuner-Str.1Freiberg09599Germany

An elastoplastic constitutive model based on the Modified Cam Clay(MCC)model is developed to describe the mechanical behaviour of soils cemented via microbially induced calcite precipitation(MICP).It considers the increase of the elastic stiffness,the change of the yield surface due to MICP cementation and the degradation of calcium carbonate bonds during ***,to capture the typical contraction-dilation transition in MICP soils,the original volumetric hardening rule in the MCC model is modified to a combined deviatoric and volumetric hardening *** model could reproduce a series of drained triaxial tests on MICP-treated soils with different calcium carbonate ***,we carry out a parametric study and observe numerical instability in some *** combination with an analytical analysis,our numerical modelling has identified the benefits and limitations of using MCCbased models in the simulation of MICP-cemented soils,leading to suggestions for further model development.

关键词： Microbially induced calcite precipitation(MICP) Elastoplasticity Modified cam clay(MCC) OpenGeoSys MFront Contraction-dilation transition

Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis

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Journal of Traditional Chinese Medicine 2024年第2期44卷 408-416页

作者： LI Zhenxuan wang xuerui Luis Ulloa Ayman Youssef BAI Yunjing XU Xiaolong LIU Qingquan Department of Infectious Diseases Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases Beijing 100010China Infection immunity laboratory Beijing Institute of Traditional Chinese MedicineBeijing 100010China Clinical College of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Center for Perioperative Organ Protection Department of AnesthesiologyDuke University Medical CenterDurhamNorth Carolina 27710USA

Sepsis-associated encephalopathy(SAE)is a common manifestation of sepsis,ranging from mild confusion and delirium to severe cognitive impairment and deep *** is associated with higher mortality and long-term outcomes,particularly substantial declines in cognitive *** mechanisms of SAE probably include neuroinflammation that is mediated by systemic inflammation and ischemic lesions in the brain,a disrupted blood–brain barrier,oxidative stress,neurotransmitter dysfunction,and severe microglial *** evidence suggests that complementary and alternative medicine,especially Traditional Chinese Medicine(TCM),is favorable in alleviating cognitive decline after ***,we summarized the studies of traditional herbal remedies,TCM formulas and acupuncture therapy in animal models of neurological dysfunctions after sepsis in recent decades and reviewed their potential mechanisms.

关键词： sepsis-associated encephalopathy cognitive dysfunction complementary therapies neuroinflammatory diseases medicine Chinese traditional review

Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

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Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe Meng Shihong Zheng Zequn Yin xuerui wang Daigang Yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan Jihong Han Yajun Duan Xiaoxiao Yang Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianjin Key Laboratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured by patches on the *** is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key ***(API)is a natural flavonoid with anti-inflammatory and immunoregulatory ***,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse *** results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic *** differentiation of immune cells was restored in API-treated ***,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A ***,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)***,API reduced expression of inflammatory cytokines through inactivation of NF-κ*** together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)

1920-1950年代“建筑艺术”词义演变考

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建筑学报 2024年第4期 92-98页

作者：王雪睿李翔宁同济大学建筑与城市规划学院上海200092

以语义学与语用学作为建筑理论史的潜在分析框架,考察1920-1950年代间“建筑艺术”概念在中国建筑界发生的意义演变。在回顾中国传统建筑观念的基础上,指出“建筑艺术”一词是近代中国建筑师特有的语义创造;1950年代,“建筑艺术”概念... 详细信息

以语义学与语用学作为建筑理论史的潜在分析框架,考察1920-1950年代间“建筑艺术”概念在中国建筑界发生的意义演变。在回顾中国传统建筑观念的基础上,指出“建筑艺术”一词是近代中国建筑师特有的语义创造;1950年代,“建筑艺术”概念则经历了从被特殊强调到遭受批判的复杂变迁。通过分析“建筑艺术”在不同时代语境中的表意与翻译,旨在为理解“建筑”与“艺术”之间的关联提供批判性的解读框架。

关键词：建筑艺术建筑理论词义演变中国现代建筑观念史

L-Ergothioneine ameliorates MPTP-induced Parkinson's disease in C57BL/6J mice by activating DJ-1

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Food Science and Human Wellness 2024年

作者： Xianshe Meng# Huawen Meng# Shuzeng Hou Zequn Yin xuerui wang Ke Gong Feng Zhang Qingshan Li Shuang Zhang Yuanli Chen Xiaoxiao Yang Zhiwei Zhao Chenzhong Liao Yajun Duan Department of Cardiology， the First Affiliated Hospital of USTC， Division of Life Sciences and Medicine， University of Science and Technology of China Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes， Hefei University of Technology

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. The loss of dopaminergic (DAergic) neurons in the substantia nigra and the decrease of dopamine (DA) levels accelerate the process of PD. L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms， especially in edible mushrooms. EGT can penetrate blood-brain barrier and its levels are significantly decreased in the plasma of PD patients. Therefore， we speculated that EGT could ameliorate PD， and determined its effect on PD development by using 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine (MPTP)-induced PD mouse models and neurotoxin 1-methyl-4-phenylpyridinium (MPP+)-induced cell models. Our results show that EGT alleviated MPTP-induced behavioral dysfunction in mice. Mechanistically， we innovatively revealed that EGT is a key regulator of DJ-1. EGT restored DA levels by activating the DJ-1-Nuclear receptor-related factor 1(Nurr1) axis. Furthermore， it reduced reactive oxygen species (ROS) levels by regulating the DJ-1-Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway， which inhibited oxidative stress-induced DAergic neuronal apoptosis. Combined treatment with DJ-1-siRNA transfection revealed that blocking DJ-1 reversed EGT upregulated Nurr1 and Nrf2 expression in the nucleus， which significantly decreased the benefits of EGT. Taken together， our study suggests that EGT can ameliorate PD and be considered as a strategy for PD treatment.

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低能N^(+)注入诱导大肠杆菌的16S rRNA遗传进化

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辐射研究与辐射工艺学报 2024年第1期42卷 52-61页

作者：唐朝王婷王雪瑞陈明晖蔡长龙西安工业大学光电工程学院西安710021 陕西科技大学食品与生物工程学院西安710021 中国北方车辆研究所北京100072

为了探究低能N^(+)注入对大肠杆菌16S rRNA遗传进化与耐药表征的作用,本研究利用低能N^(+)注入诱变筛选耐药大肠杆菌,通过基因组de novo测序获得其16S rRNA基因序列,通过K-B法检测诱变菌株的耐药特征。结果共诱变获得了25株耐药菌株,其... 详细信息

为了探究低能N^(+)注入对大肠杆菌16S rRNA遗传进化与耐药表征的作用,本研究利用低能N^(+)注入诱变筛选耐药大肠杆菌,通过基因组de novo测序获得其16S rRNA基因序列,通过K-B法检测诱变菌株的耐药特征。结果共诱变获得了25株耐药菌株,其中5株诱变菌16S rRNA基因分别出现片段缺失,点突变(A257C),GC%含量增高,二级结构变异,并获得多药耐药特性。结果提示:低能N^(+)注入可以驱动大肠杆菌16S rRNA基因的随机突变和进化,进而调节耐药基因从头合成或变异,使大肠杆菌耐药性改变。

关键词：低能N^(+)注入大肠杆菌 16S rRNA 耐药性

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建构当代中国建筑理论的新议程

建筑学报 2024年第1期 6-13页

作者：李翔宁莫万莉王雪睿闻增鑫同济大学建筑与城市规划学院上海200092

基于建筑理论之概念溯源、历史回顾及其当下所面临的挑战,勾勒出当代中国建筑理论体系建构的新议题、新方法与新特征。基于对1960年代以来全球建筑理论发展的回顾,指出建筑理论在当下需要应对建成环境、社会文化、新兴技术和气候变化4... 详细信息

基于建筑理论之概念溯源、历史回顾及其当下所面临的挑战,勾勒出当代中国建筑理论体系建构的新议题、新方法与新特征。基于对1960年代以来全球建筑理论发展的回顾,指出建筑理论在当下需要应对建成环境、社会文化、新兴技术和气候变化4方面的挑战。基于对当代中国建筑理论发展状况的梳理,指出其在连续性、原创性、体系性方面的欠缺。在上述基础上,讨论未来建筑理论体系建构的新议程。

关键词：建筑理论当代中国建筑新兴技术文化身份全球视野

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热处理车间智能制造系统开发及应用

金属热处理 2024年第8期49卷 254-260页

作者：楚西征邓小虎郭嘉毅王学锐肖枫许王立天津职业技术师范大学机械工程学院天津300222 海思特(苏州)材料科技有限公司江苏苏州215100

为提升热处理车间智能化水平,解决车间管理方式落后与“数据孤岛”等问题,根据热处理车间离散型的生产特点,设计并开发了热处理车间智能制造系统。首先,系统采用信息化技术管理车间生产全过程,实现了车间生产信息流通共享,执行过程透明... 详细信息

为提升热处理车间智能化水平,解决车间管理方式落后与“数据孤岛”等问题,根据热处理车间离散型的生产特点,设计并开发了热处理车间智能制造系统。首先,系统采用信息化技术管理车间生产全过程,实现了车间生产信息流通共享,执行过程透明可控以及生产历史追溯可查等功能;其次,系统通过建立数字化模型,绑定并存储实时数据,同时在设计中引进了安全环保的理念,达到了对车间的设备管理、安全生产以及异常预警的目标;最后,基于完整的车间数据,利用数据分析技术将车间各设备的能耗成本与工作效率进行全方位自动统计与分析,实现了车间各项指标精细化管理。本系统在车间成功应用后,改进了车间生产和设备的管理方式,提升了车间智能化水平,并为热处理车间的绿色制造和节能减排提供了支持。

关键词：热处理车间智能制造系统车间生产全过程数字化模型数据分析技术