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Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion

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Neuroscience Bulletin 2022年第2期38卷 181-199页

作者： Jie Cao Di Yao Rong Li xuequn guo Jiahuan Hao Minjie Xie Jia Li Dengji Pan Xiang Luo Zhiyuan Yu Minghuan Wang Wei Wang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Respiratory Medicine Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362000China Key Laboratory of Neurological Diseases of the Chinese Ministry of Education School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

The glymphatic system plays a pivotal role in maintaining cerebral *** cerebral hypoperfusion,arising from small vessel disease or carotid stenosis,results in cerebrometabolic disturbances ultimately manifesting in white matter injury and cognitive ***,whether the glymphatic system serves as a potential therapeutic target for white matter injury and cognitive decline during hypoperfusion remains ***,we established a mouse model of chronic cerebral hypoperfusion via bilateral common carotid artery *** found that the hypoperfusion model was associated with significant white matter injury and initial cognitive impairment in conjunction with impaired glym・phatic system *** glymphatic dysfunction was associated with altered cerebral perfusion and loss of aquaporin 4 *** of digoxin rescued changes in glymphatic transport,white matter structure,and cognitive *** of glymphatic functions by treatment with the AQP4 inhibitor TGN-020 abolished this protective effect of digoxin from hypoperfusion *** research yields new insight into the relationship between hemodynamics,glymphatic transport,white matter injury,and cognitive changes after chronic cerebral hypoperfusion.

关键词： Chronic cerebral hypoperfusion Cognitive impairment Digoxin Glymphatic system White matter injury

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入院血清磷酸盐水平对于ICU/RICU重症肺炎患者短期病死率的预测作用

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中国呼吸与危重监护杂志 2023年第7期22卷 486-491页

作者：郭学群林洪盛福建医科大学附属泉州第一医院呼吸与危重症医学科福建泉州362000

目的探讨重症监护室(intensive care unit,ICU)/呼吸重症监护室(respiratory intensive care unit,RICU)重症肺炎患者入院时血清磷酸盐水平与短期(<30 d)病死率之间的关系。方法纳入2019年11月—2021年9月福建医科大学附属泉州第一医院I... 详细信息

目的探讨重症监护室(intensive care unit,ICU)/呼吸重症监护室(respiratory intensive care unit,RICU)重症肺炎患者入院时血清磷酸盐水平与短期(<30 d)病死率之间的关系。方法纳入2019年11月—2021年9月福建医科大学附属泉州第一医院ICU/RICU收治的重症肺炎患者。通过Logistic分析和受试者操作特征(receiver operator characteristic,ROC)曲线验证血清磷酸盐水平是否为ICU/RICU重症肺炎患者短期死亡的独立危险因素。根据磷酸盐浓度对患者进行分类,探讨血清磷酸盐水平与短期病死率的关系。结果对生存组54例患者和非生存组46例患者入院时各项基线指标进行比较,结果显示生存组与非生存组间血清磷酸盐含量差异有统计学意义[0.9(0.8,1.2)mmol/L比1.2(0.9,1.5)mmol/L,P<0.05]。单因素及多因素Logistic分析表明血清磷酸盐水平升高是短期死亡的独立危险因素。ROC曲线分析显示血清磷酸盐预测重症肺炎患者短期死亡的能力与肺炎严重指数(pneumonia severity index,PSI)接近。将血清磷酸盐与PSI评分、CURB65评分及序贯器官衰竭评分合并后,上述评分对短期死亡的预测能力均得到提升。高磷血症组患者的短期病死率明显高于正常血磷组及低磷血症组(85.7%比47.3%和25.8%,P<0.05)。结论入院时血清磷酸盐水平对ICU/RICU重症肺炎患者短期死亡有较好的预测作用。入住ICU或者RICU时伴有高磷血症的重症肺炎患者具有较高的短期死亡风险。

关键词：血清磷酸盐重症肺炎短期病死率重症监护室

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数字化转型对制造业企业绩效的影响研究

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经济研究导刊 2023年第9期 22-24页

作者：郭雪群江苏大学财经学院江苏镇江212000

在数字经济浪潮的冲击下,越来越多的实体企业开始进行数字化转型,制造业企业作为实体经济的主力军,也踏上了转型之路。但是制造业企业的工序流程不是一朝一夕可以改变的,目前仅有少数制造业企业在数字化转型道路上取得了明显成果,而多... 详细信息

在数字经济浪潮的冲击下,越来越多的实体企业开始进行数字化转型,制造业企业作为实体经济的主力军,也踏上了转型之路。但是制造业企业的工序流程不是一朝一夕可以改变的,目前仅有少数制造业企业在数字化转型道路上取得了明显成果,而多数制造业企业数字化转型带来的企业绩效并不明显。通过分析数字化转型的动因和制造业企业数字化转型的机制,从中探寻影响制造业企业数字化转型绩效的因素,进而针对性地提出提升制造业企业数字化转型绩效的建议。

关键词：数字化转型制造业企业绩效

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聚甲醛基增韧改性材料研究进展

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工程塑料应用 2012年第7期40卷 100-103页

作者：高存生徐泽夕李武斌曹志奎郭学群刘常进河南煤化集团开封龙宇化工有限公司河南开封475201

聚甲醛(POM)共混增韧是高分子学术界迄今未能很好解决的一个世界性难题,从弹性体增韧、刚性粒子增韧、合金化改性增韧等方面综述了国内外POM增韧改性的最新研究进展,同时对今后POM增韧改性的方向提出了建议。

关键词：聚甲醛共混增韧弹性体刚性粒子合金化

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： guo-Fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： Fan YANG Zhaoyang MA Xingming guo Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli guo Chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： Chikako Harada Xiaoli guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru C.guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British Columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science Core Collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P GC-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple Tin Compounds Modified Carbon Fibers to Construct Heterogeneous Interfaces for Corrosion Prevention and Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第1期17卷 507-527页

作者： Zhiqiang guo Di Lan Zirui Jia Zhenguo Gao Xuetao Shi Mukun He Hua guo Guanglei Wu Pengfei Yin College of Science Sichuan Agricultural UniversityYa’an 625014People’s Republic of China School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002People’s Republic of China Institute of Materials for Energy and Environment State Key Laboratory of Bio‑Fibers and Eco‑TextilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071People’s Republic of China Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China

Currently,the demand for electromagnetic wave(EMW)absorbing materials with specific functions and capable of withstanding harsh environments is becoming increasingly ***-component interface engineering is considered an effective means to achieve high-efficiency EMW ***,interface modulation engineering has not been fully discussed and has great potential in the field of EMW *** this study,multi-component tin compound fiber composites based on carbon fiber(CF)substrate were prepared by electrospinning,hydrothermal synthesis,and high-temperature thermal *** utilizing the different properties of different substances,rich heterogeneous interfaces are *** effectively promotes charge transfer and enhances interfacial polarization and conduction *** prepared SnS/SnS_(2)/SnO_(2)/CF composites with abundant heterogeneous interfaces have and exhibit excellent EMW absorption properties at a loading of 50 wt%in epoxy *** minimum reflection loss(RL)is−46.74 dB and the maximum effective absorption bandwidth is 5.28 ***,SnS/SnS_(2)/SnO_(2)/CF epoxy composite coatings exhibited long-term corrosion resistance on Q235 steel ***,this study provides an effective strategy for the design of high-efficiency EMW absorbing materials in complex and harsh environments.

关键词： Electrostatic spinning Component regulation Heterogeneous interfaces Electromagnetic wave absorption Corrosion protection

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