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氟喹诺酮类药物免疫分析方法的研究进展

食品与发酵工业 2024年第7期50卷 374-382页

作者：王雪晴陈秀金李兆周王耀安彪白玉冰代明慧陈佳琪河南科技大学食品与生物工程学院河南洛阳471000 河南省食品绿色加工与质量安全控制国际联合实验室河南洛阳471000 食品加工与安全国家级实验教学示范中心河南洛阳471000

氟喹诺酮类药物具有广谱高效的优点,现已广泛用于预防和治疗动物的各种感染性疾病。然而,氟喹诺酮类药物长期大量的滥用,在食品中的残留超标,导致体内耐药病原菌的产生,引起人类的耐药性问题。因此,建立快速灵敏的氟喹诺酮类药物检测方... 详细信息

氟喹诺酮类药物具有广谱高效的优点,现已广泛用于预防和治疗动物的各种感染性疾病。然而,氟喹诺酮类药物长期大量的滥用,在食品中的残留超标,导致体内耐药病原菌的产生,引起人类的耐药性问题。因此,建立快速灵敏的氟喹诺酮类药物检测方法具有重要意义。免疫分析法具有高灵敏和低成本的优势,故受到食品安全领域的广泛关注。因此,该文对氟喹诺酮类药物的抗体制备、各种免疫分析方法(包括酶联免疫吸附法、免疫层析法、荧光免疫分析法和免疫传感器)的原理、特点和应用进行总结,并对氟喹诺酮类药物免疫分析方法的发展趋势进行了展望。

关键词：氟喹诺酮类药物酶联免疫吸附法免疫层析法荧光免疫分析法免疫传感器

Responses of ephemeral plant germination and growth to water and heat conditions in the southern part of Gurbantunggut Desert

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Chinese Science Bulletin 2006年第A01期51卷 110-116页

作者： wang xueqing JIANG Jin wang Yuanchao LUO Weilin SONG Chunwu CHEN Junjie Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China Xinjiang Administration of Engineering Construction in Erqis River Basin Urumqi 830000 China Graduate School of Chinese Academy of Sciences Beijing 100039 China

在 Gurbantunggut 沙漠的南部的部分的短暂植物系统地从 2002 ～ 2004 被监视，气象学的数据和土壤潮湿在一样的时期期间被分析。结果证明短暂植物萌芽和生长对水和热状况的变化敏感。超过 0 的每日的温度的时间 ?????????

关键词：短生植物水热环境 Gurbantunggut沙漠积极响应

Fault Tolerant Control of Multiphase Multilevel Motor Drives-Technical Review

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Chinese Journal of Electrical Engineering 2017年第2期3卷 76-86页

作者： Zheng wang xueqing wang Yibo wang Jian Chen Ming Cheng School of Electrical Engineering Southeast UniversityNanjing210096China

The multiphase multilevel motor drives are a promising solution for some high-power and high-reliability applications,since they have multiple power conversion routes,a large amount of redundant voltage vectors,higher equivalent switching frequencies and superior harmonic *** has great significance to exploit their remedial control strategies in depth to fully utilize their high fault tolerant *** paper will present an updated technical review of fault tolerant control schemes for multiphase multilevel motor *** on exemplification of the diode neutral-point-clamping three-level(DNPC-3L)inverters and T-type NPC three-level(TNPC-3L)inverters fed asymmetric six-phase PMSM drives,the study is taken for both phase-leg faults and switch ***,the discussion on multiple-switch faults,short-circuit switch faults and switch and leg hybrid faulty conditions are discussed in this paper.

关键词： Fault tolerant control multiphase multilevel drives modulation strategy phase-level faults switch-level faults

The role of caveolin-1 in the biofate and efficacy of anti-tumor drugs and their nano-drug delivery systems

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Acta Pharmaceutica Sinica B 2021年第4期11卷 961-977页

作者： Canyu Yang Bing He Wenbing Dai Hua Zhang Ying Zheng xueqing wang Qiang Zhang Department of Pharmacy Administration and Clinical Pharmacy School of Pharmaceutical SciencePeking UniversityBeijing 100191China Beijing Key Laboratory of Molecular Pharmaceutics New Drug Delivery SystemsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

As one of the most important components of caveolae,caveolin-1 is involved in caveolaemediated endocytosis and transcytosis pathways,and also plays a role in regulating the cell membrane cholesterol homeostasis and mediating signal *** recent years,the relationship between the expression level of caveolin-1 in the tumor microenvironment and the prognostic effect of tumor treatment and drug treatment resistance has also been widely *** addition,the interplay between caveolin-1 and nano-drugs is ***-1 could determine the intracellular biofate of specifc nano-drugs,preventing from lysosomal degradation,and facilitate them penetrate into deeper site of tumors by transcytosis;while some nanocarriers could also affect caveolin-1 levels in tumor cells,thereby changing certain biophysical function of *** article reviews the role of caveolin-1 in tumor prognosis,chemotherapeutic drug resistance,antibody drug sensitivity,and nano-drug delivery,providing a reference for the further application of caveolin-1 in nano-drug delivery systems.

关键词： Caveolin-1 Cancer Drug resistance Transcytosis Nano-drug delivery systems Biofate

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生牛乳中游离寡糖的提取工艺优化

食品研究与开发 2024年第1期45卷 138-146页

作者：孙超仁王凤玲王雪青赵焯然黄璜天津商业大学生物技术与食品科学学院天津市食品生物技术重点实验室天津300134

为提取生牛乳中游离寡糖,并且排除乳中蛋白质和乳糖的干扰,利用乙腈在不同提取条件(反应时间、相对离心力、反应温度和料液比)下去除蛋白质沉淀并提取总糖,并通过优化Sep-Pak C18固相柱和石墨碳柱条件对游离寡糖进行富集、纯化,减少乳... 详细信息

为提取生牛乳中游离寡糖,并且排除乳中蛋白质和乳糖的干扰,利用乙腈在不同提取条件(反应时间、相对离心力、反应温度和料液比)下去除蛋白质沉淀并提取总糖,并通过优化Sep-Pak C18固相柱和石墨碳柱条件对游离寡糖进行富集、纯化,减少乳糖的干扰,利用高效液相色谱法测定乳糖去除率。结果显示,生牛乳中寡糖最佳提取条件为反应时间2.5 h,相对离心力4 000×g,反应温度-1℃,料液比1∶2(g/mL)。在该提取条件下,蛋白质去除率为93.5%,总糖含量为48.42 mg/mL。利用4%乙腈(含0.1%三氟乙酸)冲洗石墨碳柱可将游离寡糖样品中大部分乳糖去除,乳糖去除率达98.91%。

关键词：生牛乳游离寡糖提取工艺衍生化液相色谱

Thermal-physiological Strategies Underlying the Sympatric Occurrence of Three Desert Lizard Species

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Asian Herpetological Research 2019年第3期10卷 190-196页

作者： xueqing wang Shuran LI Li LI Fushun ZHANG Xingzhi HAN Junhuai BI Baojun SUN College of Life Science Inner Mongolia Normal UniversityHohhot010022Inner MongoliaChina Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing100101China College of Life and Environmental Science Wenzhou UniversityWenzhou325035ZhejiangChina Grassland research institute Chinese Academy of Agricultural SciencesHohhot010010Inner MongoliaChina College of wildlife Resources Northeast Forestry UniversityHarbin150040HeilongjiangChina

Sympatric reptiles are the ideal system for investigating temperature-driven coexistence. Understanding thermally physiological responses of sympatric lizards is necessary to reveal the physiological mechanisms that underpin the sympatric occurrence of reptiles. In this study, we used three lizard species, Eremias argus, E. multiocellata, and Phrynocephalus przewalskii, which are sympatric in the Inner Mongolia desert steppe, as a study system. By comparing their resting metabolic rates(RMR) and locomotion at different body temperatures, we aimed to better understand their physiological responses to thermal environments, which may explain the sympatric occurrence of these lizards. Our results showed that E. argus had significantly higher RMR and sprint speed than E. multiocellata, and higher RMR than P. przewalskii. In addition, the optimal temperature that maximized metabolic rates and locomotion for E. argus and E. multiocellata was 36°C, whereas for P. przewalskii it was 39°C. Our study revealed the physiological responses to temperatures that justify the sympatric occurrence of these lizards with different thermal and microhabitat preferences and active body temperatures. Eremias argus and E. multiocellata, which have lower body temperatures than P. przewalskii, depend on higher RMR and locomotion to compensate for their lower body temperatures in field conditions. Our study also highlights the importance of using an integrative approach, combining behavior and physiology, to explore the basis of sympatric occurrence in ectothermic species.

关键词： Sympatric lizards resting metabolic rate locomotion Eremias argus E.multiocellata Phrynocephalus przewalskii

A reciprocal inhibitory module for Pi and iron signaling

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Molecular Plant 2022年第1期15卷 138-150页

作者： Meina Guo Wenyuan Ruan Yibo Zhang Yuxin Zhang xueqing wang Zhenhui Guo Long wang Tian Zhou Javier Paz-Ares Keke Yi Key Laboratory of Plant Nutrition and Fertilizer Ministry of AgricultureInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China Department of Plant Molecular Genetics Centro Nacional de Biotecnología-Consejo Superior de Investigaciones Cientificas28049 MadridSpain

Phosphorous(P)and iron(Fe),two essential nutrients for plant growth and development,are highly abundant elements in the earth's crust but often display low availability to *** to the ability to form insoluble complexes,the antagonistic interaction between P and Fe nutrition in plants has been noticed for ***,the underlying molecular mechanism modulating the signaling and homeostasis between them re-mains ***,we show that the possible iron sensors HRZs,the iron deficiency-induced E3 ligases,could interact with the central regulator of phosphate(Pi)signaling,PHR2,and prompt its ubiquitination at lysine residues K319 and K328,leading to its degradation in *** with this,the hrzs mutants dis-played a high Pi accumulation ***,we found that iron deficiency could attenuate Pi star-vation signaling by inducing the expression of HRZs,which in turn trigger PHR2 protein ***-estingly,on the other hand,rice PHRs could negatively regulate the expression of HRZs to modulate iron deficiency ***,PHR2 and HRZs form a reciprocal inhibitory module to coordinate Pi and iron signaling and homeostasis in *** together,our results uncover a molecular link between Pi and iron master regulators,which fine-tunes plant adaptation to Pi and iron availability in rice.

关键词： Phosphate(Pi) Iron(Fe) PHRs HRZs Pi/Fe signaling and homeostasis

Multiple isotopes reveal the driving mechanism of high NO_(3)^(-) level and key processes of nitrogen cycling in the lower reaches of Yellow River

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Journal of Environmental Sciences 2024年第4期138卷 597-606页

作者： Qianqian Zhang Huiwei wang Lu Liu Tianlun Zhai xueqing Zhang Hebei and China Geological Survey Key Laboratory of Groundwater Remediation Institute of Hydrogeology and Environmental GeologyChinese Academy of Geological SciencesHebei 050061China Geo-Environmental Monitoring Institute of Hebei Province Hebei 050011China Hebei Provincial Laboratory of Water Environmental Science Hebei 050037China Hebei Provincial Academy of Ecological Environmental Science Hebei 050037China

The continuous increase of nitrate(NO_(3)^(-))level in rivers is a hot issue in the ***,the driving mechanism of high NO_(3)^(-)level in large rivers is still lacking,which has limited the use of river water and increased the cost of water *** this study,multiple isotopes and source resolution models are applied to identify the driving mechanism of high NO_(3)^(-)level and key processes of nitrogen cycling in the lower reaches of the Yellow River(LRYR).The major sources of NO_(3)^(-)were sewage and manure(SAM)in the low-flow season and soil nitrogen(SN)and chemical fertilizer(CF)in the high-flow *** was the most key process of nitrogen cycling in the ***,in the biological removal processes,denitrification may not occur *** temporal variation of contributions of NO_(3)^(-)sources were estimated by a source resolution model in the *** proportional contributions of SAM and CF to NO_(3)^(-)in the low-flow and high-flow season were 32.5%-52.3%,44.2%-46.2%and 36.0%-40.8%,54.9%-56.9%,*** driving mechanisms of high NO_(3)^(-)level were unreasonable sewage discharge,intensity rainfall runoff,nitrification and lack of nitrate removal *** control the NO_(3)^(-)concentration,targeted measures should be implemented to improve the capacity of sewage and wastewater treatment,increase the utilization efficiency of nitrogen fertilizer and construct ecological *** study deepens the understanding of the driving mechanism of high nitrate level and provides a vital reference for nitrogen pollution control in rivers to other area of the world.

关键词： Nitrate Driving mechanism Nitrogen cycle Source apportionment Transformation Yellow River

Dual-targeting nanovesicles enhance specificity to dynamic tumor cells in vitro and in vivo via manipulation of αvβ3-ligand binding

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Acta Pharmaceutica Sinica B 2020年第11期10卷 2183-2197页

作者： Yang Song Xiangfu Guo Jijun Fu Bing He xueqing wang Wenbing Dai Hua Zhang Qiang Zhang Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijing 100191China Guangzhou Medical University School of Pharmaceutical SciencesGuangzhou 511436China

The dynamic or flowing tumor cells just as leukemia cells and circulating tumor cells face a microenvironment difference from the solid tumors,and the related targeting nanomedicines are rarely *** existence of fluidic shear stress in blood circulation seems not favorable for the binding of ligand modified nanodrugs with their target ***,the binding feature is very essential in this ***,we utilized HSPC,PEG-DSPE,cholesterol and two avb3 ligands(RGDm7 and DT4)with different binding rates to build dual-targeting nanovesicles,in an effort to achieve a"fast-binding/slow-unbinding"*** was demonstrated that the dual-targeting nanovesicles actualized effi-cient cellular uptake and antitumor effect in vitro both for static and dynamic tumor ***,the potency of the dual-targeting vesicles for flowing tumor cells was better than that for static tumor ***,a tumor metastasis mice model and a leukemia mice model were established to detect the killing ability of the drug-loaded dual-targeting vesicles to dynamic tumor cells in *** therapy efficacy of the dual-targeting system was higher than other controls including single-targeting ***,it seems possible to strengthen drug-targeting to dynamic tumor cells via the control of ligandereceptor interaction.

关键词： Dual-targeting Lipid vesicle Flowing condition Leukemia Circulating tumor cells Fluidic shear stress