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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-Ying Ji feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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Descent of Ordinary Differential Equations with Rational General Solutions

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Journal of Systems Science & Complexity 2020年第6期33卷 2114-2123页

作者： feng Shuang feng Ruyong KLMM Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China School of Mathematics University of Chinese Academy of SciencesChinese Academy of SciencesBeijing100190China

Let F be an irreducible differential polynomial over k(t)with k being an algebraically closed field of characteristic *** authors prove that F=0 has rational general solutions if and only if the differential algebraic function field over k(t)associated to F is generated over k(t)by constants,i.e.,the variety defined by F descends to a variety over *** a consequence,the authors prove that if F is of first order and has movable singularities then F has only finitely many rational solutions.

关键词： Algebraic ordinary differential equation differential descent rational general solution

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Metabolic pathway modulation by olanzapine:Multitarget approach for treating violent aggression in patients with schizophrenia

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World Journal of Psychiatry 2025年第1期15卷 37-53页

作者： Yan-Ning Song Shuang Xia Zhi Sun Yong-Chao Chen Lu Jiao Wen-Hua Wan Hong-Wei Zhang Xiao Guo Hua Guo Shou-feng Jia Xiao-Xin Li Shi-Xian Cao Li-Bin Fu Meng-Meng Liu Tian Zhou Lv-feng Zhang Qing-Quan Jia Department of Pharmacy The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Pharmacy The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Pharmacy Zhumadian First People's HospitalZhumadian 463000Henan ProvinceChina Scientific Education Section The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Department of Psychiatry The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Clinical Laboratory The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina Publicity Division The Affiliated Encephalopathy Hospital of Zhengzhou University(Zhumadian Second People's Hospital)Zhumadian 463000Henan ProvinceChina

BACKGROUND The use of network pharmacology and blood metabolomics to study the patho-genesis of violent aggression in patients with schizophrenia and the related drug mechanisms of action provides new directions for reducing the risk of violent aggression and optimizing treatment *** To explore the metabolic regulatory mechanism of olanzapine in treating patients with schizophrenia with a moderate to high risk of violent *** Metabolomic technology was used to screen differentially abundant metabolites in patients with schizophrenia with a moderate to high risk of violent aggression before and after olanzapine treatment,and the related metabolic pathways were *** pharmacology was used to establish protein-protein interaction networks of the core targets of *** Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were subsequently *** Compared with the healthy group,the patients with schizophrenia group presented significant changes in the levels of 24 metabolites related to the disruption of 9 metabolic pathways,among which the key pathways were the alanine,aspartate and glutamate metabolism and arginine biosynthesis *** treatment with olanzapine,the levels of 10 differentially abundant metabolites were significantly reversed in patients with *** effectively regulated six metabolic pathways,among which the key pathways were alanine,aspartate and glutamate metabolism and arginine biosynthesis *** core targets of olanzapine were involved in several key *** The metabolic pathways of alanine,aspartate,and glutamate metabolism and arginine biosynthesis are the key pathways involved in olanzapine treatment for aggressive schizophrenia.

关键词： Schizophrenia Violent aggression Olanzapine Metabolomics Network pharmacology

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Synergistic effects of hyperthermia and cisplatin on human lung adenocarcinoma cell line H1299

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The Chinese-German Journal of Clinical Oncology 2007年第1期6卷 5-8页

作者： xueqin Ghen Shenglin Ma Hanzhou Mou Jianguo feng Department of Tumor Hangzhou First People＇s Hospital Hangzhou 310006 China Institute of Oncology Zhejiang Cancer Hospital Hangzhou 310022 China

Objective： To observe the synergistic effects of hyperthernia and cisplatin on human lung adenocarcinoma cell line H 1299. Methods： Cells treated with or without hyperthermia at 42 ℃ for 2 h were detected cisplatin sensitivity with CCK-8 assay. After managed with hyperthermia at 42 ℃ for 2 h, ciplatin 10 μg/mL for 24 h or both of two sides, inhibition ratio was detected with CCK-8 assay and flow cytometry analyzed DNA contents in every phase of cell proliferation. Results： After hyperthermia, IC50 values of cell to cisplatin decreased from 9.51 μg/mL to 6.07 μg/mL. CCK-8 assay showed hyperthermia and ciplatin had synergistic killing effects, and FCM also showed hyperthermia had significant effects on cell cycle with increase of Go/G1 phase population and reduction of S phase population. Conclusion： Hyperthermia can significantly increase the sensitivity of H1299 cell line to cisplatin.

关键词： hyperthermia cisplatin lung neoplasms cytotoxicity cell cycle

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Determination of Metalaxyl Residues in Watermelon and Banana by HPLC

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Plant Diseases and Pests 2014年第4期5卷 35-38页

作者： Zheng Xuehong Fu xueqin Pan Yongbo Xie Defang feng Xinping Analyzing and Testing Center CATAS Laboratory of Quality & Safety Risk Assessment for Tropical Products Ministry of Agriculture Hubei Branch of China Seed Group Co. Ltd.

A determination method for metalaxyl （MEL） residues in watermelon and banana had been established by automated solid-phase extraction （SPE） cou- pled with high performance liquid hromatography （HPLC）. Samples were extracted by acetonitrile, homogenized, filtrated, extracted by automated solid-phase ex- traction （SPE）, and finally purified by C18 column. The experiment was carried on SunFireTM C18 column with the mobile phase of acetonitrile-water-methanol （25： 40： 35, by vol） at the flow rate of 1.0 mL/min. The detection wavelength and injection volume were set at 220 nm and 10 uL, respectively. The recoveries of three different concentrations （0.02, 0.20, 1.00 mg/kg） for watermelon and banana were 94.3 % - 101.0% and 81.5% - 99.6%, respectively. RSD （ n = 5 ） were 1.30% -5.29% and 2.66% -6.67%, respectively. The lower detection limit for metalaxyl was 0. 006 mg/kg. This method met with the requirements of pesticide residue detection. Key words Metalaxyl; HPLC; Watermelon; Banana

关键词： Metalaxyl HPLC Watermelon Banana

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Nucleation/growth design by thermo-kinetic partition

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Journal of Materials Science & Technology 2023年第24期155卷 72-81页

作者： feng Liu Analytical & Testing Center Northwestern Polytechnical University Xi'an Shaanxi 710072 China State Key Lab. of Solidification Processing Northwestern Polytechnical University Xi'an Shaanxi 710072 China

Departing from nucleation and growth involved in phase transformations (PTs) and/or plastic deformations (PDs), thermodynamics, kinetics, and thermo-kinetic partition are described. It has been shown that the thermo-kinetic partition reflects the scale of the so-called thermo-kinetic correlation, and by combining with the reference state of PT or PD, corresponds to so-called generalized stability. Regarding the universality of nucleation/growth and thermo-kinetic partition, the principle of high thermodynamic driving force-high generalized stability has been reinterpreted by integrating nucleation and growth, separating nucleation and growth, and designing so-called negative driving forces, respectively. As such, the current materials design is classified, summarized, and prospected. This work is helpful to realize high strength and high plasticity by designing nucleation and growth.

关键词： Nucleation Growth Thermo-kinetic partition

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Modern pollen assemblages of the surface lake sediments from the steppe and desert zones of the Tibetan Plateau

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Science China Earth Sciences 2021年第3期64卷 425-439页

作者： feng QIN Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China

Modern pollen analysis is the basis for revealing the palaeovegetation and palaeoclimate changes from fossil pollen *** studies pertaining to the modern pollen assemblages on the Tibetan Plateau have been conducted,but little attention has been paid to pollen assemblages of surface lake *** this study,modern pollen assemblages of surface lake sediments from 34 lakes in the steppe and desert zones of the Tibetan Plateau are investigated and results indicate that the two vegetation zones are dominated by non-arboreal pollen taxa and show distinctive *** pollen assemblages from the desert zone contain substantially high relative abundance of Chenopodiaceae while those from the steppe zone are dominated by *** ratios show great potential in terms of separating different vegetation zones and to indicate climate changes on the Tibetan *** Artemisia/Chenopodiaceae ratio and arboreal/non-arboreal pollen ratio could be used as proxies for winter ***/Cyperaceae ratio and the sum of relative abundance of xerophilous elements increase with enhanced warming and *** considering the vegetation coverage around the lakes,hierarchical cluster analysis suggests that the studied sites can be divided into four clusters:meadow,steppe,desert-steppe,and *** pollen-based vegetation classification models are established using a random forest *** random forest model can effectively separate the modern pollen assemblages of the steppe zone from those of the desert zone on the Tibetan *** model for distinguishing the four vegetation clusters shows a weaker but still valid classifying *** is expected that the random forest model can provide a powerful tool to reconstruct the palaeovegetation succession on the Tibetan Plateau when more pollen data from surface lake sediments are included.

关键词： Modern pollen assemblage Tibetan Plateau Surface lake sediment Pollen-climate relationship Pollen-based vegetation classification model

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基于特征融合和模板更新的孪生网络跟踪算法

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电光与控制 2025年第1期32卷 41-47,85页

作者：吴国瑞王峰李杰太原理工大学电子信息与光学工程学院山西晋中030000 太原理工大学电气与动力工程学院太原030000

针对现有孪生网络跟踪算法仅使用主干网络最后一层的特征进行相似度匹配,以及缺少有效模板更新策略的问题,提出基于多尺度特征融合和自适应模板更新的孪生网络跟踪算法。首先,结合深度过参数化卷积设计非填充单元,提取更深层的前景特征... 详细信息

针对现有孪生网络跟踪算法仅使用主干网络最后一层的特征进行相似度匹配,以及缺少有效模板更新策略的问题,提出基于多尺度特征融合和自适应模板更新的孪生网络跟踪算法。首先,结合深度过参数化卷积设计非填充单元,提取更深层的前景特征和语义背景;然后,设计新的全局-局部特征融合模块,充分聚合浅、中层特征的全局和局部信息,捕获丰富的浅层外观特征和中层过渡特征;最后,采用自适应模板更新机制在线更新模板。为验证算法的有效性,在公开数据集上对所提算法进行详尽评估,实验结果显示,所提算法在OTB2015和VOT2018数据集上的精确度分别达到0.878和0.588,GOT10K数据集上平均重叠率达到0.526,优于其他主流算法。

关键词：目标跟踪孪生网络计算机应用多层特征融合模板更新

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Azobenzene‑Based Solar Thermal Fuels:A Review

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Nano-Micro Letters 2022年第8期14卷 232-268页

作者： Bo Zhang Yiyu feng Wei feng School of Materials Science and Engineering Tianjin UniversityTianjin 300350People’s Republic of China Tianjin Key Laboratory of Composite and Functional Materials Tianjin 300350People’s Republic of China Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou 450002People’s Republic of China

The energy storage mechanism of azobenzene is based on the transformation of molecular cis and trans isomerization,while NBD/QC,DHA/VHF,and fulvalene dimetal complexes realize the energy storage function by changing the molecular *** as“molecular batteries,”they can exhibit excellent charging and discharging behavior by converting between trans and cis isomers or changing molecular structure upon absorption of ultraviolet *** properties determining the performance of STFs are stored energy,energy density,half-life,and solar energy conversion *** review is aiming to provide a comprehensive and authoritative overview on the recent advancements of azobenzene molecular photoswitch system in STFs fields,including derivatives and carbon nano-templates,which is emphasized for its attractive *** the energy storage performance of Azo-STFs has already reached the level of commercial lithium batteries,the cycling capability and controllable release of energy still need to be further *** this,some potential solutions to the cycle performance are proposed,and the methods of azobenzene controllable energy release are ***,energy stored by STFs can be released in the form of mechanical energy,which in turn can also promote the release of thermal energy from STFs,implying that there could be a relationship between mechanical and thermal energy in Azo-STFs,providing a potential direction for further research on Azo-STFs.

关键词： Azobenzene Solar thermal fuels Nanocarbon template Controllable energy release Phase change materials

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State estimate for stochastic systems with dual unknown interference inputs

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Chinese Journal of Aeronautics 2020年第9期33卷 2395-2407页

作者： Xiaoxue feng Shuhui LI feng PAN School of Automation Beijing Institute of TechnologyBeijing 100081China Kunming-BIT Industry Technology Research Institute INC Kunming 650106China

Stochastic system state estimation subject to the unknown interference input widely exists in many fields,such as the control,communication,signal processing,and fault ***,the research results are mostly limited to the stochastic system in which only the dynamic state model or the measurement model concerns the individual unknown interference input,and the state model and the measurement model are both with the same unknown interference *** estimate of the stochastic systems where the state model and the measurement model contain dual Unknown Interference inputs(dual-UI)with different physical meanings and mathematical definitions is concerned ***,the decoupling condition with the Unknown Interference input in the State model(S-UI)is shown,which introduces the decoupled system with the adjacent Measurement concerned Unknown Interference inputs(M-UI)appearing in the state model and the measurement ***,through defining the Differential term of the adjacent M-UI(M-UID),the equivalent system with only M-UID in the state model is ***,considering the design freedom of the equivalent system,the decoupling filter in the minimum mean square error sense and the adaptive minimum upper filter with different applicable conditions are represented to obtain the optimal and sub-optimal state estimate,*** simulation cases verify the effectiveness and superiority compared with the traditional methods.

关键词： Adaptive filter Decoupling filter State estimate Stochastic system Unknown interference input

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