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Aldh2 deficiency plays a dual role in lung tumorigenesis and tumor progression

Genes & Diseases 2024年第3期11卷 144-147页

作者： Hongjia Zhang xueqian sun Zhanming Li Tingting Liu Fang Zhang Xinyu Meng Kaimi Li Jianhua Xu Wei He Bo Jing Tong Wang Na Ni Beibei sun Feng Yao Yadi Wu Qi Wang Jing Du Eugene Y.Chin Binhua P.Zhou Ping Jiang Lishun Wang Jiong Deng Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education Department of PathophysiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory for Tumor Microenvironment and Inflammation Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Pathology Kunming Medical UniversityKunmingYunnan 650500China Medical Research Center Binzhou Medical University HospitalBinzhouShandong 256600China Center for Traditional Chinese Medicine and Gut Microbiota Minhang HospitalFudan UniversityShanghai 201100China Department of Radiation Oncology Yantai Affiliated Hospital of Binzhou Medical UniversityYantaiShandong 264100China Department of Pathology Molecular Pathology Research CenterPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Laboratory Medicine Shanghai Pulmonary Hospital Affiliated Tongji UniversityShanghai 200080China Department of Physiology School of Basic Medical SciencesWeifang Medical UniversityWeifangShandong 261021China Department of Thoracic Surgery Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Molecular and Celular Biochemistry Markey Cancer CenterUniversity of Kentucky College of MedicineLexingtonKY40506USA Department of Respiratory Medicine The Second Affiliated HospitalDalian Medical UniversityDalianLiaoning116023China Peninsular Cancer Center Binzhou Medical UniversityYantaiShandong 264003China

Alcohol consumption contributes to global mortality and cancer ***(ACE),the oxidized metabolite of alcohol,is highly reactive towards DNA,resulting in DNA *** can be detoxified to acetate by acetaldehyde dehydrogenase... 详细信息

关键词： mortality damage ALDH2

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多基原中药质量评价研究进展

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中草药 2024年第12期55卷 4214-4224页

作者：孙雪倩杨彬李遇伯天津中医药大学中药学院天津301617

多基原中药质量评价是保障其临床用药有效性和安全性的重要环节。目前,多基原中药质量评价仍存在基原鉴定方法专属性较差,多基原中药品种间药效和毒性物质基础不明确,有效性、安全性数据缺乏等问题。近年来,围绕多基原中药质量评价涌现... 详细信息

多基原中药质量评价是保障其临床用药有效性和安全性的重要环节。目前,多基原中药质量评价仍存在基原鉴定方法专属性较差,多基原中药品种间药效和毒性物质基础不明确,有效性、安全性数据缺乏等问题。近年来,围绕多基原中药质量评价涌现出许多新思路、新模式及新方法。在整理《中国药典》2020年版收载的多基原中药概况的基础上,对多基原中药基原鉴定及质量评价新思路、新方法进行综述。为完善多基原中药质量评价体系,保障多基原中药临床用药的有效性和安全性提供支持。

关键词：多基原中药质量评价有效性安全性基原鉴定

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The Asymmetric Connection of SST in the Tasman Sea with Respect to the Opposite Phases of ENSO in Austral Summer

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Advances in Atmospheric Sciences 2022年第11期39卷 1897-1913页

作者： xueqian sun Shuanglin LI Stefan LIESS Climate Change Research Center(CCRC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Atmospheric Science/Centre for Severe Weather and Climate and Hydro-geological Hazards China University of GeosciencesWuhan 430074China College of Earth and Planetary Science University of Chinese Academy of SciencesBeijing 100049China Department of Soil Waterand ClimateUniversity of MinnesotaTwin CitiesSt.Paul MN 55108MinnesotaUSA

This study uses linear regression and composite analyses to identify a pronounced asymmetric connection of sea surface temperature(SST)in the Tasman Sea with the two opposite phases of El Ni?o-Southern Oscillation(ENSO)during austral *** El Ni?o years,the SST anomalies(SSTAs)in the Tasman Sea exhibit a dipolar pattern with weak warmth in the northwest and modest cooling in the southeast,while during La Ni?a years the SSTAs exhibit a basin-scale warmth with greater *** into the underlying mechanism suggest that this asymmetry arises from a mechanism related to oceanic heat transport,specifically the anomalous Ekman meridional heat transport induced by the zonal wind stress anomalies,rather than the surface heat fluxes on the air-sea *** analysis reveals that the asymmetry of oceanic heat transport between El Ni?o and La Ni?a years is driven by the asymmetric atmospheric circulation over the Tasman Sea stimulated by the asymmetric diabatic heating in the tropical Pacific between the two opposite ENSO phases.

关键词： El Ni?o-Southern Oscillation SST in the Tasman Sea asymmetric connection surface heat fluxes oceanic heat transport

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以轻烧镁粉为镁源的MAP沉淀法去除废水中氨氮研究

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山西化工 2024年第4期44卷 240-242页

作者：黄骏攀孙雪倩王楠攀枝花市仁和生态环境监测站四川攀枝花617061 攀枝花市米易生态环境监测站四川攀枝花617061 四川劳研科技有限公司四川攀枝花617061

向氨氮废水中投加磷源和镁源可以形成磷酸铵镁(MAP)沉淀。本实验采用轻烧镁粉作为MAP法的镁源,考察了磷源与镁源配比、反应时间等因素对氨氮去除率的影响,确定了最佳反应条件。实验结果表明:当N、Mg、P物质的量比为1∶8∶1(将轻烧镁粉... 详细信息

向氨氮废水中投加磷源和镁源可以形成磷酸铵镁(MAP)沉淀。本实验采用轻烧镁粉作为MAP法的镁源,考察了磷源与镁源配比、反应时间等因素对氨氮去除率的影响,确定了最佳反应条件。实验结果表明:当N、Mg、P物质的量比为1∶8∶1(将轻烧镁粉看作纯氧化镁计算)、反应时间为50 min时,氨氮去除率达到90%。

关键词：轻烧镁粉氨氮磷酸铵镁沉淀

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藏猪和大约克猪INHBA基因多态性及差异表达分析

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高原农业 2024年第2期8卷 163-170页

作者：孙雪倩段梦琪周林聪商鹏张健西藏农牧学院动物科学学院西藏自治区农业科技园区西藏林芝860000 江苏省南通市通州区金沙中学江苏南通226000

为探究INHBA基因在藏猪与大约克猪中的多态性与表达差异。在DNA水平上对藏猪、大约克猪INHBA基因5'侧翼区和CDS区进行了单核苷酸多态性(Single nucleotide polymorphism,SNP)位点筛选,同时在mRNA水平上用荧光定量PCR(qRT-PCR)方法检测IN... 详细信息

为探究INHBA基因在藏猪与大约克猪中的多态性与表达差异。在DNA水平上对藏猪、大约克猪INHBA基因5'侧翼区和CDS区进行了单核苷酸多态性(Single nucleotide polymorphism,SNP)位点筛选,同时在mRNA水平上用荧光定量PCR(qRT-PCR)方法检测INHBA基因在卵巢组织中的相对表达量。结果发现:INHBA基因在5'侧翼区存在一个突变位点A-1589T,并在藏猪与大约克猪2个品种间存在极显著差异(P<0.01);经转录因子预测,发现该突变位点与繁殖性能相关,并推测消失的转录因子结合位点可能是导致藏猪繁殖力低的主要原因之一。INHBA基因在卵巢中,藏猪表达量极显著高于大约克猪(P<0.01),推测INHBA基因可能与猪繁殖性能有关,并对提高猪的繁殖性能起到积极作用。本研究结果为进一步探究INHBA基因在猪繁殖性能的作用机制提供理论支撑。

关键词：藏猪 INHBA基因繁殖性能基因表达

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Comparative Analysis of the Mechanisms of Intensified Summer Warming over Europe-West Asia and Northeast Asia since the Mid-1990s through a Process-based Decomposition Method

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Advances in Atmospheric Sciences 2019年第12期36卷 1340-1354页

作者： xueqian sun Shuanglin LI Bo LIU Climate Change Research Center(CCRC) and Nansen-Zhu International Research CentreInstitute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Atmospheric Science China University of GeosciencesWuhan 430074China College of Earth and Planetary Science University of Chinese Academy of SciencesBeijing 100049China

Previous studies have found amplified warming over Europe-West Asia and Northeast Asia in summer since the mid- 1990s relative to elsewhere on the Eurasian continent, but the cause of the amplification in these two regions remains unclear. In this study, we compared the individual contributions of influential factors for amplified warming over these two regions through a quantitative diagnostic analysis based on CFRAM (climate feedback-response analysis method). The changes in surface air temperature are decomposed into the partial changes due to radiative processes (including CO2 concentration, incident solar radiation at the top of the atmosphere, surface albedo, water vapor content, ozone concentration, and clouds) and non-radiative processes (including surface sensible heat flux, surface latent heat flux, and dynamical processes). Our results suggest that the enhanced warming over these two regions is primarily attributable to changes in the radiative processes, which contributed 0.62 and 0.98 K to the region-averaged warming over Europe-West Asia (1.00 K) and Northeast Asia (1.02 K), respectively. Among the radiative processes, the main drivers were clouds, CO2 concentration, and water vapor content. The cloud term alone contributed to the mean amplitude of warming by 0.40 and 0.85 K in Europe-West Asia and Northeast Asia, respectively. In comparison, the non-radiative processes made a much weaker contribution due to the combined impact of surface sensible heat flux, surface latent heat flux, and dynamical processes, accounting for only 0.38 K for the warming in Europe-West Asia and 0.05 K for the warming in Northeast Asia. The resemblance between the influential factors for the amplified warming in these two separate regions implies a common dynamical origin. Thus, this validates the possibility that they originate from the Silk Road pattern.

关键词： CFRAM(climate feedback-response analysis method) amplified summer warming radiative processes nonradiative processes

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Two-dimensional materials for light emitting applications:Achievement,challenge and future perspectives

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Nano Research 2021年第6期14卷 1912-1936页

作者： Yi Zhu xueqian sun Yilin Tang Lan Fu Yuerui Lu Engineering and Computer Science the Australian National UniversityCanberraACT2601Australia Department of Electronic Materials Engineering Research School of Physics and Engineeringthe Australian National UniversityCanberraACT2601Australia

The two-dimensional(2D)materials have been widely developed recently in material characteristics with advanced optical and electrical properties,and they have been extensively studied as candidates for the next generation of optoelectronic *** review will mainly focus on the preparation methods and the light emitting applications of 2D transition metal dichalcogenides(TMDs),2D black phosphorene(BP)and 2D *** review will first introduce the preparation methods for TMDs and *** to the variations of band structure,exciton binding energies and light-matter interaction in TMDs and BP,the different light emitting devices(LEDs)designs based on TMDs and BP will be discussed and *** the review will turn the focus to 2D perovskites,starting with a description of the preparation methods for the different structural *** order to review and summarize the achievements of 2D perovskites-based LEDs,the high efficiency perovskites LEDs are ***,the review will present challenges,opportunities,and outlook for the future development of 2D materials-based light emitting applications.

关键词： two-dimensional materials light emitting devices optoelectronic devices perovskite transition metal dichalcogenides(TMDs) perovskite light emitting device(LED)

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Simulated Influence of the Atlantic Multidecadal Oscillation on Summer Eurasian Nonuniform Warming since the Mid-1990s

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Advances in Atmospheric Sciences 2019年第8期36卷 811-822页

作者： xueqian sun Shuanglin LI Xiaowei HONG Riyu LU Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Department of Atmospheric Science China University of GeosciencesWuhan 430074China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

Based on ensemble experiments with three atmospheric general circulation models(AGCMs), this study investigates the role of the Atlantic Multidecadal Oscillation(AMO) in shaping the summer nonuniform warming over the Eurasian continent since the mid-1990 s. The results validate that the positive-phase AMO can indeed cause nonuniform warming,with predominant amplified warming over Europe–West Asia and Northeast Asia, but with much weaker warming over Central Asia. The underlying mechanism is then diagnosed from the perspective that the boundary forcing modulates the intrinsic atmospheric variability. The results highlight the role of the Silk Road Pattern(SRP), an intrinsic teleconnection pattern across the subtropical Eurasian continent propagating along the Asian jet. The SRP can not only be identified from the AGCM control experiments with the climatological sea surface temperature(SST), but can also be simulated by the AMO-related SST anomaly(SSTA) forcing. Furthermore, diagnostic linear baroclinic model experiments are conducted, and the results suggest that the SRP can be triggered by the AMO-related tropical diabatic heating. The AMO-triggered SRP-like responses feature anticyclonic circulations over Europe–West Asia and Northeast Asia, but cyclonic circulation over Central Asia. These responses cause increased warm advection towards Europe–West Asia and Northeast Asia, reduced precipitation and cloud cover, and then increased downward shortwave radiation. This increased warm advection and increased downward shortwave radiation together cause amplified warming in Europe–West Asia and Northeast Asia. The situation is opposite for Central Asia.

关键词： Atlantic Multidecadal Oscillation nonuniform warming Silk Road Pattern

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Highly Efficient Broadband Achromatic Microlens Design Based on Low-Dispersion Materials

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Engineering 2024年第7期38卷 194-200页

作者： xueqian Wang Chuanbao Liu Feilou Wang Weijia Luo Chengdong Tao Yuxuan Hou Lijie Qiao Ji Zhou Jingbo sun Yang Bai Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China School of Materials and Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Metalenses with achromatic performance offer a new opportunity for high-quality imaging with an ultracompact configuration;however,they suffer from complex fabrication processes and low focusing *** this study,we propose an efficient design method for achromatic microlenses on a wavelength scale using materials with low dispersion,an adequately designed convex surface,and a thickness profile *** taking into account the absolute chromatic aberration,relative focal length shift(FLS),and numerical aperture(NA),microlens with a certain focal length can be realized through our realized map of geometric ***,the designed achromatic microlenses with low-dispersion fused silica were fabricated using a focused ion beam,and precise surface profiles were *** fabricated microlenses exhibited a high average focusing efficiency of 65%at visible wavelengths of 410-680 nm and excellent achromatic capability via white light ***,the design exhibited the advantages of being polarization-insensitive and *** results demonstrate the effectiveness of our proposed achromatic microlens design approach,which expands the prospects of miniaturized optics such as virtual and augmented reality,ultracompact microscopes,and biological endoscopy.

关键词： Broadband achromatic focusing Metamaterials Low dispersion materials Visible wavelength Microlenses

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Divergent responses of runoff to climate change in the upper basins of the Third Pole dominated by westerlies and monsoon

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Science China Earth Sciences 2024年第8期67卷 2592-2614页

作者： Qikai sun Fengge SU He sun State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China

The diverse climates,distribution of snow and glaciers,and geographic locations directly affect the runoff response to climate change in the upper basins of the Third *** present,a comprehensive analysis of runoff variations and their distinct responses to climate change in the westerlies-and monsoon-dominated upper basins is still *** study comprehensively analyzed annual runoff variations in westerlies-dominated basins(the upper basins of the Aksu(UAKS),Syr Darya(USRD),Yarkant(UYK),Hotan(UHT),Amu Darya(UAMD),and Indus(UI))and monsoon-dominated basins(the upper basins of the Yangtze(UYA),Yellow(UYE),Lancang(ULC),Nujiang(UNJ),and Yarlung Zangbo(UYZ))of the Third Pole from 1961 *** multi-source meteorological data and large-scale circulation factors,this study investigated the divergent responses of runoff in the upper basins to climate change,and explored the large-scale circulation mechanisms underlying runoff variations in these upper *** results showed that:(1)The annual runoff in the majority of upper basins(except for the UYE and UYZ)exhibited an increasing trend,and the annual runoff in the UAKS,UYK,and UI showed a significant increasing trend from1961 to *** annual runoff in the upper basins of the Third Pole changed abruptly from decreasing to increasing between the 1980s and 2000s,with the exception of the UYE.(2)The runoff in the monsoon-dominated upper basins has been controlled primarily by changes in precipitation over the past 55 *** contrast,the runoff in the westerlies-dominated upper basins exhibited three distinct long-term responses to climate change:temperature-dominated(UYK and UHT),precipitation-dominated(USRD and UAMD),and the combined influence of precipitation and temperature(UAKS and UI).Since the 1960s,the sensitivity of runoff to warm season temperature changes in the most westerlies-dominated upper basins has decreased,while the response of runoff to precipitation changes has intensified.(3)The stud

关键词： Upper basins of the Third Pole Climate change Westerlies and monsoon Runoff variations Large-scale circulation factors

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