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A surface-eroding poly(1,3-trimethylene carbonate)coating for magnesium based cardiovascular stents with stable drug release and improved corrosion resistance

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Bioactive Materials 2022年第1期7卷 144-153页

作者： Hongyan Tang Shuangshuang Li Yuan Zhao Cunli Liu xuenan gu Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing10083China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing102402China

Magnesium alloys with integration of degradability and good mechanical performance are desired for vascular stent application.Drug-eluting coatings may optimize the corrosion profiles of magnesium substrate and reduce the incidence of restenosis simultaneously.In this paper,poly(trimethylene carbonate)(PTMC)with different molecular weight(50,000 g/mol named as PTMC5 and 350,000 g/mol named as PTMC35)was applied as drug-eluting coatings on magnesium alloys.A conventional antiproliferative drug,paclitaxel(PTX),was incorporated in the PTMC coating.The adhesive strength,corrosion behavior,drug release and biocompatibility were investigated.Compared with the PLGA control group,PTMC coating was uniform and gradually degraded from surface to inside,which could provide long-term protection for the magnesium substrate.PTMC35 coated samples exhibited much slower corrosion rate 0.05μA/cm^(2)in comparison with 0.11μA/cm^(2)and 0.13μA/cm^(2)for PLGA and PTMC5 coated counterparts.In addition,PTMC35 coating showed more stable and sustained drug release ability and effectively inhibited the proliferation of human umbilical vein vascular smooth muscle cells.Hemocompatibility test indicated that few platelets were adhered on PTMC5 and PTMC35 coatings.PTMC35 coating,exhibiting surface erosion behavior,stable drug release and good biocompatibility,could be a good candidate as a drug-eluting coating for magnesium-based stent.

关键词： Magnesium alloy Polymeric coating Surface erosion Drug release Cardiovascular stents

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In vitro and in vivo evaluation of micro-alloyed magnesium for potential application in alveolar bone fixation screws

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Journal of Materials Science & Technology 2023年第13期144卷 62-69页

作者： Hongyan Tang Qing Li Min Li xuenan gu Chengkung Cheng Yubo Fan Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Center of Digital Dentistry Peking University School and Hospital of StomatologyBeijing 100081China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Beijing 100081China School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Alveolar bone augmentation with fixation screws has difficulties such as non-degradable materials that could lead to secondary surgery and insufficient osseointegration due to the subgingival environment in dental practice.With degradability and a high degree of osteogenesis,Mg alloy is a successful biodegrad-able material for orthopedic applications,and its application in dentistry has made certain progress.How-ever,considering the unique subgingival healing properties of oral implants,there is still a gap between the desired material properties for clinical applications and available materials.Indeed,studies on the use of Mg-based fixation screws for dentistry applications are still rare.In this study,we reported a magnesium alloy with low combined addition of strontium and lanthanum.The mechanical properties,degradation behavior,osteogenesis,and gingival compatibility were systematically investigated for assess-ing its potential application in alveolar bone fixation screws.With the alloying element content restricted to 0.3 wt.%,Mg-Sr-La alloy still exhibited good mechanical properties,with yield tensile and compressive strength twice higher than those of pure Mg.The in vitro degradation rate of this alloy was 0.10 mm y-1,which was slightly slower than high-purity Mg.The indirect and direct cell assay confirmed the elevated osteoblastic differentiation of MC3T3-E1 and migration of HGF-1 cells.Moreover,Mg-Sr-La alloy demon-strated a relatively slow degradation in the maxillary bone of Beagles.A remarkable promotion of the bone-implant contacts and significantly decreased fibrous encapsulation was observed in the subgingival environment,implying superior osseointegration of the experimental alloy than the titanium control.The empirical findings here reveal the great potential of Mg-Sr-La alloy for the application in alveolar bone fixation devices.

关键词： Magnesium alloys Alveolar ridge augmentation Fixation screws Osseointegration

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Current status and outlook of biodegradable metals in neuroscience and their potential applications as cerebral vascular stent materials

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Bioactive Materials 2022年第5期7卷 140-153页

作者： Ming Li Miaowen Jiang Yuan Gao Yufeng Zheng Zhi Liu Chen Zhou Tao Huang xuenan gu Ang Li Jiancheng Fang Xunming Ji School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing100191China China-America Institute of Neuroscience Xuanwu HospitalCapital Medical UniversityBeijing100053China School of Materials Science and Engineering Peking UniversityBeijing100871China Department of Cardiology Xuanwu HospitalCapital Medical UniversityBeijing100053China Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijing100053China Department of Neuroscience Xuanwu HospitalCapital Medical UniversityBeijing100053China Department of Biomedical Engineering University of MelbourneParkvilleVIC3010Australia Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Department of Biomedical Engineering Columbia UniversityNew YorkNY10032USA

Over the past two decades,biodegradable metals(BMs)have emerged as promising materials to fabricate temporary biomedical devices,with the purpose of avoiding potential side effects of permanent implants.In this review,we first surveyed the current status of BMs in neuroscience,and briefly summarized the representative stents for treating vascular stenosis.Then,inspired by the convincing clinical evidence on the in vivo safety of Mg alloys as cardiovascular stents,we analyzed the possibility of producing biodegradable cerebrovascular Mg alloy stents for treating ischemic stroke.For these novel applications,some key factors should also be considered in designing BM brain stents,including the anatomic features of the cerebral vasculature,hemodynamic influences,neuro-cytocompatibility and selection of alloying elements.This work may provide insights into the future design and fabrication of BM neurological devices,especially for brain stents.

关键词： Biodegradable metals Neuroscience Mg alloys Brain stents Ischemic stroke

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Fluid-induced corrosion behavior of degradable zinc for stent application

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Journal of Materials Science & Technology 2021年第32期91卷 134-147页

作者： Kai Chen xuenan gu Hui Sun Hongyan Tang Hongtao Yang Xianghui Gong Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Department of Materials Science and Engineering The Ohio State UniversityColumbusOH43210USA

The influence of laminar flow on the corrosion of pure zinc(Zn) and cell response was investigated and compared with the static measurements.The results revealed that laminar flow accelerated the corrosion and enhanced the localized corrosion of pure Zn.The dynamic corrosion rate was 0.184 mm/yr after 168 h corrosion.More corrosion products were formed under flow condition,which were mainly composed of Zn_(3)(PO_(4))_(2)·4 H_(2) O,Ca_(3)(PO_(4))_(2),ZnO and Zn_(5)(OH)_(6)(CO_(3))_(2).Moreover,the adhered rat aortic endothelial cells(RAEC) on Zn samples exhibited notably cell loss and round configuration under laminar flow.

关键词： Zinc Laminar flow Dynamic degradation Endothelial cells Biocompatibility

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Risk factors and treatments for brain metastasis in patients with adenocarcinoma of the lung: a retrospective analysis of 373 patients

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Chinese Neurosurgical Journal 2018年第2期4卷 76-83页

作者： Bo Li Zhaoxia Dai Shuai Liu xuenan gu Yanwei Liu Xiaoguang Qiu Department of Radiation Oncology Beijing Tiantan Hospital affiliated to Capital Medical UniversityNo.6Tiantan XiliDongcheng DistrictBeijing 100050China Department of Medical Oncology The Second Hospital of Dalian Medical UniversityNo.467Zhongshan RoadShahekou DistrictDalian 116027Liaoning ProvinceChina

Background: Risk factors and treatments for brain metastasis (BM) in patients with adenocarcinoma have not been fully profiled in previous studies because of the enrolment of patients with tumours of mixed histology. Thus, we specifically addressed the issue in patients with adenocarcinoma. Methods: Clinical data for 373 patients with pathologically confirmed adenocarcinoma were studied retrospectively. Factors including age (≤60 vs.＞60), gender (male vs. female), stage at diagnosis, T status (T1-2 vs. T3-4), N status (N0-1 vs. N2-3), epidermal growth factor receptor (EGFR) mutation status (wild-type vs. mutant) and smoking status (never vs. current) were analyzed. Results: In multivariate analysis, age (P=0.006) and N status (P=0.041) were independent risk factors for BM. In patients with BM, adding systemic therapy to local therapy improved median post-brain-metastasis survival (mPBMS) (P=0.02). However, if stratification was conducted according to the recursive partitioning analysis (RPA) classification or graded prognostic assessment (GPA) scoring, only patients in RPA class Ⅱ (P=0.020) or with GPA score 1.5-2.5 (P=0.032) could benefit from local plus systemic therapy. Those who received both pemetrexed and tyrosine kinase inhibitors (TKIs) as systemic therapies had a longer mPBMS than those who received TKIs alone, regardless of whether local therapy was applied. In patients with EGFR-sensitive mutations, TKIs therapy led to a longer mPBMS than conventional chemotherapy (P=0.002). Conclusions: Adenocarcinoma patients who were younger than 60 years of age and those with N2-3 disease have a significantly higher risk of BM. The addition of systemic therapy to local therapy can significantly prolong mPBMS, but the survival benefit confined in certain populations. Patients with opportunity to receive both pemetrexed and TKIs had the longest mPBMS.

关键词： Non-small cell lung cancer Risk factor Adenocarcinoma Brain metastasis Epidermal growth factor receptor

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In vitro and in vivo degradation behavior of Mg-2Sr-Ca and Mg-2Sr-Zn alloys

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Bioactive Materials 2020年第2期5卷 275-285页

作者： Kai Chen Xinhui Xie Hongyan Tang Hui Sun Ling Qin Yufeng Zheng xuenan gu Yubo Fan Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Beijing Advanced Innovation Centre for Biomedical Engineering Beihang UniversityBeijing100083China The Department of Orthopedics ZhongDa HospitalSchool of MedicineSoutheast UniversityNanjing210009China Department of Orthopaedics and Traumatology The Chinese University of Hong KongHong Kong National Research Center for Rehabilitation Technical AidsBeijing100176China Department of Materials Science and Engineering College of EngineeringPeking UniversityBeijing100871China National Research Center for Rehabilitation Technical Aids Beijing100176China

Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants.In this paper,Mg-2Sr-Ca and Mg-2Sr-Zn alloys were prepared and the degradation as well as the bone response were investigated.Compared with the binary Mg-2Sr alloys,the addition of Ca and Zn improved the in vitro and in vivo corrosion resistance.Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation.The in vivo corrosion rates were 0.85 mm/yr for Mg-2Sr-Zn and 1.10 mm/yr for Mg-2Sr-Ca in comparison with 1.37 mm/yr for Mg-2Sr.The in vitro cell tests indicated that Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited higher MG63 cell viability than Mg-2Sr alloy.Furthermore,these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential.

关键词： Magnesium alloys Degradation In vivo test Biocompatibility Orthopedic implants

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Risk factors of brain metastasis of lung squamous cell carcinoma:a retrospective analysis of 188 patients from single center

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Chinese Neurosurgical Journal 2018年第1期4卷 7-15页

作者： Bo Li Yanwei Liu Shuai Liu xuenan gu Xiaoguang Qiu Department of Radiation Oncology Beijing Tiantan Hospital affiliated to Capital Medical UniversityNo. 6Tiantan XiliDongcheng DistrictBeijing 100050China

Background:To explore risk factors and the efficacy of treatment strategies for brain metastasis (BM) in squamous cell carcinoma (SCC) of the lung.Methods:The clinical data of 188 pathologically confirmed as squamous cell carcinoma or adenosquamous carcinoma patients were studied retrospectively. Factors including age (<60 vs.≥60), gender, stage at diagnosis, T status (T1-2 vs. T3-4), N status (N0-1 vs. N2-3), histology (squamous vs. adenosquamous), smoking history (non-smoker vs. currentsmoker) and serum tumor markers (normal vs. elevated) were analyzed.Results:The incidence of BM was 19.1％(36/188) in our cohort. Patients who were female (p=0.005), had advanced disease at diagnosis (p<0.001), had adenosquamous carcinoma histology (p=0.033) or had elevated serum level of CEA at diagnosis (p<0.001) had significantly higher incidence of BM. In multivariate analysis, female (p=0.034, HR=18.874) and elevated serum level of CEA at diagnosis (p=0.009, HR=19.824) were independent risk factors of BM. BM patients who received additional systemic therapy after local therapy had significantly longer post-BM survival than those who received local therapy only (p=0.004, HR=0.058). Gemcitabine/platinum-containingregimen (GP) and taxans/platinum-containing regimen (TP) led to comparable brain-metastasis-free survival (BMFS) (p=0.10).Conclusions:Females and patients with elevated serum level of CEA at diagnosis had a higher risk of developing BM. The following systemic therapy after local therapy prolonged the survival of BM patient, but the efficacy of GP and TP was comparable in terms of preventing BM.

关键词： Brain metastasis Chemotherapy Non-small cell lung cancer Risk factor Squamous cell carcinoma

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Photocrosslinkable Col/PCL/Mg composite membrane providing spatiotemporal maintenance and positive osteogenetic effects during guided bone regeneration

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Bioactive Materials 2022年第7期7卷 53-63页

作者： Feilong Wang Dandan Xia Siyi Wang Ranli gu Fan Yang Xiao Zhao xuenan Liu Yuan Zhu Hao Liu Yongxiang Xu Yunsong Liu Yongsheng Zhou Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing100081China National Engineering Laboratory for Digital and Material Technology of Stomatology National Clinical Research Center for Oral DiseasesNational Center of StomatologyBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing100081China Department of Dental Materials Peking University School and Hospital of StomatologyBeijing100081China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081China

guided bone regeneration membranes have been effectively applied in oral implantology to repair bone defects.However,typical resorbable membranes composed of collagen(Col)have insufficient mechanical properties and high degradation rate,while non-resorbable membranes need secondary surgery.Herein,we designed a photocrosslinkable collagen/polycaprolactone methacryloyl/magnesium(Col/PCLMA/Mg)composite membrane that provided spatiotemporal support effect after photocrosslinking.Magnesium particles were added to the PCLMA solution and Col/PCLMA and Col/PCLMA/Mg membranes were developed;Col membranes and PCL membranes were used as controls.After photocrosslinking,an interpenetrating polymer network was observed by scanning electron microscopy(SEM)in Col/PCL and Col/PCL/Mg membranes.The elastic modulus,swelling behavior,cytotoxicity,cell attachment,and cell proliferation of the membranes were evaluated.Degradation behavior in vivo and in vitro was monitored according to mass change and by SEM.The membranes were implanted into calvarial bone defects of rats for 8 weeks.The Col/PCL and Col/PCL/Mg membranes displayed much higher elastic modulus(p0.05).The Col/PCL and Col/PCL/Mg membranes had lower degradation rates than the Col membranes,both in vivo and in vitro(p<0.05).The Col/PCL/Mg groups showed enhanced osteogenic capability compared with the Col groups at week 8(p<0.05).The Col/PCL/Mg composite membrane represents a new strategy to display space maintenance and enhance osteogenic potential,which meets clinical needs.

关键词： guided bone regeneration Magnesium Photocrosslinking Polycaprolactone methacryloyl Collagen

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使用可降解金属材料制备定向骨再生膜的可行性与挑战

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Science China Materials 2022年第10期65卷 2627-2646页

作者：陈凯赵莉孙洁顾雪楠黄晨阳苏皓然樊瑜波 Key Laboratory of Biomechanics and Mechanobiology(Beihang University) Ministry of EducationBeijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Materials Genome Engineering Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing 100083China Department of Stomatology The Fifth Medical CenterChinese PLA General HospitalBeijing 100036China

定向骨再生手术是一种用于增加牙槽骨体积的治疗手段.目前,商用的不吸收薄膜(钛膜等)需要二次手术去除,而可吸收薄膜(胶原膜等),由于强度较低,在覆盖大部分病变骨骼时可能会失效.理想的定向骨再生薄膜仍处于发展中.近年来,生物可降解金... 详细信息

定向骨再生手术是一种用于增加牙槽骨体积的治疗手段.目前,商用的不吸收薄膜(钛膜等)需要二次手术去除,而可吸收薄膜(胶原膜等),由于强度较低,在覆盖大部分病变骨骼时可能会失效.理想的定向骨再生薄膜仍处于发展中.近年来,生物可降解金属被认为是潜在的骨再生薄膜候选材料.因此,本文主要从力学和生物学角度评估了可降解金属作为定向骨再生薄膜的可行性.结果表明,可降解金属具有良好的生物相容性、足够的机械强度、可控的降解速率、良好的成骨性能、广谱抗菌能力和较好的创面愈合能力等优点,能够被用于制备定向骨再生薄膜.然而,对于镁合金来说,其较快的降解速率、析氢行为和应力腐蚀现象制约了其应用.对于锌合金而言,其降解速率适中且无氢气产生,似乎具有更好的应用前景.目前,可降解金属的发展已经为其在口腔临床中的应用奠定了一定的基础.

关键词：应力腐蚀锌合金降解速率机械强度骨再生生物相容性材料制备吸收薄膜

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应用射线束制备可见光响应的TiO_2薄膜

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催化学报 2007年第1期28卷 39-44页

作者：侯兴刚顾雪楠刘安东北京师范大学低能核物理研究所教育部射线束技术与材料改性重点实验室北京市辐射中心北京100875

由溶胶-凝胶法制备了TiO2薄膜.为了改善TiO2对光的利用效率,采用过渡金属离子(V+和Cr+)注入和电子束辐照沉积贵金属纳米颗粒(Ag和Pt)两种射线束技术对TiO2薄膜进行改性.紫外-可见光谱表明,两种射线束技术改性的TiO2薄膜的吸收光谱都发... 详细信息

由溶胶-凝胶法制备了TiO2薄膜.为了改善TiO2对光的利用效率,采用过渡金属离子(V+和Cr+)注入和电子束辐照沉积贵金属纳米颗粒(Ag和Pt)两种射线束技术对TiO2薄膜进行改性.紫外-可见光谱表明,两种射线束技术改性的TiO2薄膜的吸收光谱都发生了红移,说明这两种方法都是拓展TiO2吸收光谱的有效手段.通过光催化降解甲基橙实验,比较了两种方法对TiO2可见光光催化能力的拓展情况,结果表明,两种方法均可显著提高TiO2在可见光作用下的光催化活性.

关键词：射线束改性二氧化钛电子束离子注入可见光甲基橙降解

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