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Sodium fluoride induces apoptosis through reactive oxygen species-mediated endoplasmic reticulum stress pathway in Sertoli cells

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Journal of Environmental Sciences 2015年第4期27卷 81-89页

作者： Yang Yang Xinwei Lin Hui Huang Demin Feng Yue Ba xuemin cheng Liuxin Cui Department of Environmental Health College of Public Health Zhengzhou University Department of Nephrology 152 Hospital of PLA

Excessive fluoride exposure is known to contribute to reproductive system dysfunction,ultimately leading to pathological damage and apoptosis in cells. Although both oxidative and endoplasmic reticulum（ER） stresses have been implicated in fluorosis, the signaling pathways and their roles in sodium fluoride（Na F）-induced apoptosis of Sertoli cells have been sparsely described. In this study, oxidative damage, ER stress, and apoptosis were analyzed after Sertoli cells were treated with varying doses of Na F for 24 hr. Moreover, the antioxidant N-acetylcysteine（NAC） and pro-apoptotic transcription factor CHOP knockdown were used to clarify the precise interplay between reactive oxygen species（ROS）, ER stress and their roles in NaF-induced apoptosis in Sertoli cells. The present study indicated that NaF significantly decreased cell viability and induced apoptosis in Sertoli cells. In addition, NaF exposure facilitated the accumulation of ROS and increased nuclear translocation of nuclear factor erythroid 2-related factor 2（Nrf2） in Sertoli cells. Treatment with NAC caused remarkable recovery from these NaF-induced responses. Meanwhile, excessive NaF triggered ER stress as evidenced by up-regulated glucose-regulated protein 78 k Da（GRP78）, PKR-like ER kinase（PERK）, phosphorylation of eukaryotic translation initiation factor 2α（p-eI F2α） and CCAAT/enhancer-binding protein-homologous protein（CHOP）, without affecting total eukaryotic translation initiation factor 2α（e IF2α）. NAC effectively blocked the activation of ER stress, suggesting that Na F-induced ROS is an early event that triggers ER stress. Taken together, the results demonstrate that the ROS-mediated ER stress pathway is the crucial mechanistic event involved in NaF-induced apoptosis of Sertoli cells.

关键词： Sodium fluoride Apoptosis Reactive oxygen species Endoplasmic reticulum stress Sertoli cell

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Vertical ionization energies of halogen anions in solution

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Science China Chemistry 2010年第6期53卷 1316-1321页

作者： cheng xuemin,ZHU Quan,WANG XingJian,LI YunKui & LI XiangYuan College of Chemical Engineering,Sichuan University,chengdu 610065,China College of Chemical Engineering Sichuan University Chengdu China

Based on the constrained equilibrium state theory,the nonequilibrium solvation energy is derived in the framework of the continuum *** formula for spectral shift and vertical ionization energy are deduced for a single sphere cavity with the point charge *** new model is adopted to investigate the vertical ionization for halogen atomic and molecular anions X(X = Cl,Br,I,Cl2,Br2,I2) in aqueous *** to the calculation using the CCSD-t/aug-cc-pVQZ method in vacuum,our final estimated vertical ionization energies in solution are very close to the experimental observations,while the traditional nonequilibrium solvation theory overestimates these vertical ionization energies.

关键词： vertical ionization energy spectral shift constrained equilibrium state

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Environmental impacts in hydropower develop ent in China

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Electricity 1992年第1期 11-16页

作者： cheng xuemin China Electricity Council

Hydropower development in China has achieved greatsuccess and benefits not only in the growth of na-tional economy,but also in the improvement of environment,126.4TWh hydroelectricity generated in 1990 substituted more than 60million tons of coal which would otherwise be burnt in thermal powerplants with all harmful emissions to atmosphere,no need to say

关键词： reservoir otherwise farmland emissions harmful flood substituted sedimentation shallow filling

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Utilizing interpretable stacking ensemble learning and NSGA-Ⅲ for the prediction and optimisation of building photo-thermal environment and energy consumption

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Building Simulation 2024年第5期17卷 819-838页

作者： Yeqin Shen Yubing Hu Kai cheng Hainan Yan Kaixiang Cai Jianye Hua xuemin Fei Qinyu Wang School of Arts Jiangsu UniversityZhenjiang212013China School of Architecture and Urban Planning Nanjing UniversityNanjing210093China School of Computer Science and Communication Engineering Jiangsu UniversityZhenjiang212013China

This study develops an approach consisting of a stacking model integrated with a multi-objective optimisation algorithm aimed at predicting and optimising the ecological performance of *** integrated model consists of five base models and a meta-model,which significantly improves the prediction ***,the R2 value was improved by 9.19% and the error metrics MAE,MSE,MAPE,and CVRMSE were reduced by 69.47%,79.88%,67.32%,and 57.02%,respectively,compared to the single prediction *** to the research on interpretable machine learning,adding the SHAP value gives us a deeper understanding of the impact of each architectural design parameter on the *** the multi-objective optimisation part,we used the NSGA-Ⅲ algorithm to successfully improve the energy efficiency,daylight utilisation and thermal comfort of the ***,the optimal design solution reduces the energy use intensity by 31.6 kWh/m^(2),improves the useful daylight index by 39%,and modulated the thermal comfort index,resulting in a decrement of 0.69℃ for the summer season and an enhancement of 0.64℃ for the winter season,***,this study provides building designers and decision makers with a tool to make better design decisions at an early stage to achieve a better combination of energy efficiency,daylight utilisation and thermal comfort optimisation in an integrated manner,providing an important support for achieving sustainable building design.

关键词： building ecological performance ensemble learning multi-objective optimisation sustainable design explainable machine learning

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Spatial relationship of tertiary lymphoid structures and tumor-associated neutrophils in bladder cancer and prognostic potential for anti-PD-L1 immunotherapy

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Cancer Communications 2024年第4期44卷 499-503页

作者： Xuechun Wang Anna Juncker-Jensen Gang Huang Mate Levente Nagy xuemin Lu Liang cheng Xin Lu Department of Biological Sciences Boler-Parseghian Center for Rare and Neglected DiseasesHarper Cancer Research InstituteUniversity of Notre DameNotre DameINUSA NeoGenomics Laboratories Inc.Aliso ViejoCAUSA Department of Pathology and Laboratory Medicine Brown University Warren Alpert Medical SchoolLifespan Academic Medical CenterLegorreta Cancer Center at Brown UniversityProvidenceRIUSA Tumor Microenvironment and Metastasis Program Indiana University Melvin and Bren Simon Comprehensive Cancer CenterIndianapolisINUSA

Dear Editor,Tertiary lymphoid structures(TLSs)are organized clus-ters of immune cells found in non-lymphoid tissues of chronic inflammation,including solid tumors[1].High endothelial venules(HEVs)positive for peripheral node addressin(PNAd)are present in TLSs and may pro-vide highway entry for ***-residing TLSs may be formed by the concerted actions of cytokines and chemokines,a finding supported by the relation between a 12-chemokine signature and TLSs[2].

关键词： bladder lymphoid inflammation

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书籍形态设计中的凹凸艺术

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装饰 2010年第5期 108-109页

作者：成雪敏怀化学院设计系

现代的书籍形态设计已出现多元、饱满、立体的综合模式,更要求设计的艺术性和整体性。在书籍形态设计中介入凹凸的造型艺术手段,借助现代技术,实现书籍形态设计达到多次方的增值设计效果,设计的艺术意味因此得到了无限扩展。

关键词：设计艺术形式凹凸

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电子稳像算法的速度与精度改进

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计算机辅助设计与图形学学报 2018年第8期30卷 1543-1553页

作者：董常青程雪岷郝群清华大学深圳研究生院深圳518055 北京理工大学光电学院北京100081

电子稳像算法的目的是实时地去除视频拍摄过程中造成的随机不规则运动,以便后端的图像处理操作.针对处理时间以及精度方面进行研究提出了一种电子稳像算法.首先,实现了特征点个数的自适应提取,然后,提出并应用了满足凸优化条件的三点求... 详细信息

电子稳像算法的目的是实时地去除视频拍摄过程中造成的随机不规则运动,以便后端的图像处理操作.针对处理时间以及精度方面进行研究提出了一种电子稳像算法.首先,实现了特征点个数的自适应提取,然后,提出并应用了满足凸优化条件的三点求解和随机点校正来优化仿射矩阵,再对计算过程各阶段误差进行了优化控制,最后,通过局部提取运动目标区域进行动态补偿,将计算时间从20 ms减少到1 ms.实验结果表明,该算法每帧处理时间约为7 ms(不包括特征点提取部分),并具有较好的稳像效果.

关键词：电子稳像仿射矩阵全局补偿自适应阈值

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快速反射镜研究现状及未来发展

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应用光学 2019年第3期40卷 373-379页

作者：王震程雪岷清华大学深圳研究生院精密仪器系深圳518055

快速反射镜具有体积小、定位精度高、带宽高、响应速度快等优点,被广泛应用于激光通信、图像稳定系统、天文望远镜等光电系统中。为了对快速反射镜相关研究领域研究者提供一定便利,简要介绍了快速反射镜的工作原理,从多种角度介绍了快... 详细信息

快速反射镜具有体积小、定位精度高、带宽高、响应速度快等优点,被广泛应用于激光通信、图像稳定系统、天文望远镜等光电系统中。为了对快速反射镜相关研究领域研究者提供一定便利,简要介绍了快速反射镜的工作原理,从多种角度介绍了快速反射镜的分类,并阐述了不同种类快速反射镜的技术特点及性能差异。从技术特点、性能指标、实际应用3方面介绍了多款国内外研究机构的快速反射镜产品。展望快速反射镜的几项关键技术,指出高闭环带宽、高控制精度和数字控制是快速反射镜的发展趋势。

关键词：快速反射镜支撑结构结构设计控制性能

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makeTwin:A reference architecture for digital twin software platform

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Chinese Journal of Aeronautics 2024年第1期37卷 1-18页

作者： Fei TAO xuemin SUN Jiangfeng cheng Yonghuai ZHU Weiran LIU Yong WANG Hui XU Tianliang HU Xiaojun LIU Tingyu LIU Zheng SUN Jun XU Jinsong BAO Feng XIANG Xiaohui JIN Digital Twin International Research Center International Research Institute for Multidisciplinary ScienceBeihang UniversityBeijing 100191China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China Institute of Advanced Manufacturing and Intelligent Technology Beijing University of TechnologyBeijing 100124China RIAMB(Beijing)Technology Development Co Ltd(R.T.D.)Beijing 100120China School of Mechanical Engineering Shandong UniversityJinan 250061China School of Mechanical Engineering Southeast UniversityNanjing 211189China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049China College of Mechanical Engineering Donghua UniversityShanghai 201620China School of Machinery and Automation Wuhan University of Science and TechnologyWuhan 430081China Beijing Aero-top Hi-tech Co LtdBeijing 100176China

Digital twin is currently undergoing a significant transformation from the conceptual and theoretical research phase to the implementation and application ***,a universally adaptable research and development platform for digital twin is critically needed to meet the development ***,a publicly accessible simulation,testing,and validation platform which can support digital twin model building,data processing,algorithm design,configuration,etc.,is urgently required for ***,for developers from the industry,a lowcode development platform that can offer a customizable suite of functions such as model creation,data management,protocol configuration,and visualization is urgently ***,for enterprise users,there is a lack of an application management platform that can be configured and migrated for various application scenarios,functions,and ***,based on the system research of digital twin theories and key technologies by the authors(such as the five-dimension digital twin model,digital twin modeling and digital twin data theory,digital twin standards,and so on),a digital twin software platform reference architecture,namely make Twin,is proposed and designed,as well as its ten core *** workflow of the make Twin and the interaction mechanisms among its core functions are ***,a digital twin application system for a chemical fiber textile shop floor(CFTS)which was developed according to make Twin,is introduced,which validates the proposed reference architecture.

关键词： Digital twin Digital twin software platform Industrial software makeTwin Reference architecture

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高校思想政治理论课微电影教学美育功能三论

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思想教育研究 2020年第6期 77-81页

作者：柴素芳程雪敏河北大学马克思主义学院河北保定071000

思想政治理论课微电影教学模式具有"以美怡情、以美立德、以美启智"等美育功能,对于提升大学生的审美素养,塑造大学生的健全人格,培养大学生的创新能力具有重要意义。探究思想政治理论课微电影教学的美育功能,既是切实加强新时代高校美... 详细信息

思想政治理论课微电影教学模式具有"以美怡情、以美立德、以美启智"等美育功能,对于提升大学生的审美素养,塑造大学生的健全人格,培养大学生的创新能力具有重要意义。探究思想政治理论课微电影教学的美育功能,既是切实加强新时代高校美育工作的需要,也是思想政治理论课微电影教学实现自身"立德树人"时代价值的必然选择。

关键词：微电影美育功能以美怡情以美立德以美启智

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