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小鼠淋巴结内肥大细胞生长抑素免疫组织化学观察

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四川解剖学杂志 2003年第1期11卷 16-18页

作者：贾雪梅潘小梅王盛花王惠珠安徽医科大学组织学与胚胎学教研室安徽合肥230032 深圳市人民医院

目的　观察小鼠淋巴结内肥大细胞的分布特点及神经肽性质。　方法　采用甲苯胺蓝染色和免疫组织化学ABC方法。结果　淋巴结内肥大细胞多为圆形或椭圆形 ,主要分布于淋巴窦内 ;经与甲苯胺蓝邻片比较 ,肥大细胞呈生长抑素 (SS)免疫反应性 ... 详细信息

目的　观察小鼠淋巴结内肥大细胞的分布特点及神经肽性质。　方法　采用甲苯胺蓝染色和免疫组织化学ABC方法。结果　淋巴结内肥大细胞多为圆形或椭圆形 ,主要分布于淋巴窦内 ;经与甲苯胺蓝邻片比较 ,肥大细胞呈生长抑素 (SS)免疫反应性 ,可见免疫反应阳性颗粒充满于胞质内 ,细胞核为阴性反应。结论　小鼠淋巴结肥大细胞呈SS免疫反应性。

关键词：免疫组织化学肥大细胞生长抑素淋巴结

Consensus for clinical applications of transcranial magnetic resonance-guided focused ultrasound

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中华医学杂志(英文版) 2024年第22期137卷 2684页

作者： pan Longsheng Xiong Yongqin Li Yongjie Sun Bomin Li xuemei Zhou Shouguo Lou Xin Department of Neurosurgery Chinese PLA General Hospital Beijing China Department of Radiology Chinese PLA General Hospital Beijing China Neuromedicine Center The University of Hong Kong-Shenzhen Hospital Shenzhen Guangdong China Department of Neurosurgery Center for Functional Neurosurgery Shanghai Jiao Tong University Ruijin Hospital Shanghai China Clinics of Cadre Department of Outpatient Chinese PLA General Hospital Beijing China Department of Radiology Foshan Hospital of Traditional Chinese Medicine Foshan Guangdong China

Items Recommendations Indications Current indications ET PD potential indications NP OCD MDD Epilepsy Dystonia Contraindications Absolute MRI contraindication Abnormal bleeding and/or coagulopathy Poorly controlled medical conditions Lack of cooperation Currently pregnant or lactating Relative Low skull density ratio Anatomical variations affecting target accessibility Preprocedural System preparation DQA Patient preparation Planning scans and target selection Hair shave Head frame placement Intravenous access Intraprocedural Alignment of the ultrasound focus Low-energy sonications (Temperature: between 40°C and 45°C) Target correction Confirmation of the target Increase energy (Temperature: between 46°C and 52°C) Physical exam Therapeutic ablation High-energy sonications (Temperature: between 54°C and 60°C) Physical exam and target correction Intraprocedural scans Postprocedural Post procedure MRI (within 24 hours) Post procedure physical exam Complications Surgical complications Head frame and procedure-related complications MRI environment effects Target-related Complications Neurological deficits associated with the adjacent areas DQA:Despite the encouraging preliminary outcomes, it is essential to underscore that the existing body of evidence remains at a nascent stage and lacks robustness.[...]although this procedure suggests a novel avenue for NP relief, it has not yet been endorsed for routine clinical deployment.[...]the patient populations primarily suitable for MRgFUS interventions are those diagnosed with conditions that are traditionally managed invasively, specifically those for which DBS constitutes the standard therapeutic intervention.Preoperative assessment (1) A comprehensive evaluation of MRgFUS treatment, including indications, contraindications, medications, and cost-effectiveness.

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miR319-TCPs-TGA9/TGA10/ROXY2 regulatory module controls cell fate specification in early anther development in Arabidopsis

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Science China(Life Sciences) 2024年第4期67卷 839-842页

作者： Jinyuan Tao Zijie pan Wenwen Kong Beixin Mo xuemei Chen Yu Yu Guangdong Provincial Key Laboratory for Plant Epigenetics Longhua Bioindustry and Innovation Research InstituteCollege of Life Sciences and OceanographyShenzhen UniversityShenzhen 518060China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China School of Life Sciences Peking-Tsinghua Joint Center for Life SciencesPeking UniversityBeijing 100871China

Dear Editor,The process of anther development is generally conserved across plant species(Ma,2005).Many protein-coding genes and noncoding RNAs have been identified to participate in early anther development in Arabidopsis(Walbot and Egger,2016).mi R319 is one of the most ancient and conserved mi RNA families in land plants(Chávez Montes et al.,2014).

关键词： Arabidopsis miR319 ancient

2004-2014年连州市艾滋病流行状况分析

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河南预防医学杂志 2016年第8期27卷 611-613,F0004页

作者：陈振波潘雪梅邓友良陈卓彤谢新妹黄金梅连州市疾病预防控制中心广东连州513400

目的分析连州市艾滋病流行状况,为探讨有效的防制策略提供科学依据。方法收集2004-2014年连州市艾滋病疫情资料和个案调查表进行描述性流行病学分析。结果2004-2014年连州市累计报告HIV/AIDS病例151例,其中HIV感染者99例,艾滋病病人52例... 详细信息

目的分析连州市艾滋病流行状况,为探讨有效的防制策略提供科学依据。方法收集2004-2014年连州市艾滋病疫情资料和个案调查表进行描述性流行病学分析。结果2004-2014年连州市累计报告HIV/AIDS病例151例,其中HIV感染者99例,艾滋病病人52例,累计报告死亡病例54例。病例主要集中在30至60岁年龄组,共报告118例,占病例总数的78.15%;50岁以上71例,占47.02%。男性119例,占78.81%;女性32例,占21.19%;男女性别比为3.72:1。职业以农民、家务及待业和工人为主,初中及以下文化程度者占77.83%,已婚占55.63%,异性传播占86.09%。样本来源以其他就诊者检测、术前检测和受血(制品)前检测为主,合计占病例总数的64.91%。结论 2011年后连州市艾滋病发病率明显上升,50岁以上老年人和MSM成为艾滋病防控的重点人群,必须加强对老年男性的艾滋病宣传教育力度,并对MSM开展有针对性的、持续的、有效的干预措施,以遏制艾滋病的扩散和蔓延。

关键词：艾滋病流行流行病学分析

苏氏接骨胶囊对胫骨干骨折大鼠模型促早期愈合作用及BMP-2表达的影响

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天津中医药 2018年第11期35卷 858-862页

作者：俞媛杨雅琼冯凯强屈金辉潘雪梅白雪王毅天津市天津医院检验科天津300211 天津市天津医院药学部天津300211

[目的]探讨苏氏接骨胶囊(简称Su)对大鼠胫骨干骨折早期愈合的促进作用及骨形态发生蛋白-2(BMP-2)表达的影响。[方法] 36只6周龄雄性SD大鼠按照随机数字表分为假干预组、Su剂量140 mg/(kg·d)组(Su-140组)和Su剂量280 mg/(kg·d)组(Su-28... 详细信息

[目的]探讨苏氏接骨胶囊(简称Su)对大鼠胫骨干骨折早期愈合的促进作用及骨形态发生蛋白-2(BMP-2)表达的影响。[方法] 36只6周龄雄性SD大鼠按照随机数字表分为假干预组、Su剂量140 mg/(kg·d)组(Su-140组)和Su剂量280 mg/(kg·d)组(Su-280组)。分组建立胫骨干闭合骨折髓内钉固定模型,术后第2天开始给予相应的药物干预。造模后10 d,过度麻醉心脏取血并处死各组大鼠。对大鼠患肢胫骨进行取材后,通过X线对骨折愈合情况进行初步检查;通过Micro-CT技术计算骨痂的骨体积分数(BV/TV)、骨小梁厚度(***)、骨小梁数量(Tb.N),并对骨痂进行组织形态学观察;通过免疫组化技术观察骨痂中BMP-2的表达,实时荧光聚合酶链反应(Real Time-PCR)定量检测血清BMP-2的含量。[结果]骨折造模术后10 d,假干预组、Su-140组及Su-280组3组大鼠的骨折断端均可见骨痂形成,骨折端愈合尚稳定,部分标本骨折断端稍有微动。经X线观察Su-280组骨折端愈合情况好于Su-140组及假干预组,Su-140组优于假干预组。Micro-CT检测结果提示,Su-140组和Su-280组的BV/TV值均高于假干预组,差异有统计学意义(P0.05),Su-280组与假干预组间比较有统计学差异(P0.05)。[结论]苏氏接骨胶囊能促进大鼠胫骨干骨折的早期愈合及BMP-2的表达,且随药物浓度的增加,骨折愈合越快,其机制可能为Su促进BMP-2的表达,进而诱导成骨细胞及胞外基质的分化增殖,促进骨形成及骨愈合。

关键词：苏氏接骨胶囊骨折愈合 Micro-CT BMP-2

Two-dimensional molecular crystalline semiconductors towards advanced organic optoelectronics

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Nano Research 2022年第10期15卷 9554-9572页

作者： xuemei Dong Heshan Zhang Yinxiang Li Bin Liu Keyuan pan Yijie Nie Mengna Yu Mustafa Eginligil Juqing Liu Wei Huang Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(Nanjing Tech)Nanjing 211816China Center for Molecular Systems and Organic Devices(CMSOD) State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM)Nanjing University of Posts&TelecommunicationsNanjing 210023China Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

The compelling demand for higher performance and lower cost in the optoelectronics industry has driven the development of organic *** crystalline semiconductors(MCSs),especially two-dimensional MCSs(2D-MCSs),possess intrinsic ordered structure,quantum confinement effect,high mobility,unique optical and electrical properties,and more ecological and cheaper production,which make great promises in high-performance optoelectronic *** we provide a review of design principles and synthetic strategies for 2D-MCS materials,exploiting their potential as a revolution option in associated optoelectronic *** merits and limitations of each strategy are presented,and these molecular crystals are considered as a competitive choice for emerging semiconducting materials in information ***,the current challenges and future perspectives in this field are also elaborated.

关键词： two-dimensional molecular crystalline semiconductors(2D-MCSs) molecular design strategies preparation techniques photoelectronic applications

iBIG:An Integrative Network Tool for Supporting Human Disease Mechanism Studies

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Genomics, Proteomics & Bioinformatics 2013年第3期11卷 166-171页

作者： Jiya Sun Yuyun pan xuemei Feng Huijuan Zhang Yong Duan Hongxing Lei CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences UC Davis Genome Center and Department of Biomedical Engineering

Understanding the mechanism of complex human diseases is a major scientitic challenge. Towards this end, we developed a web-based network tool named iBIG （stands for integrative BioloGy）, which incorporates a variety of information on gene interaction and regulation. The generated network can be annotated with various types of information and visualized directly online. In addition to the gene networks based on physical and pathway interactions, networks at a functional level can also be constructed. Furthermore, a supplementary R package is provided to process microarray data and generate a list of important genes to be used as input for iBIG. To demonstrate its usefulness, we collected 54 microarrays on common human diseases including cancer, neurolog- ical disorders, infectious diseases and other common diseases. We processed the microarray data with our R package and constructed a network of functional modules perturbed in common human diseases. Networks at the functional level in combination with gene networks may provide new insight into the mechanism of human diseases, iBIG is freely available at http：//***/ibig.

关键词： Network Functional module Disease mechanism Microarray Web server

Tuning crystal structure and redox potential of NASICON-type cathodes for sodium-ion batteries

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Nano Research 2020年第12期13卷 3330-3337页

作者： xuemei Ma Xinxin Cao Yifan Zhou Shan Guo Xiaodong Shi Guozhao Fang Anqiang pan Bingan Lu Jiang Zhou Shuquan Liang School of Material Science and Engineering Central South UniversityChangsha410083China Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South UniversityChangsha410083China School of Physics and Electronics Hunan UniversityChangsha410082China

Sodium superionic conductor(NASICON)-type compounds have been regarded as promising cathodes for sodium-ion batteries(SIBs)due to their favorable ionic conductivity and robust structural ***,their high cost and relatively low energy density restrict their further practical application,which can be tailored by widening the operating voltages with earth-abundant elements such as ***,we propose a rational strategy of infusing Mn element in NASICON frameworks with sufficiently mobile sodium ions that enhances the redox voltage and ionic migration *** optimized structure of Na3.5Mn0.5V1.5(PO4)3/C is achieved and investigated systematically to be a durable cathode(76.6%capacity retention over 5,000 cycles at 20 C)for SIBs,which exhibits high reversible capacity(113.1 mAh·g^−1 at 0.5 C)with relatively low volume change(7.6%).Importantly,its high-areal-loading and temperature-resistant sodium ion storage properties are evaluated,and the full-cell configuration is *** work indicates that this Na3.5Mn0.5V1.5(PO4)3/C composite could be a promising cathode candidate for SIBs.

关键词： sodium superionic conductor(NASICON)-type crystal structure cathode material full cell sodium ion battery

基于时序InSAR技术的常州市地表形变监测与影响因素分析

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测绘工程 2025年第1期34卷 53-61页

作者：夏璐文徐佳肖儒雅潘伯鸣孙雪梅河海大学地球科学与工程学院南京211100 常州市测绘院江苏常州213003

地面沉降是常州市的主要地质灾害之一,为了准确掌握地面沉降动态,确保区域可持续发展,利用时序InSAR技术监测常州主城区地表形变,并对其影响因素进行分析。文中采用长短基线组合的方式对2016年1月—2022年12月的186景Sentinel-1A SAR影... 详细信息

地面沉降是常州市的主要地质灾害之一,为了准确掌握地面沉降动态,确保区域可持续发展,利用时序InSAR技术监测常州主城区地表形变,并对其影响因素进行分析。文中采用长短基线组合的方式对2016年1月—2022年12月的186景Sentinel-1A SAR影像进行干涉测量处理,从而生成形变时间序列,并通过相位闭合环误差检测筛选高质量干涉对、使用通用型大气改正在线服务(GACOS)进行大气延迟误差改正,获取常州市主城区2016—2022年地面沉降信息,结果与同期水准数据一致,均方根误差为2.5 mm;再结合地质条件和地下水资料对影响地表形变的因素进行分析,结果表明常州市主城区地面沉降形势总体趋于稳定,仅在邹区镇西侧、武进区南部前黄礼嘉一带局部地区存在沉降现象,而中心城区地面形变总体抬升趋势。

关键词：形变监测时序InSAR 通用型大气改正在线服务相位闭合环