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中药穴位热熨敷的不同推熨频率对促进结肠癌根治术后患者胃肠功能恢复的影响

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天津中医药 2024年第5期41卷 622-627页

作者：樊奕丹王珍妮全小明林雪梅符梅华李楠周坚广州中医药大学第一临床医学院广州510000 武汉第一医院康复医学科武汉430000 广州中医药大学第一附属医院护理部广州510000 广州中医药大学第一附属医院急诊中心广州510000 广州中医药大学第一附属医院胃肠外科广州510000 广州中医药大学第一附属医院耳鼻咽喉头颈外科广州510000 广州中医药大学第一附属医院乳腺科广州510000

[目的]观察中药穴位热熨敷的不同推熨频率对促进结肠癌根治术后患者胃肠功能恢复的影响。[方法]选取2020年1月—2023年3月在广州中医药大学第一附属医院二外科住院的腹腔镜下结肠癌根治术后患者108例,随机分为试验A组、试验B组、对照组... 详细信息

[目的]观察中药穴位热熨敷的不同推熨频率对促进结肠癌根治术后患者胃肠功能恢复的影响。[方法]选取2020年1月—2023年3月在广州中医药大学第一附属医院二外科住院的腹腔镜下结肠癌根治术后患者108例,随机分为试验A组、试验B组、对照组各36例。对照组采用常规护理方法,试验组在常规护理基础上实施子午流注理论指导下的中药热熨敷干预,试验A组的推熨频率为90~95次/min,试验B组的推熨频率为115~120次/min,从术后第1天开始,每日2次,直至肛门排气和排便。观察3组患者胃肠功能恢复、住院时间、中医证候积分变化情况以及不良反应发生情况,评价3组患者的临床疗效。[结果]干预后,试验B组术后肠鸣音恢复时间、首次肛门排气时间明显短于试验A组和对照组(P<0.05),试验B组首次排便时间和术后住院时间均明显短于对照组(P<0.05或P<0.01);3组患者中医证候积分的组间效应、时间效应及交互效应均有统计学差异(P<0.05);3组患者中医证候积分随时间推移均呈下降趋势,试验B组术后72 h的中医证候积分低于试验A组和对照组,且试验A组低于对照组(P<0.05);试验A组和试验B组的临床治疗总有效率均明显优于对照组(P<0.05)。[结论]中药热熨敷能有效促进结肠癌根治术后患者胃肠功能恢复,以推熨频率为115~120次/min的整体治疗效果更为显著。

关键词：频率中药热熨敷结肠癌胃肠功能

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用正交试验法分析四种表面活性剂的复配性能

中国洗涤用品工业 2024年第1期 50-60页

作者：杨碧云胡卫华邱美纯纪晓虹燕道贵林学镁拉芳家化股份有限公司广东汕头515041

用正交试验设计法研究月桂醇聚醚硫酸酯钠、十二烷基硫酸钠、椰油酰胺丙基甜菜碱和月桂酰肌氨酸钠复配的最佳使用比例,摸索四种表面活性剂对泡沫、洗后皮肤水分含量及刺激性的影响。结果显示,在给定的因素水平数里,泡沫高度的优方案为AE... 详细信息

用正交试验设计法研究月桂醇聚醚硫酸酯钠、十二烷基硫酸钠、椰油酰胺丙基甜菜碱和月桂酰肌氨酸钠复配的最佳使用比例,摸索四种表面活性剂对泡沫、洗后皮肤水分含量及刺激性的影响。结果显示,在给定的因素水平数里,泡沫高度的优方案为AES:13%,K12:4%,CAB:6%,LS30:5%;洗后皮肤水分含量的优方案为AES:14.5%,K12:3%,CAB:6%,LS30:2%;刺激性最小的优方案为AES:11.5%,K12:1%,CAB:6%,LS30:3%。通过试验数据分析可知,AES对泡沫高度和鸡胚试验评分有显著影响;K12对泡沫高度和洗后皮肤水分含量有显著影响;CAB对泡沫高度有影响;而LS30有助于降低鸡胚评分,在3%时效果最好。

关键词：正交试验表面活性剂复配泡沫高度皮肤水分含量鸡胚绒毛尿囊膜试验

老年轻型急性缺血性卒中患者非HDL-C/HDL-C比值与1年卒中复发的关系研究

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神经损伤与功能重建 2024年第4期19卷 211-216页

作者：王欢刘仲仲蔺雪梅张娜逯青丽刘佩常乔乔刘燕吴松笛西北大学附属第一医院/西安市第一医院神经内科西安710002 西安市神经免疫疾病创新转化重点实验室西安710002 西安交通大学医学部公共卫生学院流行病与卫生统计学系西安710061

目的:探讨非高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和HDL-C的比值与老年轻型急性缺血性卒中(acute ischemic stroke,AIS)患者1年卒中复发风险之间的关系。方法:通过西安卒中登记研究数据库,连续收集患者入院... 详细信息

目的:探讨非高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和HDL-C的比值与老年轻型急性缺血性卒中(acute ischemic stroke,AIS)患者1年卒中复发风险之间的关系。方法:通过西安卒中登记研究数据库,连续收集患者入院时的总胆固醇、HDL-C及相关临床信息和确诊起3、6、12个月随访复发性脑卒中事件。非HDL-C通过从总胆固醇中减去HDL-C来计算。非HDL-C/HDL-C比值分别按照连续变量和四分位分组(Q1~Q4)处理。采用多因素Cox回归分析非HDL-C/HDL-C比值与老年轻型AIS患者1年卒中复发风险之间的关系。并采用Kaplan-Meier法进行不同非HDL-C/HDL-C比值的1年卒中复发分析。结果:研究共纳入老年轻型AIS患者826例。校正相关混杂因素后多因素Cox回归分析发现,非HDL-C/HDL-C比值每升高1个单位,1年卒中复发的风险升高54%(HR=1.54,95%CI 1.15~2.07,P=0.004)。与Q1组相比,Q4组的1年卒中复发风险升高2.27倍(HR=3.27,95%CI 1.21~8.81,P=0.019),其他组(Q2和Q3组)中1年卒中复发风险与Q1组差异无统计学意义。趋势检验显示,Q1~Q4组的1年复发风险增加有显著性统计学意义(趋势检验P=0.004)。曲线拟合分析显示随着非HDL-C/HDL-C比值的升高,1年卒中复发的风险逐步升高。四分组的K-M生存分析发现,与其他组相比,Q4组(≥3.58)的1年卒中复发率明显升高。结论:非HDL-C/HDL-C比值升高是老年轻型AIS患者1年卒中复发的独立危险因素,非HDL-C/HDL-C比值≥3.58可显著增加老年轻型AIS患者1年卒中复发的风险。

关键词：急性缺血性卒中老年非传统血脂复发

维普期刊数据库博看期刊

Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity

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Chinese Chemical Letters 2023年第3期34卷 378-382页

作者： Huili Wang Yishuo Sun xuemei lin Wei Feng Zhanxian Li Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersInstitutes of Biomedical Sciences&Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200433China

The normal operation of lysosome, mitochondria, Golgi apparatus and endoplasmic reticulum plays a significant role in maintaining cell homeostasis. Reflecting the state and function of lysosomes, viscosity is a pivotal parameter to assess the stability of microenvironment. Herein, based on TICT mechanism,a new NIR pH-dependent fluorescent probe DCIC with push-pull electronic moiety was synthesized to identify the lysosomes viscosity. In viscous media, DCIC was highly sensitive to viscosity, fluorescence intensity increased by 180 times as viscosity increased from 1.0 cp to 438.4 cp. In addition, DCIC have high localization ability for lysosome, mitochondria, Golgi apparatus, and endoplasmic reticulum and can monitor lysosomal viscosity fluctuations with laser confocal microscopy.

关键词： NIR Lysosomal viscosity PH-dependent Multi-organelle localization

Curcumin reduces inflammatory reactions following transient cerebral ischemia/reperfusion injury

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Neural Regeneration Research 2011年第3期6卷 219-223页

作者： Zhao, Jing Yu, Shanshan Li, Lan lin, xuemei Zhao, Yong Chongqing Med Univ Dept Pathophysiol Chongqing 400016 Peoples R China Chongqing Med Univ Dept Pathol Chongqing 400016 Peoples R China

Inflammatory reactions are important pathophysiological mechanisms of ischemic brain injury. The present study analyzed the anti-inflammatory characteristics of curcumin via myeloperoxidase activity and nitric oxide content after 2-hour ischemia/24-hour reperfusion in Sprague Dawley rats. In addition, expressions of nuclear factor kappa B, tumor necrosis factor-α and interleukin-lβ protein were measured. Curcumin significantly reduced myeloperoxidase and nitric oxide synthase activities and suppressed expressions of nuclear factor kappa B, tumor necrosis factor-α, and interleukin-lβ in ischemia/reperfusion brain tissue. Results suggested that the neuroprotective effect of curcumin following cerebral ischemia/reperfusion injury could be associated with inhibition of inflammatory reactions.

关键词： curcumin inflammation tumor necrosis factor-a nuclear factor kappa B neuroprotection stroke ischemiaJreperfusion

Fluorescence enhancement of Tb^(3+) complexes by adding silica-coated silver nanoparticles

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Science China Chemistry 2015年第6期58卷 979-985页

作者： Dan Zhou xuemei lin Ailing Wang Jingjing Li Yanrong Qu Haibin Chu Yongliang Zhao College of Chemistry and Chemical Engineering Inner Mongolia University

Six kinds of terbium ternary complexes with halo-benzoic acids were synthesized. Their compositions were determined by C, H elemental analyzer and EDTA titration. The infrared spectra, ultraviolet absorption spectra, and fluorescence spectra were also measured to identify the complexes. Elemental analysis showed that the compositions of these complexes were Tb(p-Br BA)3?H2O, Tb(p-Cl BA)3?2H2O, Tb(p-FBA)3?H2O, Tb(o-FBA)3?2H2O, Tb(o-Cl BA)3?H2O, and Tb(o-Br BA)3?H2O, respectively. The monodispersed Ag@Si O2 core-shell nanoparticles with silica thicknesses of 10, 15, and 25 nm were successfully prepared and characterized by transmission-electron microscopy. Fluorescence intensities of the complexes were detected before and after Ag@Si O2 core-shell nanoparticles were added; the enhancement times were related to the silica-shell thickness. The fluorescence enhancement times were largest when the thickness of the silica shell was 25 nm. The mechanism may be attributed to the localized surface-plasmon resonance. Furthermore, the enhancement effect of terbium fluoro-benzoate complexes was the strongest in these complexes. This result may be attributed to the hydrogen bond between the hydroxyl on the surface of the silica shell and the fluorine atom.

关键词：银纳米颗粒铽配合物二氧化硅荧光增强表面等离子体共振透射电子显微镜滴定法测定元素分析仪

儿童发育性髋关节发育不良闭合复位术后结局预测模型的构建

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临床小儿外科杂志 2024年第6期23卷 509-520页

作者：黎艺强刘行郭跃明石伟哲林雪梅徐晨晨韦胜刘远忠徐宏文中国儿童骨科多中心研究协作组广州医科大学附属妇女儿童医疗中心儿童骨科广州510623 重庆医科大学附属儿童医院骨一科重庆400000 佛山市中医院小儿骨科佛山528000 不详

目的建立儿童发育性髋关节发育不良(developmental dysplasia of the hip,DDH)闭合复位术后结局预测模型,并利用该模型指导DDH闭合复位术后残余髋臼发育不良(residual acetabulalr dysplasia,RAD)手术时机的选择。方法回顾性分析国内多... 详细信息

目的建立儿童发育性髋关节发育不良(developmental dysplasia of the hip,DDH)闭合复位术后结局预测模型,并利用该模型指导DDH闭合复位术后残余髋臼发育不良(residual acetabulalr dysplasia,RAD)手术时机的选择。方法回顾性分析国内多个医疗中心2004-2015年采用闭合复位术治疗的449例(522髋)DDH患儿临床资料,患儿年龄(16.3±5.1)个月。术前在骨盆正位X线片上评估脱位程度的国际髋关节发育不良协会(International Hip Dysplasia Institute,IHDI)分型、股骨头骨化核以及髋臼指数(acetabular index,AI)。术后测量第1、2、3、4年及末次随访时的AI、中心边缘角(centre-edge angle of Wiberg,CEA)和Reimer指数(Reimer's index,RI),评估股骨头缺血性坏死(avascular necrosis of the femoral head,AVN)情况。根据末次随访时Severin影像学评级以及是否接受二期骨盆截骨术,将患儿分成两组:SeverinⅠ、Ⅱ级为痊愈组,SeverinⅢ、Ⅳ级或接受了骨盆截骨术者为RAD组。利用Cox回归构建DDH闭合复位术后痊愈预测模型,并用受试者操作特征(receiver operating characteristic,ROC)曲线进行内部验证。结果522髋中,IHDI分型为Ⅱ型70髋(13.4%),Ⅲ型223髋(44.6%),Ⅳ型219髋(42%)。复位前410髋(78.5%)已出现股骨头骨化核。总体AVN(Ⅱ型以上)发生率为12.8%。痊愈组329髋(63%),痊愈时间(33.3±14.7)个月(8.4~111.4个月),93.6%(308/329)的痊愈患儿痊愈时间在术后5年以内。Cox回归分析显示,IHDI分型、股骨头骨化核、复位年龄、当前AI、CEA、RI、AVN是DDH闭合复位术后累积痊愈概率的影响因素,利用上述影响因素,本研究成功构建了DDH闭合复位术后痊愈预测模型。该模型中所有因素的总分为-11~17分,对应痊愈概率为0.02~1.0。在该模型下,ROC曲线分析显示,术后第1、2、3、4年总分小于2.5、1.5、2.5、1.5分时,患儿痊愈概率显著较高(81.4%~96.1%),ROC曲线下面积为0.808~0.910,Kappa系数为0.497~0.618。相反,当总分大于1.5~2.5分时,RAD发生率显著升高,建议行骨盆截骨术。结论本研究构建的痊愈预测模型可以有效预测RAD,并指导骨盆截骨手术时机的选择。在该模型下,如果术后第1、2、3、4年时模型中所有因素总分大于2.5、1.5、2.5、1.5分,则RAD发生率显著升高。

关键词：发育性髋关节发育不良闭合复位治疗结果残余髋臼发育不良截骨术,骨盆预测模型

Magnetic resonance-guided focused ultrasound for essential tremor:a prospective,single center,single-arm study

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Neural Regeneration Research 2024年第9期19卷 2075-2080页

作者： Rui Zong xuemei Li Chunyu Yin Jianfeng He Dekang Zhang Xiangbing Bian Lichao Huang Jiayou Zhou Zhipei ling lin Ma Xin Lou Longsheng Pan Xinguang Yu Seniro Department of Neurosurgery The First Medical Center of the PLA General HospitalBeijingChina Clinics of Cadre Department of OutpatientThe First Medical Center of the PLA General HospitalBeijingChina Department of Radiology The First Medical Center of the PLA General HospitalBeijingChina

The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential *** 2018,the first magnetic resonance-guided focused ultrasound system in Chinese mainland was installed at the First Medical Center of the PLA General *** prospective,single center,open-label,single-arm study was part of a worldwide prospective multicenter clinical trial(*** Identifier:NCT03253991)conducted to confirm the safety and efficacy of magnetic resonance-guided focused ultrasound for treating essential tremor in the local *** 2019 to 2020,10 patients with medication refractory essential tremor were recruited into this open-label,single arm *** treatment efficacy was determined using the Clinical Rating Scale for *** was evaluated according to the incidence and severity of adverse *** of the subjects underwent a unilateral thalamotomy targeting the ventral intermediate *** the baseline assessment,the estimated marginal mean of the Clinical Rating Scale for Tremor total score was 58.3±3.6,and this improved after treatment to 23.1±6.4 at a 12-month follow-up assessment.A total of 50 adverse events were recorded,and 2 were defined as *** most common intraoperative adverse events were nausea and *** most frequent postoperative adverse events were paresthesia and equilibrium *** of the adverse events were mild and usually disappeared within a few *** findings suggest that magnetic resonance-guided focused ultrasound for the treatment of essential tremor is effective,with a good safety profile,for patients in Chinese mainland.

关键词： efficacy essential tremor magnetic resonance-guided focused ultrasound(MRgFUS) movement disorder safety stereotactic therapy thalamotomy ventral intermediate nucleus

Modulation of Microstructure and Charge Transport in Polymer Monolayer Transistors by Solution Aging

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Chinese Journal of Chemistry 2021年第11期39卷 3079-3084页

作者： xuemei lin Ruochen Liu Chenming Ding Junyang Deng Yifu Guo Shibing Long ling Li Mengmeng Li Key Laboratory of Microelectronic Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing100029 China School of Microelectronics University of Science and Technology of ChinaHefeiAnhui230026 China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing100049 China E-mail:

A few monolayers of organic semiconductors adjacent to the dielectric layer are of vital importance in organic field-effect transistors due to their dominant role in charge *** this report,the 2-nm-thick polymer monolayers based on poly(3-hexylthiophene)with different molecular weights(M_(n))were fabricated using dip-coating *** the monolayer(solid state)formation from the solution,a disorder-to-order transition of polymer conformation is observed through UV-vis absorption ***,high Mn polymer monolayer generates higher crystalline fibrillar microstructure than the low Mn one due to the strongerπ–πintermolecular packing between *** importantly,the solution aging procedure is utilized to further improve the morphology of polymer *** is obvious that after aging for 6 d,both fiber dimension and density as well as conjugation length are significantly increased under the same processing conditions in comparison to the fresh solution,and consequently the field-effect mobilities are remarkably enhanced by 2—4 *** that the maximum mobility of 0.027 cm2·V^(–1)·s^(–1)is among the highest reported values for poly(3-hexylthiophene)monolayer *** results demonstrate a simple but powerful strategy for boosting the device performance of polymer monolayer transistors.

关键词： Aggregation Conjugation Monolayers Solution aging Charge transport