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Multi-organelle-targeting pH-dependent NIR fluorescent probe for lysosomal viscosity

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Chinese Chemical Letters 2023年第3期34卷 378-382页

作者： Huili Wang Yishuo Sun xuemei lin Wei Feng Zhanxian Li Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry State Key Laboratory of Molecular Engineering of PolymersInstitutes of Biomedical Sciences&Collaborative Innovation Center of Chemistry for Energy MaterialsFudan UniversityShanghai 200433China

The normal operation of lysosome, mitochondria, Golgi apparatus and endoplasmic reticulum plays a significant role in maintaining cell homeostasis. Reflecting the state and function of lysosomes, viscosity is a pivotal parameter to assess the stability of microenvironment. Herein, based on TICT mechanism,a new NIR pH-dependent fluorescent probe DCIC with push-pull electronic moiety was synthesized to identify the lysosomes viscosity. In viscous media, DCIC was highly sensitive to viscosity, fluorescence intensity increased by 180 times as viscosity increased from 1.0 cp to 438.4 cp. In addition, DCIC have high localization ability for lysosome, mitochondria, Golgi apparatus, and endoplasmic reticulum and can monitor lysosomal viscosity fluctuations with laser confocal microscopy.

关键词： NIR Lysosomal viscosity PH-dependent Multi-organelle localization

Fluorescence enhancement of Tb^(3+) complexes by adding silica-coated silver nanoparticles

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Science China Chemistry 2015年第6期58卷 979-985页

作者： Dan Zhou xuemei lin Ailing Wang Jingjing Li Yanrong Qu Haibin Chu Yongliang Zhao College of Chemistry and Chemical Engineering Inner Mongolia University

Six kinds of terbium ternary complexes with halo-benzoic acids were synthesized. Their compositions were determined by C, H elemental analyzer and EDTA titration. The infrared spectra, ultraviolet absorption spectra, and fluorescence spectra were also measured to identify the complexes. Elemental analysis showed that the compositions of these complexes were Tb（p-BrBA）3- H20, Tb（p-CIBA）3- 2H20, Tb（p-FBA）3- H20, Tb（o-FBA）3·2H20, Tb（o-CIBA）3· H20, and Tb（o-BrBA）3. H20, respectively. The monodispersed Ag@SiO2 core-shell nanoparticles with silica thicknesses of 10, 15, and 25 nm were success- fully prepared and characterized by transmission-electron microscopy. Fluorescence intensities of the complexes were detected before and after Ag@SiO2core-shell nanoparticles were added; the enhancement times were related to the silica-shell thick- ness. The fluorescence enhancement times were largest when the thickness of the silica shell was 25 nm. The mechanism may be attributed to the localized surface-plasmon resonance. Furthermore, the enhancement effect of terbium fluoro-benzoate complexes was the strongest in these complexes. This result may be attributed to the hydrogen bond between the hydroxyl on the surface of the silica shell and the fluorine atom.

关键词： Tb3+ complexes halobenzoic acids Ag@SiO2 core-shell nanoparticles metal-enhanced fluorescence

Modulation of Microstructure and Charge Transport in Polymer Monolayer Transistors by Solution Aging

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Chinese Journal of Chemistry 2021年第11期39卷 3079-3084页

作者： xuemei lin Ruochen Liu Chenming Ding Junyang Deng Yifu Guo Shibing Long ling Li Mengmeng Li Key Laboratory of Microelectronic Devices and Integrated Technology Institute of MicroelectronicsChinese Academy of SciencesBeijing100029 China School of Microelectronics University of Science and Technology of ChinaHefeiAnhui230026 China School of Electronic Electrical and Communication EngineeringUniversity of Chinese Academy of SciencesBeijing100049 China E-mail:

A few monolayers of organic semiconductors adjacent to the dielectric layer are of vital importance in organic field-effect transistors due to their dominant role in charge *** this report,the 2-nm-thick polymer monolayers based on poly(3-hexylthiophene)with different molecular weights(M_(n))were fabricated using dip-coating *** the monolayer(solid state)formation from the solution,a disorder-to-order transition of polymer conformation is observed through UV-vis absorption ***,high Mn polymer monolayer generates higher crystalline fibrillar microstructure than the low Mn one due to the strongerπ–πintermolecular packing between *** importantly,the solution aging procedure is utilized to further improve the morphology of polymer *** is obvious that after aging for 6 d,both fiber dimension and density as well as conjugation length are significantly increased under the same processing conditions in comparison to the fresh solution,and consequently the field-effect mobilities are remarkably enhanced by 2—4 *** that the maximum mobility of 0.027 cm2·V^(–1)·s^(–1)is among the highest reported values for poly(3-hexylthiophene)monolayer *** results demonstrate a simple but powerful strategy for boosting the device performance of polymer monolayer transistors.

关键词： Aggregation Conjugation Monolayers Solution aging Charge transport

Rapid Prediction of Wastewater Index Using CNN Architecture and PLS Series Statistical Methods

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Open Journal of Statistics 2024年第3期14卷 243-258页

作者： Qiushuang Mo Lili Xu Fangxiu Meng Shaoyong Hong xuemei lin School of Mathematics and Statistics Guilin University of Technology Guilin China College of Marine Sciences Beibu Gulf University Qinzhou China School of Data Science Guangzhou Huashang College Guangzhou China Community Management Office Guilin University of Technology Guilin China

Chemical oxygen demand (COD) is an important index to measure the degree of water pollution. In this paper, near-infrared technology is used to obtain 148 wastewater spectra to predict the COD value in wastewater. First, the partial least squares regression (PLS) model was used as the basic model. Monte Carlo cross-validation (MCCV) was used to select 25 samples out of 148 samples that did not conform to conventional statistics. Then, the interval partial least squares (iPLS) regression modeling was carried out on 123 samples, and the spectral bands were divided into 40 subintervals. The optimal subintervals are 20 and 26, and the optimal correlation coefficient of the test set (RT) is 0.58. Further, the waveband is divided into five intervals: 17, 19, 20, 22 and 26. When the number of joint intervals under each interval is three, the optimal RT is 0.71. When the number of joint subintervals is four, the optimal RT is 0.79. Finally, convolutional neural network (CNN) was used for quantitative prediction, and RT was 0.9. The results show that CNN can automatically screen the features inside the data, and the quantitative prediction effect is better than that of iPLS and synergy interval partial least squares model (SiPLS) with joint subinterval three and four, indicating that CNN can be used for quantitative analysis of water pollution degree.

关键词： Wastewater Near-Infrared Spectroscopy Chemistry Oxygen Demand Partial Least Squares Convolutional Neural Network Statistical Optimization

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行政执法中法律与习惯的冲突及其处理

中国行政管理 2013年第6期 37-40页

作者：林雪梅西南大学法学院副教授博士研究生重庆400715

习惯是人们在长期的生产和生活中逐渐形成的一种行为模式,它根植于社会生活,是一种支配人们行为和生活的无形力量。习惯是法律的重要渊源和社会基础。社会生活纷繁复杂,要使统一的抽象的法律适用于我国幅员辽阔多民族的不同风俗习惯,冲... 详细信息

习惯是人们在长期的生产和生活中逐渐形成的一种行为模式,它根植于社会生活,是一种支配人们行为和生活的无形力量。习惯是法律的重要渊源和社会基础。社会生活纷繁复杂,要使统一的抽象的法律适用于我国幅员辽阔多民族的不同风俗习惯,冲突是不可避免的。行政管理中要谨慎处理法律与习惯的冲突。行政机关制定法规规章时要慎重对待习惯;行政执法时,当习惯符合法律的原则、精神和立法目的,只是与法律的个别条款相冲突,则应按习惯处理。

关键词：行政执法习惯法律

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侵袭性血管黏液瘤研究进展

中国肿瘤临床 2020年第18期47卷 965-968页

作者：林雪梅(综述) 王琼(审校) 川北医学院附属医院病理科川北医学院病理教研室四川省南充市637000

侵袭性血管黏液瘤(aggressive angiomyxoma,AA)是一种少见的、通常发生在生育期女性外阴和盆腔等部位的间叶源性肿瘤。虽然具有局部浸润和局部复发的生物学行为特点,但目前的观点认为其并非恶性肿瘤。2003年第3版和2013年第4版世界卫生... 详细信息

侵袭性血管黏液瘤(aggressive angiomyxoma,AA)是一种少见的、通常发生在生育期女性外阴和盆腔等部位的间叶源性肿瘤。虽然具有局部浸润和局部复发的生物学行为特点,但目前的观点认为其并非恶性肿瘤。2003年第3版和2013年第4版世界卫生组织(WHO)肿瘤分类将其纳入骨和软组织肿瘤类别,并将其划入分化不确定的肿瘤类型。迄今为止国内外报道的AA病例数已超过350例,这些报道均以病例报告并文献复习的形式为主。本文将结合最新文献就AA的研究进展进行综述。

关键词：侵袭性血管黏液瘤软组织肿瘤间叶源性肿瘤

HClO_4/H_2SO_4混酸体系制备低硫可膨胀石墨的研究

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精细石油化工 2005年第6期22卷 48-51页

作者：林雪梅潘功配南京理工大学化工学院江苏南京210094

探索了 HCIO_4/H_2SO_4/KMnO_4/CH_3COOH 氧化插层体系制备低硫可膨胀石墨的新方法。研究发现,采用氧化插层体系可制得膨胀性能优良的低硫可膨胀石墨,最佳反应条件为:m(石墨)/m(混酸)/m(冰乙酸)/m(高锰酸钾)=1∶(1～1.5)∶0.75∶0.1,混... 详细信息

探索了 HCIO_4/H_2SO_4/KMnO_4/CH_3COOH 氧化插层体系制备低硫可膨胀石墨的新方法。研究发现,采用氧化插层体系可制得膨胀性能优良的低硫可膨胀石墨,最佳反应条件为:m(石墨)/m(混酸)/m(冰乙酸)/m(高锰酸钾)=1∶(1～1.5)∶0.75∶0.1,混酸中 m(浓硫酸)/m(高氯酸)=(1～1.5)∶1,氧化温度为25℃,氧化时间为30 min。在此条件下制备的低硫可膨胀石墨在900℃的膨胀容积可达352 mL/g。

关键词：低硫可膨胀石墨氧化插层体系制备工艺膨胀性能

HClO_4/H_2SO_4体系制备的低硫可膨胀石墨的结构与性能

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非金属矿 2005年第5期28卷 8-10页

作者：林雪梅潘功配南京理工大学化工学院南京210094

采用多种分析手段,对HClO4/H2SO4/KMnO4/CH3COOH氧化插层体系制备的低硫可膨胀石墨的结构和性能进行了研究。发现制备的可膨胀石墨从181.2℃开始发生明显的热失重,具有低温膨胀性能,300℃时的膨胀容积为115mL/g,400℃时可达263mL/g,可... 详细信息

采用多种分析手段,对HClO4/H2SO4/KMnO4/CH3COOH氧化插层体系制备的低硫可膨胀石墨的结构和性能进行了研究。发现制备的可膨胀石墨从181.2℃开始发生明显的热失重,具有低温膨胀性能,300℃时的膨胀容积为115mL/g,400℃时可达263mL/g,可膨胀石墨的石墨片层间存在SO42-、ClO4-、CH3COO-阴离子插层物和H2SO4、HClO4、CH3COOH等中性分子插层物,可膨胀石墨的X射线衍射图谱在2θ为29.25°处出现一个不太强的衍射特征峰。

关键词：低硫可膨胀石墨低温膨胀红外光谱热失重 X射线衍射低硫可膨胀石墨结构与性能制备 SO4^2- ClO4^- 衍射图谱结构和性能 H2SO4 HClO4

HClO_4/HNO_3混合酸法制备无硫可膨胀石墨研究

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非金属矿 2005年第6期28卷 24-26页

作者：林雪梅潘功配南京理工大学化工学院南京210094

探索了以高氯酸-硝酸混合酸为复合氧化插层剂、冰乙酸为辅助插层剂,制备无硫可膨胀石墨的工艺。其最佳反应条件为:石墨∶混合酸∶冰乙酸为1∶2∶(1￣1.5),混合酸中浓硝酸与高氯酸之比值为1,氧化温度为40℃,氧化时间为1h,该条件下制备的... 详细信息

探索了以高氯酸-硝酸混合酸为复合氧化插层剂、冰乙酸为辅助插层剂,制备无硫可膨胀石墨的工艺。其最佳反应条件为:石墨∶混合酸∶冰乙酸为1∶2∶(1￣1.5),混合酸中浓硝酸与高氯酸之比值为1,氧化温度为40℃,氧化时间为1h,该条件下制备的无硫可膨胀石墨的膨胀容积可达240mL/g,灰分为0.9%。

关键词：无硫可膨胀石墨高氯酸-硝酸混合酸制备工艺膨胀性能