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Antidepressant mechanism of Jieyu No.1 decoction in a rat model of depression

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Neural Regeneration Research 2011年第18期6卷 1386-1390页

作者： Liping Zhang Li Wu Meng Xia xueli shi Man Zhang Chi Tan Rui Yang Department of Basic Theory of Traditional Chinese Medicine School of Basic Medicine Guangxi Traditional Chinese Medical UniversityNanning 300073 Guangxi Zhuang Autonomous Region China

Rats were subjected to unpredictable chronic stress and isolation-induced depression, and were then intragastrically perfused with Jieyu No.1 decoction or amitriptyline water solution for 21 consecutive days. Open-field test showed that Jieyu No.1 decoction and amitriptyline water solution significantly improved the abnormal behaviors of the depressed rats; it reduced plasma surfactant protein, corticosterone, and corticotropin releasing hormone levels, increased neuropeptide Y and somatostatin levels, and upregulated interleukin-ll3, -2, -6 protein expression in the hippocampal CA3 region. Somatostatin and interleukin-l[3 protein expression were negatively correlated with corticosterone level, and interleukin-113 protein expression was negatively correlated with corticotropin releasing hormone level. Results demonstrated that Jieyu No.1 decoction improved abnormal behaviors of depressed animals by regulating the function of the neuroimmunoendocrine system.

关键词： modified Wendan decoction depression model animal neuroimmunoendocrine neural regeneration

Assessment of coal gasification in a pressurized fixed bed gasifier using an ASPEN plus and Euler–Euler model

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International Journal of Coal Science & Technology 2020年第3期7卷 516-535页

作者： Tamer M.Ismail Mingliang shi Jianliang Xu xueli Chen Fuchen Wang M.Abd El-Salam Mechanical Engineering Department Suez Canal UniversityIsmailiaEgypt Key Laboratory of Coal Gasification and Energy Chemical Engineering of Ministry of Education East China University of Science and TechnologyShanghaiChina Shanghai Engineering Research Center of Coal Gasification East China University of Science and TechnologyShanghaiChina Department of Basic Science Cairo UniversityGizaEgypt

With the help of Aspen Plus,a two-dimensional unsteady CFD model is developed to simulate the coal gasification process in a fixed bed gasifier.A developed and validated two dimensional CFD model for coal gasification has been used to predict and assess the viability of the syngas generation from coal gasification employing the updraft fixed bed gasifier.The process rate model and the sub-model of gas generation are determined.The particle size variation and char burning during gasification are also taken into account.In order to verify the model and increase the understanding of gasification characteristics,a set of experiments and numerical comparisons have been carried out.The simulated results in the bed are used to predict the composition of syngas and the conversion of carbon.The model proposed in this paper is a promising tool for simulating the coal gasification process in a fixed bed gasifier.

关键词： Fixed bed gasifier Aspen plus Euler-Euler model Coal

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市售调制乳中香精关注成分的分析及风险评估

食品科学技术学报 2022年第6期40卷 153-162页

作者：石丽丽李婷李昊泽曹学丽北京食品营养与人类健康高精尖创新中心/北京工商大学轻工科学技术学院北京100048

香精在调制乳中可起到提供、补充、稳定风味的作用。由于香精使用具有“自我限量”的特性,用量较低,因此对香精成分潜在的安全风险关注较少。采用经过方法学评价的顶空固相微萃取-气相色谱串联质谱(多反应监测模式)的定量分析方法,对25... 详细信息

香精在调制乳中可起到提供、补充、稳定风味的作用。由于香精使用具有“自我限量”的特性,用量较低,因此对香精成分潜在的安全风险关注较少。采用经过方法学评价的顶空固相微萃取-气相色谱串联质谱(多反应监测模式)的定量分析方法,对25种品牌100个市售调制乳样品中的19种香精关注成分的含量进行了分析测定。发现检出率较高的4种成分分别是苯甲醛(100%)、2,3-丁二酮(96%)、芳樟醇(88%)和正己醇(86%),平均含量较高的4种分别是香兰素(18 886.03μg/kg)、乙基麦芽酚(6 271.15μg/kg)、麦芽酚(2 522.64μg/kg)和苯甲醇(1 937.60μg/kg),其检出率分别是47%、71%、40%和30%。香精成分在不同的调制乳样品中的含量差异很大,即使相同口味不同品牌之间也存在很大的差异。基于各人群调制乳日摄入量的调查结果,对19种香精关注成分进行了暴露水平评估和安全风险评价。全人群和不同人群的暴露分析均显示,乙基麦芽酚和香兰素的人均日摄入量有超出毒理学关注阈值的情况,且不同人群情况不同,但是整体风险较低,其余调制乳的香精关注成分在现有摄入量下基本不存在安全风险。

关键词：调制乳香精关注成分乙基麦芽酚香兰素暴露水平风险评估

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蓄热毛型针织物的开发与评价

上海纺织科技 2023年第9期51卷 51-55页

作者：林雪丽史丽敏北京服装学院材料设计与工程学院北京100029 北京服装学院服装艺术与工程学院北京100029

为研究蓄热毛型针织物的最佳保暖织造方案,设计开发了11种蓄热毛型针织物,采用3因素3水平正交试验设计了9种织造方案,以克罗值和20min内平均蓄热升温值作为评价指标,对保暖性较好且面密度适中的8种织物进行服用性能测试并用模糊数学对... 详细信息

为研究蓄热毛型针织物的最佳保暖织造方案,设计开发了11种蓄热毛型针织物,采用3因素3水平正交试验设计了9种织造方案,以克罗值和20min内平均蓄热升温值作为评价指标,对保暖性较好且面密度适中的8种织物进行服用性能测试并用模糊数学对其进行综合评价。得出以下结论:组织结构对织物克罗值影响较大,芝麻点提花组织的保暖性较好交织纱线对织物蓄热升温性能影响最大,咖啡碳涤纶丝的蓄热升温性能较好;羊毛/石墨烯涤纶(4根)交织芝麻点提花织物的综合性能最好,羊毛/咖啡碳涤纶(4根)交织芝麻点提花织物次之,且两种织物的保暖性能也最优。

关键词：针织物织物组织保暖性纱线织造工艺模糊综合评价

Safety of endovascular therapy for symptomatic intracranial artery stenosis:a national prospective registry

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Stroke & Vascular Neurology 2022年第2期7卷 166-171页

作者： Yabing Wang Tao Wang Adam Andrew Dmytriw Kun Yang Liqun Jiao Huaizhang shi Jie Lu Tianxiao Li Yujie Huang Zhenwei Zhao Wei Wu Jieqing Wan Qinjian Sun Bo Hong Yongli Li Liyong Zhang Jianfeng Chu Qiong Cheng Yiling Cai Pengfei Wang Qi Luo Hua Yang Baijing Dong Yang Zhang Jun Zhao Zuoquan Chen Wei Li Xiaoxin Bai Weiwen He xueli Cai Maimai Ti Osama O Zaidat Department of Neurosurgery Xuanwu HospitalBeijingChina Neuroendovascular Program Massachusetts General HospitalBostonMassachusettsUSA Department of Evidence-Based Medicine Xuanwu HospitalBeijingChina Department of Neurosurgery First Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Radiology Xuanwu HospitalBeijingChina Center of Neurointerventional Therapy Henan Provincial People's HospitalZhengzhouChina Department of Neurology Nanjing Drum Tower HospitalNanjingJiangsuChina Department of Neurosurgery Tangdu Hospital Fourth Military Medical UniversityXi'anShaanxiChina Department of Neurology Shandong University Qilu HospitalJinanShandongChina Department of Neurosurgery Shanghai Jiao Tong University School of Medicine Affiliated Renji HospitalShanghaiShanghaiChina Department of Neurology Shandong Provincial HospitalJinanShandongChina Neusurgery Changhai HospitalShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Liaocheng People's HospitalLiaocheng CityShandongChina Department of Neurosurgery Jining First People's HospitalJiningShandongChina Department of Neurology Fujian Provincial HospitalFuzhouFujianChina Department of Neurology 306 Hospital of People's Liberation ArmyBeijingChina Department of Neurosurgery Tianjin Huanhu HospitalTianjinTianjinChina Department of Neurosurgery Jilin University First HospitalChangchunJilinChina Department of Neurology Affiliated Hospital of Guiyang Medical CollegeGuiyangGuizhouChina Department of Neurosurgery Fourth Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiangChina Department of Neurosurgery Peking University First HospitalBeijingBeijingChina Department of Neurology Liaocheng Second People's HospitalLiaochengChina Department of Neurology Shanghai Tenth People's HospitalShanghaiChina Department of Neurosurgery Tianjin Medical University General HospitalTianjinTianjin

Introduction The safety outcomes of endovascular therapy for intracranial artery stenosis in a real-world stetting are largely unknown.The Clinical Registration Trial of Intracranial Stenting for Patients with Symptomatic Intracranial Artery Stenosis(CRTICAS)was a prospective,multicentre,real-world registry designed to assess these outcomes and the impact of centre experience.Methods 1140 severe,symptomatic intracranial arterial stenosis(ICAS)patients treated with endovascular therapy were included from 26 centres,further divided into three groups according to the annual centre volume of intracranial angioplasty and stent placement procedures over 2 years:(1)high volume for≥25 cases/year;(2)moderate volume for 10–25 cases/year and(3)low volume for<10 cases/year.Results The rate of 30-day stroke,transient ischaemic attack or death was 9.7%(111),with 5.4%,21.1%and 9.7%in high-volume,moderate-volume and low-volume centres,respectively(p<0.05).Multivariable logistic regression confirmed high-volume centres had a significantly lower primary endpoint compared with moderate-volume centres(OR=0.187,95%CI:0.056 to 0.627;p≤0.0001),while moderate-volume and low-volume centres showed no significant difference(p=0.8456).Conclusion Compared with the preceding randomised controlled trials,this real-world,prospective,multicentre registry shows a lower complication rate of endovascular treatment for symptomatic ICAS.Non-uniform utilisation in endovascular technology,institutional experience and patient selection in different volumes of centres may have an impact on overall safety of this treatment.

关键词： intracranial prospective stenosis

酸枣仁-合欢花药对在抑郁症模型大鼠的治疗作用

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中国实验方剂学杂志 2023年第24期29卷 87-94页

作者：武尚志施学丽张亚光祁祥李玲广西中医药大学南宁530200

目的:研究酸枣仁-合欢花药对对慢性温和不可预知性应激(CUMS)抑郁模型大鼠海马组织中核苷酸结合寡聚化结构域样受体蛋白1(NLRP1)/趋化因子配体1(CXCL1)/趋化因子受体2(CXCR2)通路的影响。方法:120只雄性SD大鼠随机分为正常组、CUMS组、C... 详细信息

目的:研究酸枣仁-合欢花药对对慢性温和不可预知性应激(CUMS)抑郁模型大鼠海马组织中核苷酸结合寡聚化结构域样受体蛋白1(NLRP1)/趋化因子配体1(CXCL1)/趋化因子受体2(CXCR2)通路的影响。方法:120只雄性SD大鼠随机分为正常组、CUMS组、CUMS+酸枣仁-合欢花低、中、高剂量组(4、8、16 g·kg^(-1))、CUMS+盐酸文拉法辛组(0.008 g·kg^(-1)),每组20只。采用孤养结合CUMS来复制抑郁模型,通过糖水消耗实验、悬尾试验、强迫游泳实验及Morris水迷宫实验测定大鼠行为学和空间学习记忆能力;采用实时荧光定量聚合酶链式反应(Real-time PCR)和蛋白免疫印迹法(Western blot)检测大鼠海马组织中NLRP1/CXCL1/CXCR2通路相关因子的变化情况;酶联免疫吸附测定法(ELISA)检测大鼠海马组织中肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-18、IL-1β及IL-6的含量;组织免疫荧光检测海马组织中活性氧(ROS)水平。结果:与正常组比较,CUMS各处理组大鼠的糖水偏爱度和穿台次数显著降低(P<0.01),而悬尾不动时间、强迫游泳漂浮时间和逃避潜伏期则显著升高(P<0.01);与CUMS组比较,酸枣仁-合欢花各剂量组和盐酸文拉法辛组则明显改变CUMS对上述大鼠行为学和空间学习记忆能力的影响(P<0.05,P<0.01)。与正常组比较,CUMS组大鼠海马组织中NLRP1、CXCL1和CXCR2的蛋白水平均有显著升高(P<0.01),炎性因子IL-18、IL-1β、TNF-α和IL-6的含量显著升高(P<0.01)。与模型组比较,酸枣仁-合欢花和盐酸文拉法辛组明显降低CUMS大鼠海马中NLRP1/CXCL1/CXCR2信号通路的活化及炎症因子的水平(P<0.05,P<0.01),此外,酸枣仁-合欢花药对明显降低CUMS大鼠海马组织中的ROS水平(P<0.05,P<0.01)。结论:酸枣仁-合欢花药对能够改善CUMS抑郁模型大鼠的抑郁行为,其作用机制可能与其抑制ROS/NLRP1/CXCL1/CXCR2信号通路的活化有关。

关键词：酸枣仁-合欢花抑郁症核苷酸结合寡聚化结构域样受体蛋白1 趋化因子配体1 趋化因子受体2

基于疏水改性的超低密度控水支撑剂的制备及其性能

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油田化学 2022年第3期39卷 401-406,437页

作者：史斌苏延辉邢洪宪郑晓斌耿学礼中海油能源发展股份有限公司工程技术分公司天津300452

针对常规陶粒支撑剂密度高且不具备控水性能的问题,先将超低密度有机支撑剂基体的表面进行高温氧化使其表面产生活性基团,然后通过全氟羧酸在活化支撑剂表面通过亲核加成反应合成超疏水层得到超低密度控水支撑剂,评价了该支撑剂的润湿... 详细信息

针对常规陶粒支撑剂密度高且不具备控水性能的问题,先将超低密度有机支撑剂基体的表面进行高温氧化使其表面产生活性基团,然后通过全氟羧酸在活化支撑剂表面通过亲核加成反应合成超疏水层得到超低密度控水支撑剂,评价了该支撑剂的润湿性、阻水性能及油水相渗流性能,并进行了现场应用试验。研究表明,水在该支撑剂表面的接触角达到158.6°,阻水高度为25 cm,与改性前相比地层水渗流阻力增加40%,具有明显的选择性控水效果,且耐冲刷性能优异。超低密度控水支撑剂现场试验充填率达到了100%,且投产后含水率及含水上升速率远低于邻井,产油量显著好于邻井,显示了很好的应用前景。

关键词：疏水超低密度控水支撑剂聚苯乙烯全氟羧酸

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冰球服装面料服用性能的综合评价

北京服装学院学报（自然科学版） 2023年第2期43卷 44-49,57页

作者：朱鲁婧史丽敏林雪丽北京服装学院服装艺术与工程学院北京100029 北京服装学院材料设计与工程学院北京100029

为满足冰球运动对服装热湿舒适性、运动舒适性及耐用性的功能需求,选取绞花纱罗网眼、凹凸提花鸟眼、菱形纱罗网眼、四角网眼共4种组织的8款冰球服用针织面料对其进行透气性、透湿性、弹性、耐磨性等测试与分析,采用模糊综合评价方法对... 详细信息

为满足冰球运动对服装热湿舒适性、运动舒适性及耐用性的功能需求,选取绞花纱罗网眼、凹凸提花鸟眼、菱形纱罗网眼、四角网眼共4种组织的8款冰球服用针织面料对其进行透气性、透湿性、弹性、耐磨性等测试与分析,采用模糊综合评价方法对面料的性能进行综合评价。结果表明:在材料组成相同情况下,纱罗网眼织物结构疏松,透气性优于提花鸟眼织物;单位面积内网眼密度越大,透气性越好。在材料组成相同、厚度相近情况下,面密度较大的织物透湿性较差。与纯涤纶织物相比,四角网眼织物由锦氨包芯纱制成,其横、纵向弹性回复率均较佳,但因其质地相对轻薄,耐磨性显著下降。模糊综合评价结果可为冰球服不同功能区域的面料选用提供建议。

关键词：冰球服服用性能模糊综合评价

基于改进Multi-ResUnet算法的黏结集料图像分割方法

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同济大学学报（自然科学版） 2022年第5期50卷 741-749页

作者：郝雪丽李玉峰裴莉莉李伟石丽曹磊长安大学信息工程学院陕西西安710064 安徽科力信息产业有限责任公司智能交通安徽省重点实验室安徽合肥230088

为提高黏结集料图像的分割精度,提出了基于Inception网络与残差连接优化的黏结集料图像分割模型(Multi-ResUnet模型)。利用实验室自主研发的集料三维特性分析系统V3.0对黏结集料图像进行采集,并建立图像分割模型样本集,然后采用图像分... 详细信息

为提高黏结集料图像的分割精度,提出了基于Inception网络与残差连接优化的黏结集料图像分割模型(Multi-ResUnet模型)。利用实验室自主研发的集料三维特性分析系统V3.0对黏结集料图像进行采集,并建立图像分割模型样本集,然后采用图像分割模型对样本集进行训练。结果表明:相较于分水岭算法和Unet模型,该图像分割模型的精确率分别提升了30.46%和2.11%,召回率分别提升了4.68%和1.85%,准确率分别提升了25.95%和2.47%。

关键词：沥青混合料黏结集料图像分割 Multi-ResUnet模型分水岭算法