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Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis

Bone Research 2024年第1期12卷 215-226页

作者： Yuhang Liu Ruihan Hao Jia Lv Jie Yuan xuelei Wang Churong Xu Ding Ma Zhouyi Duan Bingjun Zhang Liming Dai Yiyun Cheng Wei Lu Xiaoling Zhang Department of Orthopedic Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(SJTUSM)Shanghai 200092China National Facility for Translational Medicine Shanghai 200240China Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Orthopaedic Surgery The Second Hospital of Shanxi Medical UniversityTaiyuan 030001China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China School of Medicine Shanghai UniversityShanghai 200444China

Osteoarthritis(OA)is a common degenerative disease worldwide and new therapeutics that target inflammation and the crosstalk between immunocytes and chondrocytes are being developed to prevent and treat *** attempts involve repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype in *** this study,we found that phosphoglycerate mutase 5(PGAM5)significantly increased in macrophages in OA synovium compared to controls based on histology of human samples and single-cell RNA sequencing results of mice *** address the role of PGAM5 in macrophages in OA,we found conditional knockout of PGAM5 in macrophages greatly alleviated OA symptoms and promoted anabolic metabolism of chondrocytes in vitro and in ***,we found that PGAM5 enhanced M1 polarization via AKT-mTOR/p38/ERK pathways,whereas inhibited M2 polarization via STAT6-PPARγpathway in murine bone marrow-derived ***,we found that PGAM5 directly dephosphorylated Dishevelled Segment Polarity Protein 2(DVL2)which resulted in the inhibition ofβ-catenin and repolarization of M2 macrophages into M1 *** knockout of both PGAM5 andβ-catenin in macrophages significantly exacerbated osteoarthritis compared to PGAM5-deficient *** by these findings,we successfully designed mannose modified fluoropolymers combined with siPGAM5 to inhibit PGAM5 specifically in synovial macrophages via intra-articular injection,which possessed desired targeting abilities of synovial macrophages and greatly attenuated murine ***,these findings defined a key role for PGAM5 in orchestrating macrophage polarization and provides insights into novel macrophage-targeted strategy for treating OA.

关键词： osteoarthritis metabolism inhibited

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高体积分数CO2气调包装对冷藏凡纳滨对虾品质的影响

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食品科学 2016年第18期37卷 197-201页

作者：谢晶程颖杨胜平章缜钱韻芳邓雪蕾上海海洋大学食品学院上海水产品加工及贮藏工程技术研究中心上海201306

为研究高体积分数CO_2气调包装对凡纳滨对虾品质的影响,以空气包装为对照,分别采用100%CO_2、80%CO_2+20%N_2和50%CO_2+10%O_2+40%N_2气调包装对虾,并在(4±1)℃条件下贮藏10 d,期间每2 d测定对虾细菌总数及其挥发性盐基氮值、肌肉纤维... 详细信息

为研究高体积分数CO_2气调包装对凡纳滨对虾品质的影响,以空气包装为对照,分别采用100%CO_2、80%CO_2+20%N_2和50%CO_2+10%O_2+40%N_2气调包装对虾,并在(4±1)℃条件下贮藏10 d,期间每2 d测定对虾细菌总数及其挥发性盐基氮值、肌肉纤维长度、硬度、多酚氧化酶活性、白度、感官评分的变化。结果表明:在冷藏条件下,高体积分数CO_2气调包装能有效抑制细菌的生长繁殖和多酚氧化酶的活性,且CO_2体积分数越高抑制效果越明显;但100%CO_2处理的对虾与80%CO_2组相比,其样品挥发性盐基氮值较高,肌肉纤维长度和硬度均较小,感官品质较差;50%CO_2组对虾白度较低,与空白对照组差异不明显。因此,所选取高体积分数CO_2气调包装中,80%CO_2组的保鲜效果最佳,能有效延长凡纳滨对虾的冷藏货架期至8 d。

关键词：凡纳滨对虾二氧化碳气调包装品质

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Application of Regularization Methods in the Sky Map Reconstruction of the Tianlai Cylinder Pathfinder Array

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Research in Astronomy and Astrophysics 2024年第2期24卷 24-35页

作者： Kaifeng Yu Shifan Zuo Fengquan Wu Yougang Wang xuelei Chen National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Key Laboratory of Radio Astronomy and Technology Chinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Center of High Energy Physics Peking UniversityBeijing 100871China

The Tianlai cylinder pathfinder is a radio interferometer array to test 21 cm intensity mapping techniques in the post-reionization *** works in passive drift scan mode to survey the sky visible in the northern *** deal with the large instantaneous field of view and the spherical sky,we decompose the drift scan data into m-modes,which are linearly related to the sky *** sky map is reconstructed by solving the linear interferometer *** to incomplete uv coverage of the interferometer baselines,this inverse problem is usually ill-posed,and regularization method is needed for its *** this paper,we use simulation to investigate two frequently used regularization methods,the Truncated Singular Value Decomposition(TSVD),and the Tikhonov regularization *** the regularization parameter is very important for its *** employ the generalized cross validation method and the L-curve method to determine the optimal *** compare the resulting maps obtained with the different regularization methods,and for the different parameters derived using the different *** both methods can yield good maps for a range of regularization parameters,in the Tikhonov method the suppression of noisy modes are more gradually applied,produce more smooth maps which avoids some visual artefacts in the maps generated with the TSVD method.

关键词： techniques interferometric-methods numerical-cosmology observations-radio continuum general

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数字经济推进京津冀协同发展的内在机理与前进路径

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经济纵横 2024年第4期 54-61页

作者：吴学磊武汉大学马克思主义学院湖北武汉430072

新时代,京津冀空间功能协同、产业协同、创新协同和市场协同构成了三地协同发展的重要维度。数字经济作为高质量发展的新引擎,具有提升京津冀空间功能承载力、增强产业协同度、优化创新生态、提升市场协同度等功能,可以为京津冀协同发... 详细信息

新时代,京津冀空间功能协同、产业协同、创新协同和市场协同构成了三地协同发展的重要维度。数字经济作为高质量发展的新引擎,具有提升京津冀空间功能承载力、增强产业协同度、优化创新生态、提升市场协同度等功能,可以为京津冀协同发展注入强劲动力。目前,京津冀数字产业协同度不高、数据要素利用不充分、数字人才区域分布与培养体系不合理、数字基础设施建设的协同度有限等现实问题,制约了京津冀协同发展质效的提升。需要加强顶层设计,优化产业布局,释放数据要素活力,构建数字人才协同引培机制,加快推进数字基础设施建设,推动形成一体化的数字经济发展格局,为京津冀协同发展注入新动能。

关键词：数字经济京津冀数据协同发展

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Systematic identification of wheat spike developmental regulators by integrated multiomics, transcriptional network, GWAS, and genetic analyses

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Molecular Plant 2024年第3期17卷 438-459页

作者： xuelei Lin Yongxin Xu Dongzhi Wang Yiman Yang Xiaoyu Zhang Xiaomin Bie Lixuan Gui Zhongxu Chen Yiliang Ding Long Mao Xueyong Zhang Fei Lu Xiansheng Zhang Cristobal Uauyo Xiangdong Fu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Nanjing Agricultural University NanjingJiangsu 210095China Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTaianShandong 271018China Department of Life Science Tcuni Inc.ChengduSichuan 610000China John Innes Centre Norwich Research ParkNorwich NR47UHUK Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyCASBeijing 100101China

The spike architecture of wheat plays a crucial role in determining grain number,making it a key trait for optimization in wheat breeding *** this study,we used a multi-omic approach to analyze the transcriptome and epigenome profiles of the young spike at eight developmental stages,revealing co-ordinated changes in chromatin accessibility and H3K27me3 abundance during the flowering *** constructed a core transcriptional regulatory network(TRN)that drives wheat spike formation and experimentally validated a multi-layer regulatorymodule involving TaSPL15,TaAGLG1,and *** integrating the TRN with genome-wide association studies,we identified 227 transcription factors,including 42 with known functions and 185 with unknown *** investigation of 61 novel transcription factors using multiple homozygous mutant lines revealed 36 transcription factors that regulate spike architecture or flowering time,such as TaMYC2-A1,TaMYB30-A1,and *** particular interest,TaMYB30-A1,downstream of and repressed by WFzP,was found to regulate fertile spikelet ***,the excellent haplotype of TaMYB30-A1,which contains a C allele at the WFzP binding site,was enriched during wheat breeding improvement in China,leading to improved agronomic ***,we constructed a free and open access Wheat Spike Multi-Omic Database(http://39.***.48.156:8800/#/).Our study identifies novel and high-confidence regulators and offers an effective strategy for dissecting the genetic basis of wheat spike development,with practical value forwheat breeding.

关键词： wheat spike development epigenome TRN TaMYB30-A1 breeding selection

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TabHLH27 orchestrates root growth and drought tolerance to enhance water use efficiency in wheat

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Journal of Integrative Plant Biology 2024年第7期66卷 1295-1312页

作者： Dongzhi Wang Xiuxiu Zhang Yuan Cao Aamana Batool Yongxin Xu Yunzhou Qiao Yongpeng Li Hao Wang xuelei Lin Xiaomin Bie Xiansheng Zhang Ruilian Jing Baodi Dong Yiping Tong Wan Teng Xigang Liu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Center for Agricultural Resources Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesShijiazhuang 050022China Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai'an 271018China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Ministry of Education Key Laboratory of Molecular and Cellular Biology Hebei Research Center of the Basic Discipline of Cell BiologyHebei Collaboration Innovation Center for Cell Signaling and Environmental AdaptationHebei Key Laboratory of Molecular and Cellular BiologyCollege of Life SciencesHebei Normal UniversityShijiazhuang 050024China Centre of Excellence for Plant and Microbial Science(CEPAMS) JIC‐CASBeijing 100101China

Cultivating high-yield wheat under limited water resources is crucial for sustainable agriculture in semiarid *** water scarcity,plants activate drought response signaling,yet the delicate balance between drought tolerance and development remains *** genome-wide association studies and transcriptome profiling,we identified a wheat atypical basic helix-loop-helix(b HLH)transcription factor(TF),Tab HLH27-A1,as a promising quantitative trait locus candidate for both relative root dry weight and spikelet number per spike in *** HLH27-A1/B1/D1 knockout reduced wheat drought tolerance,yield,and water use efficiency(WUE).Tab HLH27-A1 exhibited rapid induction with polyethylene glycol(PEG)treatment,gradually declining over *** activated stress response genes such as Ta CBL8-B1 and Ta CPI2-A1 while inhibiting root growth genes like Ta SH15-B1 and Ta WRKY70-B1 under short-term PEG *** distinct transcriptional regulation of Tab HLH27-A1 involved diverse interacting factors such as Ta ABI3-D1 and Tab *** variations of Tab HLH27-A1influence its transcriptional responses to drought stress,with Tab HLH27-A1^(Hap-II)associated with stronger drought tolerance,larger root system,more spikelets,and higher WUE in ***,the excellent Tab HLH27-A1^(Hap-II)was selected during the breeding process in China,and introgression of Tab HLH27-A1^(Hap-II)allele improved drought tolerance and grain yield,especially under water-limited *** study highlights Tab HLH27-A1's role in balancing root growth and drought tolerance,providing a genetic manipulation locus for enhancing WUE in wheat.

关键词： drought tolerance GWAS root growth wheat WUE

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Significant carbon isotope excursions in the Cambrian and their implications for global correlations

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Science China Earth Sciences 2011年第12期54卷 1686-1695页

作者： FAN Ru deng ShengHui ZHANG xuelei Research Institute of Petroleum Exploration ＆ Development PetroChina Beijing 100083 China State Key Laboratory of Enhanced Oil Recovery Beijing 100083 China Key Laboratory of OU and Gas Reservoir CNPC Beijing 100083 China

The existing δ 13C data in the Cambrian from different regions of the world are analyzed here. There are four well-documented carbon isotope excursions with global significance. In ascending order, they are：（1） a large negative excursion, comparable to ＂BACE＂（BAsal Cambrian Carbon isotope Excursion） event, which occurs near the Precambrian-Cambrian boundary with a magnitude of 4‰-10‰ （PDB）; （2） the ＂ZHUCE＂（ZHUjiaqing Carbon isotope Excursion） event, a distinct positive excursion （over 5%0） that can be recognized at the Fortunian Stage to Stage 2 transition; （3） another strong negative one, so-called ＂ROECE＂（Redlichiid-Olenellid Extinction Carbon isotope Excursion） event, shifting at the interval between Series 2 and Series 3, peaking at -3‰--5‰ （PDB）; （4） the famous Steptoean positive carbon isotope excursion （SPICE）, which has been widely identified at the base of Furongian Series, Paibian Stage, with an amplitude about 4‰ （PDB）. The four sharp σ13C shifts correlate well with coeval paleoceanographic changes and bioevents. Besides, there are some σ13C excursions from a few sections in previous studies, and more data are required to identify whether they are global or regional ones.

关键词： carbon isotope excursions global correlations Cambrian

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融合知识图谱与协同过滤的微地图推荐

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地球信息科学学报 2024年第4期26卷 967-977页

作者：牛雪磊杨军闫浩文兰州交通大学测绘与地理信息学院兰州730070 地理国情监测技术应用国家地方联合工程研究中心兰州730070 甘肃省地理国情监测工程实验室兰州730070

针对推荐系统中数据稀疏问题,传统的协同过滤算法无法捕捉辅助信息之间的相关性,从而降低了推荐的准确性。为此,本文提出融合知识图谱的协同过滤模型(Knowledge Graph Embedding Collaborative Filtering,KGCF),引入知识图谱作为辅助信... 详细信息

针对推荐系统中数据稀疏问题,传统的协同过滤算法无法捕捉辅助信息之间的相关性,从而降低了推荐的准确性。为此,本文提出融合知识图谱的协同过滤模型(Knowledge Graph Embedding Collaborative Filtering,KGCF),引入知识图谱作为辅助信息,利用知识图谱中多源结构性的数据来缓解数据稀疏问题。KGCF模型结合知识图谱的语义信息和协同过滤的偏好信息,能够挖掘出用户和微地图的隐语义交互信息,从而达到“千人千面”的推荐效果。(1)融合知识图谱和协同过滤算法对微地图数据集进行采集训练;(2)通过皮尔逊相关系数计算出用户之间的相似矩阵,并对稀疏的评分矩阵进行隐语义矩阵分解,采用基准(Baseline)得到用户和微地图地名的偏好信息;(3)通过知识图谱将微地图语义信息转化为低维向量,采用余弦相似度计算出微地图地名之间的相似矩阵;(4)将用户和微地图地名结合为一个推荐结果集。通过在微地图数据集上实验,证明了本文提出的KGCF模型能有效解决数据稀疏,可准确为用户推荐感兴趣的微地图。

关键词：知识图谱协同过滤数据稀疏微地图推荐系统结构性数据隐语义

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上游行业进口中间品对企业出口韧性的影响——基于中国企业数据的分析

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国际商务研究 2024年第3期45卷 1-15页

作者：杜运苏陈雪雷南京林业大学江苏南京210037 南京财经大学江苏南京210023

在中国出口形势日益严峻的背景下,如何增强企业出口韧性成为重要的课题。基于中国工业企业数据库和海关贸易数据库的匹配数据,以2008年金融危机为外生冲击,本文将企业出口韧性划分为抵抗力和恢复力两方面,研究上游行业进口中间品对企业... 详细信息

在中国出口形势日益严峻的背景下,如何增强企业出口韧性成为重要的课题。基于中国工业企业数据库和海关贸易数据库的匹配数据,以2008年金融危机为外生冲击,本文将企业出口韧性划分为抵抗力和恢复力两方面,研究上游行业进口中间品对企业出口韧性的影响路径。结果表明:上游行业进口中间品会显著增强下游企业出口韧性,该结论经过一系列检验仍然稳健;从作用机制来看,上游行业进口中间品可以通过出口升级效应和成本降低效应提高企业出口韧性。考虑企业异质性发现,上游行业进口中间品对企业出口韧性的促进作用在抵抗期对中小规模企业、国有企业的影响更显著;在经济抵抗期和恢复调整期,上游行业进口中间品对东部地区企业、加工贸易为主企业的出口韧性的促进作用更显著。此外,通过进一步研究发现,国内上游行业垄断和市场分割会削弱上游行业进口中间品对下游企业出口韧性的提升效果。

关键词：出口韧性上游中间品进口出口产品质量出口技术复杂度

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智慧图书馆未来学习中心建设的探索

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嘉兴学院学报 2024年第4期36卷 113-116页

作者：梁雪雷邓文龙嘉兴大学图书馆浙江嘉兴314001

通过分析智慧图书馆的演变历程和未来学习中心出现的必然性,深入剖析了“智慧”的本源,找寻从智能到智慧过渡的分界线——“形”,进而探索智慧图书馆未来学习中心建设的核心理念与发展方向:通过元宇宙技术突破“形”的界限,打造未来学... 详细信息

通过分析智慧图书馆的演变历程和未来学习中心出现的必然性,深入剖析了“智慧”的本源,找寻从智能到智慧过渡的分界线——“形”,进而探索智慧图书馆未来学习中心建设的核心理念与发展方向:通过元宇宙技术突破“形”的界限,打造未来学习中心的智慧学习范式,为高校智慧图书馆未来学习中心建设提供参考。

关键词：智慧图书馆未来学习中心元宇宙建设

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