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Particuology 2024年第1期84卷 168-177页

作者： Qingye Meng Shuangling Zhong Jingfei Wang Zhenqian Zhang Yan gao xuejun Cui College of Chemistry Jilin University Changchun130012China College of Resources and Environment Jilin Agricultural University Changchun130118China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun130012China Weihai Institute for Bionics-Jlin University Weihai264400China

In this study,sodium alginate(SA),a non-toxic natural polysaccharide with good biocompatibility and biodegradability,was developed for targeted delivery of curcumin(CUR)in tumor therapy.The strategy is to sulfhydrylate the folic acid(FA)modified SA,and the CUR dissolved in ethyl acetate(EAC)phase is coated in microcapsules by a quick,efficient and environment-friendly sonochemical method.The EAC in the microcapsule core is volatile,which can be recycled and reused to reduce cost.The prepared mi-crocapsules(FA-RSMCs@CUR)exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro.FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro.It is expected to become a low-cost tumor targeting vector in the future,and has the potential to be promoted in clinical application.

关键词： Reductive-responsive Sodium alginate Microcapsule Targeted delivery Sonochemical

Advances in controlled-release fertilizer encapsulated by organic-inorganic composite membranes

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Particuology 2024年第1期84卷 236-248页

作者： Xueping Wang Yongyan Yang Shuangling Zhong Qingye Meng Yiwei Li Jia Wang Yan gao xuejun Cui College of Chemistry Jilin UniversityChangchun130012China College of Resources and Environment Jilin Agricultural UniversityChangchun130118China State Key Laboratory of Supramolecular Structure and Materials Jilin UniversityChangchun130012China Weihai Institute for Bionics-Jilin University Weihai264400China

Heavy use of conventional fertilizers can lead to negative environmental concerns.Controlled-release fertilizers(CRFs)can effectively reduce the amounts of fertilizers used,improve the availability of fer-tilizers,and which is conducive to the protection of the ecological environment and sustainable devel-opment of agriculture.Therefore,it is imperative to develop and use CRFs as an alternative to traditional fertilizers.This review aims to present the classification,raw material composition,benefits,release process,release mode,and manufacturing methods of fertilizers coated with organic-inorganic com-posite membranes(OICMs)in order to provide an overall update and summarize CRFs encapsulated by OICMs and provide an insight for future trends in the field of fertilizers.It is expected that utilizing CRFs encapsulated by OICMs and their characteristics for agricultural applications can provide innovative ideas and suggestions for developing novel CRFs suitable for modern and sustainable agriculture.

关键词： Controlled-release fertilizers Organic-inorganic composite membranes Surface treatments

Catalytic oxidation of toluene by manganese oxides:Effect of K^(+)doping on oxygen vacancy

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Journal of Environmental Sciences 2024年第8期142卷 43-56页

作者： Zhenzhen Huang Haiyang Li xuejun Zhang Yanli Mao Yinghan Wu Wei Liu Hongrun gao Mengru Zhang Zhongxian Song Faculty of Environmental and Municipal Engineering Henan Key Laboratory of Water Pollution Control and Rehabilitation TechnologyHenan University of Urban ConstructionPingdingshan 467036China College of Environmental and Safety Engineering Shenyang University of Chemical TechnologyShenyang 110142China

Alkali metal potassium was beneficial to the electronic regulation and structural stability of transition metal oxides.Herein,K ions were introduced into manganese oxides by different methods to improve the degradation efficiency of toluene.The results of activity experiments indicated that KMnO_(4)-HT(HT:Hydrothermal method)exhibited outstanding low-temperature catalytic activity,and 90%conversion of toluene can be achieved at 243℃,which was 41℃and 43℃lower than that of KNO_(3)-HT and Mn-HT,respectively.The largest specific surface area was observed on KMnO_(4)-HT,facilitating the adsorption of toluene.The formation of cryptomelane structure over KMnO_(4)-HT could contribute to higher content of Mn^(3+)and lattice oxygen(Olatt),excellent low-temperature reducibility,and high oxygen mobility,which could increase the catalytic performance.Furthermore,two distinct degradation pathways were inferred.PathwayⅠ(KMnO_(4)-HT):toluene→benzyl→benzoic acid→carbonate→CO_(2)and H2O;PathwayⅡ(Mn-HT):toluene→benzyl alcohol→benzoic acid→phenol→maleic anhydride→CO_(2)and H2O.Fewer intermediates were detected on KMnO_(4)-HT,indicating its stronger oxidation capacity of toluene,which was originated from the doping of K^(+)and the interaction between K-O-Mn.More intermediates were observed on Mn-HT,which can be attributed to the weaker oxidation ability of pure Mn.The results indicated that the doping of K^(+)can improve the catalytic oxidation capacity of toluene,resulting in promoted degradation of intermediates during the oxidation of toluene.

关键词： Catalytic oxidation Preparation method Cryptomelane Mn^(3+)and lattice oxygen

MRCKα is a novel regulator of prolactin-induced lactogenesis in bovine mammary epithelial cells

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Animal Nutrition 2022年第3期10卷 319-328页

作者： Fang Wang Jürgen van Baal Lu Ma xuejun gao Jan Dijkstra Dengpan Bu State Key Laboratory of Animal Nutrition Institute of Animal ScienceChinese Academy of Agricultural SciencesBeijing100193China Animal Nutrition Group Wageningen University and ResearchWageningen6708WDthe Netherlands College of Animal Science Yangtze UniversityJingzhou434020China Joint Laboratory on Integrated Crop-Tree-Livestock Systems of the Chinese Academy of Agricultural Sciences(CAAS) Ethiopian Institute of Agricultural Research(EIAR)and World Agroforestry Center(ICRAF)Beijing100193China

Myotonic dystrophy-related Cdc42-binding kinase alpha(MRCKα)is an integral component of signaling pathways controlling vital cellular processes,including cytoskeletal reorganization,cell proliferation and cell survival.In this study,we investigated the physiological role of MRCKα in milk protein and fat production in dairy cows,which requires a dynamic and strict organization of the cytoskeletal network in bovine mammary epithelial cells(BMEC).Within a selection of 9 Holstein cows,we found that both mRNA and protein expression of MRCKα in the mammary gland were upregulated during lactation and correlated positively(r>0.89)with the mRNA and protein levels of b-casein.Similar positive correlations(r>0.79)were found in a primary culture of BMEC stimulated with prolactin for 24 h.In these cells,silencing of MRCKα decreased basal b-casein,sterol-regulatory element binding protein(SREBP)-1 and cyclin D1 protein level,phosphorylation of mTOR,triglyceride secretion,cell number and viabilitydwhile overexpression of MRCKα displayed the reversed effect.Notably,silencing of MRCKα completely prevented the stimulatory action of prolactin on the same parameters.These data demonstrate that MRCKα is a critical mediator of prolactin-induced lactogenesis via stimulation of the mTOR/SREBP1/cyclin D1 signaling pathway.

关键词： Myotonic dystrophy-related Cdc42-binding kinase alpha Bovine mammary gland Prolactin Mechanistic target of rapamycin Sterol regulatory element-binding protein-1 Cyclin D1

Microbial communities and their influencing factors in the sediment of upper and mid-lower reaches of the Yellow River

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Journal of Earth Science 2024年

作者： Yanmin Zhang Zewei Gui Xiaofei gao Jingxiao Zhang Yunni gao Man Zhang Guokun Yang Xindang Zhang Xulu Chang Zixuan Gan Xiaolin Meng xuejun Li Hongchen Jiang College of Fisheries Henan Normal University State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Wuhan College of Agricultural and Environmental Sciences University of California Davis

Sedimentary microbial communities play an important role in driving biogeochemical cycles in river ecosystems. However， limited is known about the microbial variation and its influencing factors in the high-turbid Yellow River. In this study， microbial communities and their influencing factors in the sediment of upper and mid-lower reaches of the Yellow River were examined. The results showed that Gammaproteobacteria were most dominant in Yellow River sediments. Deltaproteobacteria， Nitrospirae and family of Bacillaceae， Geobaceraceae were more abundant in the mid-lower reaches， while Gammaproteobacteria， Verrucomicrobia and family of Caldilineaceae， Llumatobacteraceae were more abundant in the upper reaches. The microbial communities were predominantly affected by nutrient factors (NH4+， TN and TP)， followed by the spatial factors and Chla content in the mid-lower reaches， while they were by predominantly affected by spatial factors， followed by the nutrient factors and Chla content in the upper reaches. The dominant microbial taxa were mostly correlated with COD， NH4+， TP and temperature. In summary， the sedimentary microbial communities differ between the upper and mid-lower reaches and respond differently to the environmental and spatial factors in the sediment of the Yellow River.

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Toll样受体和白细胞介素-17单核苷酸多态性与口腔扁平苔藓易感性的相关性研究

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国际口腔医学杂志 2024年第1期51卷 45-51页

作者：李然胡月张宁高瑞芳王翔宇葛学军山西医科大学口腔医(学)院儿童口腔预防科太原030001 山西医科大学口腔医(学)院口腔疾病防治与新材料山西省重点实验室太原030001 太原恒伦悦伦口腔医院有限公司儿童口腔科太原030006 北京应急总医院口腔科北京100028

目的探讨Toll样受体(TLR)和白细胞介素-17(IL-17)基因的遗传多态性及与口腔扁平苔藓(OLP)的相关性。方法选取病例组(OLP组)患者与对照组(未患OLP人群)外周血提取的DNA为研究对象,选取TLR与IL-17上的7个单核苷酸多态性(SNP)位点,分别是T... 详细信息

目的探讨Toll样受体(TLR)和白细胞介素-17(IL-17)基因的遗传多态性及与口腔扁平苔藓(OLP)的相关性。方法选取病例组(OLP组)患者与对照组(未患OLP人群)外周血提取的DNA为研究对象,选取TLR与IL-17上的7个单核苷酸多态性(SNP)位点,分别是TLR3中的rs5743312、TLR2中的rs121917864和IL-17A中的5个SNP位点(rs4711998、rs3819024、rs8193036、rs3748067和rs17878530)。采用高分辨率熔解曲线分析法进行外周血细胞PCR产物基因多态性检测,并与DNA测序结果比对。统计分析SNP位点与OLP发生的相关性。结果rs5743312(TLR3)、rs3819024(IL-17A)与OLP的发生相关,并有统计学意义(P<0.05)。其余5个SNP位点未检测出与OLP相关。结论rs5743312(TLR3)和rs3819024(IL-17A)可能与OLP的易感性相关。

关键词：单核苷酸多态性高分辨率熔解曲线分析口腔扁平苔藓易感性

丝素蛋白纳米载体在抗肿瘤药物递送系统中的应用进展

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中国药学杂志 2024年第5期59卷 377-384页

作者：王雪军李明娟张洁高欢杨根生丁宝月嘉兴学院医学院浙江嘉兴314001 浙江工业大学药学院杭州310014

丝素蛋白(silk fibroin)是一种天然高分子材料,因其具有良好的生物相容性、生物可降解性、结构可修饰性、低细胞毒性以及无免疫原性而被广泛应用于抗肿瘤药物递送。抗肿瘤药物大都具有溶解度低、药物代谢动力学特征差和靶外毒性高的缺点... 详细信息

丝素蛋白(silk fibroin)是一种天然高分子材料,因其具有良好的生物相容性、生物可降解性、结构可修饰性、低细胞毒性以及无免疫原性而被广泛应用于抗肿瘤药物递送。抗肿瘤药物大都具有溶解度低、药物代谢动力学特征差和靶外毒性高的缺点,因此,寻找和使用合适的药物递送系统解决抗肿瘤药物的这些问题已成为当务之急。本文简要综述了丝素蛋白的结构、特点,丝素蛋白纳米载体的制备及其用于抗肿瘤药物递送的类型及研究进展,并综述了丝素蛋白纳米载体应用于光动力治疗、光热治疗以及基因治疗中治疗恶性肿瘤的研究进展。丝素蛋白作为抗肿瘤药物的递送载体具有广阔应用前景和重要意义。

关键词：丝素蛋白纳米载体抗肿瘤药物递送系统光动力治疗光热治疗基因治疗

采用超声引导下颈神经根阻滞治疗慢性颈源性疼痛的效果评估

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中国医药指南 2024年第12期22卷 25-27页

作者：赵学军高丽花东营市东营区中心医院疼痛科东营257064 东营市东营区中心医院妇产科东营257064

目的研究分析慢性颈源性疼痛采用超声引导下颈神经根阻滞方式治疗的临床功效。方法选取2023年9月至2024年3月于东营市东营区中心医院就诊患有慢性颈源性疼痛患者50例,应用随机数字表法分为常规组、观察组,各25例。常规组采用盲穿下颈部... 详细信息

目的研究分析慢性颈源性疼痛采用超声引导下颈神经根阻滞方式治疗的临床功效。方法选取2023年9月至2024年3月于东营市东营区中心医院就诊患有慢性颈源性疼痛患者50例,应用随机数字表法分为常规组、观察组,各25例。常规组采用盲穿下颈部侧入路颈神经根阻滞,观察组采用超声引导下颈神经根阻滞,比较两组颈椎功能与疼痛相关指标、疼痛程度汇总数据,分析治疗效果。结果两组不同颈神经根阻滞实施后,观察组颈椎功能障碍指数、颈椎活动度与疼痛发作次数、疼痛持续时间均较常规组更为良好,差异有统计学意义(P<0.05)。患者疼痛程度比较,观察组治疗后无、轻、中、重度疼痛等级患者较治疗前有显著改善(P<0.05),且治疗后观察组较常规组患者疼痛等级更为良好,差异有统计学意义(χ^(2)=21.4188,P<0.05)。结论慢性颈源性疼痛患者就诊,应用超声引导下颈神经根阻滞方式予以患者治疗,能够有效改善患者疼痛情况及颈椎功能,有良好治疗效果。

关键词：超声引导颈神经根阻滞慢性颈源性疼痛临床疗效应用价值