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Prognostic value of interim ^(18)F-FDG PET/CT in diffuse large B-cell lymphoma

Chinese Journal of Cancer Research 2013年第1期25卷 95-101页

作者： Zhitao Ying xuejuan wang Yuqin Song Wen Zheng Xiaopei wang Yan Xie Ningjing Lin Meifeng Tu Lingyan Ping Weiping Liu Lijuan Deng Chen Zhang Zhi Yang Jun Zhu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of LymphomaPeking University Cancer Hospital & Institute Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of Nuclear MedicinePeking University Cancer Hospital & Institute

Objective： Diffuse large B-cell lymphoma （DLBCL） is a heterogeneous disease. The prognostic factor currently used is not accurate enough to predict the outcomes of patients with DLBCL. The prognostic significance of interim PET/CT in DLBCL remains controversial. The aim of this study is to determine the predictive value of interim 18F-FDG PET/CT after first-line treatment in patients with DLBCL. Methods： Thirty-two patients with DLBCL underwent baseline, interim and post-treatment lSF-FDG PET/CT scans. Imaging results were analyzed for the survival of patients via software SPSS 13.0, retrospectively. Results： Thirty-one of the 32 patients were treated with R-CHOP regimen, and interim 18F-FDG PET/CT of 24 patients was performed after 2 cycles of treatment. After a median follow-up period of 16.7 months, the 2-year progression-free survival （PFS） rates were significantly different between the groups above and below SUVmax CUt-Off value of 2.5 （P=0.039）. No significant differences were found in the 2-year PFS rates if SUVm, cut-offvalues were set as 2.0 and 3.0, respectively （P=0.360; P=0.113）. Conclusions： Interim PET/CT could predict the prognosis of DLBCL patients with the SUVmax cut-off value of 2.5, but more clinical data should be concluded to confirm this conclusion.

关键词： Fludeoxy-glucose F18 lyrnphoma large cell diffuse prognosis standard utility value

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Prognostic value of pre-and post-transplantation 18F-fluorodeoxyglucose positron emission tomography results in non-Hodgkin lymphoma patients receiving autologous stem cell transplantation

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Chinese Journal of Cancer Research 2017年第6期29卷 561-571页

作者： Zhitao Ying Lan Mi xuejuan wang Yuewei Zhang Zhi Yang Yuqin Song Xiaopei wang WenZheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu LijuanDeng Jun Zhu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing 100142China

Objective： High-dose chemotherapy （HDC） followed by autologous stem cell transplantation （ASCT） is the standard of care in the upfront or relapsed/refractory setting in some patients with non-Hodgkin lymphoma （NHL）. However, a proportion of patients do not respond to ASCT. lSF-fluorodeoxyglueose （FDG） positron emission tomography （PET）/computed tomography （CT） has been widely used for staging, response evaluation, and prognosis prediction. Here, we investigated the prognostic role of PET/CT in NHL patients before and after ASCT. Methods： A retrospective study was conducted at Peking University Cancer Hospital. All NHL patients who underwent ASCT between March 2010 and July 2016 were identified. Patients who had PET/CT scan before and after ASCT were included. Deauville criteria （5-point scale） were used to interpret PET scans. Univariate and multivariate survival analyses were performed using Cox regression. The predictive value of PET scanning was estimated by comparing the area under the receiver operating characteristic （ROC） curve. Results： In total, 79 patients were enrolled in this study. In univariate analysis, pre- and post-ASCT PET result was identified as prognostic factors for 3-year progression-free survival （PFS） and overall survival （OS）. Patients with negative pre-ASCT PET result demonstrated significantly better PFS （84.2% vs. 54.2%） and OS （89.2% vs. 63.6%） than patients with positive pre-ASCT PET result. PFS （91.6% vs. 25.3%） and OS （96.5% vs. 36.8%） were also significantly different between patients with negative and positive post-ASCT PET result. Multivariate analysis also showed a significant association between survival and post-ASCT PET result. ROC analysis revealed that the predictive value of post-ASCT PET result was superior to that of pre-ASCT PET result alone. Combined pre- and post-ASCT PET result is better for predicting outcomes in patients with NHL receiving transplantation. Deauville criteria score 〉3 was identified as the best cutof

关键词： 18F-fluorodeoxyglucose positron emission tomography computed tomography autologous stem celltransplantation high-dose chemotherapy non-Hodgkin lymphoma

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Prognostic value of ^(18)F-fluorodeoxyglucose positron emission tomography using Deauville criteria in diffuse large B cell lymphoma treated with autologous hematopoietic stem cell transplantation

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Chinese Journal of Cancer Research 2019年第1期31卷 162-170页

作者： Zhitao Ying Lan Mi Nina Zhou xuejuan wang Zhi Yang Yuqin Song Xiaopei wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Chen Zhang Weiping Liu Lijuan Deng Jun Zhu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of LymphomaPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Nuclear MedicinePeking University Cancer Hospital&InstituteBeijing 100142China

Objective: High-dose chemotherapy(HDC) followed by autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in improving outcomes of diffuse large B cell lymphoma(DLBCL) patients.18 F-fluorodeoxyglucose(18 F-FDG) positron emission tomography(PET)/computed tomography(CT) has been widely accepted in response assessment and prediction of prognosis in DLBCL. Here, we report the value of 18 FFDG PET/CT pre-and post-HSCT in predicting outcomes of patients with ***: DLBCL patients who had PET/CT scan before and after HSCT were included. PET results were interpreted based upon Deauville criteria. The prognostic value of 18 F-FDG PET/CT in auto-HSCT was ***: Eighty-four patients were enrolled. In univariate analysis, pre-and post-HSCT PET findings were correlated with 3-year progression-free survival(PFS) [hazard ratio(HR)=4.391, P=0.001; HR=7.607, P<0.001] and overall survival(OS)(HR=4.792, P=0.008; HR=26.138, P<0.001). Patients receiving upfront auto-HSCT after firstline treatment had better outcomes than relapsed/refractory DLBCL patients(3-year PFS, P<0.001; 3-year OS,P<0.001). In the relapsed/refractory patients, pre-and post-HSCT PET findings were also associated with 3-year PFS(P=0.003 vs. P<0.001) and OS(P=0.027 vs. P<0.001). A significant correlation was observed between clinical response to chemotherapy before auto-HSCT and outcomes of patients in the entire cohort(3-year PFS, P<0.001;3-year OS, P<0.001) and in the subgroup of 21 patients with positive pre-HSCT PET(3-year PFS, P=0.084; 3-year OS, P=0.240). A significant association between survival and post-HSCT PET findings was observed in multivariate analysis(HR=5.168, P<0.001).Conclusions: PET results before and after HSCT are useful prognostic factors for DLBCL patients receiving HSCT. Patients who responded to chemotherapy, even those with positive pre-HSCT PET, are appropriate candidates for auto-HSCT.

关键词： Positron emission tomography computed tomography autologous hematopoietic stem cell transplantation high-dose chemotherapy diffuse large B cell lymphoma

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A Review of Atmospheric Electricity Research in China from 2019 to 2022

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Advances in Atmospheric Sciences 2023年第8期40卷 1457-1484页

作者： Weitao LYU Dong ZHENG Yang ZHANG Wen YAO Rubin JIANG Shanfeng YUAN Dongxia LIU Fanchao LYU Baoyou ZHU Gaopeng LU Qilin ZHANG Yongbo TAN xuejuan wang Yakun LIU Shaodong CHEN Lyuwen CHEN Qingyong LI Yijun ZHANG State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Laboratory of Lightning Physics and Protection Engineering Chinese Academy of Meteorological SciencesBeijing 100081China Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China Chinese Academy of Sciences Key Laboratory of Geospace Environment School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD) Nanjing University of Information Science&TechnologyNanjing 210044China Department of Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200030China Institute of Tropical and Marine Meteorology China Meteorological AdministrationGuangzhou 510641China Beijing Key Lab of Transportation Data Analysis and Mining Beijing Jiaotong UniversityBeijing 100044China Department of Atmospheric and Oceanic Sciences and Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China

Atmospheric electricity is composed of a series of electric phenomena in the *** advances in atmospheric electricity research conducted in China have been achieved in recent *** this paper,the research progress on atmospheric electricity achieved in China during 2019-22 is reviewed focusing on the following aspects:(1)lightning detection and location techniques,(2)thunderstorm electricity,(3)lightning forecasting methods and techniques,(4)physical processes of lightning discharge,(5)high energy emissions and effects of thunderstorms on the upper atmosphere,and(6)the effect of aerosol on lightning.

关键词： atmospheric electricity thunderstorm lightning lightning detection lightning physics

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EM studies of eukaryotic transcriptional complexes:structural insights into transcription regulation

EM studies of eukaryotic transcriptional complexes:structura...

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生命的分子机器及其调控网络——2012年全国生物化学与分子生物学学术大会

作者： Jianye wang xuejuan wang Zhenrui Ding JinhuaJi Qianqian Sun Gang Cai School of Life Sciences University of Science and Technology of China and Hefei National Laboratory for Physical Sciences at the Microscale

Understanding how the interplay among the macromolecular complexes of RNA PolymeraseⅡtranscription machineryregulates transcription will critically benefit from the detailed structural information about the mechanism of their ***,because of its large size and complexity and it is stabilized by a multiplicity of dynamic protein-proteinand protein-nucleic acid interactions,the structural analysis is

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提高种业市场集中度的经济学分析

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分子植物育种 2024年第18期22卷 6216-6221页

作者：王雪娟安阳职业技术学院经济管理学院安阳455000

随着全球化进程的加速,种业市场集中度的变化趋势及其对农业发展的影响成为经济学研究的重要议题。本研究以中国化工集团收购先正达为案例,探讨了这一跨国并购事件如何影响种业市场集中度,进而对农业生产效率、种子质量和创新能力产生... 详细信息

随着全球化进程的加速,种业市场集中度的变化趋势及其对农业发展的影响成为经济学研究的重要议题。本研究以中国化工集团收购先正达为案例,探讨了这一跨国并购事件如何影响种业市场集中度,进而对农业生产效率、种子质量和创新能力产生影响。通过对中国化工集团和先正达的背景调研,分析了收购过程、收购后市场集中度的变化,以及并购行为对市场竞争格局、产品多样性和创新能力的长期影响。此外,本研究还从经济学角度解释了市场集中度提高的原因和效应,探讨了政策和监管在调节市场集中度、保护竞争和促进创新中的作用。本研究旨在为理解全球种业市场变化提供理论和实证分析,为政策制定者提供加强市场监管、促进竞争和创新的政策建议,具有重要的理论意义和实践价值。

关键词：种业市场集中度中国化工集团收购先正达并购经济效应农业发展市场监管

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琥珀酰明胶及赖氨酸降低肾摄取放射性拮抗剂的药效评估

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中国医学影像学杂志 2011年第8期19卷 620-625页

作者：王雪鹃北京大学临床肿瘤学院北京肿瘤医院暨北京肿瘤防治研究所核医学科恶性肿瘤发病机制及转化研究教育部重点实验室

目的在荷瘤小鼠体内评估琥珀酰明胶和赖氨酸降低肾摄取放射性拮抗剂的能力。材料与方法预注射不同剂量的琥珀酰明胶或赖氨酸至 HEK-rsst2及 PC-3荷瘤小鼠体内，随后再注射 0.180.2MBq 生长抑素受体拮抗剂111In-DOTA- sst2-ANT或蛙皮... 详细信息

目的在荷瘤小鼠体内评估琥珀酰明胶和赖氨酸降低肾摄取放射性拮抗剂的能力。材料与方法预注射不同剂量的琥珀酰明胶或赖氨酸至 HEK-rsst2及 PC-3荷瘤小鼠体内，随后再注射 0.180.2MBq 生长抑素受体拮抗剂111In-DOTA- sst2-ANT或蛙皮素受体拮抗剂111In-RM1。各种器官摄取以每克注射剂量百分比（%ID/g）表示。结果预注射 4mg 琥珀酰明胶可使肾摄取111In-DOTA-sst2-ANT 量下降至对照组的 57.43%±4.10%，琥珀酰明胶剂量增至 6mg 时，肾摄取降为对照组的 47.06%±5.84%。20mg 及 40mg 赖氨酸均能降低约 50%的肾摄取。不同剂量的琥珀酰明胶和赖氨酸均无法减少肾摄取111In-RM1。预注射琥珀酰明胶及赖氨酸并不影响受体表达正常组织及肿瘤对放射性拮抗剂的摄取。结论琥珀酰明胶或赖氨酸能抑制肾摄取生长抑素受体拮抗剂，但不能抑制肾摄取蛙皮素受体拮抗剂。

关键词：明胶赖氨酸肾放射性拮抗剂

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应用近红外荧光淋巴显像诊断正常肢体及淋巴水肿

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中国医学影像学杂志 2011年第6期19卷 476-480页

作者：王雪鹃北京大学临床肿瘤学院北京肿瘤医院北京市肿瘤防治研究所核医学科恶性肿瘤发病机制及转化研究教育部重点实验室北京100142

目的应用近红外荧光(NIRF)显像评估正常肢体及淋巴水肿肢体的淋巴结构及功能。资料与方法肢体皮内注射吲哚青绿后,行动态NIRF淋巴显像,观测肢体的淋巴管结构及回流功能。结果正常肢体可见规则的淋巴管状结构及"弹丸"式淋巴回流,淋巴管外... 详细信息

目的应用近红外荧光(NIRF)显像评估正常肢体及淋巴水肿肢体的淋巴结构及功能。资料与方法肢体皮内注射吲哚青绿后,行动态NIRF淋巴显像,观测肢体的淋巴管结构及回流功能。结果正常肢体可见规则的淋巴管状结构及"弹丸"式淋巴回流,淋巴管外无NIRF显像剂滞留。淋巴水肿依据显像表现分为4级,诊断要点包括:淋巴管外染料聚集、弯曲的侧支淋巴管、毛细淋巴管网显影,淋巴回流减慢及逆流。结论 NIRF淋巴显像能正确地诊断肢体淋巴水肿,具有较大的临床应用潜力。

关键词：淋巴水肿近红外荧光显像诊断

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乡村振兴战略背景下我国连片特困区农产品流通治理研究

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南京社会科学 2019年第2期 19-25页

作者：辛本禄王学娟吉林大学商学院吉林大学数量经济研究中心

在乡村振兴战略背景下,解决区域性整体贫困是推动脱贫攻坚与乡村振兴有机结合相互促进的优先任务,连片特困区的脱贫攻坚战必须结合各地区的资源禀赋和独特的历史文化形成特色农业产业集群。为培育连片特困区未来经济高质量发展的内生动... 详细信息

在乡村振兴战略背景下,解决区域性整体贫困是推动脱贫攻坚与乡村振兴有机结合相互促进的优先任务,连片特困区的脱贫攻坚战必须结合各地区的资源禀赋和独特的历史文化形成特色农业产业集群。为培育连片特困区未来经济高质量发展的内生动力和建立避免返贫稳定脱贫的长效机制,本文认为连片特困区的农产品流通治理应突破原有的"政府—市场"与"市场—企业"的二分法,推理至"政府—市场—企业"的治理边界。针对我国14个连片特困区县均特产的三种类别即特产相似区、特产综合区和特产多元区,与批发市场型、契约型、平台网络型农产品流通渠道模式进行了匹配研究,并根据不同特困区域类型所面临的农产品渠道治理核心问题探讨了政府、市场与企业的治理边界。

关键词：乡村振兴连片特困区农产品流通渠道模式渠道治理

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员工-顾客认同、互动式替代学习与服务创新的机制研究

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技术经济 2019年第9期38卷 41-49页

作者：辛本禄王学娟吉林大学商学院

知识与技术的快速迭代,使得服务业企业进行服务创新的挑战更加艰巨,员工对知识与技术类操作性资源的应用能力起到关键作用。基于社会网络理论与知识基础观理论构建研究知识密集型服务业企业服务创新的微观路径,对322个服务业企业问卷调... 详细信息

知识与技术的快速迭代,使得服务业企业进行服务创新的挑战更加艰巨,员工对知识与技术类操作性资源的应用能力起到关键作用。基于社会网络理论与知识基础观理论构建研究知识密集型服务业企业服务创新的微观路径,对322个服务业企业问卷调查进行实证分析。研究结果表明员工-顾客认同对员工服务创新有正向影响,并可以通过员工的互动式替代学习影响服务创新;知识治理对员工-顾客认同与互动式替代学习的关系具有显著的调节效应。

关键词：服务创新员工-顾客认同互动式替代学习知识治理

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