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Reduction of photodynamic damage of blood vessels in the protected region by(–)-epigallocatechin gallate

Journal of Innovative Optical Health Sciences 2024年第3期17卷 93-104页

作者： Tianlong Chen Yi Shen Li Lin Huiyun Lin xuejiao song Defu Chen Buhong Li MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory of Photonics TechnologyFujian Normal UniversityFuzhou 350117P.R.China Key Laboratory of Flexible Electronics and Institute of Advanced Materials Nanjing Technology UniversityNanjing 211800P.R.China School of Medical Technology Beijing Institute of TechnologyBeijing 100081P.R.China

Photodynamic therapy(PDT)has been increasingly used in the clinical treatment of neoplastic,inflammatory and infectious skin ***,the generation of reactive oxygen species(ROS)may induce undesired side effects in normal tissue surrounding the treatment lesion,which is a big challenge for the clinical application of *** date,(–)-Epigallocatechin gallate(EGCG)has been widely proposed as an antiangiogenic and antitumor agent for the protection of normal tissue from ROS-mediated oxidative *** study evaluates the regulation ability of EGCG for photodynamic damage of blood vessels during hematoporphyrin monomethyl ether(Hemoporfin)-mediated *** quenching rate constants of EGCG for the triplet-state Hemoporfin and photosensitized 1O2 generation are determined to be 6.8×10^(8)M^(−1)S^(−1),*** vasoconstriction of blood vessels in the protected region treated with EGCG hydrogel after PDT is lower than that of the control region treated with pure hydrogel,suggesting an efficiently reduced photodamage of Hemoporfin for blood vessels treated with *** study indicates that EGCG is an efficient quencher for triplet-state Hemoporfin and 1O2,and EGCG could be potentially used to reduce the undesired photodamage of normal tissue in clinical PDT.

关键词： (–)-Epigallocatechin gallate(EGCG) photodynamic therapy hemopor¯n singlet oxygen blood vessel vasoconstriction.

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Tumor microenvironment-activated theranostic nanoreactor for NIR-II Photoacoustic imaging-guided tumor-specific photothermal therapy

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Fundamental Research 2024年第1期4卷 178-187页

作者： Nan Yang Hui Li Changyu Cao Lei Zhao xuejiao song Wenjun Wang Wenjing Xu Yewei Zhang Peng Chen Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011China School of Chemical and Biomedical Engineering Lee Kong Chian School of MedicineNanyang Technological University62 Nanyang DriveSingapore 637459Singapore

Theranostic agents that can be sensitively and specifically activated by the tumor microenvironment(TME)have recently attracted considerable *** this study,TME-activatable 3,3′,5,5′-tetramethylbenzidine(TMB)-copper peroxide(CuO_(2))@poly(lactic-co-glycolic acid)(PLGA)@red blood cell membrane(RBCM)(TCPR)nanoparticles(NPs)for second near-infrared photoacoustic imaging-guided tumor-specific photothermal therapy were developed by co-loading CuO_(2)NPs and TMB into PLGA camouflaged by *** an efficient H_(2)O_(2)supplier,once exposed to a proton-rich TME,CuO_(2)NPs can generate H_(2)O_(2)and Cu^(2+),which are further reduced to Cu^(+) by endogenous ***,the Cu^(+)-mediated Fenton-like reaction produces cytotoxic·OH to kill the cancer cells and induce TMB-mediated photoacoustic and photothermal *** with the RBCM modification-prolonged blood circulation,TCPR NPs display excellent specificity and efficiency in suppressing tumor growth,paving the way for more accurate,safe,and efficient cancer theranostics.

关键词： Nanoparticles Photoacoustic imaging Second near-infrared region Tumor microenvironment Self-sufficient H_(2)O_(2)

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An Interview-Based Study of the Factors Influencing the Quality of Professional Training of Science Education Graduates

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Journal of Contemporary Educational Research 2024年第1期8卷 147-153页

作者： xuejiao song School of Education Tibet UniversityLhasa 850000Tibet Autonomous RegionChina

The proposal of the strategy of developing the country through science education has clarified China’s demand for the development of the science and education industry and the cultivation of science and education talents,and the birth of Science Education majors is an important link in the cultivation of scientific *** on the grounded theory,we interviewed three Science Education graduates from a university and coded the interview data by using NVivo 12.0 to find eight important factors affecting their professional training and employment *** factors are“social factors,”“individual career choice factors,”“campus resources,”“employment advantages,”“professional self-development,”“teacher factors,”“planning for further education and employment,”and“student motivation.”This study analyzes the interaction between the influencing factors,constructs a theoretical model of the influencing factors of the quality of Science Education professional training,explores the problems of the training process of Science Education majors and employment dilemmas,and puts forward corresponding suggestions.

关键词： Science Education Teacher training Professional development Influencing factors Rooted research

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Recent advances in the development of organic photothermal nano-agents

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Nano Research 2015年第2期8卷 340-354页

作者： xuejiao song Qian Chen Zhuang Liu Institute of Functional Nono & Soft Materials (FUNSOM) Collaborative Innovation Center of 5uzhou Nano Science and TechnologySoochow University Suzhou 215123 Chino

Recently, photothermal therapy （PTT） has attracted tremendous attention because of its high efficacy in tumor ablation and minimal damage to normal tissues. While many inorganic nanomaterials, especially various gold nanostructures and nanocarbons, have been extensively explored for near-infrared （NIR） light triggered PTT in the past decade, a variety of organic photothermal agents have also emerged in recent years, aiming at replacing their inorganic counterparts which usually are not biodegradable. In this mini-review, we will summarize several typical classes of recently developed NIR-absorbing organic PTT nano- agents, which include NIR dye-containing micelles, porphysomes, protein-based agents, conjugated polymers, and organic/inorganic nanocomposites. The development of imaging-guided PTT and combination therapy will be introduced as well. Finally, the perspectives and challenges in the future development of PTT will be discussed.

关键词： photothermal therapy near-infrared organic nanomaterials

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Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

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Nano-Micro Letters 2020年第1期12卷 208-234页

作者： Nan Yang Wanyue Xiao xuejiao song Wenjun Wang Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(Nanjing Tech)Nanjing 211800People’s Republic of China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059People’s Republic of China School of Chemistry and Materials Science Nanjing University of Information Science and TechnologyNanjing 210044People’s Republic of China

Photodynamic therapy(PDT),as one of the noninvasive clinical cancer phototherapies,suffers from the key drawback associated with hypoxia at the tumor microenvironment(TME),which plays an important role in protecting tumor cells from damage caused by common *** concentration of hydrogen peroxide(H2O2),one of the hallmarks of TME,has been recognized as a double-edged sword,posing both challenges,and opportunities for cancer *** promising perspectives,strategies,and approaches for enhanced tumor therapies,including PDT,have been developed based on the fast advances in H2O2-enabled theranostic *** this review,we outline the latest advances in H2O2-responsive materials,including organic and inorganic materials for enhanced ***,the challenges and opportunities for further research on H2O2-responsive anticancer agents are envisioned.

关键词： Tumor microenvironment H2O2-responsive Cancer Nanomaterials Photodynamic therapy

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Liposomes co-loaded with metformin and chlorin e6 modulate tumor hypoxia during enhanced photodynamic therapy

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Nano Research 2017年第4期10卷 1200-1212页

作者： xuejiao song Liangzhu Feng Chao Liang Min Gao Guosheng song Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Suzhou 215123 China

Though photodynamic therapy （PDT） has been widely used in the non-invasive destruction of solid tumors, the therapeutic efficacy of PDT is often limited by the hypoxic tumor environment. Herein, we report the innovative use of metformin, an oral hypoglycemic agent commonly used in the treatment of type II diabetes, to improve tumor oxygenation, and overcome tumor hypoxia-associated resistance to PDT. In our design, hydrophilic metformin and modified hydrophobic chlorin e6 （HCe6） are co-encapsulated within the inner cavity and outer membrane of liposomes, respectively. Due to the high uptake of liposome nanoparticles by tumors, and the sustained release of metformin, the intravenous administration of metformin （Met）-HCe6-Liposome nanoparticles greatly improves tumor oxygena- tion in several different tumor models, as revealed by in vivo photoacoustic imaging and ex vivo immunofluorescence staining. Systemic administration of Met-HCe6-Liposomes followed by in vivo PDT achieved significantly improved therapeutic effects compared to that of PDT without metformin. Hence, our study represents a new strategy for the improvement of PDT efficacy through the modulation of tumor oxygenation by clinically approved agents.

关键词： photodynamic therapy liposomes metforrnin tumor hypoxia

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矿物类中药治疗失眠的药理作用及临床应用研究进展

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天津中医药 2024年第3期41卷 403-408页

作者：柴士伟范栢爽宋学姣庄朋伟天津中医药大学第一附属医院天津300381 天津中医药大学天津301617

矿物类中药发挥重镇安神作用治疗失眠时疗效显著,通过检索相关著作和文献,发现治疗失眠的矿物药共16种。临床常用于治疗围绝经期失眠、糖尿病相关失眠、抑郁性失眠,顽固性失眠等多种形式引起的慢性失眠。主要通过调节神经递质的异常表达... 详细信息

矿物类中药发挥重镇安神作用治疗失眠时疗效显著,通过检索相关著作和文献,发现治疗失眠的矿物药共16种。临床常用于治疗围绝经期失眠、糖尿病相关失眠、抑郁性失眠,顽固性失眠等多种形式引起的慢性失眠。主要通过调节神经递质的异常表达,减少炎性因子、氧化应激因子的释放,下调下丘脑-垂体-肾上腺(HPA)轴激素的分泌,延长慢波和快速动眼睡眠期等发挥治疗作用。现对矿物药的药理研究及临床应用进展作一综述,以期为矿物药在治疗失眠方面的开发与利用提供参考。

关键词：矿物药失眠药理作用临床应用研究进展

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医疗大数据在皮肤慢病管理中的实践与挑战

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皮肤科学通报 2024年第1期41卷 17-20页

作者：杨越宋雪骄盛宇俊左先波中日友好医院皮肤科北京10029

慢性皮肤病是一类常见的皮肤病,此类疾病病因复杂,难以查找,严重影响我国公民的身心健康。医疗大数据近年来呈爆炸式生长,其中蕴含着巨大的应用价值,为皮肤慢病管理提供了新的方向。本文从医疗大数据概念出发,分析了我国大数据在慢性皮... 详细信息

慢性皮肤病是一类常见的皮肤病,此类疾病病因复杂,难以查找,严重影响我国公民的身心健康。医疗大数据近年来呈爆炸式生长,其中蕴含着巨大的应用价值,为皮肤慢病管理提供了新的方向。本文从医疗大数据概念出发,分析了我国大数据在慢性皮肤病中的应用进展与在实践中面临的挑战与不足。

关键词：大数据慢性皮肤病疾病管理

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BSA stabilized photothermal-fenton reactor with cisplatin for chemo/chemodynamic cascade oncotherapy

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Nano Research 2022年第3期15卷 2235-2243页

作者： Nan Yang Tian Zhang Changyu Cao Genxiang Mao Jinjun Shao xuejiao song Wenjun Wang Xiaozhou Mou Xiaochen Dong Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) School of Physical and Mathematical SciencesNanjing Tech University(NanjingTech)Nanjing 211816China School of Physical Science and Information Technology Liaocheng UniversityLiaocheng 252059China Zhejiang Provincial Key Lab of Geriatrics&Geriatrics Institute of Zhejiang Province Department of GeriatricsZhejiang HospitalHangzhou 310013China Clinical Research Institute Zhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310014China

Cisplatin(CDDP)-based chemotherapy is substantially limited in the clinic due to its high postoperative recurrence *** therapy has been proven as a potent approach to minimize recurrence and achieve enhanced treatment ***,chemotherapy drug CDDP is assembled with the photothermal-Fenton agent of bovine serum albumin(BSA)stabilized gallic acid-functionalized iron nanoparticles(GA-Fe NPs)to achieve chemo/chemodynamic synergistic cascade *** Pt-GA-Fe NPs can be utilized to generate H_(2)O_(2) via the activation of nicotinamide adenine dinucleotide phosphate(NADPH)oxidases(NOXs)in the tumor microenvironment(TME),which would then greatly boost H2O2-depending chemodynamic therapy(CDT).The generated cytotoxic reactive oxygen species(hydroxyl radicals,·OH)and the depletion of glutathione(GSH)would further promote CDDP-induced DNA ***,benefiting from the absorption in the near-infrared(NIR)region,Pt-GA-Fe NPs exhibit excellent photothermal conversion efficiency(η=45.5%)and allow photoacoustic imaging(PAI)guided photothermal therapy(PTT).In vitro and in vivo experiments show that synergy therapy can effectively kill cancer cells and successfully cure cancer without systemic *** work highlights a new type of therapeutic agent based on CDDP with the ability of H_(2)O_(2) self-generation,thermal responsiveness,and enhanced CDT effects for applications in cancer therapy.

关键词： chemotherapy chemodynamic therapy cascade therapy CDDP Fenton reaction

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Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells

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Nano Research 2014年第9期7卷 1327-1336页

作者： Shuai Fang Chao Wang Jian Xiang Liang Cheng xuejiao song Ligeng Xu Rui Peng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow University Suzhou Jiangsu 215123 China

Detection of circulating tumor cells （CTCs） plays an important role in cancer diagnosis and prognosis. In this study, aptamer-conjugated upconversion nano- particles （UCNPs） are used for the first time as nanoprobes to recognize tumor cells, which are then enriched by attaching with magnetic nanoparticles （MNPs） and placing in the presence of a magnetic field. Owing to the autofluorescence- free nature of upconversion luminescence imaging, as well as the use of magnetic separation to further reduce background signals, our technique allows for highly sensitive detection and collection of small numbers of tumor cells spiked into healthy blood samples, and shows promise for CTC detection in medical diagnostics.

关键词： circulating tumar cell (CTC)detection upconversion nanoparticles magnetic nanoparticles aptamer

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