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Post-acute ischemic stroke hyperglycemia aggravates destruction of the blood-brain barrier

Neural Regeneration Research 2024年第6期19卷 1344-1350页

作者： Tianqi Xu jianhong Yang Yao Xu Xiaofeng Wang Xiang gao jie Sun Chenhui Zhou Yi Huang Department of Neurology The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Department of Neurosurgery The First Affiliated Hospital of Ningbo UniversityNingboZhejiang ProvinceChina Key Laboratory of Precision Medicine for Atherosclerotic Diseases of Zhejiang Province NingboZhejiang ProvinceChina

Post-acute ischemic stroke hyperglycemia increases the risk of hemorrhagic transformation,which is associated with blood-brain barrier *** microvascular endothelial cells are a major component of the blood-brain *** mitochondrial transfer has emerged as a novel paradigm for repairing cells with mitochondrial *** this study,we first investigated whether mitochondrial transfer exists between brain microvascular endothelial cells,and then investigated the effects of post-acute ischemic stroke hyperglycemia on mitochondrial transfer between brain microvascular endothelial *** found that healthy brain microvascular endothelial cells can transfer intact mitochondria to oxygen glucose deprivation-injured brain microvascular endothelial ***,post-oxygen glucose deprivation hyperglycemia hindered mitochondrial transfer and exacerbated mitochondrial *** established an in vitro brain microvascular endothelial cell model of the blood-brain *** found that post-acute ischemic stroke hyperglycemia reduced the overall energy metabolism levels of brain microvascular endothelial cells and increased permeability of the blood-brain *** a clinical study,we retrospectively analyzed the relationship between post-acute ischemic stroke hyperglycemia and the severity of hemorrhagic *** found that post-acute ischemic stroke hyperglycemia serves as an independent predictor of severe hemorrhagic *** findings suggest that post-acute ischemic stroke hyperglycemia can aggravate disruption of the blood-brain barrier by inhibiting mitochondrial transfer.

关键词： acute ischemic stroke blood-brain barrier brain microvascular endothelial cells mitochondrial transfer stress hyperglycemia

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Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 75-90页

作者： Mingyue Luo Yiqi Su Delphine jenny Vandeputte Yuwei jia Guanlei Li Willy Baeyens Marijke Huysmans Marc Elskens Yue gao Analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYDR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the maximum reuse of treated wastewater,but the quality of which determines its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic aromatic contaminants,PACs)contaminants were monthly monitored in an effluent of the wastewater treatment plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contaminants in these water bodies were *** addition,Diffusive Gradients in Thin-films(DGT)was used in situ to obtain bioavailable metal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environmental Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predominant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these metal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chemical Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration(MAC),the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems,at least in a short-term.

关键词： Metal contaminants DGT Labile metal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic aromatic contaminants

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Effect of the grain boundary character distribution on the sulfur corrosion behaviour and mechanisms of copper windings under different high temperatures

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High Voltage 2024年第3期9卷 566-580页

作者： Xu Dai Yuan Yuan jiang Zhou Guoyong Liu Tao Zhu Huiying Xiang Qi Yu Xue gao Ruijin Liao State Key Laboratory of Power Transmission Equipment&System Security and New Technology Chongqing UniversityChongqingChina College of Materials Science and Engineering Chongqing UniversityChongqingChina Dongfang Electric Machinery Co. LtdDeyangChina

As a typical failure phenomenon in transformers,sulfur corrosion has garnered significant attention in the field of high-voltage *** boundary character distribution(GBCD)copper windings have been introduced to enhance sulfur corrosion resistance by slowing down intergranular *** this study,the sulfur corrosion behaviour and mechanisms of the GBCD copper windings under various temperatures were experi-mentally and theoretically *** show that GBCD can enhance the corrosion resistance of copper in liquid *** the increase in temperatures,the insulating properties of oil and papers in traditional copper windings experience notable degradation,while GBCD copper windings show more stable insulating *** addition,modelling of grain boundary energy indicates that the grain boundary structure of GBCD copper windings has a lower average interface energy of 0.170 eV/Å***-culations of reaction thermodynamics show that GBCD copper windings possess a higher failure temperature(135.2℃)and inhibition degree(activation energy)of the sulfur corrosion(32,557.62 j/mol),revealing the stability and enhanced sulfur corrosion resis-tance at elevated temperatures.

关键词： corrosion grain copper

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A compact route for efficient production of high-purityβ-Ga_(2)O_(3) powder

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Rare Metals 2024年第9期43卷 4573-4584页

作者： Xiao-Wei Zhou gao-jie Chen Liang Xu Zhi-jun Shao Cheng Yang Yong-Pan Tian Zhuo Zhao School of Metallurgical Engineering Anhui University of TechnologyMa'anshan 243032China Low-Carbon Research Institute Anhui University of TechnologyMa'anshan 243032China

The present study has proposed a compact process for the production of high-purityβ-Ga_(2)O_(3)powder by simply using gallium metal and water as the raw *** process basically consists of two essential steps including hydrothermal synthesis of Ga OOH and calcination of Ga OOH for the production of the target product ofβ-Ga_(2)O_(3).Thermodynamic evaluation and systematic experiments were conducted for process parameter optimization.X-ray diffractometer(XRD),scanning electron microscopy(SEM),thermogravimetryDdifferential scanning calorimetry(TG-DSC)and X-ray photoelectron spectroscopy(XPS)were utilized to clarify the reaction mechanisms of the hydrothermal synthesis and transformation of Ga OOH toβ-Ga_(2)O_(3)by *** analysis of the final product ofβ-Ga_(2)O_(3)obtained under the optimal conditions was carried out with inductively coupled plasma mass spectrometry(ICP-MS),and the results showed that the contents of the representative impurities such as Ni,Cu,In,Mn,Co,Zn and Cr are obviously lower than the requirement of 5Nβ-Ga_(2)O_(3)standard,exhibiting excellent application prospect of the proposed process to produce high-purityβ-Ga_(2)O_(3).

关键词： β-Ga_(2)O_(3) Hydrothermal synthesis Calcination Purity Reaction mechanism

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Natural killer cell membrane doped supramolecular nanoplatform with immuno-modulatory functions for immuno-enhanced tumor phototherapy

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Chinese Chemical Letters 2024年第10期35卷 205-212页

作者： Ying gao Rong Zhou Qiwen Wang Shaolong Qi Yuanyuan Lv Shuang Liu jie Shen Guocan Yu Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhou 310015 China Department of Cardiology The First Afiliated HospitalZhejiang University School of MedicineHangzhou 310003China MEKey Laboratoryof Bioorganic Phosphorus Chemistry Chemical Bology epartmentof ChemtryTsinghua UniversityBeijing04Chin Emergency Department State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China

Photodynamic therapy(PDT)has garnered significant attention as a promising approach to cancer therapy,harnessing the combined benefits of localized light treatment and the accompanying host immune *** this study,we engineered an immuno-enhanced PDT nanoplatform,denoted as HM@p-MOF(hybrid membrane@porphyrin-metal organic framework).The core porphyrin-MOF was cloaked with a hybrid membrane derived from B16F10 cancer cells and NK cells,resulting in enhanced *** both in vitro and in vivo experiments,our finding demonstrated that the hybrid membrane conferred dual targeting capabilities to the nanoplatform,leveraging the unique properties of the B16F10 membrane and NK membrane to augment immunogenic cell death(ICD)induced by photodynamic ***,in conjunction with the immunomodulatory functions of the NK cell membrane,we observed an expansion of in situ immune infiltration leading to a systemic immune *** HM@p-MOF nanoplatform exhibited the capacity to not only inhibit the growth of mouse melanoma but also suppress *** innovative HM@p-MOF nanoplatform present a viable strategy to enhance phototherapeutic efficacy for both localized and metastatic *** provides a direction for the fabrication of biomimetic nanomedicines possessing immuno-modulatory function.

关键词： Biomimetic Cell membrane Metal-organic framework Phototherapy Tumor targeting

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Fenofibrate-promoted hepatomegaly and liver regeneration are PPARα-dependent and partially related to the YAP pathway

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2992-3008页

作者： Shicheng Fan Yue gao Pengfei Zhao Guomin Xie Yanying Zhou Xiao Yang Xuan Li Shuaishuai Zhang Frank jGonzalez Aijuan Qu Min Huangb Huichang Bi NMPA Key Laboratory for Research and Evaluation of Drug Metabolism&Guangdong Provincial Key Laboratory of New Drug Screening&Guangdong-Hongkong-Macao joint Laboratory for New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China Department of Physiology and Pathophysiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA The State Key Laboratory of Chemical Oncogenomics School of Chemical Biology and BiotechnologyShenzhen Graduate School of Peking UniversityShenzhen 518055China

Fenofibrate,a peroxisome proliferator-activated receptor α(PPARα)agonist,is widely prescribed for hyperlipidemia *** studies also showed that it has therapeutic potential in various liver ***,its effects on hepatomegaly and liver regeneration and the involved mechanisms remain ***,the study showed that fenofibrate significantly promoted liver enlargement and regeneration post-partial hepatectomy in mice,which was dependent on hepatocyteexpressed PPARα.Yes-associated protein(YAP)is pivotal in manipulating liver growth and *** further identified that fenofibrate activated YAP signaling by suppressing its K48-linked ubiquitination,promoting its K63-linked ubiquitination,and enhancing the interaction and transcriptional activity of the YAP-TEAD *** inhibition of YAP-TEAD interaction using verteporfin or suppression of YAP using AAV Yap shRNA in mice significantly attenuated fenofibrate-induced *** factors,such as MYC,KRT23,RAS,and RHOA,might also participate in fenofibrate-promoted hepatomegaly and liver *** studies demonstrate that fenofibratepromoted liver enlargement and regeneration are PPARα-dependent and partially through activating the YAP signaling,with clinical implications of fenofibrate as a novel therapeutic agent for promoting liver regeneration.

关键词： Fenofibrate PPARa Hepatomegaly Partial hepatectomy Liver regeneration YAP TEAD Ubiquitination

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Co/N co-doped flower-like carbon-based phase change materials toward solar energy harvesting

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Aggregate 2024年第1期5卷 321-330页

作者： Xiao Chen Lei Wang Yan gao Yang Li Xiaowei Zhang Yu jiang Ge Wang Institute of Advanced Materials Beijing Normal UniversityBeijingChina Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule and Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingChina

The photothermal conversion capacity of pristine organic phase change materials(PCMs)is inherently insufficient in solar energy *** upgrade their photothermal conversion capacity,we developed bimetallic zeolitic imidazolate framework(ZIF)derived Co/N co-doped flower-like carbon(Co/N-FLC)-based composite PCMs toward solar energy harvesting.3D interconnected carbon framework with low interfacial thermal resistance,abundant carbon defects and high content of nitrogen doping,excellent localized surface plasmon resonance(LSPR)effect of Co nanoparticles,and light absorber Co_(3)ZnC in Co/N-FLC synergistically upgrade the photothermal capacity of(polyethylene glycol)PEG@Co/N-FLC composite PCMs with an ultrahigh photothermal conversion efficiency of 94.8%under 0.16 W/cm^(2).Uniformly anchored Co and Co_(3)ZnC nanoparticles in carbon framework guarantee excellent photon capture *** carbon nanotubes(CNTs)in 2D carbon nanosheets further accelerate the rapid transport of phonons by constructing cross-connected heat transfer ***,PEG@Co/N-FLC exhibits a thermal energy storage density of 100.69 j/g and excellent thermal stability and durable ***,PEG@Co/N-FLC composite PCMs are promising candidates to accelerate the efficient utilization of solar energy.

关键词： bimetallic ZIF Co/N co-doped carbon phase change materials photothermal conversion thermal energy storage

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Plume-lithosphere interaction in the Comei Large Igneous Province: Evidence from two types of mafic dykes in Gyangze, south Tibet, China

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China Geology 2024年第1期7卷 80-90页

作者： Ya-ying Wang Ling-sen Zeng Li-e gao Li-long Yan Ling-hao Zhao jia-hao gao Ying-long Di Guang-xu Li Yi-hong Tian Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China China Nonferrous Metals(Guilin)Geology and Mining Co. LtdGuilin 541004China

Two suites of mafic dykes,T1193-A and T1194-A,outcrop in Gyangze area,southeast *** are in the area of Comei LIP and have indistinguishable field occurrences with two other dykes in Gyangze,T0902 dyke with 137.7±1.3 Ma zircon age and T0907 dyke with 142±1.4 Ma zircon age reported by Wang YY et al.(2016),indicating coeval formation *** all the four diabase dykes into consideration,two different types,OIB-type and weak enriched-type,can be ***“OIB-type”samples,including T1193-A and T0907 dykes,show OIB-like geochemical features and have initial Sr-Nd isotopic values similar with most mafic products in Comei Large Igneous Provinces(LIP),suggesting that they represent melts directly generated from the Kerguelen mantle ***“weak enriched-type”samples,including T1194-A and T0902 dykes,have REEs and trace element patterns showing withinplate affinity but have obvious Nb-Ta-Ti negative *** show uniform lowerεNd(t)values(−6‒−2)and higher 87Sr/86Sr(t)values(0.706‒0.709)independent of their MgO variation,indicating one enriched mantle *** their closely spatial and temporal relationship with the widespread Comei LIP magmatic products in Tethyan Himalaya,these“weak enriched-type”samples are consistent with mixing of melts from mantle plume and the above ancient Tethyan Himalaya subcontinental lithospheric mantle(SCLM)in different *** weak enriched mafic rocks in Comei LIP form one special rock group and most likely suggest large scale hot mantle plume-continental lithosphere *** process may lead to strong modification of the Tethyan Himalaya lithosphere in the Early Cretaceous.

关键词： OIB type diabase Comei Large Igneous Province Weakly enriched diabase Plume-lithosphere interaction Nb-Ta-Ti negative anomaly Kerguelen plume Geological survey engineering Tibet Plateau

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Constructed Mott-Schottky Heterostructure Catalyst to Trigger Interface Disturbance and Manipulate Redox Kinetics in Li-O_(2) Battery

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Nano-Micro Letters 2024年第12期16卷 42-58页

作者： Yongji Xia Le Wang Guiyang gao Tianle Mao Zhenjia Wang Xuefeng jin Zheyu Hong jiajia Han Dong-Liang Peng Guanghui Yue State Key Lab of Physical Chemistry of Solid Surface Fujian Key Laboratory of Surface and Interface Engineering for High Performance MaterialsCollege of MaterialsXiamen UniversityXiamen 361005People’s Republic of China

Lithium-oxygen batteries(LOBs)with high energy density are a promising advanced energy storage ***,the slow cathodic redox kinetics during cycling causes the discharge products to fail to decompose in time,resulting in large polarization and battery failure in a short ***,a self-supporting interconnected nanosheet array network NiCo_(2)O_(4)/MnO_(2)with a Mott-Schottky heterostructure on titanium paper(TP-NCO/MO)is ingeniously designed as an efficient cathode catalyst material for *** heterostructure can accelerate electron transfer and influence the charge transfer process during adsorption of intermediate by triggering the interface disturbance at the heterogeneous interface,thus accelerating oxygen reduction and oxygen evolution kinetics and regulating product decomposition,which is expected to solve the above *** meticulously designed unique structural advantages enable the TP-NCO/MO cathode catalyst to exhibit an astounding ultra-long cycle life of 800 cycles and an extraordinarily low overpotential of 0.73 *** study utilizes a simple method to cleverly regulate the morphology of the discharge products by constructing a Mott-Schottky heterostructure,providing important reference for the design of efficient catalysts aimed at optimizing the adsorption of reaction intermediates.

关键词： Mott-Schottky heterostructure Lithium-oxygen batteries Electrocatalysts Electrodeposition

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Accurate models and nutritional strategies for specific oxidative stress factors: Does the dose matter in swine production?

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journal of Animal Science and Biotechnology 2024年第2期15卷 519-534页

作者： Changming Hong Yujian Huang Shuting Cao Li Wang Xuefen Yang Shenglan Hu Kaiguo gao Zongyong jiang Hao Xiao State Key Laboratory of Swine and Poultry Breeding Industry Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South ChinaGuangdong Public Laboratory of Animal Breeding and NutritionGuangdong Provincial Key Laboratory of Animal Breeding and NutritionMaoming BranchGuangdong Laboratory for Lingnan Modern AgricultureGuangzhouChina Institute of Animal Science Guangdong Academy of Agricultural Sciences1 Dafeng 1st StreetGuangzhou 510640China

Oxidative stress has been associated with a number of physiological problems in swine,including reduced production ***,although there has been increased research into regulatory mechanisms and antioxidant strategies in relation to oxidative stress-induced pig production,it remains so far largely unsuccessful to develop accurate models and nutritional strategies for specific oxidative stress ***,we discuss the dose and dose intensity of the causes of oxidative stress involving physiological,environmental and dietary factors,recent research models and the antioxidant strategies to provide theoretical guidance for future oxidative stress research in swine.

关键词： Accurate models Dose Nutritional strategies Oxidative stress Swine

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