检索结果-南通市图书馆

Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

Science China Life Sciences 2025年

作者： Xiaonan Wang Ning Zhou xuejiao j.gao Zijing Zhu Minmin Sun Qian Wang Haolin Cao Xuetong Wu Caiyu Zhou Qingkang Zheng Ye Yuan Yuan Liu Lei Chen jing jiang Pengcheng Bu Lizeng gao CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences School of Life Sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2S_n, n≥2）, not organic polysulfides. Studies on the mechanism of action（MoA） show that H2S_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（NADP+）. However, low H2S_nyield makes garlic derivatives hard to be a reliable donor of H2S_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3S4that generates H2S_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2S_nmicroreactor（GAPSR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPSR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Clusterphene:A new two-dimensional structure from cluster selfassembly

引用

Nano Research 2022年第7期15卷 5790-5791页

作者： jian Zhou Leyun Li xuejiao j.gao Haiqing Wang Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China

Since the advent of graphene in 2004,two-dimensional(2D)materials had ignited the development of fascinating functional materials for almost 20 ***,the main members of 2D materials family are graphene,transition metal dichalcogenides(TMDs,MoS_(2),WS_(2),and others),MXenes(Ti_(3)C_(2),Ta_(4)C_(3),and others),Xenes(B,Si,P,Ge,and Sn),organic materials(COF,covalent organic frameworks),*** unique sheet-like morphology(single-or few-atomic-layer thickness)endow 2D materials with unconventional physicochemical properties for promising applications in catalysis,energy storage/conversion,electronics,biomedicine,sensors,***,the exploration and preparation of novel twodimensional materials with desired characteristics through highly controlled strategy remains one of the major challenges in this *** a recent work from Nature Chemistry published on 10 February 2022,Liu et *** a new member,clusterphene,in the family of two-dimensional materials.

关键词： MXene cluster dimensional

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Remote substituent effects on catalytic activity of metal-organic frameworks: a linker orbital energy model

引用

npj Computational Materials 2023年第1期9卷 1747-1755页

作者： Zhenzhen Wang Huan Meng xuejiao j.gao jia-jia Zheng Xingfa gao Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and Technology of ChinaBeijingChina CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology of ChinaBeijingChina College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchangChina

The Hammett equation is commonly used to theoretically depict the remote electronic effects of substituents on catalytic activitiesof metal nodes of metal-organic frameworks (MOFs). However, the application of the theory to MOF catalysts usually encountersproblems because it relies heavily on empirical parameters with unknown transferability. To develop an alternative predictiontheory, the linker orbital energy model has been proposed by density functional theory calculations. The model provides a simplemethod to approximately depict the remote electronic substituent effects on catalytic activities of metal nodes of MOFs, and itsgeneral applicability to MOFs is supported by extensively revisiting the structure-activity relationships reported in the *** model can be used to design catalytic activity of metal nodes of MOFs by engineering the electronic properties of linkers andsubstituents.

关键词： substituent catalytic orbital

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Largeπ-conjugated indium-based metal-organic frameworks for high‐performance electrochemical conversion of CO_(2)

引用

Nano Research 2023年第7期16卷 8743-8750页

作者： Zengqiang gao Yue Gong Yating Zhu junjie Li Li Li Yongxia Shi Man Hou xuejiao j.gao Zhicheng Zhang Wenping Hu Department of Chemistry School of ScienceTianjin Key Laboratory of Molecular Optoelectronic SciencesTianjin UniversityTianjin 300072China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China

The active site engineering of electrocatalysts,as one of the most economical and technological approaches,is a promising strategy to enhance the intrinsic activity and selectivity towards electrochemical CO_(2)reduction ***,an indium-based porphyrin framework(In-TCPP)with a well-defined structure,highly dispersed catalytic center,and good stability was constructed for efficient CO_(2)-to-formate ***-TCPP could achieve a high Faraday efficiency for formate(90%)and a cathodic energy efficiency of 63.8%in flow *** situ attenuated total reflectance Fourier transform infrared spectroscopy and density functional theory calculation confirm that the crucial intermediate is*COOH species which contributes to the formation of *** work is expected to provide novel insights into the precise design of active sites for high-performance electrocatalysts towards electrochemical CO_(2)reduction reaction.

关键词： electrochemical CO_(2)reduction metal-organic framework porphyrin indium formate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Confined interface engineering of self-supported Cu@N-doped graphene for electrocatalytic CO_(2) reduction with enhanced selectivity towards ethanol

引用

Nano Research 2022年第10期15卷 8872-8879页

作者： Dejin Zang xuejiao jgao Leyun Li Yongge Wei Haiqing Wang Institute of Materia Medica Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China Institute for Advanced Interdisciplinary Research(iAIR) School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Key Lab of Organic Optoelectronics&Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China

Electroreduction of greenhouse gas CO_(2) into value-added fuels and chemicals provides a promising pathway to address the issues of energy crisis and environmental ***,the regulations of the selectivity towards C2 product and the competing hydrogen evolution reaction(HER)are major challenges for CO_(2) reduction reaction(CO_(2)RR).Here,we develop an interface-enhanced strategy by depositing a thin layer of nitrogen-doped graphene(N-G)on a Cu foam surface(Cu-N-G)to selectively promote the ethanol pathway in CO_(2)*** to the undetectable ethanol selectivity of pure Cu and Cu@graphene(Cu-G),Cu-N-G has boosted the ethanol selectivity to 33.1%in total Faradic efficiency(FE)at−0.8 V *** hydrogen electrode(RHE).The experimental and density functional theory(DFT)results verify that the interconnected graphene coating can not only serve as the fast charge transport channel but also provide confined nanospace for mass *** N doping can not only trigger the intrinsic interaction between N in N-G and CO_(2) molecule for enriching the local concentration of reactants but also promote the average valence state of Cu for C–C coupling *** confinement effect at the interface of Cu-N-G can not only provide high adsorbed hydrogen(Had)coverage but also stabilize the key*HCCHOH intermediate towards ethanol *** provided interface-enhanced strategy herein is expected to inspire the design of Cubased CO_(2)RR electrocatalysts towards multi-carbon products.

关键词： CO_(2)reduction Cu-based catalyst Cu/N-doped carbon interface engineering C2 production

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Synergistic Effect of Endohedral Metal and Chemical Multi-addition on the Stability of Fullerene

The Synergistic Effect of Endohedral Metal and Chemical Mult...

引用

中国化学会第八届全国物理无机化学学术会议

作者： xuejiao j.gao Xingfa gao College of Chemistry and Chemical Engineering Jiangxi Normal University

Fullerenes are the third allotrope of carbon besides graphite and *** are cage-like molecules which are only constructed by *** inner cavities of fullerenes have diameters of about 1 nm, which allow fullerene to encapsulate metal or metal cluster forming endohedral metallofullerenes(EMFs).Fullerenes and EMFs are promising nanomaterials with potential applications in biomedical, photo sensor, solar cell and etc.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Bimetallic phthalocyanine heterostructure used for highly selective electrocatalytic CO_(2) reduction

引用

Science China Materials 2022年第1期65卷 155-162页

作者： Chenhuai Yang Zengqiang gao Dingjia Wang Shuyu Li junjun Li Yating Zhu Haiqing Wang Wenjuan Yang xuejiao j.gao Zhicheng Zhang Wenping Hu Tianjin Key Laboratory of Molecular Optoelectronic Sciences Department of ChemistrySchool of ScienceTianjin UniversityTianjin 300072China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong Institute for Advanced Interdisciplinary Research(iAIR)University of JinanJinan 250022China SZU-NUS Collaborative Innovation Centre for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China

Heterogeneous molecular catalysts,such as metal phthalocyanines,are efficient electrocatalysts for CO_(2) reduction reaction(CO_(2)RR).However,the rational design and synthesis of a molecular catalyst-based heterostructure for CO_(2)RR remains ***,we developed a crystalline bimetallic phthalocyanine heterostructure electrocatalyst(CoPc/FePc HS),which achieved an excellent CO_(2)-to-CO conversion efficiency(99%)and outstanding long-term stability after 10 h of *** functional theory calculations revealed that the enhancement of CO_(2)RR performance could be attributed to the distinct electron transfer pattern between FePc and *** heterostructural engineering in molecular catalysts would inspire a unique approach for improving CO_(2)RR performance.

关键词： molecular catalyst phthalocyanine heterostructure CO_(2)reduction electronic effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Developing a Knock Predictive Criterion in Spark Ignition Engines Fuelled with Gaseous Fuels

引用

journal of Thermal Science 1993年第4期2卷 304-311页

作者： G.A.Karim j.gao Department of Mechanical Engineering The University of Calgary

Consideration of the chemical reaction activity of the end gas in a spark ignition and operating conditions are combined to predict the onset of knock and associated performance in an engine fuelled with methane.A two-zone predictive combustion model was developed based on an estimate of the efiFective duration of the combustion period and the mass burning rate for any set of operating *** unburned end gas preignition chemical reaction activity is described by a detailed chemical reaction kinetic scheme for methane and *** variation with time of the value of a formulated dimensionless knock parameter(k)is *** is shown that whenever knocking is encountered,the value of'k' builds up to a sufficiently high value that exceeds a critical *** normal operating conditions, the value of'k'remains throughout the whole combustion period at comparatively very low levels. It is shown that the model and the use of this knock criterion'k'produce results that are in good agreement with experiment.

关键词： gas spark ignition knock predictive model knock parameter

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimizing battery deployment: Aging trajectory prediction enabling homogenous performance grouping

引用

journal of Energy Chemistry 2025年第1期100卷 565-577页

作者： Shuquan Wang Feng gao Zhan Ma Hao Tian Yusen Zhang School of Control Science and Engineering Shandong University Key Lab of Power System Intelligent Dispatch and Control of Ministry of Education Shandong University

As battery deployments in electric vehicles and energy storage systems grow, ensuring homogeneous performance across units is crucial. We propose a multi-derivative imaging fusion(MDIF) model, employing advanced imaging and machine learning to predict battery aging trajectories from minimal initial data, thus facilitating effective performance grouping before deployment. Utilizing a derivative strategy and Gramian Angular Difference Field for dimensional enhancement, the MDIF model uncovers subtle predictive features from discharge curve data after only ten cycles. The architecture includes a parallel convolutional neural network with lateral connections to enhance feature integration and *** on a self-developed dataset, the model achieves an average root-mean-square error of 0.047 Ah and an average mean absolute percentage error of 1.60%, demonstrating high precision and *** robustness is further validated through transfer learning on two publicly available datasets, adapting with minimal retraining. This approach significantly reduces the testing cycles required, lowering both time and costs associated with battery testing. By enabling precise battery behavior predictions with limited data, the MDIF model optimizes battery utilization and deployment strategies, enhancing system efficiency and sustainability.

关键词： Lithium-ion battery Battery prognostics Fusion model Convolutional neural network Transfer learning

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Unveiling the promotion role of ZnO on Zn-Al spinel oxide for CO2 hydrogenation

引用

journal of Energy Chemistry 2025年第1期100卷 18-25页

作者： Tongyao Wang Xinlong Yao Lixin Liang Hongyu Chen Pan gao Guangjin Hou State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

The Zn-Al spinel oxide stands out as one of the most active catalysts for high-temperature methanol synthesis from CO2hydrogenation. However, the structure–activity relationship of the reaction remains poorly understood due to challenges in atomic-level structural characterizations and analysis of reaction intermediates. In this study, we prepared two Zn-Al spinel oxide catalysts via coprecipitation（ZnAl-C）and hydrothermal（ZnAl-H） methods, and conducted a comparative investigation in the CO2hydrogenation reaction. Surprisingly, under similar conditions, ZnAl-C exhibited significantly higher selectivity towards methanol and DME compared to ZnAl-H. Comprehensive characterizations using X-ray diffraction（XRD）, Raman spectroscopy and electron paramagnetic resonance（EPR） unveiled that ZnAl-C catalyst had abundant ZnO species on its surface, and the interaction between the ZnO species and its ZnAl spinel oxide matrix led to the formation of oxygen vacancies, which are crucial for CO2adsorption and activation. Additionally, state-of-the-art solid-state nuclear magnetic resonance（NMR） techniques,including ex-situ and in-situ NMR analyses, confirmed that the surface ZnO facilitates the formation of unique highly reactive interfacial formate species, which was readily hydrogenated to methanol and DME. These insights elucidate the promotion effects of ZnO on the ZnAl spinel oxide in regulating active sites and reactive intermediates for CO2-to-methanol hydrogenation reaction, which is further evidenced by the significant enhancement in methanol and DME selectivity observed upon loading ZnO onto the ZnAl-H catalyst. These molecular-level mechanism understandings reinforce the idea of optimizing the ZnO-ZnAl interface through tailored synthesis methods to achieve activity-selectivity balance.

关键词： Reaction intermediates

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：