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Whole-genome and genome-wide association studies improve key agricultural traits of safflower for industrial and medicinal use

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Horticulture Research 2023年第11期10卷 59-70页

作者： jiang Chen Shuai Guo Xueli Hu Rui Wang Donghai Jia Qiang Li Xianmei Yin xuejiao Liao Zunhong Hu Peiqi Wang Chaoxiang Ren Shuai Dong Chao Chen Shilin Chen jiang Xu Jin Pei State Key Laboratory of Southwestern Chinese Medicine Resources College of PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Industrial Crops Research Institute Yunnan Academy of Agricultural SciencesKunming 650205China Institute of Economic Crops Xinjiang Academy of Agricultural SciencesUrumchi 830091China

Safflower(Carthamus tinctorius)is widely cultivated around the world for its seeds and *** presence of linoleic acid(LA)in its seeds and hydroxysafflor yellow A(HSYA)in its flowers are the crucial traits that enable safflower to be used for industrial and medicinal *** the genetic control of these traits is essential for optimizing the quality of safflower and its *** further this research,we present a chromosome-scale assembly of the genome of the safflower variety‘Chuanhonghua 1’,which was achieved using an integrated strategy combining Illumina,Oxford Nanopore,and Hi-C *** obtained a 1.17-Gb assembly with a contig N50 of 1.08 Mb,and all assembled sequences were assigned to 12 ***’s evolution involved the core eudicotγ-triplication event and a whole-genome duplication event,which led to large-scale genomic *** genomic shuffling has occurred since the divergence of the ancestor of *** conducted metabolite and transcriptome profiles with time-and part-dependent changes and screened candidate genes that significantly contribute to seed lipid *** also analyzed key gene families that participate in LA and HSYA ***,we re-sequenced 220 safflower lines and carried out a genome-wide association study using high-quality SNP data for eight agronomic *** identified SNPs related to important traits in ***,the candidate gene HH_034464(CtCGT1)was shown to be involved in the biosynthesis of ***,we provide a high-quality reference genome and elucidate the genetic basis of LA and HSYA biosynthesis in *** vast amount of data will benefit further research for functional gene mining and breeding in safflower.

关键词： flowers Whole breeding

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50th anniversary of artemisinin:From the discovery to allele-aware genome assembly of Artemisia annua

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Molecular Plant 2022年第8期15卷 1243-1246页

作者： jiang Xu Baosheng Liao Ling Yuan Xiaofeng Shen xuejiao Liao Jigang Wang Haoyu Hu Zhihai Huang Li Xiang Shilin Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Quality Evaluation of Chinese Medicine of the Guangdong Provincial Medical Products Administration the Second Clinical CollegeGuangzhou University of Chinese MedicineGuangzhou 510006China Kentucky Tobacco Research and Development Center and Department of Plant and Soil SciencesUniversity of KentuckyLexingtonKY 40546USA institute of Medicinal Plant Development Chinese Academy of Medical SciencesBeijing 100193China Artemisinin Research Center China Academy of Chinese Medical SciencesBeijing 100700China Chengdu University of Traditional Chinese Medicine ChengduChina

Over the past half century,the fight against malaria has been a resounding success mainlydue to thediscoveryof *** to the World Health Organization(WHO),morbidity and mortality due to malaria have been cut by half sin... 详细信息

关键词： mortality malaria allele

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Novel resonant pressure sensor based on piezoresistive detection and symmetrical in-plane mode vibration

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Microsystems & Nanoengineering 2020年第1期6卷 165-175页

作者： Xiangguang Han Qi Mao Libo Zhao xuejiao Li Li Wang Ping Yang Dejiang Lu Yonglu Wang Xin Yan Songli Wang Nan Zhu Zhuangde jiang State Key Laboratory for Manufacturing Systems Engineering International Joint Laboratory for Micro/Nano Manufacturing and Measurement TechnologiesXi’an Jiaotong University710049 Xi’anChina School of Mechanical Engineering Xi’an Jiaotong University710049 Xi’anChina Xi’an Flight Automatic and Control Institute 710049 Xi’anChina

In this paper,a novel resonant pressure sensor is developed based on electrostatic excitation and piezoresistive *** measured pressure applied to the diaphragm will cause the resonant frequency shift of the *** working mode stress–frequency theory of a double-ended tuning fork with an enhanced coupling beam is proposed,which is compatible with the simulation and experiment.A unique piezoresistive detection method based on small axially deformed beams with a resonant status is proposed,and other adjacent mode outputs are easily *** to the structure design,high-vacuum wafer-level packaging with different doping in the anodic bonding interface is fabricated to ensure the high quality of the *** pressure sensor chip is fabricated by dry/wet etching,high-temperature silicon bonding,ion implantation,and wafer-level anodic *** results show that the fabricated sensor has a measuring sensitivity of~19 Hz/kPa and a nonlinearity of 0.02%full scale in the pressure range of 0–200 kPa at a full temperature range of−40 to 80°*** sensor also shows a good quality factor>25,000,which demonstrates the good vacuum ***,the feasibility of the design is a commendable solution for high-accuracy pressure measurements.

关键词： resonant mode anodic

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基于TLR4/NF-κB/iNOS通路的截断逆挽方药物血清对L02细胞氧化应激损伤的影响

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中国中医药信息杂志 2022年第4期29卷 87-91页

作者：窦博马重阳侯伟欣魏晓艺姜雪娇叶倩伶胡文涵张海天张秋云首都医科大学中医药学院中医肝病研究北京市重点实验室北京100069

目的观察截断逆挽方药物血清对D-氨基半乳糖(D-GaLN)诱导的L02细胞氧化应激损伤的影响,从TLR4/NF-κB/iNOS通路探讨其作用机制。方法体外培养L02细胞,D-GaLN诱导L02细胞损伤模型,将细胞分为正常组、模型组、截断逆挽方药物血清组、N-乙... 详细信息

目的观察截断逆挽方药物血清对D-氨基半乳糖(D-GaLN)诱导的L02细胞氧化应激损伤的影响,从TLR4/NF-κB/iNOS通路探讨其作用机制。方法体外培养L02细胞,D-GaLN诱导L02细胞损伤模型,将细胞分为正常组、模型组、截断逆挽方药物血清组、N-乙酰半胱氨酸组。CCK-8法检测细胞存活率,丙二醛(MDA)和谷胱甘肽(GSH)检测试剂盒检测细胞MDA和GSH含量,流式细胞术检测细胞活性氧(ROS)含量,Western blot检测Toll样受体4(TLR4)、核因子-κB p65(NF-κB p65)、一氧化氮合酶(iNOS)蛋白表达。结果与正常组比较,模型组L02细胞存活率明显降低(P<0.01),ROS、MDA含量明显增加,GSH含量明显减少,TLR4、NF-κB p65、iNOS蛋白表达明显升高,差异均有统计学意义(P<0.01);与模型组比较,截断逆挽方药物血清组L02细胞存活率明显升高(P<0.01),ROS、MDA含量明显减少,GSH含量明显增加,TLR4、NF-κB p65、iNOS蛋白表达明显降低,差异均有统计学意义(P<0.01)。结论截断逆挽方药物血清能抑制TLR4/NF-κB/iNOS通路介导的氧化应激,减轻D-GaLN诱导的L02细胞损伤。

关键词：截断逆挽方药物血清氧化应激慢加急性肝衰竭 TLR4/NF-κB/iNOS通路 L02细胞

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中医药治疗表皮生长因子受体抑制剂相关皮疹的系统性评价

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世界中医药 2020年第8期15卷 1137-1143页

作者：郑舒月段桦彭艳梅张静怡申文孙晨耀张旭谭可欣姜雪娇崔慧娟北京中医药大学北京100029 中日友好医院中西医结合肿瘤科北京100029 北京中医药大学房山医院北京102499

目的:评价中医药治疗表皮生长因子受体抑制剂(EGFRIs)相关皮疹的疗效及安全性。方法:在外文Web of Science、PubMed、Cochrane Library和维普数据库(VIP)、中国学术期刊全文数据库(CNKI)、万方数据库中检索从创建以来至2018年3月关于中... 详细信息

目的:评价中医药治疗表皮生长因子受体抑制剂(EGFRIs)相关皮疹的疗效及安全性。方法:在外文Web of Science、PubMed、Cochrane Library和维普数据库(VIP)、中国学术期刊全文数据库(CNKI)、万方数据库中检索从创建以来至2018年3月关于中医药治疗EGFRIs相关皮疹的随机对照试验,并手工检索补充相应文献。由研究人员对文献进行筛选和数据提取,并用Rev Man5.3进行异质性检验、敏感性分析和Meta分析。结果:纳入21项研究,共1394例肿瘤患者,Meta分析结果显示中医药治疗EGFRIs相关皮疹的有效率、减轻皮肤瘙痒的有效率、中医症状缓解的有效率明显优于对照组(P0.05)。结论:中医药治疗可明显缓解EGFRIs相关皮疹和瘙痒,明显缓解中医证候,提高患者的生命质量,且不影响EGFRI的抗肿瘤疗效。

关键词：表皮生长因子受体抑制剂皮疹中医药 Meta分析

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基于数据挖掘探析钱英治疗原发性肝癌用药规律

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中国中医药信息杂志 2024年第8期31卷 52-57页

作者：张海天马重阳侯伟欣窦博方娴姜雪娇房鹏梁嘉俊魏晓艺胡文涵张秋云首都医科大学中医药学院中医络病研究北京市重点实验室北京100069

目的通过数据挖掘技术分析钱英教授治疗原发性肝癌的用药规律,为临床辨治原发性肝癌提供思路。方法收集2008年11月-2020年8月钱英教授治疗原发性肝癌的门诊中药处方,整理后建立数据资料表,通过Excel2019对药物频次及性味归经进行分析;... 详细信息

目的通过数据挖掘技术分析钱英教授治疗原发性肝癌的用药规律,为临床辨治原发性肝癌提供思路。方法收集2008年11月-2020年8月钱英教授治疗原发性肝癌的门诊中药处方,整理后建立数据资料表,通过Excel2019对药物频次及性味归经进行分析;通过名医传承辅助平台医案分析模块对筛选出的中药处方进行核心药物分析,药对之间的共生性分析,药症关联分析及药物聚类分析。结果共纳入处方108首,涉及中药188味,药物总频次为1322。高频用药包括白花蛇舌草、黄芪、槲寄生、郁金、丹参等。药性以寒、平、温为主,药味以苦、甘、辛为主,归经以肝经、脾经、肾经、胃经为主。药物关联中高频药物组合有郁金-水红花子、槲寄生-莪术等9对。药症关联分析中关联度较高的有“胃痛-丹参”“癥瘕-赤芍、陈皮”“耳鸣-南沙参、枸杞子、槲寄生”“舌下络脉延长-莪术、水红花子、丹参”等。药物聚类分为3类潜在的药物群。结论钱英教授治疗原发性肝癌多用清热药、补虚药、行气活血药,以槲芪散为主方随证加减,以清热解毒、疏肝解郁、逐瘀通络治其标,补气健脾、和血调肝、滋补肝肾治其本,可为临床治疗原发性肝癌提供一定参考。

关键词：原发性肝癌钱英用药规律数据挖掘

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Effect of Dandelion(Taraxacum mongolicum Hand.-Mazz.)Intercropping with Different Plant Spacing on Blight and Growth of Pepper(Capsicum annuum L.)

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Phyton-International Journal of Experimental Botany 2023年第8期92卷 2227-2244页

作者： Peixin Li Hanbing Liu Yingtong Chen Xin Zhang Ning Cao Ying Sun Meimei Jia Mengran Wu xuejiao Tong Xinmei jiang Xihong Yu Yao Cheng College of Horticulture and Landscape Architecture Northeast Agricultural UniversityHarbin150030China Key Laboratory of Biology and Genetic Improvement of Horticulture Crops(Northeast Region) Ministry of Agriculture and Rural AffairsHarbinChina State Key Laboratory of Improvement and Utilization of Saline-Alkali Soils(Inland Saline-Alkali Land of Northeast China) Ministry of Agriculture and Rural Affairs of ChinaJilin Agricultural UniversityJilinChina

Intercropping of crops that can secrete bacteriostatic active substances can not only inhibit the occurrence of disease but also have an important effect on plant ***,the effects of dandelion intercropping on pepper blight control and pepper growth remain *** this study,the control effect of dandelion on pepper blight was studied by inoculating the pepper leaves with Phytophthora infestans,and it also discusses the correlation of the occurrence of pepper epidemic disease with the pepper canopy environment,soil environment,pepper photo-synthesis,and yield *** results showed that best plant distance for dandelion intercropping was 20 cm(P20),and the control effect reached 43.31%.As compared to the CK,SOD enzyme,POD enzyme,and PAL enzyme were signiﬁcantly up-regulated during the growth of pepper;chlorophyll content in pepper leaves was signiﬁcantly increased;photosynthetic characteristics were signiﬁcantly increased;stem diameter and yield of crop pepper were effectively improved;and the quality of the pepper product was better,but intercropping dandelion resulted in a signiﬁcant decrease of nutrients in the soil environment of pepper,so a reasonable intercropping distance was *** correlation analysis shows that the incidence of pepper blight(A)was signiﬁcantly positively correlated with soil temperature(Q),intercellular carbon dioxide(L),and canopy air temperature(O).The incidence of capsicum blight(A)was signiﬁcantly negatively correlated with chlorophyll content(F),net photo-synthetic rate(K),stomatal conductance(M),ww rate(N),soil sucrase activity(W),vitamin C(AB),and leaf PAL enzyme(J).Finally,it was deduced that intercropping dandelion could effectively control the occurrence of pepper blight while also demonstrating a complex interaction with the pepper growing environment.

关键词： Intercropping pepper blight dandelion plant growth correlation analysis

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Mitochondrial flashes are interlinked with adaptive thermogenesis in brown adipocytes

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hLife 2024年第4期2卷 179-188页

作者： Xinyu Chen Huwatibieke Bahetiyaer xuejiao Song Zuzhi jiang Wenfeng Qi Weizheng Gao Lin Zhang Jue Zhang Heping Cheng Xianhua Wang State Key Laboratory of Membrane Biology Institute of Molecular MedicineCollege of Future TechnologyPeking UniversityBeijingChina Academy for Advanced Interdisciplinary Studies Peking UniversityBeijingChina College of Engineering Peking UniversityBeijingChina Research Unit of Mitochondria in Brain Diseases Chinese Academy of Medical SciencesPKU-Nanjing Institute of Translational MedicineJiangsuChina

Mitochondrial flash(mitoflash)is the electrochemical excitation of a single mitochondrion and plays diverse signaling roles in a variety of *** the viewpoint of bioenergetics,it represents the transient uncoupling of mitochondrial respiration from ATP *** adipose tissue(BAT)produces heat,primarily via mitochondrial uncoupled ***,we aim to illustrate the mitoflash activity in BAT *** show that BAT mitochondria undergo stochastic and intermittent mitoflashes at the levels of isolated mitochondria,cultured brown adipocytes,and even intact BAT.A BAT mitoflash contains multiple signals,including transient depolarization of mitochondrial membrane potential,transient matrix alkalization,and bursting production of reactive oxygen ***,thermogenic activation by b3-adrenergic stimulation dramatically augments mitoflash incidence,with mild effects on its unitary *** of the thermogenic uncoupling protein 1(UCP1)showed little effect on mitoflash biogenesis during heat ***,our results suggest that mitoflash might constitute an elemental signaling activity of mitochondria to regulate BAT thermogenesis.

关键词： mitochondrial flash(mitoflash) mitochondria thermogenesis brown adipocyte

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The KL system in wheat permits homoeologous crossing over between closely related chromosomes

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The Crop Journal 2023年第3期11卷 808-816页

作者： Chaolan Fan jiangtao Luo Jiaojiao Sun Hong Chen Liqiong Li Lanyue Zhang Xue Chen Yazhou Li Shunzong Ning Zhongwei Yuan Bo jiang Lianquan Zhang xuejiao Chen Adam J.Lukaszewski Dengcai Liu Ming Hao State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130SichuanChina Department of Botany and Plant Sciences University of CaliforniaRiversideCA 92521USA Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130SichuanChina Crop Research Institute Sichuan Academic of Agricultural ScienceChengdu 610066SichuanChina

The Chinese wheat landrace Kaixianluohanmai(KL)expresses the ph-like phenotype.A major QTL,***-3A(***),responsible for this effect has been mapped to chromosome arm *** study presents some characteristics of homoeologous pairing and recombination induced by *** KL haploids,the level of homoeologous pairing was elevated relative to Ph1 Chinese Spring(CS)*** was a clear preference for A–D pairing and less frequent for A–B and B–D,reflecting the higher levels of affinity between genomes A and D in *** characteristics of pairing were affected by temperature and magnesium ion *** suitability of phKL for chromosome engineering was tested on three pairs of homoeologues:2Sv-2B,2Sv-2D,and *** recombination rates were 1.68%,0.17%,and 0%,*** phKL locus in KL induced a moderate level of homoeologous chromosome pairing and recombination when the Ph1 locus of wheat was present,both in wheat haploids and *** Ph1-imposed criteria for chromosome pairing and crossing over were relaxed to some degree,permitting homoeologous crossing over but only between closely related chromosomes;there was no crossing over between more differentiated ***,the phKL system(***-3A)can be a useful tool in chromosome engineering of wheat to transfer genes from closely related species with the benefit of reduced genomic chaos generated by the ph1b mutation.

关键词： ph-like gene phKL Homoeologous recombination Homoeology

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考虑拉裂缝的斜坡软弱地基路堤稳定性分析

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铁道学报 2018年第5期40卷 109-115页

作者：蒋鑫梁雪娇刘红坡姜春亮邱延峻西南交通大学土木工程学院四川成都610031 西南交通大学道路工程四川省重点实验室四川成都610031 西南交通大学高速铁路线路工程教育部重点实验室四川成都610031

评述斜坡软弱地基路堤稳定性研究面临的挑战性,应用极限平衡法软件Slide、有限元法软件Phase2,分别从推力线分布状况、达到临界剪切强度折减时单元拉伸屈服分布状况角度出发,探讨斜坡软弱地基路堤稳定性分析中引入拉裂缝的必要性;在极... 详细信息

评述斜坡软弱地基路堤稳定性研究面临的挑战性,应用极限平衡法软件Slide、有限元法软件Phase2,分别从推力线分布状况、达到临界剪切强度折减时单元拉伸屈服分布状况角度出发,探讨斜坡软弱地基路堤稳定性分析中引入拉裂缝的必要性;在极限平衡法基础上,利用敏感性分析法确定拉裂缝分别在干燥和完全充水条件下的最不利深度;分析拉裂缝引入后对稳定安全系数、最危险滑面形态及条间法向力的影响,阐述拉裂缝水分充填对稳定性的不利作用。研究结果表明,敏感性分析法可较好地确定拉裂缝的深度;考虑拉裂缝后,滑块土条条间法向拉力消失,稳定安全系数降低,设计更趋于安全,拉裂缝完全充水将进一步加剧斜坡软弱地基路堤稳定安全系数的降低;滑面由上部垂线和下部圆弧共同组成,其形态更真实客观。

关键词：斜坡软弱地基路堤稳定性拉裂缝敏感性分析极限平衡法

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