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The bioelectrical properties of bone tissue

Animal Models and Experimental Medicine 2023年第2期6卷 120-130页

作者： Boon Chin Heng Yunyang Bai Xiaochan Li Yanze meng Yanhui Lu xuehui Zhang Xuliang Deng Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingPR China Central Laboratory Peking University School and Hospital of StomatologyBeijingPR China School of Medical and Life Sciences Sunway UniversitySubang JayaMalaysia Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingPR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingPeople's Republic of China

Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries,as well as improving the design and fabrication of scaffold implants for bone tissue engineering.The bioelectrical properties of bone tissue can be attributed to the interaction of its various cell lineages(osteocyte,osteoblast and osteoclast)with the surrounding extracellular matrix,in the presence of various biomechanical stimuli arising from routine physical activities;and is best described as a combination and overlap of dielectric,piezoelectric,pyroelectric and ferroelectric properties,together with streaming potential and electro-osmosis.There is close interdependence and interaction of the various electroactive and electrosensitive components of bone tissue,including cell membrane potential,voltage-gated ion channels,intracellular signaling pathways,and cell surface receptors,together with various matrix components such as collagen,hydroxyapatite,proteoglycans and glycosaminoglycans.It is the remarkably complex web of interactive cross-talk between the organic and non-organic components of bone that define its electrophysiological properties,which in turn exerts a profound influence on its metabolism,homeostasis and regeneration in health and disease.This has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering,to recapitulate the natural electrophysiological microenvironment of healthy bone tissue to facilitate bone defect repair.

关键词： bone dielectric electric ferroelectric homeostasis metabolism piezoelectric pyroelectric regeneration

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On the process of filtration of fractional viscoelastic liquid food

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Communications in Theoretical Physics 2021年第4期73卷 29-44页

作者： Yahui meng Botong Li Xinhui Si xuehui Chen Fawang Liu School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China School of Mathematical Sciences Queensland University of TechnologyGPO Box 2434BrisbaneQld.4001Australia

In the process of filtration,fluid impurities precipitate/accumulate;this results in an uneven inner wall of the filter,consequently leading to non-uniform suction/injection.The Riemannian-Liouville fractional derivative model is used to investigate viscoelastic incompressible liquid food flowing through a permeable plate and to generalize Fick's law.Moreover,we consider steady-state mass balance during ultrafiltration on a plate surface,and a fractional-order concentration boundary condition is established,thereby rendering the problem real and complex.The governing equation is numerically solved using the finite difference algorithm.The effects of the fractional constitutive models,generalized Reynolds number,generalized Schmidt number,and permeability parameter on the velocity and concentration fields are compared.The results show that an increase in fractional-orderαin the momentum equation leads to a decrease in the horizontal velocity.Anomalous diffusion described by the fractional derivative model weakens the mass transfer;therefore,the concentration decreases with increasing fractional derivativeγin the concentration equation.

关键词： non-uniform permeable surface viscoelastic fluid fractional calculus implicit numerical method

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Distribution of elements extracted from symptom patterns and characteristics of polysomnograph of common symptom patterns of insomnia with Traditional Chinese Medicine

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Journal of Traditional Chinese Medicine 2016年第5期36卷 649-653页

作者： Cui Yinglin Zheng Weifeng Xu Li meng Yi Wang Yuqin Chang xuehui Brain Disease Ward 2 Henan Province Hospital of Traditional Chinese Medicine Basic Medical Henan University of Traditional Chinese Medicine

OBJECTIVE: To analyze the distribution and combined regulation of elements of symptom patterns in the diagnosis of insomnia with Traditional Chinese Medicine(TCM).METHODS: The samples were collected from the patients, diagnosed with insomnia, of Henan Province Hospital of TCM between June 2011 and September 2013. The symptom patterns in insomnia were extracted. Next, symptom differentiation,characteristics of polysomnography(PSG), distribution and combined regulation of these symptom patterns were conducted by tests.RESULTS: In total, 286 eligible patients were recruited. The main locations of the disease symptom elements were the brain and heart, and the main characteristics of the disease symptom elements were phlegm-heat, Yin-deficiency and Qi-stagnation. The elements from two or three symptom patterns were commonly manifested in patients with insomnia, especially from three symptom patterns. We also found that all TCM symptom patterns had an effect on polysomnographic indicators in PSG tests.CONCLUSION: The elements of symptom patterns in insomnia were identified as mainly fire-heat and phlegm-heat. The most common patterns of excess were pathogenic fire derived from stagnation of liver-Qi, and mental disturbance due to phlegm-heat,while the most common patterns of deficiency in both the heart and the spleen. There are many differences in PSG indicators of different syndrome patterns of insomnia.

关键词： Sleep initiation and maintenance disorders Symptom elements Polysomnogram Polysomnography

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Role of social organization engagement in high-risk groups intervention against HIV/AIDS:a case study from 176 cities of China

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Infectious Diseases of Poverty 2022年第6期11卷 70-83页

作者： Zhiwei Leng Sha Sha Shuyu Dai Xuehui Meng Jinfeng Li Junyi Jin Wenlin Zheng Weihua Yang Chuanju Mao Zhenzhong Wang Liujin Zhang Peng Wang Tao Yang Weizhong Yang School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina Chinese Preventive Medicine Association BeijingChina Zhejiang Chinese Medical University HangzhouChina Centre for Health Management and Policy Research School of Public HealthCheeloo College of MedicineShandong UniversityJinanChina Chinese Academy of Medical Sciences&Peking Union Medical College BeijingChina

Background: A high-risk prevention strategy is an effective way to fight against human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS). The China AIDS Fund for Non-Governmental Organizations (CAFNGO) was established in 2015 to help social organizations intervene to protect high-risk populations in 176 cities. This study aimed to evaluate the role of social organizations in high-risk population interventions against HIV/AIDS.Methods: This study was based on the CAFNGO program from 2016 to 2020. The collected data included the number and types of social organizations participating in high-risk group interventions and the amount of funds obtained by these organizations each year. We explored the factors influencing the number of newly diagnosed AIDS cases using a spatial econometric model. Furthermore, we evaluated the effectiveness of intervention activities by comparing the percentages of the individuals who initially tested positive, and the individuals who took the confirmatory test, as well as those who retested positive and underwent the treatment.Results: Overall, from 2016 to 2020, the number of social organizations involved in interventions to protect HIV/AIDS high-risk populations increased from 441 to 532, and the invested fund increased from $3.98 to $10.58 million. The number of newly diagnosed cases decreased from 9128 to 8546 during the same period. Although the number of cities with overall spatial correlations decreased, the spatial agglomeration effect persisted in the large cities. Citywise, the number of social organizations (direct effect 19.13), the permanent resident population (direct effect 0.12), GDP per capita (direct effect 17.58;indirect effect -15.38), and passenger turnover volume (direct effect 5.50;indirect effect -8.64) were the major factors influencing new positive cases confirmed through the testing interventions performed by the social organizations. The initial positive test rates among high-risk populations were below 5.5%, the retesting rates among

关键词： Social organization High-risk groups HIV/AIDS Spatial effect

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DRG支付方式改革背景下公立医院高质量发展机制——基于双重嵌入性视角的单案例研究

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公共管理学报 2024年第1期21卷 134-145,174页

作者：孟翠湖辛至明孟雪晖南京财经大学会计学院南京210023 浙江中医药大学人文与管理学院杭州311403

目前,中国DRG(Diagnosis-Related Group)支付方式改革已初显成效,公立医院如何在这一制度背景下迈向高质量发展道路备受关注。本文采用诠释主义案例研究范式,深描在DRG支付制度背景下公立医院“谋生行义”的过程,归纳出公立医院“义生... 详细信息

目前,中国DRG(Diagnosis-Related Group)支付方式改革已初显成效,公立医院如何在这一制度背景下迈向高质量发展道路备受关注。本文采用诠释主义案例研究范式,深描在DRG支付制度背景下公立医院“谋生行义”的过程,归纳出公立医院“义生耦合”的高质量发展机制:正式制度嵌入设计激励约束机制,而政治嵌入若发挥纠正作用将促使组织激励结构趋同;医院通过非正式制度嵌入传导激励约束机制,实现组织生存和制度落地;制度嵌入性与政治嵌入性嵌合形成公立医院高质量发展助力,有利于实现利益主体间激励相容。DRG支付制度背景下公立医院变革及公共治理的实践已十分丰富,本文界定了制度嵌入性和政治嵌入性的概念,为上述情境提供了新的理论解释框架,并通过质性案例研究进行学理归纳;另外,文章拓展了新经济社会学理论在中国行政事业单位的应用。

关键词： DRG(Diagnosis-Related Group)支付制度嵌入性政治嵌入性高质量发展公立医院

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Causal Association of Cardiac Function by Magnetic Resonance Imaging with Frailty Index:A Mendelian Randomization Study

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Phenomics 2022年第6期2卷 430-437页

作者： Hui Zhang meng Hao Zixin Hu Yi Li Xiaoxi Hu Xiaoyan Jiang Zuyun Liu xuehui Sun Xiaofeng Wang Human Phenome Institute Zhangjiang Fudan International Innovation CenterFudan UniversityShanghai 200433China Fudan University-the People’s Hospital of Rugao Joint Research Institute of Longevity and Ageing Rugao 226599JiangsuChina Key Laboratory of Arrhythmias of the Ministry of Education of China Tongji University School of MedicineShanghai 200092China Center for Clinical Big Data and Analytics Second Affiliated Hospital and Department of Big Data in Health ScienceSchool of Public HealthZhejiang University School of MedicineHangzhou 310030ZhejiangChina

Owing to the susceptibility of conventional observational studies to confounding factors and reverse causation,the causal association between cardiac function and frailty is unclear.We aimed to investigate whether cardiac function has causal effects on frailty.In this study,a two-sample Mendelian randomization(MR)study was conducted using genetic variants associated with cardiac function assessed by magnetic resonance imaging phenotypes as instrumental variables.Genetic variants asso-ciated with cardiac function by magnetic resonance imaging(including seven cardiac function phenotypes)and the frailty index(FI)were obtained from two large genome-wide association studies.MR estimates from each genetic instrument were combined using inverse variance weighted(IVW),weighted median,and MR‒Egger regression methods.We found that the increase in genetically determined stroke volume(beta-0.13,95%CI-0.16 to-0.10,p=1.39E-6),rather than other cardiac phenotypes,was associated with lower FI in MR analysis of IVW after Bonferroni correction.Sensitivity analyses examining potential bias caused by pleiotropy or reverse causality revealed similar findings(e.g.,intercept[SE],-0.008[0.011],p=0.47 by MR‒Egger intercept test).The leave-one-out analysis indicated that the association was not driven by single nucleotide polymorphisms.No evidence of heterogeneity was found among the genetic variants(e.g.,MR‒Egger:Q statistic=14.4,p=0.156).In conclusion,we provided evidence that improved cardiac function could contribute to reducing FI.These findings support the hypothesis that enhancing cardiac function could be an effective prevention strategy for frailty.

关键词： Cardiac function Frailty Mendelian randomization Genetics

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浙江省县域中医药服务能力的空间效应研究

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卫生经济研究 2024年第5期41卷 73-76页

作者：肖晓月李鹏孟雪晖浙江中医药大学人文与管理学院浙江杭州310000 杭州师范大学卫生管理学院浙江杭州310000

目的:对浙江省县域中医药服务能力进行综合评价,为优化县域中医药卫生资源配置提供参考。方法:计算浙江省71家县级中医院中医药服务能力莫兰指数,采用LISA聚类分析探究空间自相关关系,构建空间回归模型,分析影响县域中医药服务能力的影... 详细信息

目的:对浙江省县域中医药服务能力进行综合评价,为优化县域中医药卫生资源配置提供参考。方法:计算浙江省71家县级中医院中医药服务能力莫兰指数,采用LISA聚类分析探究空间自相关关系,构建空间回归模型,分析影响县域中医药服务能力的影响因素。结果:浙江省县域中医药服务能力莫兰指数为0.193(P<0.05),存在显著的空间正相关关系;人均生产总值、农村居民人均可支配收入和60岁以上人口占比等因素对县域中医药服务能力具有显著影响。结论:健全中医药管理体制、考核机制和综合评价体系,加大财政对中医药的投入与政策倾斜,推进优质医疗资源有效扩容和均衡布局,提升县域中医药服务能力。

关键词：县级中医院中医药服务能力空间自相关莫兰指数

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GPS约束下九寨沟地区断裂带现今运动速率的非连续接触模拟研究

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地震研究 2018年第3期41卷 390-397页

作者：孟庆筱党学会中国地震局第一监测中心天津300180 中国地震局地球物理研究所北京100081 中国地震局地震研究所湖北武汉430071

以中国地壳运动观测网络2009—2013年GPS观测数据为边界条件,使用非连续接触有限元技术构建九寨沟地区二维有限元模型,在不确定性分析的基础之上,计算区内主要断裂带现今运动速率。研究结果表明:在巴颜喀拉块体整体近于NE向的推挤过程中... 详细信息

以中国地壳运动观测网络2009—2013年GPS观测数据为边界条件,使用非连续接触有限元技术构建九寨沟地区二维有限元模型,在不确定性分析的基础之上,计算区内主要断裂带现今运动速率。研究结果表明:在巴颜喀拉块体整体近于NE向的推挤过程中,九寨沟地区的塔藏断裂、虎牙断裂、树正断裂均呈现为较高的左旋走滑兼具挤压的现今运动特征;岷江断裂、龙日坝断裂和龙门山断裂则呈现为右旋走滑兼有挤压的运动特性。结合区域主应变率计算结果,发现九寨沟地区仍然具有较高的应变积累背景。树正断裂作为2017年8月8日九寨沟M7.0地震的发震断层,其现今左旋滑动速率为3.0 mm/a,与东昆仑断裂带玛沁—玛曲段附近的左旋走滑速率4.1mm/a基本匹配,说明该断裂可能是东昆仑断裂带东端分支断裂之一,而东昆仑断裂与虎牙断裂之间的历史地震空区可能已被九寨沟地震事件贯通。

关键词：九寨沟地震 GPS 有限元接触单元树正断裂

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A complete telomere-to-telomere assembly provides new reference genome for rice

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Molecular Plant 2023年第9期16卷 1370-1372页

作者： xuehui Huang Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China

High-quality reference genome sequences are fundamental for genetic studies in most species,including rice.In 1998,a pioneering project was launched to obtain a highly accurate finished sequence of the japonica rice accession Nipponbare.The project used a clone-by-clone strategy,sequencing 3401 P1 artificial chromosome and bacterial artificial chromosome clones through classical Sanger sequencing technology.The sequencing reads were assembled,ordered,and anchored to chromosomes based on high-resolution genetic and physical maps.The resulting genome assembly provided coverage of approximately 95%of the Nipponbare genome,with a size of 370 Mb(International Rice Genome Sequencing Project,2005).

关键词： artificial finished assembly

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间歇式充气压力治疗仪联合无缝隙护理对肺癌根治术后患者血流动力学、深静脉血栓形成发生率的影响

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反射疗法与康复医学 2023年第13期4卷 181-183页

作者：孟洪玮宫学慧滨州医学院附属医院胸外科山东滨州251613

目的分析间歇式充气压力治疗仪配合无缝隙护理对肺癌根治术后患者血流动力学、深静脉血栓形成(DVT)发生率的影响.方法选择2022年3月—2023年3月我院收治的76例肺癌根治术患者为研究对象,通过随机数字表法将其分为观察组(n=38)和对照组(n... 详细信息

目的分析间歇式充气压力治疗仪配合无缝隙护理对肺癌根治术后患者血流动力学、深静脉血栓形成(DVT)发生率的影响.方法选择2022年3月—2023年3月我院收治的76例肺癌根治术患者为研究对象,通过随机数字表法将其分为观察组(n=38)和对照组(n=38).对照组予以无缝隙护理,观察组在此基础上加入间歇式充气压力治疗仪治疗,两组均持续干预7d.观察比较两组患者血流动力学指标、术后相关指标、DVT发生率.结果干预后,观察组股静脉血流量多于对照组,股静脉血流峰值高于对照组,股静脉平均血流速度快于对照组,组间差异有统计学意义(P0.05).观察组DVT发生率2.63%低于对照组的23.68%,差异有统计学意义(P<0.05).结论间歇式充气压力治疗仪配合无缝隙护理能有效改善肺癌根治术后患者的血流动力学指标,预防DVT形成,值得推广.

关键词：肺癌根治术无缝隙护理间歇式充气压力治疗仪血流动力学深静脉血栓

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