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Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing Wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao xuehong ran Hui Zhou Lihong Liu Binghua Wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping Su Hang Su Yu Yang Xiaobao Xie Huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated

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塞利尼索治疗骨髓增生异常综合征/骨髓增殖性肿瘤伴中性粒细胞增多症1例及文献复习

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安徽医药 2024年第11期28卷 2311-2315页

作者：孙振容赖琴城刘昊东綦畅鹏冉学红潍坊市人民医院血液内科山东潍坊261000

目的探讨塞利尼索治疗含有多个不良预后因素的骨髓增生异常综合征/骨髓增殖性肿瘤(MDS/MPN)伴中性粒细胞增多症的疗效。方法回顾性分析潍坊市人民医院2021年5月收治的1例MDS/MPN伴中性粒细胞增多症的病人的临床资料,并复习相关文献。结... 详细信息

目的探讨塞利尼索治疗含有多个不良预后因素的骨髓增生异常综合征/骨髓增殖性肿瘤(MDS/MPN)伴中性粒细胞增多症的疗效。方法回顾性分析潍坊市人民医院2021年5月收治的1例MDS/MPN伴中性粒细胞增多症的病人的临床资料,并复习相关文献。结果70岁男性,血常规示白细胞计数明显增高,主要为中性粒细胞及前体细胞,骨髓形态示粒系增生活跃伴有发育异常,二代测序示SETBP1、ASXL1、NRAS、KRAS、U2AF1基因突变,诊为MDS/MPN伴中性粒细胞增多症。应用去甲基化药物联合塞利尼索治疗有效,疾病病程由进展恶化转为稳定,生存质量提高,血液学指标改善。结论MDS/MPN伴中性粒细胞增多症是罕见的血液肿瘤,目前无标准治疗方法;应用去甲基化药物联合塞利尼索治疗安全有效,为不适合异基因造血干细胞移植的病人带来了新的治疗选择,并可能为病人带来临床获益。

关键词：塞利尼索骨髓增生异常综合征骨髓增殖性肿瘤中性粒细胞增多症基因突变治疗

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非血缘脐血移植后兼有温冷双抗体Evans综合征1例并文献复习

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临床血液学杂志 2024年第3期37卷 210-213页

作者：时月孙艳花李乾鹏徐曼刘昊东冉学红山东第二医科大学(临床医学院) 山东潍坊261000 潍坊市人民医院血液科

Evans综合征国内外报道较为少见,兼有温冷双抗体Evans综合征更为罕见。文章报道了1例重型再生障碍性贫血患者行首次非血缘脐血移植后发生植入失败,再次输入非血缘脐血植入后病毒感染下引发兼有温冷双抗体Evans综合征,给予利妥昔单抗联... 详细信息

Evans综合征国内外报道较为少见,兼有温冷双抗体Evans综合征更为罕见。文章报道了1例重型再生障碍性贫血患者行首次非血缘脐血移植后发生植入失败,再次输入非血缘脐血植入后病毒感染下引发兼有温冷双抗体Evans综合征,给予利妥昔单抗联合血浆置换治疗后患者各项指标均明显好转。笔者建议对于移植后早期并发Evans综合征的患者在给予传统方案治疗效果差时,应尽早考虑血浆置换和利妥昔单抗的联合和序贯应用。

关键词：非血缘脐血移植 Evans综合征重型再生障碍性贫血血浆置换利妥昔单抗

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A Fuzzy Trust Management Mechanism with Dynamic Behavior Monitoring for Wireless Sensor Networks

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China Communications 2024年第5期21卷 177-189页

作者： Fu Shiming Zhang Ping Shi xuehong School of Artificial Intelligence Chongqing University of EducationChongqing 400065China School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information *** wireless communication methods adopted by sensor nodes may make the network highly vulnerable to various *** encryption and authentication mechanisms cannot prevent attacks launched by internal malicious *** trust-based security mechanism is usually adopted to solve this problem in ***,the behavioral evidence used for trust estimation presents some uncertainties due to the open wireless medium and the inexpensive sensor ***,how to efficiently collect behavioral evidences are rarely *** address these issues,in this paper,we present a trust management mechanism based on fuzzy logic and a cloud ***,a type-II fuzzy logic system is used to preprocess the behavioral evidences and alleviate ***,the cloud model is introduced to estimate the trust values for sensor ***,a dynamic behavior monitoring protocol is proposed to provide a balance between energy conservation and safety *** results demonstrate that our trust management mechanism can effectively protect the network from internal malicious attacks while enhancing the energy efficiency of behavior monitoring.

关键词： behavior monitoring cloud fuzzy trust wireless sensor networks

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A Cyclic Constitutive Model Based on Crystal Plasticity for Body-Centered Cubic Cyclic Softening Metals

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Acta Mechanica Solida Sinica 2024年第1期37卷 33-42页

作者： xuehong Ren Wenjie Zhao Shaopu Yang Guilin Wen State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan UniversityChangsha 410082China School of Mechanical Engineering Tianjin Sino-German University of Applied SciencesTianjin 300350China State Key Laboratory of Mechanical Behavior in Traffic Engineering Structure and System Safety Shijiazhuang Tiedao UniversityShijiazhuang 050043China

Under the framework of the small deformation crystal plasticity theory,a crystal plastic cyclic constitutive model for body-centered cubic(BCC)cyclic softening polycrystalline metals is *** constitutive model introduces the isotropic softening rule that includes two different mechanisms:namely softening under monotonic deformation and softening under cyclic deformation on each slip ***,a modified Armstrong-Frederick nonlinear kinematic hardening rule is *** appropriate explicit scale transition rule is selected to extend the single crystal constitutive model to the polycrystalline constitutive *** the model is used to predict the uniaxial and multiaxial ratcheting deformation of BCC axle steel EA4T to verify the rationality of the proposed *** simulation results indicate that the newly established crystal plasticity model can not only describe the cyclic softening characteristics of BCC axle steel EA4T well,but also reasonably describe the evolution laws of uniaxial ratcheting and nonproportional multiaxial ratcheting ***,the established crystal plastic cyclic constitutive model can reasonably predict the ratcheting behavior of BCC single crystal as well.

关键词： Crystal plasticity Constitutive model Softening Ratcheting

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Asymmetric copolyimide membranes fabricated by nonsolvent-induced phase separation for He/CH_(4) and He/N_(2) separation

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Frontiers of Chemical Science and Engineering 2024年第4期18卷 97-106页

作者： Ying Li Lu Wang Junyan Xie Yong Dai xuehong Gu Xuerui Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China Quzhou Membrane Material Innovation Institute Quzhou 324000China

Membrane gas separation is considered an energy-saving technique to extract He from natural gas due to no phase change and room temperature ***,the membrane performance was strongly limited by the trade-off between permeance and ***,novel 4,4′-(hexafluoroisopropylidene)diphthalic anhydride(6FDA)-2,2′-bis(3-amino-4-hydroxyphenyl)hexafluoropropane(APAF)-5-amino-2-(4-aminobenzene)benzimidazole(BIA)asymmetric membranes with a thickness of 300 nm were successfully prepared by the non-solvent induced phase separation *** membrane performance was modulated by regulating dope solution compositions(e.g.,tetrahydrofuran and polymer concentration).The ideal He/CH_(4) selectivity was 124 and the optimized He permeance reached 87 GPU,beyond the current upper ***/CH_(4) selectivity was 75 and He permeance was 73 GPU for the binary mixture feed containing 0.2 mol%*** membrane showed good resistance to CO_(2) and C_(2)H_(6),which are the typical impurities in natural *** 6FDA-APAF-BIA membranes have good stability(>160 h),which can provide great potential in He extraction from natural gas.

关键词： He separation membrane natural gas copolyimide

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Mesoporous molecular sieve confined phase change materials with high absorption,enhanced thermal conductivity,and cooling energy charging/discharging capacity

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Frontiers of Materials Science 2024年第1期18卷 1-14页

作者： Qi Zhang Chongyang Liu xuehong Wu Xueling Zhang Jun Song School of Energy and Power Engineering Zhengzhou University of Light IndustryZhengzhou 450007China

The biggest challenge for organic phase change materials(PCMs)used in cold energy storage is to maintain high heat storage capacity while reducing the leakage risk of PCMs during the phase transition *** is crucial for expanding their applications in the more demanding cold storage *** this study,novel formstable low-temperature composite PCMs are prepared with mesoporous materials,namely SBA-15 and CMK-3(which are prepared using the template method),as supporting matrices and dodecane as the *** to the combined effects of capillary forces within mesoporous materials and interactions among dodecane molecules,both dodecane/SBA-15 and dodecane/CMK-3 exhibit outstanding shape stability and thermal cycling stability even after 200 heating/cooling *** comparison to those of dodecane/SBA-15,dodecane/CMK-3 exhibits superior cold storage performance and higher thermal ***,the phase transition temperature of dodecane/CMK-3 is-8.81℃ with a latent heat of 122.4 J·g^(-1).Additionally,it has a thermal conductivity of 1.21 W·m^(-1)·K^(-1),which is 9.45 times that of dodecane *** these highlight its significant potential for applications in the area of cold energy storage.

关键词： cold energy storage phase change material mesoporous molecular sieve CMK-3 SBA-15 cooling energy charging/discharging capacity

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一种极化复用的聚焦惠更斯超表面设计

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电子与信息学报 2023年第4期45卷 1330-1337页

作者：郝宏刚冉雪红郑森唐逸豪阮巍重庆邮电大学光电工程学院重庆400065 重庆邮电大学高等科学研究院重庆400065

针对无源超表面功能单一的问题,该文提出一款极化复用的透射型惠更斯超表面,可实现x极化和y极化入射波的独立聚焦特性。超表面单元由一层厚度为0.17λ的介质基板和位于两侧的不对称电偶极子元件组成,利用反向流动的表面电流构成磁偶极子... 详细信息

针对无源超表面功能单一的问题,该文提出一款极化复用的透射型惠更斯超表面,可实现x极化和y极化入射波的独立聚焦特性。超表面单元由一层厚度为0.17λ的介质基板和位于两侧的不对称电偶极子元件组成,利用反向流动的表面电流构成磁偶极子,在物理结构上消除了磁性元件的需求,使单元更加紧凑。通过单元结构尺寸的调整,实现双极化独立调控和360°相位覆盖。根据双极化聚焦的效果设定,基于全息理论对单元进行排列,设计并制备出在35 GHz下具有独立聚焦特性的极化复用惠更斯超表面,模拟和实测结果基本一致。所提出的惠更斯超表面无多层堆叠和金属过孔,具有结构简单、低剖面、易加工等特点。

关键词：惠更斯超表面极化复用聚焦全息理论

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应用于经颅磁刺激的双8字线圈设计与优化

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电子器件 2022年第1期45卷 59-65页

作者：陈海雷冉雪红重庆邮电大学光电工程学院重庆400065

为了改善经颅磁刺激线圈的聚焦性,提高线圈刺激深度,在传统8字形线圈结构的基础上探讨了应用于经颅磁刺激的双8字线圈,优化了线圈内径和匝数比,与头部模型联合仿真分析了刺激效果,并进行了实验研究。研究结果表明,当上、下层线圈内半径... 详细信息

为了改善经颅磁刺激线圈的聚焦性,提高线圈刺激深度,在传统8字形线圈结构的基础上探讨了应用于经颅磁刺激的双8字线圈,优化了线圈内径和匝数比,与头部模型联合仿真分析了刺激效果,并进行了实验研究。研究结果表明,当上、下层线圈内半径比为5/7,匝数比为0.9时,与传统线圈相比,双八字线圈的半功率值提高了20.9%,目标平面内场极值提高了57.8%,双八字线圈在聚焦性及刺激强度方面优势明显。

关键词：经颅磁刺激 8字形线圈双8字线圈聚焦性刺激深度

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γδT细胞淋巴瘤一例并文献复习

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白血病．淋巴瘤 2017年第9期26卷 549-552页

作者：张晓婷邱志远冉学红山东省潍坊市人民医院血液内科 261000

目的探讨γδT细胞淋巴瘤的临床特点和诊疗方法，提高对γδT细胞淋巴瘤的认知和诊疗水平。方法回顾性分析1例γδT细胞淋巴瘤患者的临床特点及治疗情况并复习相关文献。结果患者经hyperCVAD-A（环磷酰胺＋吡柔比星＋长春新碱＋地塞米... 详细信息

目的探讨γδT细胞淋巴瘤的临床特点和诊疗方法，提高对γδT细胞淋巴瘤的认知和诊疗水平。方法回顾性分析1例γδT细胞淋巴瘤患者的临床特点及治疗情况并复习相关文献。结果患者经hyperCVAD-A（环磷酰胺＋吡柔比星＋长春新碱＋地塞米松）、hyperCVAD-B（甲氨蝶呤＋阿糖胞苷）方案化疗后，病情一过性好转，后病情进行性加重，出现骨髓转移，最终临床死亡，生存时间4个月。结论非肝脾来源的γδT细胞淋巴瘤是一种罕见的高度侵袭性肿瘤，病情进展快，预后差，主要通过组织病理学、免疫组织化学及克隆性T细胞抗原受体γ和（或）δ基因重排诊断，早期诊断，尽早行造血干细胞移植有望改善患者预后。

关键词：淋巴瘤,T细胞,外周诊断,鉴别药物疗法,联合

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