检索结果-南通市图书馆

含整体煤气化燃料电池-碳捕集电厂的风火储系统分布鲁棒调度方法

在线全文

学校读者我要写书评

暂无评论

中国电机工程学报 2024年第9期44卷 3573-3587,I0020页

作者：王骞张学广朱玲徐殿国哈尔滨工业大学电气工程及自动化学院黑龙江省哈尔滨市150001 南瑞集团有限公司(国网电力科学研究院有限公司) 江苏省南京市211106

整体煤气化燃料电池(integrated gasification fuel cell,IGFC)是与碳捕集技术高度适配的清洁、高效、稳定的绿色煤电技术,有望克服传统碳捕集技术在低浓度CO_(2)环境下产生的高成本、高能耗问题。该文构建含IGFC碳捕集电厂的风火储发... 详细信息

整体煤气化燃料电池(integrated gasification fuel cell,IGFC)是与碳捕集技术高度适配的清洁、高效、稳定的绿色煤电技术,有望克服传统碳捕集技术在低浓度CO_(2)环境下产生的高成本、高能耗问题。该文构建含IGFC碳捕集电厂的风火储发电系统。研究IGFC碳捕集电厂的运行机理,对IGFC内部各环节建立数学模型,提出工况匹配时燃烧利用率和阴极空气利用率需要满足的运行条件,并针对该型碳捕集电厂的电碳特性进行分析。为计及风电出力的不确定性,构建风火储系统的两阶段分布鲁棒经济调度模型,引入k阶适应性理论,提出基于正交支撑子集策略的求解方法来获得鲁棒对等式。最后,在改进IEEE-30节点系统中进行算例分析,结果表明,该型碳捕集电厂可利用阳极碳富集的优势,实现系统低碳经济调度的目标,并验证所提优化方法能为可行解提供可解释性。

关键词：整体煤气化燃料电池(IGFC) 碳捕集电厂风火储系统经济调度分布鲁棒优化有限适应性理论

维普期刊数据库博看期刊

N~6-甲基腺嘌呤修饰及其调控因子在男性生殖中的作用

在线全文

学校读者我要写书评

暂无评论

四川大学学报（医学版） 2024年第3期55卷 527-534页

作者：蒋婷张学广许文明四川大学华西第二医院生殖遗传与表观遗传调控研究室成都610041 出生缺陷与相关妇儿疾病教育部重点实验室(四川大学) 成都610041

在哺乳动物中,精子发生是一个高度复杂且协调的生殖细胞分化过程,这一过程受到转录、转录后和翻译水平的精确调控,以确保不同发育阶段的生精细胞正确表达特定基因并维持正常的生精过程。N~6-甲基腺嘌呤(N~6-methyladenosine,m~6A)是真... 详细信息

在哺乳动物中,精子发生是一个高度复杂且协调的生殖细胞分化过程,这一过程受到转录、转录后和翻译水平的精确调控,以确保不同发育阶段的生精细胞正确表达特定基因并维持正常的生精过程。N~6-甲基腺嘌呤(N~6-methyladenosine,m~6A)是真核生物m RNA上最丰富的修饰,在诸如m RNA剪接、转运和翻译等多个生物过程发挥关键作用。RNA甲基化修饰是一个动态可逆的过程,主要通过编码器(writers)催化、消码器(erasers)去除和读码器(readers)识别来调控修饰水平。本文首先概述了精子发生的主要阶段,然后重点介绍m~6A修饰及相关蛋白在雄性生殖细胞不同发育阶段的关键功能,最后简要总结了目前检测m~6A的主要方法,以期深入了解RNA修饰在调控精子发生以及在男性不育中发挥的作用和机制。

关键词：精子发生 N~6-甲基腺嘌呤 RNA修饰男性不育表观遗传学综述

静止坐标系下无电网电压传感器虚拟同步机控制策略

在线全文

学校读者我要写书评

暂无评论

太阳能学报 2024年第8期45卷 174-181页

作者：张斌韦甘王鑫达张相军杨华张学广哈尔滨工业大学电气工程及自动化学院哈尔滨150000 国网江苏省电力有限公司电力科学研究院南京211103

针对采用虚拟磁链算法的无电网电压传感器存在的直流偏移等问题,提出基于一阶低通滤波器和高通滤波器串联结构的改进磁链观测器,利用改进的磁链观测器得出虚拟磁链,提高了观测的精度。在得到虚拟磁链的基础上,针对不同电网频率运行条件... 详细信息

针对采用虚拟磁链算法的无电网电压传感器存在的直流偏移等问题,提出基于一阶低通滤波器和高通滤波器串联结构的改进磁链观测器,利用改进的磁链观测器得出虚拟磁链,提高了观测的精度。在得到虚拟磁链的基础上,针对不同电网频率运行条件,利用锁相环思想提出电网角频率的计算结构,并由虚拟出的磁链与电压的关系来重构电网电压。此外,将所提无电网电压传感器策略应用于网侧变流器系统中,在两相静止坐标系下设计虚拟同步控制结构,相比于旋转坐标系,可省去控制内环的解耦环节,同时还能简化坐标变换环节,避免了因坐标变换中角度不准而引入的不稳定因素。最后,通过仿真与实验验证所提控制策略与磁链观测器的有效性与可靠性。

关键词：变流器磁链无传感器控制虚拟同步控制静止坐标系

维普期刊数据库博看期刊

高质量发展是真正解决人类实践三重矛盾的发展

在线全文

学校读者我要写书评

暂无评论

唐都学刊 2024年第3期40卷 5-9,2页

作者：张学广西北大学哲学学院西安710127

党的二十大报告将“高质量发展”提到中国式现代化本质要求的高度,将它当作全面建设社会主义现代化国家的首要任务。由此可见,高质量发展并不仅仅是一个经济问题,而是涉及中国式现代化方方面面的根本问题。从价值哲学角度看,高质量发展... 详细信息

党的二十大报告将“高质量发展”提到中国式现代化本质要求的高度,将它当作全面建设社会主义现代化国家的首要任务。由此可见,高质量发展并不仅仅是一个经济问题,而是涉及中国式现代化方方面面的根本问题。从价值哲学角度看,高质量发展之所以对中国式现代化如此重要,是因为它总结了千百年来尤其近百年来人类发展的经验教训,旨在从根本上解决人类实践的三重矛盾,即人与自然之间、人与人之间、人与自身之间的矛盾,实现真正意义上的全面和谐。

关键词：高质量发展人类实践三重矛盾

IL-17 initiates tertiary lymphoid organ formation

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2012年第1期9卷 9-10页

作者： xueguang zhang BinfengLu Biotechnology Institute Soochow UniversitySuzhouChina Department of Immunology University of Pittsburgh Cancer InstitutePittesburegPAUSA

Chronic inflammatory infiltrates that take on the form of organized lymphoid organs are called tertiary lymphoid organs(TLOs).The inflammatory cytokine interleukin-17 is now found to be the critical participant driving the development of a type of TLO called inducible bronchus-associated lymphoid tissue(iBALT)in an animal model of neonatal pulmonary inflammation.

关键词： lymphoid organs neonatal

基于人工智能算法的风电机组状态监测和故障诊断技术研究综述

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

东北电力大学学报 2024年第1期44卷 42-51页

作者：王中行周元贵张学广哈尔滨工业大学电气工程及自动化学院黑龙江哈尔滨150000 中国大唐集团科学技术研究总院有限公司西北电力试验研究院陕西西安710000

随着我国风电产业高速发展,风电机组服役时间延长,故障率和运维成本随之增加。利用人工智能算法对风电大数据进行数据挖掘,实现风电机组的状态监测与故障诊断,对风电产业提质增效具有重要的现实意义,近年来逐渐成为研究热点。文中介绍... 详细信息

随着我国风电产业高速发展,风电机组服役时间延长,故障率和运维成本随之增加。利用人工智能算法对风电大数据进行数据挖掘,实现风电机组的状态监测与故障诊断,对风电产业提质增效具有重要的现实意义,近年来逐渐成为研究热点。文中介绍了风电机组数据采集与监控(Supervisory Control and Data Acquisition, SCADA)系统和振动信号数据的特性,阐述了风电机组状态监测和故障诊断智能算法的框架,归纳总结了相关研究成果,并对风电机组状态监测和故障诊断技术所面临的挑战和发展趋势进行了展望。

关键词：风电机组数据驱动深度学习状态监测故障诊断

Upregulation of stromal cell-derived factor-1 alpha/CXCR4 axis-induced migration of human neural progenitors by tumor necrosis factor-alpha and interleukin-8

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2009年第11期4卷 832-837页

作者： Jing Qu Hongtao zhang Guozhen Hui xueguang zhang Huanxiang zhang Department of Cell Biology Medical College of Soochow University Suzhou 215123 Jiangsu Province China Jiangsu Province Key Laboratory of Stem Cell Research Suzhou 215016 Jiangsu Province China Department of Orthopaedics First Affiliated Hospital of Soochow University Suzhou 215007 Jiangsu Province China Department of Neurosurgery First Affiliated Hospital of Soochow University Suzhou 215007 Jiangsu Province China

BACKGROUND： Studies of several animal models of central nervous system diseases have shown that neural progenitor cells （NPCs） can migrate to injured tissues. Stromal cell-derived factor 1 alpha （SDF-la）, and its primary physiological receptor CXCR4, have been shown to contribute to this process. OBJECTIVE： To investigate migration efficacy of human NPCs toward a SDF-1α gradient, and the regulatory roles of tumor necrosis factor-α （TNF-α） and interleukin-8 （IL-8） in SDF-1α/CXCR4 axis-induced migration of NPCs. DESIGN, TIME AND SETTING： An in vitro, randomized, controlled, cellular and molecular biology study was performed at the Laboratory of Department of Cell Biology, Medical College of Soochow University between October 2005 and November 2007. MATERIALS： SDF-1α and mouse anti-human CXCR4 fusion antibody were purchased from R＆D Systems, USA. TNF-αwas purchased from Biomyx Technology, USA and IL-8 was kindly provided by the Biotechnology Research Institute of Soochow University. METHODS： NPCs isolated from forebrain tissue of 9 to 10-week-old human fetuses were cultured in vitro. The cells were incubated with 0, 20, and 40 ng/mL TNF-α, or 0, 20, and 40 ng/mL IL-8, for 48 hours prior to migration assay. For antibody-blocking experiments, cells were further pretreated with 0, 20, and 40 μg/mL mouse anti-human CXCR4 fusion antibody for 2 hours. Subsequently, the transwell assay and CXCR4 blockade experiments were performed to evaluate migration of human NPCs toward a SDF-1α gradient. Serum-free culture medium without SDF-1α served as the negative control. MAIN OUTCOME MEASURES： The transwell assay was performed to evaluate migration of human NPCs toward a SDF-1α gradient, which was blocked by fusion antibody against CXCR4. In addition, CXCR4 expression in human NPCs stimulated by TNF-α and IL-8 was measured by flow cytometry. RESULTS： Results from the transwell assay demonstrated that SDF-1α was a strong chemoattractant for human NPCs （P 〈 0.01）, and 20 ng/mL produced

关键词： human neural progenitor cells migration stromal cell-derived factor 1 alpha CXCR4 tumor necrosis factor-α interleukin-8

B7-H3:Another Molecule Marker for Mo-DCs?

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2005年第4期2卷 307-311页

作者： Guangbo zhang Qiuming Dong Ying Xu Gehua Yu xueguang zhang Clinical Immunology Laboratory of Jiangsu Province Suzhou University No.1 Affiliated Hospital 96 Shizi Street Suzhou 215006 China Biotechnology Institute Suzhou University 48 Renmin Road Suzhou 215007 China

Using a newly generated monoclonal antibody （2E6） against human B7-H3, we explored the expression of the molecule on dendritic cells derived from monocytes （Mo-DCs）. Its expression was examined by means of immunostaining and flow cytometric （FCM） analysis. The results showed that B7-H3 was expressed in the course of Mo-DC maturation induced with interleukin 4 （IL-4） and granulocyte/macrophage colony-stimulating factor （GM-CSF）. The expression could be detected at all the stages of Mo-DC differentiation, and remained at a quite stable level. Interestingly, B7-H3 was not expressed by T cells and B cells, even these cells were activated respectively by PHA or PWM. A weak expression could be detected on resting monocytes. These data showed that constitutive expression of B7-H3 at a high level was found on imDCs and mDCs derived from monocytes. Due to no expression on T cells and B cells, we speculate that B7-H3 might be another valuable molecule marker for Mo-DCs.

关键词： B7-H3 costimulatory molecule Mo-DC monoclonal antibody

Distinct Effect of CD40 and TNF-Signaling on the Chemokine/Chemokine Receptor Expression and Function of the Human Monocyte-Derived Dendritic Cells

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2008年第2期5卷 121-131页

作者： Yu Xia Jun Dai Peirong Lu Yong Huang Yipei Zhu xueguang zhang Medical Biotechnology Institute Soochow University Suzhou 215007China Department of Immunology Soochow University Suzhou 215007 China Clinic Immunology Laboratory of Jiangsu Province The First Affiliated Hospital of Soochow University Suzhou 215006 China These authors contributed equally to this work

A key and limiting step in the process of human monocyte-derived dendritic cells （mDCs） for clinical use is their in vitro maturation and in vivo migration. We previously observed that CD40 signal facilitated human mDC growth and maturation. To further explore this process, mDCs generated with GM-CSF and IL-4 were co-cultured with apoptotic tumor cells for 24 hours, followed by incubating with anti-CD40 monoclonal antibody or TNF-a for 48 hours to generate mature DCs. The chemokine/chemokine receptor expression and functions of mature DCs upon various stimuli were determined. The expression of costimulatory molecules on apoptotic tumor cell-loaded mature DCs co-cultured with either anti-CD40 antibody （anti-CD40-DCs） or TNF-a （TNF-DCs） were up-regulated compared to immature DCs, consistent with the abilities of these cytokine to drive DC maturation in vitro. The mRNA levels of chemokines such as stromal cell-derived factor-1a （SDF-1a）, EBV-induced molecule 1 ligand chemokine （ELC）, and IFN inducible protein-10 （IP-10） in anti-CD40 activated DCs were increased and the dendritic cell-specific chemokine 1 （DC-CK1） was moderately up-regulated as compared with other mature DCs. The corresponding chemokine receptors CXCR4 and CCR7 of anti-CD40-DCs were significantly expressed. The CXCR3 expression on activated T cells stimulated by anti-CD40-DCs was also increased. Moreover, the anti-CD40-DCs had a stronger ability to stimulate T cell proliferation than any other DCs. The NF-xB activity was much higher in anti-CD40-DCs than that of TNF-DCs. These results offer further evidence of the importance of the CD40 signal in developing efficient human DC vaccines for cancer immune therapy. Cellular ＆ Molecular Immunology.

关键词： dendritic cell chemokine chemokine receptor CD40 CD40 ligand