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Comparative Proteomics Based on 18O labeling to Evaluate the Hepatotoxicity of Tris（2,3-dibromopropyl） Isocyanuratein Rats

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Journal of Beijing Institute of Technology 2019年第3期28卷 659-666页

作者： Yu li xuefei lü Yuanzhan Yang Yulin Deng School of life Science Beijing Institute of Technology

Detecting protein expression levels in organisms exposed to environmental pollutants can help us understand the action mechanism of toxicity. In the present study, adult female Sprague-Dawley (SD) rats received a consecutive intraperitoneal injection of tris(2,3-dibromopropyl) isocyanurate (TBC) for seven days, and the ^16O/^18O labeling comparative proteomic approach was used to study the change of liver proteome in these rats. Thirty six differential proteins were identified between the control group and the high-dose-exposed group (8 mg/kg), of which, twenty eight proteins were down-regulated and eight proteins were up-regulated. Bioinformatics analysis revealed that most of the differential proteins were related with the metabolic and cellular processes. In addition, the contents of malondialdehyde (MDA), catalase (CAT), and glutathione (GSH) in liver were measured to evaluate the oxidative stress status induced by TBC exposure. Together, these findings showed that TBC might be toxic to liver by disrupting metabolic process and apoptosis. The results might provide a better insight into the mechanism of toxicity induced by TBC.

关键词： comparative proteomic hepatotoxicity ^18O labeling oxidative stress tris(2,3-dibromopropyl) isocyanurate (TBC)

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基于多角度弯曲高压输流管道流固耦合分析

吉林化工学院学报 2024年第1期41卷 37-42页

作者：张友军甘树坤吕雪飞吉林化工学院机电工程学院吉林吉林132022

弯曲高压输流管道在工程实践中应用广泛,为分析其输流特性,通过构建动力学模型,应用SolidWorks软件建立定圆角多弯曲角度管道有限元模型,ANSYS的Workbench平台搭建Fluent模块和瞬态结构模块进行流固耦合,创建数据传输进行模态分析,进而... 详细信息

弯曲高压输流管道在工程实践中应用广泛,为分析其输流特性,通过构建动力学模型,应用SolidWorks软件建立定圆角多弯曲角度管道有限元模型,ANSYS的Workbench平台搭建Fluent模块和瞬态结构模块进行流固耦合,创建数据传输进行模态分析,进而研究高压流体流入管道后在弯道处对管壁的冲击力大小、应力、应变的数值变化。结果表明,不同角度输流管道对管壁的影响不同,从而为工程实践合理规避管道压力的危害提供理论参考。

关键词：弯曲高压输流管道流固耦合应力应变

Effects of cadmium,17 β-estradiol and their interaction in the male Chinese loach (Misgurnus anguillicaudatus)

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Chinese Science Bulletin 2012年第8期57卷 858-863页

作者： lÜ xuefei lIU FeiYuan ZHOU XiaoPing ZHOU QunFang DENG Yulin School of life Science Beijing Institute of TechnologyBeijing 100081China State Key laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy ofSciencesBeijing 100085China Beijing Centre for Physical and Chemical Analysis Beijing 100094China

To assess the interaction effect between cadmium (Cd) and 17-estradiol (E2),male Chinese loaches (Misgurnus anguillicaudatus) were exposed to E2 (1 g/l) and Cd (50 or 500 g/l) alone and in combination using a semi-static waterborne exposure *** effects of E2 on the accumulation and distribution of Cd,as well as the effects of Cd on vitellogenin (Vtg) synthesis induced by E2,were *** mainly accumulated in the kidneys,liver,intestines,and gills,with little amounts in muscles,bones,and ***-exposure with E2 did not change the main targets for Cd.E2 could induce Vtg synthesis in male Chinese loaches,and co-exposure with 50 or 500 g/l Cd could inhibit the Vtg induced by 1 g/l *** with the results reported in the literature,it can be concluded that factors such as fish species,Cd dosage,and manner of exposure might make contributions to the interaction between Cd and *** results also suggested that male Chinese loaches are susceptible to Cd,and can be recommended as a potential sentinel species to study the ecotoxicology of heavy metals.

关键词：镉(Cd) 泥鳅中国雌二醇卵黄蛋白原生态毒理学互动效应曝光系统

Aptamer-Based Fluorescent Assay for Sensitive Detection of Cardiac Troponin Ⅰ

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Journal of Beijing Institute of Technology 2020年第1期29卷 45-51页

作者： Yu li Yuanzhan Yang xuefei lu Yulin Deng School of life Science Beijing Institute of TechnologyBeijing 100081China

Acute myocardial infarction(AMI)is a major health problem leading to high rates of mortality and *** cardiac troponin I(cTnI)has shown high sensitivity and specificity towards AMI detection,and has been regarded as"gold standard".An ultrasensitive method to detectcTnI with low concentration in human fluid is *** this paper,we developed an aptamer-based assay coupled with rolling circle amplification(RCA)and molecular beacon probe for sensitive detection *** this strategy,aptamer acts as a bridge to communicate between oligonucleotides *** reaction produces a single-stranded tandem repeated copy of the circular template,which are recognized by fluorescence molecular beacon *** this strategy,highly sensitive and specific detection of cTnI was realized with the lowest detectable concentration of 7.24 pg/m *** developed aptamer-RCA assay can be a promising tool in clinical samples *** assay can also analyze other disease-related biomarkers by replacing the aptamer.

关键词： aptamer cardiac troponin I(cTnI) molecular beacon rolling circle amplification sensitive detection

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多因素影响下的S型管道冲刷腐蚀速率分析

吉林化工学院学报 2024年第1期41卷 43-50页

作者：马忠贞张友军吕雪飞甘树坤吉林化工学院机电工程学院吉林吉林132022

S型管道应用于输运过程中的复杂地形,在上下游弯头处,会形成不同程度的冲刷腐蚀,造成安全隐患。为分析其腐蚀影响因素,建立S型管道腐蚀模型,采用ANSYS的Workbench平台搭建Fluent模块对不同影响因素下的腐蚀模型进行研究,创建数据传输,... 详细信息

S型管道应用于输运过程中的复杂地形,在上下游弯头处,会形成不同程度的冲刷腐蚀,造成安全隐患。为分析其腐蚀影响因素,建立S型管道腐蚀模型,采用ANSYS的Workbench平台搭建Fluent模块对不同影响因素下的腐蚀模型进行研究,创建数据传输,进而研究流体在流入弯管后各因素与冲蚀速率的关系。结果表明,S型管道冲刷腐蚀受到多因素的影响,尤其是下游弯头处的冲刷腐蚀更为明显。适当减小颗粒物直径、颗粒物质量流量,增大管径和弯径比可以减缓腐蚀及减小腐蚀区域。研究可为管道安全稳定运行提供理论依据。

关键词： DPM S型管冲刷腐蚀腐蚀速率数值模拟

Space life Science in China

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空间科学学报 2022年第4期42卷 795-802页

作者： MA Hong ZHANG Chen lI Yujuan lÜxuefei lI Xiaoqiong ZHANG Ying YANG Chunhua lIU Huayan FAN Yunlong DENG Yulin School of life Science Beijing Institute of TechnologyBeijing 100081 School of Medical Technology Beijing Institute of TechnologyBeijing 100081

With the further advancement of China’s major manned spaceflight project,the national space laboratory was successfully *** has also made considerable progress and breakthroughs in the field of space life *** paper reviews the related biological effects under space flight conditions,mainly including epigenetic effects,skeleton remodeling and peripheral body fluid circulation effects,as well as the research and application of space life science related biotechnology in the field of microbial culture and biological regeneration life support system.

关键词： Space life sciences Space biology technology Microgravity Ionizing radiation

Prescribed-time leader-following consensus of linear multi-agent systems by bounded linear time-varying protocols

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Science China(Information Sciences) 2024年第1期67卷 140-153页

作者： Kai ZHANG Bin ZHOU xuefei YANG Guangren DUAN Center for Control Theory and Guidance Technology Harbin Institute of Technology

This paper considers the prescribed-time leader-following consensus problem of input-constrained linear multi-agent systems under generally directed communication topology in two cases:the laplacian matrix related to the entire communication topology between agents is either known or *** particular,the consensus problem for the former case is solved by a novel bounded linear time-varying(lTV) protocol,where the feedback gain is formulated by the parametric lyapunov equation and the knowledge of the laplacian ***,by utilizing a distributed observer,a fully bounded lTV protocol is proposed for the latter *** should be noted that,compared with the existing results,the system under consideration is more general,the designed protocols are linear,and the consensus problem is accomplished even in a fully distributed ***,the effectiveness of the proposed approach is verified by a numerical example.

关键词： leader-following consensus time-vary feedback prescribed-time control fully distributed consensus

Guanine-derived F,N co-doped carbon-shell encapsulated iron carbide nanoparticles for enhanced CO_(2)electroreduction activity

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Nano Research 2024年第6期17卷 4744-4752页

作者： Shuo Chen lishun Pei Ying Peng xuefei Zhang Zailai Xie Key laboratory of Advanced Carbon-Based Functional Materials(Fujian Province University) Fuzhou UniversityFuzhou 350016China

The development of highly selective,cost-effective,and energy-efficient electrocatalysts is critical for carbon dioxide reduction reaction(CO_(2)RR)to produce high-value ***,we propose a facile strategy to obtain F,N co-doped carbon-coated iron carbide(Fe3C)nanoparticles by using biomolecule guanine and hexadecafluorophthalocyanine iron as raw ***,this method involves only one-step pyrolysis and does not require any guiding agent or sacrificial *** from the advantageous surface microenvironment adjustments achieved through graphitic N(GN)and F co-doping,Fe3C@NF-G-1000 demonstrates exceptional efficacy in the electroreduction of CO_(2)to carbon monoxide(CO)with an impressive Faradic efficiency(FEco)up to 98%at the potential of−0.55 V(*** hydrogen electrode(RHE)).Furthermore,it delivers a remarkable current density of up to−43 mA·cm^(−2)and exhibits virtually no current attenuation over a span of 20 h within the flow *** from density functional theory(DFT)calculations reveal that the composite structure of GN and F co-doped graphitic layer and Fe3C exhibits different electron density distributions from that of iron carbide *** is attributed to the synergistic effect of the composite structure leading to the enrichment of electrons in the graphite layer on the surface,which contributes to the stability of the key reaction intermediate*COOH,thus,resulting in an enhanced catalytic activity and ***,this work introduces a new and promising approach to the design of green and low-cost carbon-coated metal materials for CO_(2)reduction reactions.

关键词： guanine F,N co-doped carbon dioxide reduction reaction(CO_(2)RR) Fe-based catalyst

A review of CFD simulation in pressure driven membrane with fouling model and anti-fouling strategy

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Frontiers of Environmental Science & Engineering 2024年第8期18卷 1-29页

作者： Shiyong Miao Jiaying Ma xuefei Zhou Yalei Zhang Huaqiang Chu State Key laboratory of Pollution Control and Resource Reuse Tongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China

Pressure-driven membrane filtration systems are widely utilized in wastewater treatment,desalination,and water reclamation and have received extensive attention from *** fluid dynamics(CFD)offers a convenient approach for conducting mechanistic studies of flow and mass transfer characteristics in pressure-driven *** a signature phenomenon in membrane systems,the concentration polarization that accompanies the permeation process is a key factor in membrane performance degradation and membrane fouling *** fouling models(scaling,biofouling and colloidal particle fouling)based on CFD theory have been constructed,and considerable research has been *** representative antifouling strategies with special simulation methods,including patterned membranes,vibration membranes,rotation membranes,and pulsatile flows,have also been *** studies should focus on refining fouling models while considering local hydrodynamic characteristics;experimental observation tools focusing on the internal structure of inhomogeneous fouling layers;techno-economic model of antifouling strategies such as vibrational,rotational and pulsatile flows;and unfavorable hydraulic phenomena induced by rapidly changing flows in simulations.

关键词： Computational fluid dynamics Membrane Fouling model Concentration polarization