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Efficacy of Combined Administration of 0.2% Brimonidine and 0.5% Betaxolol in Treatment of Primary Open Angle Glaucoma and Ocular Hypertension

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Eye Science 2013年第4期28卷 190-194页

作者： Wei Chi An Li Shuqin Wang xuefei zhu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University Department of Ophthalmology the People's Hospital of Hechi The Affiliated Optometry Eye Hospital of Wenzhou Medical Hospital The First Affiliated Hospital of Soochow University

Purpose:To observe the efficacy of combined use of brimonidine and betaxolol in treatment of primary open angle glaucoma(POAG)and ocular ***:A total of 54 patients(90 eyes)with POAG and ocular hypertension were randomly divided into three groups(receiving betaxolol,.brimonidine and combined administration of betaxolol and brimonidine respectively).The administration was given twice daily in all groups(0.5%betaxolol,0.2%brimonidine and 0.5%betaxolol combined with 0.2%brimonidine).The changes in intraocular pressure(IOP)were observed before,and 2,4,6,and 8 weeks after *** addition,the adverse reactions were also recorded ***:.The mean IOPs at all the time points after treatment were significantly reduced compared with pre-treatment levels(P<0.05).Patients receiving brimonidine had a greater reduction in IOP compared with their counterparts in the betaxolol group but the difference was not statistically *** IOP decline was significantly higher in the combined therapy group than in the other two groups(P<0.01).Few cases presented with slight discomfort,.such as sensation of foreign bodies,.ocular irritation,.dizziness,.headache,.fatigue,.and dryness of mouth and *** severe adverse reactions were noted following ***:Combined use of brimonidine and betaxolol is an efficacious treatment of reducing IOP without severe side effects.

关键词：疗效观察青光眼原发性眼压联合用药溴联合治疗行政管理

A Study on the Effects of Different Interaction Combinations and Language Levels on Continuous Writing in Online Environments

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Journal of Contemporary Educational Research 2024年第4期8卷 255-263页

作者： xuefei zhu Leling No.2 Middle School Dezhou 253600Shandong ProvinceChina

This study was conducted with non-English sophomore students,aiming to explore the effects of different interaction combinations and language levels on continuous writing in an online environment,and compare the differences in lexical alignments and composition quality of learners with different interaction combinations and language levels in the same continuous writing task through *** results show that the mean values of the word-phrase alignment of the paired group were higher than those of the individual group in different interaction combinations,and the two groups showed significant differences;in terms of composition quality,the individual group was better than the paired group,but there was no significant difference between the two groups in terms of task ***,the word-phrase alignment and composition scores of the different language-level groups were higher than those of the same language-level groups,and there was a significant difference between the two groups in terms of word-phrase alignments,but not in terms of composition *** results of this study can be useful and informative for second language teachers in future continuous teaching in online environments.

关键词： Online environment Continuous writing Interaction combinations Language levels

Particulate aggregation through a modulated annular one-dimensional acoustic field at resonant frequencies

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Particuology 2021年第4期19卷 82-94页

作者： Zhenghui Qiao Xiaojun Pan Shaohua Liang Xiaolong Bi Juan Wang Wei Xie Kang Wang Yanwen Wang Jun Fang xuefei zhu Shaoxin Sun Shaohui Li College of Energy and Power Engineering Nanjing Institute of TechnologyNanjing 211167China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

The visualization and analysis of a novel acoustic-particulate system is the objective of this study. The system is composed of rice-husk fired smoke particulates (36.7 nm-840 μm) and one annular resonant circular-tube waveguide contrarily coupled with two sound sources. The collective interaction behavior process of smoke particulates in an inhomogeneous acoustic field is displayed during an experiment and a simulation. The result shows that the aggregation and fragmentation of particles under a change in resonant frequencies and sound pressure amplitude is extremely complex. This complex process consists of dynamically tuning the particle characteristics to attain stripes shaped like thin-films/umbrellas and clusters with volume-change/fragmentation. The balanced modulation of the acoustic radiation force and secondary radiation force to alter the particle characteristics (size and stack density) is verified to be the control mechanism of the particle system. The intermediate variable of the process control is the acoustic contrast factor (Φ) related to the physical characteristics of the growing particulates. The value plus-minus alternation of Φ results in different particulate processes. This study can enhance the application of aerodynamic acoustic-particulate-fluid systems for environment protection, energy fuel conversion, and industrial production.

关键词： Acoustic aggregation Porous particulates Secondary radiation force Acoustic radiation force Stripe pattern Inhomogeneous field

Miro2 supplies a platform for Parkin translocation to damaged mitochondria

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Science Bulletin 2019年第11期64卷 730-747页

作者： Jiu-Qiang Wang Shu zhu Yihan Wang Fengli Wang Chaoqiang An Dongfang Jiang Lijie Gao Yingfeng Tu xuefei zhu Yun Wang Hongmei Liu Juanjuan Gong Zhongshuai Sun Xi Wang Leimei Liu Keyan Yang Caixia Guo Tie-Shan Tang State Key Laboratory of Membrane Biology Institute of ZoologyUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Key Laboratory of Genomics and Precision Medicine Beijing Institute of GenomicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China Department of Foresight and Evaluation Research Chinese Academy of Science and Technology for DevelopmentBeijing 100038China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

PINK1/Parkin-mediated mitophagy is an important process in selective removal of damaged mitochondria, in which translocation of Parkin to damaged mitochondria is recognized as an initiation step. At present, how the damaged mitochondria are selectively recognized and targeted by Parkin is not fully understood. Here we show that Miro2, an outer mitochondrial membrane protein, undergoes demultimerization from a tetramer to a monomer and alteration in mitochondrial localization upon CCCP treatment, suggesting a CCCP-induced realignment of Miro2. The realignment of Miro2 is tightly regulated by PINK1-mediated phosphorylation at Ser325/Ser430 and by Ca^2+binding to EF2 domain, which are both essential for the subsequent Parkin translocation. Interestingly, ablation of Miro2 in mouse causes delayed reticulocyte maturation, lactic acidosis and cardiac disorders. Furthermore, several Miro2 mutations found in the congenital lactic acidosis patients also disable its realignment and Parkin translocation. These findings reveal an important role of Miro2 to mediate Parkin translocation by sensing both depolarization and Ca^2+release from damaged mitochondria to ensure the accuracy of mitophagy.

关键词： Miro2 Parkin Mitochondria Ca^2+ Mitophagy PINK1

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水基钻井液硫酸铝污染处理工艺

钻井液与完井液 2020年第2期37卷 192-195页

作者：祝学飞席云飞游伟川庆钻探工程有限公司新疆分公司新疆库尔勒841000

KS19井三开φ311.2 mm井眼在钻至6243~6387 m井段时,使用的高密度KCl-聚磺水基钻井液被含有硫酸铝的清洁化生产用工业废水污染,流变性每日不断呈现上涨趋势至发生突变,一是φ6与φ3读值、初切值、动切力均上涨较高,而其他参数均比较正常... 详细信息

KS19井三开φ311.2 mm井眼在钻至6243~6387 m井段时,使用的高密度KCl-聚磺水基钻井液被含有硫酸铝的清洁化生产用工业废水污染,流变性每日不断呈现上涨趋势至发生突变,一是φ6与φ3读值、初切值、动切力均上涨较高,而其他参数均比较正常;二是上水罐、过渡槽钻井液表面粗糙,大量针眼型气泡包裹其中,流态缓慢;三是循环系统加重泵上水困难、泥浆泵抖动严重,泵冲泵压变化较大,钻进期间被迫使用灌注泵辅助泥浆泵上水。分别在套管鞋、井底分2次进行循环调整处理,采用稀释置换、气泡界面张力改变、提高碱度进行中和、流变性改变、提高油含量等至恢复正常钻进,上水罐、过渡槽钻井液仅包裹有少量针眼型气泡,泥浆泵、加重泵上水正常。

关键词：硫酸铝污染突变处理

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中职院校体育教学对学生职业能力的影响分析

体育科技文献通报 2020年第3期28卷 61-62页

作者：朱学飞南京体育学院江苏南京210014

随着国家整体水平的不断上升与发展,中职院校毕业的学生工作竞争压力也变得越来越大,因此对中职院校体育教学对学生职业能力的影响分析。从体育教学能够培养学生劳动所需的体能进行分析,进一步探讨体育教学能够培养学生职业心理的素质,... 详细信息

随着国家整体水平的不断上升与发展,中职院校毕业的学生工作竞争压力也变得越来越大,因此对中职院校体育教学对学生职业能力的影响分析。从体育教学能够培养学生劳动所需的体能进行分析,进一步探讨体育教学能够培养学生职业心理的素质,并论证体育教学能够帮助学生提高工作的效率。通过相关理论探究,以期为中职院校体育教学对学生职业能力的影响分析相关课题提供一定理论上的支撑。

关键词：中职院校体育教学学生职业能力影响

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基于PLC控制的微波干燥箱设计与研究

现代信息科技 2020年第9期4卷 26-28,32页

作者：朱学飞新疆石河子职业技术学院新疆石河子832000

文章分析了微波干燥原理及特性,设计了一套基于PLC和触摸屏等设备构成的自动控温干燥箱.利用PLC编写程序实现PID控制PWM输出和SSR输出,通过控制磁控管的开关状态,实现温度恒定控制;利用变频器对系统参数进行调节和设置,触摸屏监测生产... 详细信息

文章分析了微波干燥原理及特性,设计了一套基于PLC和触摸屏等设备构成的自动控温干燥箱.利用PLC编写程序实现PID控制PWM输出和SSR输出,通过控制磁控管的开关状态,实现温度恒定控制;利用变频器对系统参数进行调节和设置,触摸屏监测生产过程中微波干燥箱内的温度和湿度.该设备操作简单,控制方便,自动化程度高,具备一定的推广及应用价值.

关键词：微波干燥箱 PLC 触摸屏 PID控温

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高职院校《电工电子技术》的课程教学探讨

科技与创新 2014年第2期 131-131,134页

作者：朱学飞新疆石河子职业技术学院新疆石河子832000

《电工电子技术》课程是高职院校工科专业的基础课程。通过学习该课程,学生可以获得电工和电子方面的基础知识、理论和技能,为学生今后的职业培养和职业养成提供基本支撑。结合教师的自身教学经验对该课程的教学实施和教学思路作了简要... 详细信息

《电工电子技术》课程是高职院校工科专业的基础课程。通过学习该课程,学生可以获得电工和电子方面的基础知识、理论和技能,为学生今后的职业培养和职业养成提供基本支撑。结合教师的自身教学经验对该课程的教学实施和教学思路作了简要的探讨。

关键词：电工电子技术课程教学教学实施教学目标

HPLC测定千里光提取物及千柏鼻炎胶囊中金丝桃苷在大鼠体内的血药浓度及药动学研究

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山东化工 2019年第6期48卷 71-74页

作者：朱雪飞江苏省扬州市食品药品检验检测中心江苏扬州225000

目的:建立RP-HPLC测定大鼠血浆中金丝桃苷浓度的方法,研究千里光提取物及千柏鼻炎胶囊中金丝桃苷的在动物体内药动学特征,评价复方中药物配伍对金丝桃苷药动学的影响。方法 :大鼠分别灌胃给予千里光提取物、千柏鼻炎胶囊内容物,眼眶后... 详细信息

目的:建立RP-HPLC测定大鼠血浆中金丝桃苷浓度的方法,研究千里光提取物及千柏鼻炎胶囊中金丝桃苷的在动物体内药动学特征,评价复方中药物配伍对金丝桃苷药动学的影响。方法 :大鼠分别灌胃给予千里光提取物、千柏鼻炎胶囊内容物,眼眶后静脉丛取血,离心得血浆,加乙腈沉淀蛋白处理后测定金丝桃苷的血药浓度,DAS2.0软件处理数据。结果金丝桃苷血浆浓度在0.341～13.64μg·mL^(-1)之间线性关系良好,检测限为0.079μg·mL^(-1),高,中,低浓度样品回收率分别为96.46%,98.62%,98.99%。大鼠灌胃千里光提取物和千柏鼻炎胶囊后的药-时曲线均符合二房室模型。灌胃千柏鼻炎胶囊后测定的金丝桃苷较千里光提取物的Cmax和AUC_(0→∞)分别比其增加了1.25和1.74倍。结论:本研究建立的RP-HPLC测定法,专属、准确、灵敏,适用于千里光提取物及千柏鼻炎胶囊中金丝桃苷的药动学研究。且研究显示,千柏鼻炎胶囊中的其他药材配伍可以促进金丝桃苷的吸收,提高金丝桃苷的生物利用度。

关键词：金丝桃苷千里光提取物千柏鼻炎胶囊高效液相色谱法药动学