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Regional Disparity and Convergence of China's Inbound Tourism Economy

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Chinese Geographical Science 2011年第6期21卷 715-722页

作者： wang Shuxin HE Yuanqing wang xueding ZHU Guofeng CAO Weihong State Key Laboratory of Cryosphere Science Cold and Arid Regions Environmental and Engineering Research Institute ChineseAcademy of Sciences Lanzhou 730000 Chin1 Chengdu Branch of Chinese Academy of Sciences Chengdu 610041 China

Comprehending regional characteristics and influencing factors of China＇s inbound tourism economy is im- portant to make effective policies that will help inbound tourism develop harmoniously and shrink regional disparity. This paper studied the regional disparity and convergence of China＇s inbound tourism economy during 1996-2008 with the methods of a-convergence, club convergence and r-convergence. The results indicate that 1） inbound tourism receipts per capita （ITRPC） of the whole country, the eastern, central and western regions presented the rapid increasing trend; 2） ITRPC of the whole country was characterized by convergence; 3） the eastern region presented club con- vergence, but the central and western regions did not show this trend; 4） the star-hotel levels and investment in fixed assets for the tourism industry per capita had a same trend to growth rates of ITRPC, promoting inbound tourism de- velopment, and there was no difference among the 31 provinces （municipalities） in the mainland of China; 5） but the proportion of employed persons in the tourism industry accounting for total population and the proportion of the terti- ary industry accounting for GDP had a reversal trend to growth rates of ITRPC, shrinking the provincial disparity in inbound tourism economy, and there were differences between the developed provinces and the developing provinces. Based on these analyses, we put forward some suggestions for the developing provinces to speed up inbound tourism economy.

关键词： inbound tourism receipts regional disparity a-convergence club convergence fl-convergence China

FOXO3 mutation predicting gefitinib-induced hepatotoxicity in NSCLC patients through regulation of autophagy

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Acta Pharmaceutica Sinica B 2022年第9期12卷 3639-3649页

作者： Shaoxing Guan Xi Chen Youhao Chen Guohui Wan Qibiao Su Heng Liang Yunpeng Yang Wenfeng Fang Yan Huang Hongyun Zhao Wei Zhuang Shu Liu Fei wang Wei Feng Xiaoxu Zhang Min Huang xueding wang Li Zhang Laboratory of Drug Metabolism and Pharmacokinetics School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510060China State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China College of Health Science Guangdong Pharmaceutical UniversityGuangzhou 510006China Sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou 510080China Ersha Department of Pharmacy the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510105China

Hepatotoxicity is a common side effect for patients treated with gefitinib,but the related pathogenesis is unclear and lacks effective predictor and management strategies.A multi-omics approach integrating pharmacometabolomics,pharmacokinetics and pharmacogenomics was employed in non-small cell lung cancer patients to identify the effective predictor for gefitinib-induced hepatotoxicity and explore optional therapy ***,we found that patients with rs4946935 AA,located in Forkhead Box O3(FOXO3)which is a well-known autophagic regulator,had a higher risk of hepatotoxicity than those with the GA or GG variant(OR=18.020,95%CI=2.473 to 459.1784,P=0.018)in a gefitinib-concentration dependent ***,functional experiments identified that rs4946935_A impaired the expression of FOXO3 by inhibiting the promotor activity,increasing the threshold of autophagy initiation and inhibiting the autophagic activity which contributed to gefitinib-induced liver *** contrast,erlotinib-induced liver injury was independent on the variant and expression levels of *** study reveals that FOXO3 mutation,leading to autophagic imbalance,plays important role in gefitinib-induced hepatotoxicity,especially for patients with high concentration of *** conclusion,FOXO3 mutation is an effective predictor and erlotinib might be an appropriately and well-tolerated treatment option for patients carrying rs4946935 AA.

关键词： Gefitinib Hepatotoxicity Pharmacometabolomic Pharmacokinetics Pharmacogenomics FOXO3 Autophagy

Preface to the special issue on“Biomedical Optics”

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Frontiers of Optoelectronics 2020年第4期13卷 305-306页

作者： Dan ZHU Walter BLONDEL Junie QU xueding wang Sihua YANG Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Universite de Lorraine CNRSCRAN UMR 7039Nancy 54000France Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Department of Radiology University of MichiganAnn ArborMI 48109-0553USA MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science College of BiophotonicsSouth China Normal UniversityGuangzhou 510631China

Biomedical optics is an interdisciplinary subject of optics and life *** recent years,as researches of life scienee have entered microscopic scale at cellular level,the application of optics in biomedical researches has been extensively *** optics can be divided into two major blanches according to research *** is to use advaneed optical methods to obtain biomedical information,whose recent trend of development is highspeed in vivo imagi ng,such as super-resoluti on imaging[1],fluoresce nee imagi ng[2],optical cohere nee tomography[3],and photoacoustic imaging[4],The other is to use the interaction of light and biological tissues for disease treatment,such as photodynamic therapy[5],whose recent trend of development is precise *** special issue on"Biomedical Optics" in eludes two reviews and six research articles,coveri ng most of the topics mentioned.

关键词： optics Biomedical mentioned

Bone mineral density value evaluation based on photoacoustic spectral analysis combined with deep learning method

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Chinese Optics Letters 2020年第4期18卷 63-66页

作者： Xue Zhou Zhibin Jin Ting Feng Qian Cheng xueding wang Yao Ding Hongchen Zhan Jie Yuan Jinling College Nanjing UniversityNanjing 210089China School of Electronic Science and Engineering Nanjing UniversityNanjing 210008China Nanjing Drum Tower Hospital Nanjing 210093China Institution of Acoustics Tongji UniversityShanghai 200092China

The diagnosis of osteoporosis is eventually converted to the measurement of bone mineral density(BMD)in clinical *** our previous work had proved the ability of using photoacoustic spectral analysis(PASA)to efficiently detect osteoporosis,in this contribution,we proposed a fully connected multi-layer deep neural network combined with PASA to semi-quantify BMD values corresponding to varying degrees of bone loss and to further evaluate the degree of *** were carried out on swine femur heads,and the performance of our proposed method is satisfying for future clinical screening.

关键词： photoacoustics osteoporosis neural network

Targeted Blue Nanoparticles as Photoacoustic Contrast Agent for Brain Tumor Delineation

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Nano Research 2011年第11期4卷 1163-1173页

作者： Aniruddha Ray xueding wang Yong-Eun Koo Lee Hoe Jin Hah Gwangseong Kim Thomas Chen Daniel A. Orringer Oren Sagher Xiaojun Liu Raoul Kopelman Biophysics University of Michigan Ann Arbor MI 48109 USA Department of Radiology University of Michigan Ann Arbor MI 48109 USA Department of Chemistry University of Michigan Ann Arbor MI 48109 USA Department of Neurosurgery University of Michigan Ann Arbor MI 48109 USA Institute of Acoustics Naniing University Nanjing 210093 China

Distinguishing a tumor from non-neoplastic tissue is a challenging task during cancer surgery. Several attempts have been made to use visible or fluorescent agents to aid in the visualization of a tumor during surgery. We describe a novel method to delineate brain tumors, using a highly sensitive photoacoustic imaging technique that is enhanced by tumor-targeting blue nanoparticles serving as a contrast agent. Experiments on phantoms and on rat brains, ex vivo, demonstrate the high sensitivity of photoacoustic imaging in delineating tumors containing contrast agent at a concentration much lower than needed for visualization by the naked eye. The limit of detection of the system for the nanoparticles is about 0.77 μg/mL in water （equivalent to 0.84 μmol/L Coomassie Blue dye）. The present exploratory study suggests that photoacoustic imaging, when used with strongly optical absorbing contrast agents, could facilitate cancer surgery intraoperatively by revealing the distribution and extent of the tumor.

关键词： Brain tumor surgery targeted nanoparticles F3 peptide Coomassie Blue dye photoacoustic imaging

Enhancing convolutional neural network scheme for rheumatoid arthritis grading with limited clinical data

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Chinese Physics B 2019年第3期28卷 391-398页

作者： Jian Tang Zhibin Jin Xue Zhou Weijing Zhang Min Wu Qinghong Shen Qian Cheng xueding wang Jie Yuan School of Electronic Science and Engineering Nanjing University Nanjing Drum Tower Hospital Institution of Acoustics Tongji University

The gray-scale ultrasound(US) imaging method is usually used to assess synovitis in rheumatoid arthritis(RA) in clinical practice. This four-grade scoring system depends highly on the sonographer's experience and has relatively lower validity compared with quantitative indexes. However, the training of a qualified sonographer is expensive and timeconsuming while few studies focused on automatic RA grading methods. The purpose of this study is to propose an automatic RA grading method using deep convolutional neural networks(DCNN) to assist clinical assessment. Gray-scale ultrasound images of finger joints are taken as inputs while the output is the corresponding RA grading results. Firstly,we performed the auto-localization of synovium in the RA image and obtained a high precision in localization. In order to make up for the lack of a large annotated training dataset, we performed data augmentation to increase the number of training samples. Motivated by the approach of transfer learning, we pre-trained the GoogLeNet on ImageNet as a feature extractor and then fine-tuned it on our own dataset. The detection results showed an average precision exceeding 90%. In the experiment of grading RA severity, the four-grade classification accuracy exceeded 90% while the binary classification accuracies exceeded 95%. The results demonstrate that our proposed method achieves performances comparable to RA experts in multi-class classification. The promising results of our proposed DCNN-based RA grading method can have the ability to provide an objective and accurate reference to assist RA diagnosis and the training of sonographers.

关键词： rheumatoid arthritis convolutional neural network medical ultrasound images

CO-ESTABLISHMENT OF AN R&D CENTER BASED ON A TRIPARTITE PARTNERSHIP

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Bulletin of the Chinese Academy of Sciences 1996年第3期10卷 258-261页

作者： wang xueding(CAS Lanzhou Branch)

This article explains the necessity for the co-establishment of the center by the CAS Lanzhou Branch, Lanzhou University and Gansu Provincial S&T Commission. It additionally gives an introductory account of the center... 详细信息

关键词： CAS

Crystallization kinetics of (Ni_(0.75)Fe_(0.25))_(78-x)Nb_xSi_(10)B_(12)(x=0,5) amorphous alloys

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北京科技大学学报 2006年第8期28卷 789-789页

作者： CHEN xueding WEI Hengdou wang Xiaojun State Key Laboratory of Advanced New Non-ferrous Materials Lanzhou University of Technology Lanzhou 730050 China

Amorphous ribbons of (Ni0.75Fe0.25)78-xNbxSi10B12（x=0,5） were prepared by a single roller melt-spinning technique in air atmosphere. The crystallization kinetics of the alloys were investigated by means of continuous heating,and the activation energies of the alloys were calculated using Kissinger plot method and Ozawa plot method on the basis of differential thermal analysis data. The crystallization products were analyzed by X-ray diffraction. After the (Ni0.75Fe0.25)78-xNbxSi10B12 amorphous alloy was annealed at the temperatures 715 and 745?K,a single phase of γ-（Fe,Ni） solid solution with grain sizes of about 10.3 and 18.5?nm,respectively,precipitates in the amorphous matrix. The crystallized phases are γ-（Fe,Ni） solid solution,Fe2Si,Ni2Si,and Fe3B after annealing at 765?K. The (Ni0.75Fe0.25)78-xNbxSi10B12 amorphous alloy was annealed at 720,750,and 800?K; and the crystallization phases,γ-（Fe,Ni） solid solution,（Fe,Ni） 23 B6,Ni 31 Si 12 and Nb2NiB 0.16 form simultaneously.

关键词：非晶态合金热分析结晶动力学活化能非晶态材料 (Ni0.75 Fe0.25)78-xNbxSi10B12

Functional Photoacoustic and Ultrasonic Assessment of Osteoporosis:A Clinical Feasibility Study

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Biomedical Engineering Frontiers 2020年第1期1卷 35-49页

作者： Ting Feng Yunhao Zhu Richard Morris Kenneth M.Kozloff xueding wang Department of Biomedical Engineering University of Michigan Medical SchoolMI 48109USA IF LLCWI 53589USA Department of Orthopaedic Surgery University of Michigan Medical SchoolMI 48109USA Department of Radiology University of Michigan Medical SchoolMI 48109USA

Objective and Impact *** study the feasibility of combined functional photoacoustic(PA)and quantitative ultrasound(US)for diagnosis of osteoporosis in vivo based on the detection of chemical and microarchitecture(BMA)information in calcaneus *** available X-ray or US technologies for the diagnosis of osteoporosis do not report important parameters such as chemical information and *** unique advantages,including good sensitivity to molecular and metabolic properties,PA bone assessment techniques hold a great potential for clinical *** performing multiwavelength PA measurements,the chemical information in the human calcaneus bone,including mineral,lipid,oxygenated-hemoglobin,and deoxygenated-hemoglobin,were *** parallel,by performing PA spectrum analysis,the BMA as an important bone physical property was *** unpaired t-test and a two-way ANOVA test were conducted to compare the outcomes from the two subject *** PA measurement is capable of assessing the relative contents of several chemical components in the trabecular bone in vivo,including both minerals and organic materials such as oxygenated-hemoglobin,deoxygenated-hemoglobin,and lipid,which are relevant to metabolic activities and bone *** addition,PA measurements of BMA show good correlations(R^(2)up to 0.65)with *** the chemical and microarchitectural measurements from PA techniques can differentiate the two subject *** results from this initial clinical study suggest that PA techniques,by providing additional chemical and microarchitecture information relevant to bone health,may lead to accurate and early diagnosis,as well as sensitive monitoring of the treatment of osteoporosis.

关键词： diagnosis Clinical architectural