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Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

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Genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng Rongcheng Yu Yiqi Tang Sihui Su Sainan Wang Chenxi liao xuecong li Jiabin liao Dongsheng Yu Tingting Ai Wei Zhao Vicky Yau Chufeng liu liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small GTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1/2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair

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Effects of Silicon Formulations on Cold Tolerance of Rice Seedlings

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Journal of Northeast Agricultural University(English Edition) 2024年第2期31卷 43-52页

作者： Ren Hongyu Wang Wenbo li xuecong li Shuai Wen Yahuan Zhang Xingwen College of Resources and Environmental Sciences Northeast Agricultural UniversityHarbin 150030China College of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China

To investigate the effects of silicon formulations on the cold tolerance of rice seedlings,Song Japonica 16(not cold tolerant)and Dongnong 427(cold tolerant)rice varieties were used as test materials and four different types of silicon formulations,Si-50-G,Si-60-G,Si-T-G,and Si-E-G,were applied as foliar sprays at the seedling stage,and a control group CK(equal amount of distilled water)was set *** week after the first silicon spray,two types of rice were subjected to low-temperature stress treatments at day/night temperatures of 12℃/10℃for 2,4,6,and 8 *** effects of different silicon formulations on the chlorophyll,proline(Pro)and soluble sugar contents as well as superoxide dismutase(SOD),peroxidase(POD)and catalase(CAT)activities of rice seedlings under low-temperature stress were compared to find out the effects of silicon formulations on the cold tolerance of rice *** results showed that silicon formulations could significantly increase the chlorophyll content of rice seedling leaves,with Si-50-G being the most effective,with a significant increment of 40.17%compared to the CK at 2 days of low *** silicon formulations significantly increased the proline content and soluble sugar content of rice leaves at low temperature for 4-8 *** Song Japonica 16,the most significant increment in leaf POD activity was observed in Si-E-G treatment at 2,4 and 8 days of temperature stress,with 73.58%,20.95%and 217.24%increases compared to the CK,*** 4 and 6 days of temperature stress,the most significant increase in CAT activity was observed in Si-E-G treatment,with 25.70%and 75.78%increases compared to the CK,*** Dongnong 427,the Si-60-G treatment showed the highest increase in leaf SOD activity for 4 and 8 days of temperature stress,with significant increases of 58.15%and 82.76%compared to the CK,respectively,and the Si-E-G treatment showed the highest increase in leaf POD activity for 2 and 8 days of temperature st

关键词： silicon formulation rice seedling stage cold tolerance physiological indicator

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Robust multi-sensor image matching based on normalized self-similarity region descriptor

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Chinese Journal of Aeronautics 2024年第1期37卷 271-286页

作者： xuecong liU Xichao TENG Jing LUO Zhang li Qifeng YU Yijie BIAN College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China High-Tech Institute Qingzhou 262500China

Multi-modal image matching is crucial in aerospace applications because it can fully exploit the complementary and valuable information contained in the amount and diversity of remote sensing ***,it remains a challenging task due to significant non-linear radiometric,geometric differences,and noise across different *** improve the performance of heterologous image matching,this paper proposes a normalized self-similarity region descriptor to extract consistent structural *** first construct the pointwise self-similarity region descriptor based on the Euclidean distance between adjacent image blocks to reflect the structural properties of multi-modal ***,a linear normalization approach is used to form Modality Independent Region Descriptor(MIRD),which can effectively distinguish structural features such as points,lines,corners,and flat between multi-modal *** further improve the matching accuracy,the included angle cosine similarity metric is adopted to exploit the directional vector information of multi-dimensional feature *** experimental results show that the proposed MIRD has better matching accuracy and robustness for various multi-modal image matching than the state-of-the-art *** can effectively extract consistent geometric structure features and suppress the influence of SAR speckle noise using non-local neighboring image blocks operation,effectively applied to various multi-modal image matching.

关键词： Remote sensing Multi-modal image matching Template matching Feature descriptor Similarity metric Synthetic Aperture Radar(SAR)

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Study on the Algorithm of Vibration Source Identification Based on the Optical Fiber Vibration Pre-Warning System

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Photonic Sensors 2015年第2期5卷 180-188页

作者： Hongquan QU xuecong REN Guoxiang li Yonghong li Changnian ZHANG College of Information Engineering North China University of Technology Beijing 100144 China

One of the key technologies for optical fiber vibration pre-warning system （OFVWS） refers to identifying the vibration source accurately from the detected vibration signals. Because of many kinds of vibration sources and complex geological structures, the implement of identifying vibration sources presents some interesting challenges which need to be overcome in order to achieve acceptable performance. This paper mainly conducts on the time domain and frequency domain analysis of the vibration signals detected by the OFVWS and establishes attribute feature models including an energy information entropy model to identify raindrop vibration source and a fundamental frequency model to distinguish the construction machine and train or car passing by. Test results show that the design and selection of the feature model are reasonable, and the rate of identification is good.

关键词： Optical fiber vibration pre-waming system (OFVWS) vibration source identification attribute featuremodel energy information entropy fundamental frequency stability

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舒利迭联合益气宣肺汤治疗慢性支气管炎的疗效分析

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药物生物技术 2024年第3期31卷 291-294页

作者：黎学聪邢益涛卓进盛刘穗林天东琼海市中医院海南琼海571499 海南省中医院海南海口570206

探讨舒利迭联合益气宣肺汤治疗慢性支气管炎的疗效,选取2020年3月至2021年7月在琼海市中医院就诊的86例慢性支气管肺炎患者作为研究对象,按照随机数字表法将全部患者分为A组和B组,各包括43例患者。A组给予舒利迭治疗,B组在A组基础上结... 详细信息

探讨舒利迭联合益气宣肺汤治疗慢性支气管炎的疗效,选取2020年3月至2021年7月在琼海市中医院就诊的86例慢性支气管肺炎患者作为研究对象,按照随机数字表法将全部患者分为A组和B组,各包括43例患者。A组给予舒利迭治疗,B组在A组基础上结合益气宣肺汤治疗,观察两组患者临床疗效,比较两组患者临床症状消失时间、治疗前后肺功能、血气指标以及生活质量评分。结果显示:经治疗B组总有效率显著高于A组(P<0.05);B组的止咳时间、平喘时间、痰消时间显著短于A组(P<0.05);B组FVC、FEV1及FEV1/FVC显著大于A组(P<0.05);B组PaO_(2)、SpO_(2)显著高于A组,PaCO_(2)显著低于A组(P<0.05);B组生活质量评分显著高于A组(P<0.05)。慢性支气管炎患者采用舒利迭联合益气宣肺汤治疗可显著减轻患者临床症状,促进肺功能恢复,提高患者的生活质量和临床疗效,具有一定的临床推广应用价值。

关键词：舒利迭益气宣肺汤慢性支气管炎急性发作期肺功能生活质量

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Lactobacillus rhamnosus MP108 alleviates ulcerative colitis in mice by enhancing the intestinal barrier， inhibiting inflammation， and modulating gut microbiota

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Food Science and Human Wellness 2024年

作者： Huizhen li Yang Chen Huiting Fang Xinmei Guo xuecong liu Jianxin Zhao Wei Chen Bo Yang State Key Laboratory of Food Science and Resources， Jiangnan University School of Food Science and Technology， Jiangnan University Jinqiao Biotechnology Co.， Ltd. Huai'an， Jiangsu， China National Engineering Research Center for Functional Food， Jiangnan University International Joint Research Center for Probiotics & Gut Health， Jiangnan University

Ulcerative colitis (UC) is a long-term inflammatory disorder that has evolved into a worldwide challenge. The development of new therapies against UC is imperative as all current therapies for UC are flawed in some way. Thus， the present study aimed to assess the palliative effects of Lactobacillus rhamnosus MP108 on UC in mice and to explore its potential mechanisms. The results showed that L. rhamnosus MP108 ameliorated the symptoms of UC， including preventing body weight loss， DAI elevation， and colon shortening， and attenuated colonic pathological damage. L. rhamnosus MP108 dramatically increased the number of goblet cells， MUC2 level， and tight junction protein level in the colon and remarkably inhibited epithelial cell apoptosis， thereby strengthening the intestinal barrier. L. rhamnosus MP108 pronouncedly diminished pro-inflammatory cytokine levels and strikingly augmented anti-inflammatory cytokine levels， in turn suppressing inflammation. Furthermore， L. rhamnosus MP108 conspicuously boosted the proportion of short-chain fatty acids (SCFAs) producers in gut microbiota， contributing to increased levels of acetate and butyrate. Therefore， L. rhamnosus MP108 might alleviate UC via improving the intestinal barrier， inhibiting inflammation， and modulating intestinal microbiota.

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复杂地层地下连续墙施工关键技术

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施工技术（中英文） 2021年第16期50卷 38-41页

作者：李学聪广州地铁集团有限公司广东广州510220

为提高城市复杂地层条件下地下连续墙施工质量和施工效率,减少施工对周边建筑物的影响,以广州地铁13号线某车站地下连续墙施工项目为背景,针对施工过程中存在的重难点问题,提出搅拌桩加固地层、旋挖钻引孔、双轮铣成槽、套铣法连接、墙... 详细信息

为提高城市复杂地层条件下地下连续墙施工质量和施工效率,减少施工对周边建筑物的影响,以广州地铁13号线某车站地下连续墙施工项目为背景,针对施工过程中存在的重难点问题,提出搅拌桩加固地层、旋挖钻引孔、双轮铣成槽、套铣法连接、墙脚清底换浆等关键技术。实际施工过程中,该方法可显著减小成槽机械对地层的振动影响,防止上部软弱土层局部坍塌。

关键词：复杂地层地下连续墙双轮铣槽机护壁泥浆施工技术

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露天煤场不同粒径煤尘扬尘实验研究

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辽宁工程技术大学学报（自然科学版） 2020年第1期39卷 12-17页

作者：马明星荆德吉陈曦葛少成李雪聪辽宁工程技术大学安全科学与工程学院辽宁阜新123000 辽宁工程技术大学安全科学与工程研究院辽宁阜新123000 矿山热动力灾害与防治教育部重点实验室(辽宁工程技术大学) 辽宁阜新123000 太原理工大学安全与应急管理工程学院山西太原0300240

为研究露天煤场不同粒径沉积煤尘的扬尘规律,根据风洞实验和相似模拟实验基本原则搭建煤尘起尘实验装置,对露天煤场不同条件下不同粒径组成的沉积煤尘的扬尘现象和规律进行研究.采用最小二乘法和高斯牛顿法对实验数据进行回归分析.实验... 详细信息

为研究露天煤场不同粒径沉积煤尘的扬尘规律,根据风洞实验和相似模拟实验基本原则搭建煤尘起尘实验装置,对露天煤场不同条件下不同粒径组成的沉积煤尘的扬尘现象和规律进行研究.采用最小二乘法和高斯牛顿法对实验数据进行回归分析.实验结果表明:沉积煤尘的起尘量随粒径的增大呈现起尘量先增大后减小的规律,当煤尘粒径接近0.23 mm,煤尘的起尘量最大,实验30 min最大值为16.4 kg;煤尘粒径小于0.115 mm,煤尘的起尘量极小试验最小值为0.003 kg.回归分析得出平均粒径在0~0.23 mm范围内的不同含水质量分数的圆锥形煤尘静置在不同风速条件下煤尘起尘量的数学关系式.保证粉尘的含水质量分数在6%以上,煤尘所处的环境风速小于4 m/s可以有效地降低煤尘的二次扬尘.

关键词：煤尘风洞实验相似实验起尘量回归分析

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一种新型温盐深传感器的数据采集与应用

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微计算机信息 2007年第10期23卷 209-210,234页

作者：李学聪万频邓庆华李军广东工业大学自动化学院

该文主要讨论SBE37-SI MicroCAT温盐深传感器的数据采集,它能精确测量海水的温度、电导率、压力、深度、盐度、声速、密度等状态参数,能很好地满足潜水器导航控制的要求。但由于其数据的输出格式与导航设备的格式有差异,无法直接与导航... 详细信息

该文主要讨论SBE37-SI MicroCAT温盐深传感器的数据采集,它能精确测量海水的温度、电导率、压力、深度、盐度、声速、密度等状态参数,能很好地满足潜水器导航控制的要求。但由于其数据的输出格式与导航设备的格式有差异,无法直接与导航系统直接交换数据,因此需要设计数据采集电路接口,使其能和导航系统实现数据交换。

关键词：温盐深传感器导航潜水器

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汽车制动真空助力器在线测试系统

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机床与液压 2007年第1期35卷 162-164页

作者：万频熊敏李军詹宜巨李学聪广东工业大学自动化学院广州510090

简述汽车制动真空助力器测试原理及性能要求,从硬件和软件设计两方面介绍汽车制动真空助力器在线测试系统的研制。重点对测量数据的曲线拟合、测量模块的USB接口以及基于LabVIEW的虚拟仪器设计进行了阐述。

关键词：真空助力器在线测试 USB LabVIEW

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