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Combination of two target agonists of the thrombopoietin and thrombopoietin receptor in the treatment of elderly patients with refractory immune thrombocytopenia

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Cancer Pathogenesis and Therapy 2023年第2期1卷 154-156页

作者： Jundong Zhang Zining Wang Haoran Chen Xuechun Lu Department of Hematology The Second Medical CenterChinese PLA General Hospital BeijingNational Clinical Research Center for Geriatric DiseaseBeijing 100853China Medical School of Chinese PLA Beijing 100853China Management School Shanxi Medical UniversityTaiyuanShanxi 030002China

Immune thrombocytopenia(ITP)is common in the elderly.Because of the coexistence of multiple diseases,there are many reservations regarding corticosteroid use in the elderly.Thrombopoietin(TPO)and its analogs can promote platelet production,but it is often difficult to correct TP in a short period.Recombinant human TPO(rh-TPO)acting on the cell membrane and the small-molecule TPO-receptor(MPL)agonist acting on the transmembrane receptor may have synergistic effects and accelerate platelet production because of different sites of action in the signaling pathway.In this study,two elderly patients with refractory ITP were successfully treated with two TPO-MPL signaling pathway agonists:recombinant human thrombopoietin(rh-TPO)and eltrombopag.This combination is safe with rapid and lasting effects.However,in elderly patients with refractory,recurrent,and glucocorticoid contraindications,the combination of different TPO agonists'clinical efficacy and adverse reactions needs to be further evaluated.

关键词： Immune thrombocytopenia(ITP) TPO-MPL signaling Pathway rh-TPO Eltrombopag

Two cases on primary bone marrow lymphoma

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Cancer Pathogenesis and Therapy 2024年第1期2卷 58-61页

作者： Zining Wang lu Sun Yue Wang Haoran Chen Hongbin Pu Bo Yang Xuechun Lu Medical School of Chinese PLA Beijing 100853China Department of Hematology The Second Medical Center&National Clinical Research Center for Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Pathology The First Medical CenterChinese PLA General HospitalBeijing 100853China National Institutes for Food and Drug Control Beijing 102629China Management School Shanxi Medical UniversityTaiyuanShanxi 030604China

Managing Editor:Peng Lyu Primary bone marrow lymphoma(PBML)is a rare lymphoma accounting for 1.23%of non-Hodgkin lymphoma(NHL)cases.It is characterized by tumor cells invading only the bone marrow without systemic lymphadenopathy or extranodal organ involvement.Owing to the lack of standardized treatment regimens,most patients are treated using rituximab with cyclophosphamide,doxorubicin,vincristine,and prednisone(R-CHOP)regimens;however,their efficacy needs to be further investigated.

关键词： lymphoma cases involvement

Effect of Methylprednisolone on Mortality and Clinical Courses in Patients with Severe CoVID-19: A Propensity Score Matching Analysis

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Infectious Diseases & Immunity 2023年第1期3卷 20-28页

作者： Xiaoyan Li Xin Yuan Zhe Xu Lei Shi Lei Huang Xuechun Lu Junliang Fu Medical School of Chinese PLA Beijing 100853China Senior Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Infectious Diseases Beijing 100039China Department of Hematology the Second Medical Center of Chinese PLA General HospitalBeijing 100853China.

Background Whether methylprednisolone therapy can reduce the mortality rate of patients with severe coronavirus disease 2019(COVID-19)remains controversial,and its effects on the length of hospital stay and virus shedding time are also unknown.This retrospective study investigates the previous issues to provide more evidence for methylprednisolone treatment in severe COVID-19.Methods This retrospective study included 563 of 4827 patients with confirmed COVID-19 admitted to Wuhan Huoshenshan Hospital or Wuhan Guanggu Hospital between February 3,2020 and March 30,2020 who met the screening criteria.The participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical records.The primary outcome was in-hospital death,and the secondary outcomes were 2 clinical courses:length from admission to viral clearance and discharge.Univariate and multivariate logistic or linear regression analyses were used to assess the role of methylprednisolone in different outcomes.Propensity score matching was performed to control for confounding factors.Results Of the 563 patients who met the screening criteria and were included in the subsequent analysis,138 were included in the methylprednisolone group and 425 in the nonmethylprednisolone group.The in-hospital death rate between the methylprednisolone and nonmethylprednisolone groups showed a significant difference(23.91%vs.1.65%,P<0.001),which was maintained after propensity score matching(13.98%vs.5.38%,P=0.048).However,univariate logistic analysis in the matched groups showed that methylprednisolone treatment(odds ratio[OR],5.242;95%confidence interval[CI],0.802 to 34.246;P=0.084)was not a risk factor for in-hospital death in severe patients.Further multivariate logistic regression analysis found comorbidities(OR,3.327;95%CI,1.702 to 6.501;P<0.001),lower lymphocyte count(OR,0.076;95%CI,0.012 to 0.461;P=0.005),higher lactate dehydrogenase(LDH)levels(OR,1.008;95%CI,1.003 to

关键词： COVID-19 Clinical courses In-hospital death Methylprednisolone SARS-CoV-2

Effect of methylprednisolone therapy on hospital stay and viral clearance in patients with moderate COVID-19

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Infectious Medicine 2022年第4期1卷 236-244页

作者： Xiaoyan Li Xin Yuan Zhe Xu Lei Huang Lei Shi Xuechun Lu Fu-Sheng Wang Junliang Fu Medical School of Chinese PLA BeijingChina Senior Department of Infectious Diseases The Fifth Medical Center of Chinese PLA General HospitalBeijingChina National Clinical Research Center for Infectious Diseases BeijingChina Department of Hematology the Second Medical Center of Chinese PLA General HospitalBeijingChina

Background:The benefits and harms of methylprednisolone treatment in patients with moderate coronavirus disease 2019(COVID-19)remain controversial.In this study,we investigated the effect of methylprednisolone on mortality rate,viral clearance,and hospitalization stay in patients with moderate COVID-19.Methods:This retrospective study included 4827 patients admitted to Wuhan Huoshenshan and Wuhan Guanggu hospitals from February to March 2020 diagnosed with COVID-19 pneumonia.The participants’epidemiological and demographic data,comorbidities,laboratory test results,treatments,outcomes,and vital clinical time points were extracted from electronic medical records.The primary outcome was in-hospital death;secondary outcomes were time from admission to viral clearance and hospital stay.Univariate and multivariate logistic or linear regression analysis were used to assess the roles of methylprednisolone in different outcomes.The propensity score matching(PSM)method was used to control for confounding factors.Results:A total of 1320 patients were included in this study,of whom 100 received methylprednisolone.Overall,in-hospital mortality was 0.91%(12/1320);the 12 patients who died were all in the methylprednisolone group,though multivariate logistic regression analysis showed methylprednisolone treatment was not a risk factor for in-hospital death in moderate patients before or after adjustment for confounders by PSM.Methylprednisolone treatment was correlated with longer length from admission to viral clearance time and hospital stay before and after adjustment for confounders.Conclusions:Methylprednisolone therapy was not associated with increased in-hospital mortality but with delayed viral clearance and extended hospital stay in moderate COVID-19 patients.

关键词： COVID-19 Hospital stay In-hospital death Moderate Viral clearance

A case of diffuse large B-cell lymphoma with interstitial pneumonia

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Cancer Pathogenesis and Therapy 2023年第3期1卷 220-223页

作者： Ge Song Changxi Zhou Shuxia Wang Tianqi Tao Weiping Guan Xuan Wu Ping Zhu Bo Yang Xuechun Lu Department of Geriatrics The Second Medical Center&National Clinical Research Center of Geriatric DiseasesChinese PLA General HospitalBeijing 100853China Department of Hematology The Second Medical Center&National Clinical Research Center of Geriatric DiseasesChinese PLA General HospitalBeijing 100853China

This report involves a 54-year-old female patient diagnosed with diffuse large B-cell lymphoma who developed interstitial pneumonia(IP)during treatment.The patient presented to the ward with enlarged lymph nodes in the neck and was treated with the standard regimen,which included rituximab,cyclophosphamide,doxorubicin liposomes,vincristine,and prednisone(R-CDOP regimen).After 3 cycles,the treatment was assessed as effective.However,following the 4th cycle,the patient experience shortness of breath after physical activity.A repeat lung computer tomography indicated IP,which completely recovered after receiving“full coverage”treatment.Subsequently,the patient underwent 2 cycles of cyclophosphamide,doxorubicin liposomes,vincristine,and prednisone(CDOP),followed by local radiotherapy.Currently,the patient is now being followed up with regular reviews.

关键词： Diffuse large B-cell lymphoma Interstitial pneumonia Rituximab Doxorubicin liposomes

Pathogenesis of premature coronary artery disease:Focus on risk factors and genetic variants

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Genes & Diseases 2022年第2期9卷 370-380页

作者： Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang Department of Cardiovascular Medicine Chinese PLA General Hospital&Chinese PLA Medical SchoolBeijing 100853PR China The First Clinical Medical College of Inner Mongolia Medical University Hohhot 010059PR China Department of Hematology The Second Medical Center of Chinese PLA General Hospital&Chinese PLA Medical SchoolBeijing 100853PR China Department of Health Services The First Medical Center of Chinese PLA General Hospital&Chinese PLA Medical SchoolBeijing 100853PR China

The development of premature coronary artery disease(PCAD)is dependent on both genetic predisposition and traditional risk factors.Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies.Genome-wide association studies(GWASs)have identified a considerable number of common genetic variants that are associated with PCAD.Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms(SNPs).The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity.Some characteristic genetic variants have been identified in Chinese populations.Although translating this genetic knowledge into clinical applications is still challenging,these genetic variants can be used for CAD phenotype identification,genetic prediction and therapy.In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD.We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD.

关键词： Genetic clinical applications Genetic variants Genome-wide association studies Premature coronary artery disease Single-nucleotide polymorphisms

Guidelines for application of high-content screening in traditional Chinese medicine:concept,equipment,and troubleshooting

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Acupuncture and Herbal Medicine 2024年第1期4卷 1-15页

作者： xuechun Chen lu Li Mingxu Zhang Jian Yang ChunMing Lyu Yizhou Xu Yang Yang Yi Wang Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina Department of Cardiology Hangzhou First People’s HospitalHangzhouChina National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxingChina Molecular Devices Shanghai Corporation ShanghaiChina National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Science and Technology Experiment Center Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Innovative Anticancer Drugs Ministry of Educationhangzhou China

High-content screening(HCS)technology combines automated high-speed imaging hardware and single-cell quantitative analysis.It can greatly accelerate data acquisition in cellular fluorescence imaging and is a powerful research technique in traditional Chinese medicine(TCM).An increasing number of laboratories and platforms,including TCM laboratories,have begun utilizing HCS systems.However,this technology is still in its infancy in TCM research and there is a lack of sufficient experience with the associated concepts,instrument configurations,and analysis methods.To improve the understanding of HCS among researchers in the field of TCM,this paper summarizes the concept of HCS,software and hardware configuration,the overall research process,as well as common problems and related solutions of HCS in TCM research based on our team’s previous research experience,providing several research examples and an outlook on future perspectives,aiming to provide a technical guide for HCS in TCM research.

关键词： High-content imaging High-content screening Traditional Chinese medicine

LD-pumped gas-cooled multislab Nd:glass laser amplification to joule level

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High Power Laser Science and Engineering 2018年第2期6卷 20-26页

作者： Wenfa Huang Jiangfcng Wang Xinghua lu Tingrui Huang Jiangtao Guo Wei Fan xuechun Li Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800China National Laboratory on High Power Laser and Physics Shanghai 201800China

We demonstrate a laser diode end-pumped helium gas-cooled multislab Nd:glass laser amplifier. The design and thermal management of the proposed laser amplifier are discussed. The thermally induced wavefront aberration of the slabs was also measured and compared with simulation results. A small-signal single-pass longitudinal gain of 1.8 was measured with a pump energy of 7.3 J. With an injected seed energy of 0.6 m J, the output energy from the amplifier reached 0.5 J at 0.2 Hz and 0.43 J at 0.5 Hz in a multipass extraction geometry, thus demonstrating the feasibility of diode-pumped,high-energy lasers with direct gas cooling.

关键词： laser diode gas cooling Nd:glass wavefront aberration laser amplifier

Rapid and mass manufacturing of soft hydrogel microstructures for cell patterns assisted by 3D printing

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Bio-Design and Manufacturing 2022年第4期5卷 641-659页

作者： Chaofan He xuechun Chen Yuan Sun Mingjun Xie Kang Yu Jing He Jinwei lu Qing Gao Jing Nie Yi Wang Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Orthopedic Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009China Key Laboratory of Materials Processing and Mold Zhengzhou UniversityZhengzhou 450002China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027China Cancer Center Zhejiang UniversityHangzhou 310058China State Key Laboratory of Component-Based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 300072China

Micro-/nano-patterns on hydrogels are widely used in cell patterning.However,manufacturing molds with traditional lithography is time-consuming and expensive.In addition,the excessive demolding force can easily damage patterns since biocompatible hydrogels are ultra-soft or brittle.Here,we presented a novel method for rapid and mass fabrication of cell patterns.High-precision three-dimensional(3D)printing was used to manufacture a mold with a resolution of 2µm,and the gelatin-based hydrogel was cured by thermal–photo-crosslinking so that the low-concentration and low-substitutionrate hydrogel could be demolded successfully.We found that pre-cooling before illumination made gelatin-based hydrogels resilient due to the partial regain of triple-helix structures.With this method,arbitrarily customized hydrogel patterns with a feature size of 6–80µm can be fabricated stably and at low cost.When cardiomyocytes were seeded on ultra-soft hydrogels with parallel groove structures,a consistent and spontaneous beating with 216 beats per minute(BPM)could be observed,approaching the natural beating rate of rat hearts(300 BPM).Overall,this work provides a general scheme for manufacturing cell patterns which has great potential for cell ethology and tissue repair.

关键词： 3D printing Gelatin-based hydrogel Cell pattern Cardiomyocytes beating