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Properties and Acceleration Mechanism of Cement Mortar Added with Low Alkaline Liquid State Setting Accelerator

Journal of Wuhan University of Technology(Materials Science) 2014年第6期29卷 1196-1200页

作者：潘志华 wang xuebing LIU Weiqing College of Materials Science & Engineering Nanjing Tech University College of Civil Engineering Nanjing Tech University

Low alkaline liquid state setting accelerator（LSA） for Portland cement was prepared in laboratory from aqueous solution of several inorganic sulfate salts and some organic chemical substances. Properties of cement with addition of LSA relating to its setting time and strength development as well as its resistance to sulfate attack for short and long term exposure were experimentally examined. The experimental results showed that 5%-7% addition of LSA significantly accelerated the initial and final setting of Portland cement in the presence or absence of the blending of mineral admixtures, the initial and final setting time being less than 3 min and 6 min respectively. Meanwhile, the early 1 day curing age compressive strength increased remarkably by 20%, while the late 28 th day curing age compressive strength remained almost unchanged as compared with that of the reference accelerator free cement mortar specimen. Furthermore, mortar specimens of cement added with LSA and exposed to 5% Na2SO4 solution showed their excellent resistance to sulfate attack, with their short and long term curing age resistance coefficient to sulfate attack being around 1.04 to 1.17, all larger than 1.0. XRD analysis on hardened cement paste specimens at very early curing ages of several minutes disclosed the existence of more ettringite in specimens added with LSA than that of the reference specimens, meanwhile SEM observation also revealed the existence of well crystallized ettringite at very early hydration stage, suggesting that the accelerated setting of Portland cement can be attributed to the early and rapid formation of ettringite over the whole cement paste matrix due to the introduction of LSA. MIP measurement revealed that hardened cement paste specimens with the addition of LSA presented less medium diameter pores, more proportion of small pores and less proportion of large capillary pores, which is in a very good coincidence with the improvement of strength development of cem

关键词： low alkaline cement setting accelerator sulfate attack ettringite

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Bacteremia complicated with pneumonia caused by Corynebacterium diphtheriae

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Infectious Medicine 2022年第4期1卷 276-280页

作者： Xiaojun Zhou xuebing wang Hua Wua Meihui Huang Shaoling wang Xuming wang Haijian Zhou Department of Clinical Laboratory Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikou570311China State Key Laboratory of Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionChangpingBeijing102206China Hainan Center for Disease Control and Prevention Haikou570203China

Due to the use of vaccines,infections caused by Corynebacterium diphtheriae are now *** we describe a case of bacteremia complicated with pneumonia caused by *** in a 69-year-old male *** patient presented at the emergency department with a 2 days history of fever of unknown *** examinations revealed pneumonia and ***-toxigenic *** strains were isolated from blood and *** patient had antimicrobial therapy with good *** highlight the important role of *** in causing bacteremia and pneumonia,and its accurate and timely diagnosis is needed to avoid poor visual outcomes.

关键词： Corynebacterium diphtheriae Pneumonia Bacteremia China

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Treatment for triple-negative breast cancer

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The Chinese-German Journal of Clinical Oncology 2012年第9期11卷 539-543页

作者： xuebing Shi Lu wang Department of Medical Oncology Yijishan Hospital of Wannan Medical College Wuhu 241000 China

Triple-negative breast cancers (TNBCs) neither express estrogen receptor and progesterone receptor nor over- express human epidermal growth factor receptor-2. Because of the special molecular features, triple-negative breast cancer is not either sensitive to endocrine therapy or targeted therapy of trastuzumab. There has not been standard treatment regimen for triple-negative breast cancer yet and chemotherapy has still been the chief therapy currently. However, with the great progress of oncology and molecular biology, the understanding of the natural history, pathophysiology and molecular features of this disease has been greatly improved, and a growing number of novel and effective therapies and discoveries of new biological targets for this phenotype of breast cancers have been reported, which provide new insights into therapeutic strategies for the women suffering from it.

关键词： tripPe-negative breast neoplasms therapy review

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Ultrasound-guided continuous adductor canal block for analgesia after total knee replacement

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Chinese Medical Journal 2014年第23期127卷 4077-4081页

作者： Zhang Wei Hu Yan Tao Yan Liu xuebing wang Geng Department of Anesthesiology Beijing Jishuitan Hospital Beijing 100035 China

Background There are several methods for postoperative analgesia for knee *** commonly utilized method is multimodal analgesia based on continuous femoral nerve *** aim of this study was to investigate the application of continuous adductor canal block for analgesia after total knee replacement and compare this method with continuous femoral nerve *** Sixty patients scheduled for total knee replacement from June 2013 to March 2014 were randomly divided into a femoral group and an adductor *** were placed under the guidance of nerve stimulation in the femoral group and under the guidance of ultrasound in the adductor *** were performed under combined spinal and epidural *** the operations,0.2％ ropivacaine was given at a speed of 5 ml/h through catheters in all *** analogue scale （VAS） pain scores at rest and while moving were noted at 4,24,and 48 hours after the operation,and quadriceps strength was also assessed at these *** parameters such as doses of complementary analgesics and side effects were also *** There were no significant differences between the groups in VAS pain scores at rest or while moving,at 4,24,or 48 hours after the operation （P ＞0.05）.At these time-points,mean quadriceps strengths in the adductor group were 3.0 （2.75-3.0）,3.0 （3.0-4.0）,and 4.0 （3.0-4.0）,respectively,all of which were significantly stronger than the corresponding means in the femoral group,which were 2.0 （2.0-3.0）,2.0 （2.0-3.0）,and 3.0 （2.0-4.0）,respectively （P ＜0.05）.There were no significant differences between the groups in doses of complementary analgesics or side effects （P ＞0.05）.X-ray images of some patients showed that local anesthetic administered into the adductor canal could diffuse upward and reach the femoral *** Continuous adductor canal block with 0.2％ ropivacaine could be used effectively for analgesia after total knee *** with

关键词： adductor canal block femoral nerve block ropivacaine total knee replacement multimodal analgesia

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Genomic Epidemiology of Carbapenemaseproducing Klebsiella pneumoniae in China

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1154-1167页

作者： Cuidan Li Xiaoyuan Jiang Tingting Yang Yingjiao Ju Zhe Yin Liya Yue Guannan Ma xuebing wang Ying Jing Xinhua Luo Shuangshuang Li Xue Yang Fei Chen Dongsheng Zhou CAS Key Laboratory of Genome Sciences&Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Pathogenesis Prevention and Treatment of High Incidence Diseases in Central AsiaUrumqi 830011China Beijing Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China

The rapid spread of carbapenemase-producing Klebsiella pneumoniae(cpKP)poses serious threats to public health;however,the underlying genetic basis for its dissemination is still *** conducted a comprehensive genomic epidemiology analysis on 420 cpKP isolates collected from 70 hospitals in 24 provinces/autonomous regions/municipalities of China during 2009–2017 by short-/long-read *** results showed that most cpKP isolates were categorized into clonal group 258(CG258),in which ST11 was the dominant *** analysis revealed three major clades including the top one of Clade 3 for CG258 cpKP ***,carbapenemase gene analysis indicated that blaKPC was dominant in the cpKP isolates,and most blaKPC genes were located in five major incompatibility(Inc)groups of blaKPC-harboring ***,three advantageous combinations of host–blaKPC-carrying plasmid(Clade 3.1+3.2–IncFIIpHN7A8,Clade 3.1+3.2–IncFIIpHN7A8:IncR,and Clade 3.3–IncFIIpHN7A8:IncpA1763-KPC)were identified to confer cpKP isolates the advantages in both genotypes(strong correlation/coevolution)and phenotypes(resistance/growth/competition)to facilitate the nationwide spread of ST11/CG258 ***,Bayesian skyline analysis illustrated that the three advantageous combinations might be directly associated with the strong population expansion during 2007–2008 and subsequent maintenance of the population of ST11/CG258 cpKP after *** then examined drug resistance profiles of these cpKP isolates and proposed combination treatment regimens for CG258/non-CG258 cpKP ***,the findings of our systematical analysis shed light on the molecular epidemiology and genetic basis for the dissemination of ST11/CG258 cpKP in China,and much emphasis should be given to the close monitoring of advantageous cpKP–plasmid combinations.

关键词： Klebsiella pneumoniae Drug resistance Carbapenemase Plasmid Genomic epidemiology

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Effect of Pine Needle on Immunity and Serum Cholesterol of Chickens

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Animal Husbandry and Feed Science 2015年第4期7卷 233-237页

作者： Zhang Hongying wang xuebing wang Wei Du Fangfang Du Xiangyue Liu Fang College of Animal Science and Veterinary Medicine Henan Agricultural University Henan Key Laboratory of Animal-derived Food Safety

The research aimed to study the effects of pine needle on immunity and serum cholesterol of chickens. Totally 240 healthy Roman cocks （one day old） were randomly divided into four groups, three replicates each group and 20 chickens per replicate. The chickens in contrel group were fed with basal diet and nor- real drinking water; the chickens in groups I and II were fed with the basal diet added with 0.5 and 1.0 g/ehieken pine needle powder, respectively; the chickens in group HI were fed with pine needle decoction at the dose of 0.5 g/chicken. The pre-trial lasted 4 d, and the former trial lasted 70 d. The results showed that the percentages of CD3＋ CD4 ＋ T lymphocytes in groups I, II and III were higher than that in control group at the 15th day after the first immunization, but the percenta- ges in groups 1 and II were lower than that in control group at the 30th , 45th and 60th days, and the percentage in group III was lower than that in control group at the 45th day. The percentages of CD3＋ CD8 ＋ T lymphocytes in groups I, II and III were higher than that in control group at the 15th, 30th and 45th days after the first immunization, but the percentages in groups I and III were lower than that in control group at the 60th day. At the 14th and 21st days after the first immunization, the levels of NDV antibody in groups I and II were lower than that in control group, but the levels at the 28th and 35th days were higher than that in control group. The level of NDV antibody in group III was higher than that in control group at the 14th and 21st days while it was lower at the 7th and 35th days. The levels of serum total cholesterol and trigtyceride in groups I, II and III had lower trend compared with control group, and the levels of serum triglyceride in groups I and II were significantly lower than that in control group and group III （P 〈0.05 ）. The levels of serum low density lipoprotein in groups II and III were lower than that in control group, while the level o

关键词： Pine needle Chicken Immunity Serum cholesterol

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深刻把握历史自信的现实依据、理论内涵与未来指向

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广西大学学报（哲学社会科学版） 2022年第5期44卷 12-19页

作者：王学斌中共中央党校(国家行政学院)文史教研部中国史教研室

作为党中央最新提出的重大论断和理论命题,历史自信具有强烈的现实依据、深刻的理论内涵与鲜明的未来指向。这是中国共产党、中华民族源于自身历史最深处的对既有文明进程、百年奋斗历程、伟大复兴征程与人类发展前程的深厚高远且持久... 详细信息

作为党中央最新提出的重大论断和理论命题,历史自信具有强烈的现实依据、深刻的理论内涵与鲜明的未来指向。这是中国共产党、中华民族源于自身历史最深处的对既有文明进程、百年奋斗历程、伟大复兴征程与人类发展前程的深厚高远且持久坚实的信仰、信念与信心。在新的赶考之路上,我们唯有不断增强历史认知,深刻把握历史自信的现实依据,不断挖掘其理论内涵,充分彰显其未来指向,从历史进程中洞察历史发展规律和时代发展大势,才能交出一份全面建成社会主义现代化强国、胜利实现中华民族伟大复兴的优异答卷。

关键词：历史自信历史精神历史经验四个自信新的赶考之路

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin xuebing Yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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复杂条件超浅埋超大断面双连拱隧道开挖方案比选

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地下空间与工程学报 2022年第S1期18卷 243-251页

作者：王学斌刘杨厦门路桥建设集团有限公司福建厦门361026 苏州大学轨道交通学院江苏苏州215000

超浅埋大跨度双连拱隧道施工过程中围岩应力变化与衬砌荷载转化极为复杂,隧道结构安全性和围岩稳定性控制难度较大,特别是在下穿城市主干道等敏感建设环境下,选择合理的开挖方案对于保障工程顺利实施至关重要。本文依托厦门第二西通道... 详细信息

超浅埋大跨度双连拱隧道施工过程中围岩应力变化与衬砌荷载转化极为复杂,隧道结构安全性和围岩稳定性控制难度较大,特别是在下穿城市主干道等敏感建设环境下,选择合理的开挖方案对于保障工程顺利实施至关重要。本文依托厦门第二西通道双连拱隧道,通过数值模拟与现场监测等方法,对“对称”与“非对称”两种开挖方案下的围岩变形与结构受力进行了分析,并综合考虑围岩稳定性与结构安全性,以及施工工期等因素,确定了双连拱隧道最终开挖方案。研究表明:非对称开挖方案的围岩塑性区分布范围略大,对称与非对称开挖引起的最大地表沉降分别为20.24 mm和24.61 mm;两种方案的初支、二衬和临时支撑受力均在安全范围内,中墙最大偏压分别为2166.1 kPa和2131.2 kPa。在两种方案的围岩变形和结构受力均满足控制要求,且相差较小的前提下,考虑到施工工期和施工灵活性,双连拱隧道采用非对称开挖方案更为合理。研究结果可为城市复杂条件下双连拱隧道的设计施工提供有益参考。

关键词：超大断面双连拱隧道开挖方案围岩变形结构受力

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基于干扰观测器的挠性卫星姿态滑模变结构控制

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空间控制技术与应用 2017年第2期43卷 36-42页

作者：王雪冰吴忠北京航空航天大学仪器科学与光电工程学院北京100191

为抑制各种内外干扰因素对挠性卫星姿态控制性能的影响,设计基于干扰观测器的滑模变结构控制器.该控制器采用干扰观测器对系统中存在的内外干扰进行估计,并对估计值加以前馈补偿.在此基础上,采用滑模变结构控制器对未补偿的干扰进一步抑... 详细信息

为抑制各种内外干扰因素对挠性卫星姿态控制性能的影响,设计基于干扰观测器的滑模变结构控制器.该控制器采用干扰观测器对系统中存在的内外干扰进行估计,并对估计值加以前馈补偿.在此基础上,采用滑模变结构控制器对未补偿的干扰进一步抑制,实现卫星姿态与姿态角速度的渐近收敛.与单纯的滑模变结构控制器相比,本文的控制器已根据干扰估计值对干扰进行了前馈补偿,采用较小的切换增益即可抑制剩余干扰,颤振现象减弱.仿真结果表明,本文设计的控制器是可行的.

关键词：挠性航天器姿态控制干扰观测器滑模变结构控制

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