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神经退行性疾病中轴突运输障碍的机制

华中科技大学学报（医学版） 2024年第4期53卷 558-562页

作者：杨小曼徐岩曹学兵武汉大学人民医院神经内科武汉430060 华中科技大学同济医学院附属协和医院神经内科武汉430022

临床上许多神经退行性疾病包括阿尔茨海默病、帕金森病和肌萎缩侧索硬化症等,主要表现为致病蛋白的蓄积和细胞器的异常定位。这一病理特征可能与神经元中轴突运输障碍有关,轴突运输异常可能导致致病蛋白不能定向转运到特定部位降解,细... 详细信息

临床上许多神经退行性疾病包括阿尔茨海默病、帕金森病和肌萎缩侧索硬化症等,主要表现为致病蛋白的蓄积和细胞器的异常定位。这一病理特征可能与神经元中轴突运输障碍有关,轴突运输异常可能导致致病蛋白不能定向转运到特定部位降解,细胞器不能运至指定区域发挥正常生理功能,甚至轴突运输障碍极有可能是此类疾病的早期病理事件,并逐渐发展成轴突完整性的丧失与退行性改变。在此,我们对多种常见的神经退行性疾病中轴突运输障碍的发生发展机制进行探讨,为后续的基础研究提供新思路。

关键词：轴突运输障碍阿尔茨海默病肌萎缩侧索硬化症帕金森病

Heterogeneity in top management teams and outward foreign direct investment: evidenee from Chinese listed companies

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Frontiers of Business Research in China 2019年第3期13卷 344-371页

作者： Shuai Meng Jiayan Yan xuebing cao Business School Renmin University of ChinaBeijing 100872China School of Business Nanjing Audit UniversityNanjing 211815China Keele Management School Keele UniversityStaffordshire ST55BGUK

Drawing upon the knowledge-based view and team learning,we investigated how heterogeneity in top man agement teams(TMTs)in China in flue nces global expansi on *** panel data from Chinese listed firms from 2008 to 2014,we found that TMT functional background heterogeneity could positively affect firms'commitment to outward foreign direct investment(OFDI),as the diversification of TMT members can enrich the team's knowledge,facilitate efficient team learning,and enhance the decision-making capacity on overseas expansi ***,tenure heterogeneity may hinder knowledge acquisition and team learning among TMT members,hence undermining firms/OFDI commitment.

关键词： Top management teams(TMTs) Tenure heterogeneity Outward foreign direct investment(OFDI) Knowledge-based view(KBV) Team learning Multinational enterprise(MNE)

Repetitive transcranial magnetic stimulation causes significant changes of chemical substances in the brain of rabbits with experimental intracerebral hemorrhage

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Frontiers of Medicine 2008年第4期2卷 406-409页

作者： Tiecheng GUO xuebing cao Limin XIA Department of Rehabilitation Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

More and more studies have reported the use-fulness of repetitive transcranial magnetic stimulation(rTMS)in the treatment of stroke *** article is to explore if rTMS can cause changes of such chemical substances as N-acetylaspartate(NAA),choline(Cho)and creatine(Cr)in the surrounding area of experimental intracerebral hematoma of rabbits.A total of 36 rabbits were randomly divided into 3 groups:a control group(group A),a sham rTMS group(group B)and an rTMS group(group C).The experimental intracerebral hemor-rhage(ICH)was induced by intracerebral injection of self-body blood of the animals in groups B and C,while those of the group A serving as controls were injected with nor-mal *** rabbits of groups B and C were treated with sham and real rTMS,respectively,but those of group A were *** contents of chemical substances including NAA,Cho and Cr in the perihematomal brain tissues were measured by using lH-magnetic resonance spectro-scopy(1H-MRS)12 hours,72 hours,1 week and 2 weeks after the experimental ICH was *** results show that the contents of NAA,Cr and NAA/Cr ratio were decreased significantly,but Cho,Cho/Cr increased signifi-cantly in groups B and C(P,0.01)as compared against those in group A.A comparison between the groups B and C revealed that the contents of NAA,Cr,NAA/Cr were higher,but Cho and Cho/Cr were significantly lower in group C than those in group B(P,0.01).It is concluded that rTMS could result in changes of the chemical sub-stance contents in perihematomal brain tissues,which leads to neuroprotective effects in the brain.

关键词： repetitive transcranial magnetic stimulation lH-magnetic resonance spectroscopy cerebral hemotoma rabbits

Experimental Study on Heterograft of Glomus Cells of Carotid Body for Hemiparkinsonian Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第2期22卷 129-131页

作者： cao xuebing(曹学兵) SUN Shenggang(孙圣刚) TONG E＇tang(童萼塘) Department of Neurology Xiehe Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430022 Department of Neurology Xiehe Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430022 Department of Neurology Xiehe Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430022

Summary: To observe the effects of heterograft of glomus cells of carotid body on hemiparkinsonian rat models, rats with unilateral 6-hydroxydopamine (6-OHDA)-induced lesions of the right dopaminergic neurons of substantia nigra received intrastriatal glomus cells heterograft. Apomorphine-induced rotation was monitored for 30 min at various time points after grafting. The striata were cut and examined for dopamine content by HPLC and for immunohistochemical staining of tyrosine hydroxylase positive neurons (TH +) at the end of the experiments. The results showed that apomorphine-induced rotational behavior was significantly reduced for 12 weeks and the dopamine contents were significantly elevated after grafting (P<0.01), and TH + cells survived better. The present study demonstrates that intrastriatal heterograft of glomus cells within carotid body in rats with 6-OHDA-elicited lesions could reduce apomorphine-induced rotational behavior and elevate the dopamine contents and numbers of TH + cell surviving within striatum, and can serve as a new and effective alternative for Parkinson disease.

关键词： carotid body glomus cell heterograft Parkinson disease

Organizational Misbehavior and Management Control in China＇s Public Hospitals： Doctors＇ Red Packets

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Frontiers of Business Research in China 2015年第1期9卷 110-134页

作者： xuebing cao Keele Management School Keele University ST5 5BG United Kingdom

This paper investigates Chinese doctors＇ informal payment, known as red packets, with reference to the debate on organizational misbehavior, fiddles and control. It aims to examine the internal and external factors that have contributed to the emergence of red packets in health services and the strategies of hospital management in dealing with informal payment. Analysis on the data collected from two hospitals shows that doctors＇ misbehavior is influenced by health services＇ funding mechanism, payment systems and corruption. More importantly, the study demonstrates the rationality of employee fiddles and management responses. Findings indicate that doctors are mainly responsible for this fiddling, unethical and illegal activity because of the financial gains acquired from patient bribery. However, doctor misbehavior remains under management＇s latent control as long as hospital income generation and reputation are not severely threatened. The study contributes to the analysis of informal payment in the field of organizational studies and employment relations, with a fresh perspective offered to extend our understanding of red packets in the context of healthcare marketization reform.

关键词： Chinese doctors informal pay misbehavior fiddle control

Minocycline protects the apoptosis of PC12 cells induced by 1-methyl-4-phenylpyridinium

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Journal of Nanjing Medical University 2005年第5期19卷 247-250页

作者： Wei SHEN Shenggang SUN xuebing cao Department of Neurology the affiliated Union Hospital of Tongji Medical Collage Huazhong University of Science and Technology Wuhan 430022. China

Objective： To explore the protective effect of minocycline on the apoptosis of cellular parkinsonism models induced by MPP^＋ . Methods： Using PC12 cells as the apoptotic model of dopaminergic neurons, MC and MPP^＋ were added into the culture medium of PC12 cells, and using MTr to assay the cell viability and metabolic state; The cells apoptosis was assayed by electrophoresis method and using flow cytometry FACS to assay the apoptosis ratio. Results： Added the MPP^＋ to get the concentration of 10μmol/L, the cellular parkinsonism model of apoptosis had been prepared. The pre-treatment of MC （ 100/μmol/L） could significantly increase the PC12 cell viability. The apoptosis ratio of MC＋MPP^＋ group was significantly lower than that of MPP^＋ group, but was still significantly higher than that of control group. Conclusion： MC may protect the cell apoptosis induced by MPP^＋ to some extent.

关键词： minocycline PC12 cell apoptosis parkinson disease 1-methyl-4-mhenylpyridinium

Study on the effects of thrombin on AQP4 mRNA and AQP4 protein expression in rat primary astrocytes

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Journal of Nanjing Medical University 2006年第4期20卷 220-224页

作者： Jinghua Zhou xuebing cao Shenggang Sun Department of Neurology Union Hospital Tongii Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective： To study the biologic effects of various concentrations of thrombin on aquaporin 4 （AQP4） expression in rat primary cultured astrocytes, and to explore the regulation mechanism of transmembrane water transportation in astrocytes after intracerebral hemorrhage （ICH）. Methods： Primary cultured astrocytes were incubated in culture mediums containing various concentrations of thrombin for 24 h and harvested. AQP4 mRNA and AQP4 protein expression were determined by reverse transcription polymerase chain reaction （RT-PCR） and immunohistochemical technique. Cell apoptosis was detected by TdT- mediated dUTP nick end labeling （TUNEL） technique. Cell morphology was observed by phase contrast microscope, and cell viability was assayed by MTT. Results： AQP4 mRNA and AQP4 protein showed a low expression in normal astrocytes. The expression of AQP4 mRNA and AQP4 protein significantly increased in the astrocytes treated with 100 U/ml or 200 U/ml thrombin （P 〈 0.01 ）,and these astrocytes swelled. The number of TUNEL positive cells significantly increased. On the other hand, AQP4 mRNA and AQP4 protein expression were downegulated in the astrocytes treated with 0.5 U/ml or 1 U/ml thrombin （P 〈 0.05）, and the cell morphology did not change. Few TUNEL positive cells were observed. Conclusion： AQP4 overxpression induced by high concentrations of thrombin causes an increased permeability of water in astrocytic membrane. On the contrary, the decreased AQP4 expression prevents the astrocytes from swelling and apoptosis.

关键词： thrombin astrocytes aquaporin-4 apoptosis

Effect and mechanism of homocysteine on Parkinson's disease induced by 6-OHDA

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Journal of Nanjing Medical University 2008年第1期22卷 12-17页

作者： Hongxia Xing Hai Peng xuebing cao Shenggang Sun Department of Neurology The First Hospital of Xinxiang Medical College Xinxiang 453100 Henan Province China Department of Neurology Xiehe Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China

Objective： To study the effects and mechanism of homocysteine（Hcy） on Parkinson＇ s disease（PD） induced by 6-hydroxydopamine （6-OHDA） in vivo. Methods：Forty rats were divided into 4 groups. 6-OHDA or the solvent of 6-OHDA was focally administrated to induce PD, 2 h later Hcy or 0.9% sodium chloride was administrated in the ipsolateral substantial nigra（SN）. We Used behavioral testing, Immolunohistochemical techniques, biochemistry techniques to detect the injury of SN. Results：The rotary turns of PD rats induced by 6-OHDA showed significant increase after treatment with Hcy compared with the controls（P 〈 0.05）. Also the numbers of tyrosine hydroxylase（TH）-stained neurons were decreased, and dendrites were fragmented and truncated. Free radicals were increased and antioxidaat enzymes decreased. Conclusion：Focal infusion of Hcy into the SN increased the vulnerability of the doparninergic neurons to 6-OHDA-induced degeneration, it seems that the endangering effect of Hcy is due to exacerbating oxidative stress.

关键词： Parkinson's disease 6-hydroxydopamine homocysteine tyrosine hydroxylase

The gut-brain axis in the pathogenesis of Parkinson’s disease

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Brain Science Advances 2019年第2期5卷 73-81页

作者： Lanxia Meng Xin Yuan xuebing cao Zhentao Zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Neurology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Parkinson’s disease(PD)is the second most common neurodegenerative *** pathological markers include Lewy bodies and Lewy neuritis,which primarily affect the substantia ***,in recent years,mounting evidence suggests that PD is a multifocal neurodegenerative process that influences several neuronal structures aside from the substantia nigra,one of which is the enteric nervous *** clinical studies have reported that patients with PD experience gastrointestinal dysfunction for many years before the onset of motor *** evidence indicates thatα-synuclein deposition may start in the enteric nervous system and then propagate to the central nervous *** gut-brain axis plays an important role in PD *** evidence suggests that these interactions may be primarily affected by the intestinal *** this review,the authors discuss recent research,and illustrate how changes in the composition of the gut microbiota may trigger inflammation,thus contributing to neurodegeneration in PD.

关键词： Parkinson’s disease α-synuclein gut microbiota gut-brain axis inflammation