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视神经脊髓炎谱系疾病患者睡眠质量的研究进展

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中国实用神经疾病杂志 2024年第5期27卷 639-642页

作者：刘艳萍张学兵杨陈冯金洲重庆医科大学附属第一医院重庆400016 重庆医科大学附属儿童医院重庆400014

视神经脊髓炎谱系疾病是一种罕见的自身免疫性疾病,会导致中枢神经系统严重炎症,主要影响视神经和脊髓,不仅会造成身体功能的损害,也会带来心理、疲劳等一系列问题。睡眠障碍在视神经脊髓炎谱系疾病患者中普遍存在,与其他临床症状共同出... 详细信息

视神经脊髓炎谱系疾病是一种罕见的自身免疫性疾病,会导致中枢神经系统严重炎症,主要影响视神经和脊髓,不仅会造成身体功能的损害,也会带来心理、疲劳等一系列问题。睡眠障碍在视神经脊髓炎谱系疾病患者中普遍存在,与其他临床症状共同出现,相互影响,严重影响患者的预后及身心健康。越来越多的学者进行了相关的研究。本文对视神经脊髓炎谱系疾病患者睡眠障碍的评估工具、影响因素等进行综述,以期为早期识别视神经脊髓炎谱系疾病患者睡眠障碍并开展相关干预提供参考。

关键词：视神经脊髓炎谱系疾病睡眠质量影响因素评估工具

Multi-omics analysis reveals RNA splicing alterations and their biological and clinical implications in lung adenocarcinoma

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3551-3566页

作者： Quanyou Wu Lin feng Yaru Wang Yousheng Mao xuebing Di Kaitai Zhang Shujun Cheng Ting Xiao State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBejing 100021China Department of Thoracic Surgery National Cancer Center/National Clinical Research Centerfor Cancer/CancerHospitalChinese Academyof Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Alternative RNA splicing is one of the most important mechanisms of posttranscriptional gene regulation,which contributes to protein diversity in *** is well known that RNA splicing dysregulation is a critical mechanism in tumor pathogenesis and the rationale for the promising splice-switching therapeutics for cancer *** we have a comprehensive understanding of DNA mutations,abnormal gene expression profiles,epigenomics,and proteomics in lung adenocarcinoma(LUAD),little is known about its aberrant alternative splicing ***,based on the multi-omics data generated from over 1000 samples,we systematically studied the RNA splicing alterations in LUAD and revealed their biological and clinical *** identifed 3688 aberrant alternative splicing events(AASEs)in LUAD,most of which were alternative promoter and exon *** specific regulatory roles of RNA binding proteins,somatic mutations,and DNA methylations on AASEs were comprehensively *** dissected the functional implications of AASEs and concluded that AASEs mainly affected biological processes related to tumor proliferation and *** also found that one subtype of LUAD with a particular AASEs pattern was immunogenic and had a better prognosis and response rate to *** findings revealed novel events related to tumorigenesis and tumor immune microenvironment and laid the foundation for the development of splice-switching therapies forLUAD.

关键词： alterations adenocarcinoma clinical

A Comparative Study of Charging Voltage Curve Analysis and State of Health Estimation of Lithium-ion Batteries in Electric Vehicle

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Automotive Innovation 2019年第4期2卷 263-275页

作者： xuebing Han Xuning feng Minggao Ouyang Languang Lu Jianqiu Li Yuejiu Zheng Zhe Li School of Vehicle and Mobility State Key Laboratory of Automotive Safety and EnergyTsinghua UniversityBeijing 100084China College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Lithium-ion(Li-ion)cells degrade after repeated cycling and the cell capacity fades while its resistance ***-dation of Li-ion cells is caused by a variety of physical and chemical mechanisms and it is strongly influenced by factors including the electrode materials used,the working conditions and the battery *** present,charging voltage curve analysis methods are widely used in studies of battery characteristics and the constant current charging voltage curves can be used to analyze battery aging mechanisms and estimate a battery’s state of health(SOH)via methods such as incremental capacity(IC)*** this paper,a method to fit and analyze the charging voltage curve based on a neural network is proposed and is compared to the existing point counting method and the polynomial curve fitting *** neuron parameters of the trained neural network model are used to analyze the battery capacity relative to the phase change reactions that occur inside the *** method is suitable for different types of batteries and could be used in battery management systems for online battery modeling,analysis and diagnosis.

关键词： Lithium-ion battery Capacity fade Charging voltage curve Neural networks Electric vehicle

In-depth investigation of the exothermic reactions between lithiated graphite and electrolyte in lithium-ion battery

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Journal of Energy Chemistry 2022年第6期31卷 593-600,I0017页

作者： Yuejiu Zheng Zhihe Shi Dongsheng Ren Jie Chen Xiang Liu Xuning feng Li Wang xuebing Han Languang Lu Xiangming He Minggao Ouyang College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China College of Electrical Engineering University of Beijing JiaotongBeijing 100044China

Thermal runaway is a critical issue for the large application of lithium-ion *** reactions between lithiated graphite and electrolyte play a crucial role in the thermal runaway of lithium-ion ***,the role of each component in the electrolyte during the exothermic reactions with lithiated graphite has not been fully *** this paper,the exothermic reactions between lithiated graphite and electrolyte of lithium-ion battery are investigated through differential scanning calorimetry(DSC) and evolved gas *** lithiated graphite in the presence of electrolyte exhibit three exothermic peaks during DSC *** reactions between lithiated graphite and LiPF_(6) and ethylene carbonate are found to be responsible for the first two exothermic peaks,while the third exothermic peak is attributed to the reaction between lithiated graphite and *** contrast,diethylene carbonate and ethyl methyl carbonate contribute little to the total heat generation of graphite-electrolyte *** reaction mechanism between lithiated graphite and electrolyte,including the major reaction equations and gas products,are ***,DSC tests on samples with various amounts of electrolyte are performed to clarify the quantitative relationship between lithiated graphite and electrolyte during the exothermic reactions.2.5 mg of lithiated graphite (Li_(0.8627)C_(6)) can fully react with around 7.2 mg electrolyte,releasing a heat generation of 2491 J g^(-1).The results presented in this study can provide useful guidance for the safety improvement of lithium-ion batteries.

关键词： Lithium-ion battery Battery safety Thermal runaway Exothermic reaction Li-intercalated graphite Electrolyte

下颌骨外板矢状劈开自体骨充填术矫正半侧颜面短小

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中华整形外科杂志 2024年第3期40卷 249-257页

作者：归来牛峰俞冰刘剑锋陈莹付茜徐史兴乔嘉靳琦贺宇梁雪冰崔蕾陈甫寰陈琪中国医学科学院北京协和医学院整形外科医院颅颌面外科北京100144

目的探讨采用矢状劈开患侧下颌骨外板并植入健侧切取的下颌骨外板修复重建半侧颜面短小的新方法。方法回顾性分析2006年3月至2023年3月,中国医学科学院整形外科医院颅颌面外科收治的半侧颜面短小患者临床资料。术前根据临床表现和影像... 详细信息

目的探讨采用矢状劈开患侧下颌骨外板并植入健侧切取的下颌骨外板修复重建半侧颜面短小的新方法。方法回顾性分析2006年3月至2023年3月,中国医学科学院整形外科医院颅颌面外科收治的半侧颜面短小患者临床资料。术前根据临床表现和影像学检查结果进行诊断和手术设计。所有病例均在全身麻醉下完成手术。经口内入路将患侧下颌骨外板劈开,然后根据术前设计采取健侧适当形态和大小的下颌骨外板植入劈开的骨间隙并采用钛合金小夹板予以坚强内固定。术后随访患者的并发症发生、面部形态改善情况及患者对手术效果满意度,满意度评分为1~5分,分数越高表示越满意。在术前、术后即刻和术后远期(末次)随访时拍摄照片并分析畸形严重程度。将患者术前、术后即刻、术后远期随访CT数据以Dicom格式导入Surgicase Proplan医学三维图像工作站后,利用Segmentation功能重建下颌骨,测量术前、术后即刻和术后远期随访的下颌骨厚度,对其测量值比较采用重复测量方差分析,多重比较采用LSD检验;用多样本Kruskal-Wallis秩和检验对畸形矫正外观满意度评分进行统计分析,以P0.05)。结论下颌骨外板矢状劈开符合下颌骨解剖学特点并为自体骨的植入和愈合提供了良好条件。健侧下颌骨外板的切取,在充填患侧增加厚度的同时,缩小健侧下颌角区厚度,从而有效矫正下颌骨不对称畸形。该方法操作简单,并发症少,效果良好,是矫正半侧颜面短小的理想治疗手段之一。

关键词：下颌骨颜面发育不全下颌骨重建骨移植骨生成下颌骨外板下颌骨外板矢状劈开半侧颜面短小

自动电位滴定仪与化学滴定法测试硝酸铁含量的比较

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云南化工 2023年第4期50卷 58-60页

作者：孙在优王若泽方春华杨沙沙朱兴雄冯学兵田玥陈煜曲靖市麟铁科技有限公司云南曲靖655000

利用自动电位滴定仪与化学滴定法检测了硝酸铁含量,探究了自动电位滴定仪测试硝酸铁方法的可行性。自动电位滴定仪测试法主要利用滴定过程中指示电极电位的变化来判断终点,方便简洁,但稳定性稍差;而常用的化学滴定使用EDTA标准溶液手工... 详细信息

利用自动电位滴定仪与化学滴定法检测了硝酸铁含量,探究了自动电位滴定仪测试硝酸铁方法的可行性。自动电位滴定仪测试法主要利用滴定过程中指示电极电位的变化来判断终点,方便简洁,但稳定性稍差;而常用的化学滴定使用EDTA标准溶液手工滴定硝酸铁溶液到指示终点并计算其含量,测试结果稳定准确,但显色不明显,对滴定人员要求较高。该研究结果显示,自动电位滴定法与化学滴定法测试数据具有良好的一致性,批量性测试可减少人工操作误差。

关键词：自动电位滴定仪 EDTA标准溶液光度电极回收率化学滴定

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空间自由曲面砌体拱壳的结构设计与试验研究

建筑结构 2024年第7期54卷 78-84页

作者：刘博伟陈剑峰杨越来武清郑良平赵雪冰封竺汐孔德坤中机中联工程有限公司重庆400039

目前我国在薄壳砌体结构设计方面并无相应的指导标准,薄壳砌体结构的相关案例也较少,设计时无相应参考。重庆市黄桷坪涂鸦街美术廊为一个自由曲面壳体结构,为满足视觉要求,采用砖砌拱壳结构形式,为目前国内跨度最大的自由曲面无筋砌体... 详细信息

目前我国在薄壳砌体结构设计方面并无相应的指导标准,薄壳砌体结构的相关案例也较少,设计时无相应参考。重庆市黄桷坪涂鸦街美术廊为一个自由曲面壳体结构,为满足视觉要求,采用砖砌拱壳结构形式,为目前国内跨度最大的自由曲面无筋砌体拱壳结构,壳体采用多孔陶土砖和高延性混凝土砌筑。采用数值分析、材料试验、足尺荷载试验的方法,从结构的形态确立、材料试验、砌筑方式、静力分析、稳定性分析和足尺荷载试验等方面,全面介绍了项目中的关键问题。结果表明,本工程采用无筋砖砌拱壳结构是可行的,为后续类似工程提供了案例参考和设计思路。

关键词：自由曲面砌体拱壳结构找形静力分析稳定分析足尺荷载试验

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狼疮肾炎患者的临床特点及预后分析

中华医学杂志 2014年第13期94卷 973-976页

作者：任义乐冯学兵邹耀红潘文友王向党潘解萍张缪佳陶娟张育谭魁麟李晶丁翔钱先达展云王美美陈志伟孙凌云南京医科大学鼓楼临床学院风湿免疫科 210008 江苏省无锡市人民医院风湿免疫科江苏省淮安市第一人民医院免疫风湿科江苏省徐州市第四人民医院风湿免疫科江苏省常州市第一人民医院免疫风湿科南京医科大学第一附属医院风湿免疫科江苏省无锡市中医院风湿科江苏省苏北人民医院血液风湿科江苏省镇江市第一人民医院风湿免疫科江苏大学附属医院风湿科南京医科大学连云港临床学院风湿免疫科江苏省中医院风湿免疫科南通大学附属医院风湿免疫科东南大学附属中大医院风湿免疫科苏州大学附属第一医院风湿科

目的分析系统性红斑狼疮（SLE）狼疮肾炎患者的临床特点及预后因素.方法收集1999至2012年江苏省15所医院共2 078例SLE患者首次住院临床资料,将其分为狼疮肾炎组与非狼疮肾炎组,差异统计学意义比较采用秩和U检验、x2检验,应用Cox回归... 详细信息

目的分析系统性红斑狼疮（SLE）狼疮肾炎患者的临床特点及预后因素.方法收集1999至2012年江苏省15所医院共2 078例SLE患者首次住院临床资料,将其分为狼疮肾炎组与非狼疮肾炎组,差异统计学意义比较采用秩和U检验、x2检验,应用Cox回归分析影响预后的相关因素.结果（1）狼疮肾炎组883例（42.5％）,其平均发病年龄明显低于非狼疮肾炎组[（30±11）岁比（32±12）岁,P＜0.01].（2）狼疮肾炎组心肺受累、神经精神受累、胃肠受累、血液受累、眼部受累、入院时SLEDAI评分＞9分及出院时SLEDAI评分＞9分的发生率明显高于非狼疮肾炎组（31.5％、7.9％、13.9％、69.0％、1.5％、77.4％及29.8％比18.8％、5.1％、6.8％、63.1％、0.3％、43.1％及8.1％,均P＜0.01）.（3）狼疮肾炎组首次住院后1、5年死亡率明显高于非狼疮肾炎组（7.2％、15.0％比3.1％、6.3％,均P＜0.01）.（4）狼疮肾炎组患者死亡的危险因素是神经精神受累（HR 2.46）、出院时SLEDAI评分＞9分（HR2.34）、血肌酐升高（HR2.21）及丙氨酸转氨酶和（或）天冬氨酸转氨酶升高（HR2.09）,保护因素是糖皮质激素治疗（HR0.18）.结论狼疮肾炎是年轻早期SLE患者的常见并发症,且易同时并发其他重要器官受累,病情活动度高、治疗困难,尤其在神经精神受累、血肌酐升高或转氨酶升高时预后更差,糖皮质激素治疗有助于改善狼疮肾炎预后.

关键词：狼疮肾炎临床特点预后

Hydrogenation of Alkenes Catalyzed by Rare-Earth Metal Phosphinophosphinidene Complexes:1,2-Addition/Elimination Versusσ-Bond Metathesis Mechanism

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CCS Chemistry 2022年第10期4卷 3309-3318页

作者： Bin feng Hao-Yu Zhang Hongling Qin Qian Peng xuebing Leng Yaofeng Chen State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200032 State Key Laboratory of Elemento-Organic Chemistry and Frontiers Science Center for New Organic Matter College of ChemistryNankai UniversityTianjin 300071

Rare-earth metal complexes have been used as catalysts for many types of ***,the mechanistic studies showed that basically,these various reactions proceeded withσ-bond metathesis of RE–E bond(RE:rare-earth metals;E:main group elements)or RE ions acting as Lewis acid centers to activate the polar functional groups of the *** this article,a lutetium phosphinophosphinidene complex,with Lu=P double-bond character,was synthesized and structurally characterized.

关键词： rare-earthmetal phosphinidene alkene hydrogenation reaction mechanism density functional theory calculations