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肠镜下支架置入联合腹腔镜手术治疗结直肠癌并肠梗阻的临床效果

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中华医学杂志 2024年第28期104卷 2637-2641页

作者：谷军保杨惠鲍学斌马钊古朝阳河南省人民医院胃肠外科郑州河南省人民医院消化内科郑州

探讨肠镜下支架置入联合腹腔镜手术治疗结直肠癌并肠梗阻患者临床效果。回顾性分析2019年11月至2020年10月在河南省人民医院胃肠外科行开腹手术+术中肠腔冲洗治疗(46例, 传统组)、肠镜下支架置入+开腹手术(42例, 支架开腹组)、肠镜下支... 详细信息

探讨肠镜下支架置入联合腹腔镜手术治疗结直肠癌并肠梗阻患者临床效果。回顾性分析2019年11月至2020年10月在河南省人民医院胃肠外科行开腹手术+术中肠腔冲洗治疗(46例, 传统组)、肠镜下支架置入+开腹手术(42例, 支架开腹组)、肠镜下支架置入+腹腔镜手术(41例, 支架腹腔镜组)治疗结直肠癌并肠梗阻患者病例资料, 比较3组患者围手术期情况、生化指标、外周血癌胚抗原(CEA)、糖类抗原199(CA199)水平和预后。结果显示, 3组患者中, 支架腹腔镜组手术时间[(203.6±30.5)min]较长, 术后排气时间[(1.2±0.3)d]、住院时间[(10.5±2.1)d]较短, 术中出血量[(102.5±22.3)ml]较少(均Png/L;均P<0.05]。术后3个月时, 与术前相比, 3组血清CEA、CA199水平降低;3组患者中, 血清CEA、CA199水平比较差异均无统计学意义。随访3年内, 3组术后复发率、术后转移发生率比较差异均无统计学意义。本研究表明, 肠镜下支架置入联合腹腔镜手术在降低术中出血量、加快患者术后排气功能恢复、缓解患者手术应激和降低术后并发症发生率方面更具优势, 能降低患者术后血清CEA、CA199水平。

关键词：结直肠肿瘤肠梗阻支架置入腹腔镜手术癌胚抗原糖类抗原199

Arc corrosion behavior of Cu-Ti_3AlC_2 composites in air atmosphere

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Science China(Technological Sciences) 2018年第4期61卷 551-557页

作者： HUAng XiaoChen FEng Yi QIAN Gang ZHAO Hao SOng ZhaoKun ZHAng JingCheng ZHAng xuebin School of Materials Science and Engineering Hefei University of TechnologyHefei 230009China Instrumental Analysis Center Hefei University of TechnologyHefei 230009China

The arc corrosion evolution of Cu-20 vol.% Ti_3 AlC_2 cathodes is presented here. After eroded by 3, 4, 5, 6, 7, 8, 9, 10 kV DC voltage, respectively, the surface morphologies were characterized by field emission scanning electron microscope with craters and protrusions. Compared to small craters and dense protrusions of the morphology by high voltage, the eroded surface was covered with bigger craters and sparse protrusions at low voltage. No crack was discovered on the surface even at 10 kV. By means of energy dispersive spectroscopy and Raman spectroscopy, the decomposition of Cu-20 vol.% Ti_3 AlC_2 cathode to CuO,Al__2 O_3 and TiO_2 were proved. Meanwhile, w anode is oxidized to wO_2. The peak current increases with the increasing breakdown voltage, which is recorded by a digital memory oscilloscope.

关键词： Cu-Ti_3AlC_2 arc erosion FE-SEM Raman spectroscopy

FGF−21、IMA、MCP−1与急性心肌梗死患者预后的关系

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山东第一医科大学（山东省医学科学院）学报 2024年第2期45卷 78-82页

作者：马宗仑汪凤兰陈雪斌史周乾濮阳市人民医院心血管内科河南濮阳457000

目的研究成纤维细胞生长因子-21 (fibroblast growth factor 21,FGF-21)、缺血修饰白蛋白(ischemia modified albumin,IMA)、单核细胞趋化蛋白-1 (monocyte chemotactic protein-1,MCP-1)与急性心肌梗死(acute myocardial Infarction,AMI)患者预后的关系。方法选择本院2017年5月-2020年7月诊治的110例AMI患者,根据患者预后情况分为预后不良组和预后良好组,收集患者临床资料,分析其血清FGF-21、IMA、MCP-1水平与AMI患者预后的关系以及诊断主要不良心血管事件(major adverse cardiovascular event,MACE)发生的效能。结果预后良好组患者血清FGF-21、IMA、MCP-1水平低于预后不良组,差异有统计学意义(P150.12 ng/L、IMA> 75.78 U/mL、MCP-1> 49.67 pg/mL、肌酸激酶-同工酶(CK-MB)> 35 U/L以及心肌肌钙蛋白Ⅰ(cTnⅠ)> 75.78 U/mL均是影响AMI患者预后不良的独立危险因素(P<0.05)。结论血清FGF-21、IMA、MCP-1水平均可较好地预测AMI患者预后不良的发生,且三者联合预测效能更高,同时血清FGF-21、IMA、MCP-1水平增高与MACE的发生密切相关,是AMI患者预后不良的危险因素。

关键词：成纤维细胞生长因子‐21 缺血修饰白蛋白单核细胞趋化蛋白‐1 急性心肌梗死预后

Numerical study on the fracturing mechanism of shock wave interactions between two adjacent blast holes in deep rock blasting

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Earthquake Engineering and Engineering Vibration 2019年第4期18卷 735-746页

作者： Yuan wei Liu Shangge w.ng wei Su xuebin Li Zonghong Li Jiaxin wen Lei Chang Jiangfang Sun Xiaoyun School of Civil Engineering Shijiazhuang Tiedao University Shijiazhuang 050043 China Hebei Technology and Innovation Center on Safe and Effi cient Mining of Metal Mines Shijiazhuang 050043 China CCCC Second Highway Consultants Co. Ltd. Wuhan 430056 China China National Uranium Co. Ltd. Beijing 100013 China

with the application of electronic detonators, millisecond blasting is regarded as a signifi cant promising approach to improve the rock fragmentation in deep rock blasting. Thus, it is necessary to investigate the fracturing mechanisms of short-delay blasting. In this work, a rectangle model with two circle boreholes is modeled as a particles assembly based on the discrete element method to simulate the shock wave interactions induced by millisecond blasting. The rectangle model has a size of 12 × 6 m (L × w) and two blast holes have the same diameter of 12 cm. The shock waves are simplifi ed as time-varying forces applied at the particles of walls of the two boreholes. Among a series of numerical tests in this study, the spacing between two adjacent boreholes and delay time of millisecond blasting are considered as two primary variables, and the decoupling charge with a coeffi cient of 1.5 is taken into account in each case. The results show that stress superposition is not a key factor for improving rock fragmentation (tensile stress interactions rather than compressive stress superposition could aff ect the generation of cracks), whereas collision actions from isolated particles or particles with weakened constraints play a crucial role in creating the fracture network. The delay time has an infl uence on causing cracks in rock blasting, however, whether it works heavily depends on the distance between the two holes.

关键词： rock fragmentation millisecond blasting shock wave decoupling charge discrete element method

Ion diffusion,and hysteresis of magnesium hydride conversion electrode materials

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Journal of Materials Science & Technology 2023年第24期155卷 47-53页

作者： Yingtong Lv Xiang Zhang wei Chen Shunlong Ju Zhenhua Liu Guanglin Xia Takayuki Ichikawa Tengfei Zhang xuebin Yu Centre for Hydrogenergy College of Materials Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Department of Materials Science Fudan University Shanghai 200433 China Graduate School of Engineering Hiroshima University 739-8530 Higashi Hiroshima Japan

MgH_(2),ow.ng to a high theoretical capacity of 2038 mAh g^(−1),is regarded as a promising anode material for lithium-ion batteries(LIBs).However,the application of MgH_(2) is still far from satisfactory due to its poor cycling ***,nano-crystallization of MgH_(2) as an anode is applied for all-solid-state lithium-ion batteries(ASSLIBs)using LiBH4 as a solid-state *** self-assembly designed MgH_(2) electrode on graphene could effectively alleviate the volume expansion,prevent the agglomeration of active substances,improve the electron transfer,and enhance the electrochemical performance of the anode *** a result,a reversible capacity of 1214 mAh g^(−1) after 50 cycles is *** enhanced cycle life with a notable capacity of 597 mAh g^(−1) at a current density of 400 mA g^(−1) is delivered after 200 *** investigation on full cells also exhibits great application potential on ASSLIBs.

关键词： Magnesium hydride Lithium borohydrides Graphene Nano-crystallization All-solid-state lithium-ion battery

Reservoir formation conditions and key exploration & development technoloiges in the Yingdong Oilfield in western Qaidam Basin

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Petroleum Research 2018年第2期3卷 132-151页

作者： Dade Ma Yan Chen Xiaomin Xia xuebin wei Yanxiong wu Li Yuan Liu He PetroChina Qinghai Oilfield Company Gansu736202China Sinopec Chongqing Fuling Shale Gas Exploration and Development Co. Ltd.Chongqing408000China

Located in east part of Yingxiongling structural belt in the Qaidam Basin,the Yingdong oilfield has a extremely complicated ground *** to no significant discovery,this oilfield was considered to have no favorable geologic conditions for formation of oil or gas *** the past few years,with continuous improvement in the mountain 3D seismic surveys and logging data interpretation,some breakthroughs were obtained in 2010,and the Yingdong oilfield,the largest-scale reserves of a single reservoir with highest organic matter abundance,most favorable physical property and optimal development efficiencies in the Qaidam Basin,had been discovered,the production capacity was up to 0.55×10^(6) *** detailed analyses of the Yingdong oilfield,some studies,such as hydrocarbon accumulation conditions and technical challenges,are carried out,and follow.ng conclusions can be *** Yingxiongling area is located in Mangya hydrocarbon-generation sag in the west part of the Qaidam Basin,its oil sources are rich;the Neogene Xiayoushashan Formation and Shangyoushashan Formation are dominated by wide and gentle delta frontdshore-shallow lacustrine sediments with interbeds of sandstone and mudstone,the sandbodies are widely distributed with favorable physical condition,and the mudstone is the key caprock,combined with high-quality Paleogene hydrocarbon source rocks,a complete source-reservoir-cap assemblage can be ***-scale detachment faults of the Yingdong area connect high-quality Paleogene hydrocarbon source rocks with middle-shallow buried structural traps,thus,reservoirs formed in the early stage are modified,and at the same time,hydrocarbons formed in the later stage continue to migrate and accumulate;in this way,the deep and shallow faults form a relay-style hydrocarbon transport system,and hydrocarbons are accumulated in the shallow structural traps in the later stage;in this area,the middle-shallow faults have good lateral plugging performance w

关键词： Neotectonic movement Structural traps Faulted block Complex mountain areas High-efficiency development Xiayoushashan Formation and Shangyoushashan Formation Yingdong oilfield Qaidam basin

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宽分布聚乙烯管材树脂结构与性能差异性

塑料工业 2024年第5期52卷 124-128,168页

作者：郎学彬武志鹏唐文睿马雄韩向艳王长全钱建华胡跃鑫辽宁石油化工大学石油化工学院辽宁抚顺113001 抚顺石化公司烯烃厂辽宁抚顺113004

本文采用高温凝胶渗透色谱(GPC)、差示扫描量热仪(DSC)、万能拉伸试验机、冲击试验机和动态力学分析仪(DMA)等研究了Hostalen(两釜串联)和Hostalen ACP(三釜串联)淤浆聚合工艺制备的宽分布聚乙烯管材树脂GC1和GC2结构与性能的差异性。... 详细信息

本文采用高温凝胶渗透色谱(GPC)、差示扫描量热仪(DSC)、万能拉伸试验机、冲击试验机和动态力学分析仪(DMA)等研究了Hostalen(两釜串联)和Hostalen ACP(三釜串联)淤浆聚合工艺制备的宽分布聚乙烯管材树脂GC1和GC2结构与性能的差异性。结果表明,三釜串联生产的GC2平均分子量更大,分子量分布更宽,高分子量级分(重均分子量M_(w)>10^(6))相对含量更高且共聚单体的含量更高。同时,GC2还具有更高的拉伸强度和冲击强度,耐蠕变性能更优异,高剪切速率下具有更好的加工流动性。

关键词：聚乙烯管材树脂淤浆聚合工艺力学性能

Conditional Deletion of Foxg1 Alleviates Demyelination and Facilitates Remyelination via the wnt Signaling Pathway in Cuprizone-Induced Demyelinated Mice

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Neuroscience Bulletin 2021年第1期37卷 15-30页

作者： Fuxing Dong Dajin Liu Feiyu Jiang Yaping Liu Xiuxiang wu xuebin Qu Jing Liu Yan Chen Hongbin Fan Ruiqin Yao Department of Cell Biology and Neurobiology Xuzhou Key Laboratory of NeurobiologyJiangsu Key Laboratory of New Drug Research and Clinical PharmacyXuzhou Medical UniversityXuzhou 221004China Public Experimental Research Center Xuzhou Medical UniversityXuzhou 221004China Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221006China

The massive loss of oligodendrocytes caused by various pathological factors is a basic feature of many demyelinating diseases of the central nervous system(CNS). Based on a variety of studies, it is now well established that impairment of oligodendrocyte precursor cells(OPCs) to differentiate and remyelinate axons is a vital event in the failed treatment of demyelinating diseases. Recent evidence suggests that Foxg1 is essential for the proliferation of certain precursors and inhibits premature neurogenesis during brain development. To date, very little attention has been paid to the role of Foxg1 in the proliferation and differentiation of OPCs in demyelinating diseases of the CNS. Here, for the first time, we examined the effects of Foxg1 on demyelination and remyelination in the brain using a cuprizone(CPZ)-induced mouse model. In this work, 7-week-old Foxg1 conditional knockout and wild-type(wT) mice were fed a diet containing 0.2% CPZ w/w for 5 weeks, after which CPZ was withdrawn to enable remyelination. Our results demonstrated that, compared with wT mice, Foxg1-knockout mice exhibited not only alleviated demyelination but also accelerated remyelination of the demyelinated corpus callosum. Furthermore, we found that Foxg1 knockout decreased the proliferation of OPCs and accelerated their differentiation into mature oligodendrocytes both in vivo and in vitro. wnt signaling plays a critical role in development and in a variety of diseases. GSK-3 b, a key regulatory kinase in the wnt pathway, regulates the ability of b-catenin to enter nuclei, where it activates the expression of wnt target genes. we then used SB216763,a selective inhibitor of GSK-3 b activity, to further demonstrate the regulatory mechanism by which Foxg1 affects OPCs in vitro. The results showed that SB216763 clearly inhibited the expression of GSK-3 b, which abolished the effect of the proliferation and differentiation of OPCs caused by the knockdown of Foxg1. These results suggest that Foxg1

关键词： Foxg1 Oligodendrocyte precursor cells Demyelination Remyelination wnt

Ti-6Al-4V绝热剪切带的厚度及应变率效应研究

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稀有金属材料与工程 2009年第2期38卷 214-218页

作者：王学滨辽宁工程技术大学辽宁阜新123000

通过引入与Batra及Kim类似的论点,将绝热剪切带宽度定义为绝热剪切带的中心区域的宽度(w5%),在该区域上温度比其峰值小5%,利用Johnson-Cook模型及梯度塑性理论分析Ti-6Al-4V绝热剪切带的厚度及应变率的影响。计算表明,在名义应变率的下... 详细信息

通过引入与Batra及Kim类似的论点,将绝热剪切带宽度定义为绝热剪切带的中心区域的宽度(w5%),在该区域上温度比其峰值小5%,利用Johnson-Cook模型及梯度塑性理论分析Ti-6Al-4V绝热剪切带的厚度及应变率的影响。计算表明,在名义应变率的下限(800s-1)及上限(1400s-1)之间,当绝热剪切带的总厚度选取为0.3235及0.0705mm时,计算结果非常接近于绝热剪切带宽度的上限(55μm)及下限(12μm)。当应变率较低时,绝热剪切带较宽。随着应变率的增加,绝热剪切带宽度快速降低。在高应变率时,绝热剪切带宽度基本保持恒定。该理论结果与Dodd及Bai的理论结果有类似之处,与weerasooriya及Beaulieu针对钨合金的实验结果非常一致,与Klepaczko及Rezaig的数值结果的前半部分相似。

关键词： Ti-6Al-4V 绝热剪切带应变率梯度塑性理论 Johnson—Cook模型