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The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

Chemical characteristics and sources apportionment of volatile organic compounds in the primary urban area of Shijiazhuang,North China Plain

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Journal of environmental Sciences 2025年第3期149卷 465-475页

作者： Xiao Zhang Junfeng Wang Jiangwei zhao Junliang He Yali Lei Kai Meng RuiWei xue Zhang Miaomiao Zhang Shuangying Ni eleonora Aruffo College of geographical sciences and environment Shijiazhuang UniversityShijiazhuang 050035China Jiangsu Key Laboratory of Atmospheric environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China Hebei Province ecology environmental Monitoring Center Shijiazhuang 050037China Key Lab of Geographic Information Science of the Ministry of education School of Geographic SciencesEast China Normal UniversityShanghai 200241China Hebei Provincial Institute of Meteorological Sciences Shijiazhuang 050021China Key Laboratory of Meteorology and ecological environment of Hebei Province Shijiazhuang 050021China Hebei Provincial Academy of ecological environmental Science Shijiazhuang 050037China Department of Advanced Technologies in Medicine&Dentistry University“G.d’Annunzio”of Chieti-PescaraChieti 66100Italy Center for Advanced Studies and Technology-CAST Chieti 66100Italy

VOCs(Volatile organic compounds)exert a vital role in ozone and secondary organic aerosol production,necessitating investigations into their concentration,chemical characteristics,and source apportionment for the effective implementation of measures aimed at preventing and controlling atmospheric *** to October 2020,onlinemonitoringwas conducted in the main urban area of Shijiazhuang to collect data on VOCs and analyze their concentrations and ***,the PMF(positive matrix factorization)method was utilized to identify the VOCs *** indicated that the TVOCs(total VOCs)concentration was(96.7±63.4μg/m^3),with alkanes exhibiting the highest concentration of(36.1±26.4μg/m^3),followed by OVOCs(16.4±14.4μg/m^3).The key active components were alkenes and aromatics,among which xylene,propylene,toluene,propionaldehyde,acetaldehyde,ethylene,and styrene played crucial roles as reactive *** sources derived from PMF analysis encompassed vehicle emissions,solvent and coating sources,combustion sources,industrial emissions sources,as well as plant sources,the contribution of which were 37.80%,27.93%,16.57%,15.24%,and 2.46%,***,reducing vehicular exhaust emissions and encouraging neighboring industries to adopt low-volatile organic solvents and coatings should be prioritized to mitigate VOCs levels.

关键词： Volatile organic compounds Pollution characteristics Ozone formation potential OH radical loss rate Source apportionment

Density functional theory studies of Pt-based catalysts for CO oxidation

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Science China Technological Sciences 2025年第3期68卷 58-75页

作者： xue LI Yang ZOU Yongqi zhao Xiaolong LIU Tingyu ZHU CAS Key Laboratory of Green Process and engineering Institute of Process Engineering Chinese Academy of Sciences Key Laboratory of Green and High-value Utilization of Salt Lake Resources Chinese Academy of Sciences

CO is highly toxic and seriously harmful to human health, so it is meaningful to control CO emissions, especially from industrial plants. Catalytic oxidation is regarded to be an effective method for CO removal, in which Pt-based catalysts show excellent performance. Studies of catalytic CO oxidation employing Pt-based catalysts often encounter challenges such as CO poisoning, challenges in activating O2, significant temperature sensitivity, and inadequate tolerance to water and sulfur species. These experimental hurdles have been corroborated by density functional theory（DFT） computations, which model adsorption, reaction pathways, and electronic structures at catalyst surfaces. DFT analysis has elucidated the underlying mechanisms behind these limitations, laying the foundation for enhancing the efficacy of Pt-based catalysts within the scope of academic discourse. DFT has been used intensively in recent years to study the reaction mechanism and functioning characteristics of Pt-based catalysts in CO oxidation. Consequently, advancements in research on DFT experiments on Pt-based catalysts are described. This review provides a comprehensive overview and insights into the mechanism of CO adsorption on the surface of single-atom and multi-atom Pt-based catalysts, its effect on CO oxidation performance, and reaction pathways of CO oxidation in the hope of providing theoretical guidance for the structural design of most effective catalysts.

关键词： platinum catalytic oxidation carbon monoxide density functional theory

Phase equilibria of slag systems“FeO”−SiO_(2)−CaO−Al_(2)O_(3)and“FeO”−SiO_(2)−CaO−MgO at 1200℃and p(O_(2))of 10^(−7)kPa

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Transactions of Nonferrous Metals Society of China 2025年第1期35卷 338-348页

作者： Sui XIe Qin-meng WANG xue-yi GUO Chun-fa LIAO Bao-jun zhao Faculty of Materials Metallurgy and ChemistryJiangxi University of Science and TechnologyGanzhou 341000China National Rare earth Functional Material Innovation Center Ganzhou 341000China School of Metallurgy and environment Central South UniversityChangsha 410083China Sustainable Minerals Institute The University of QueenslandBrisbane 4072Australia

High-temperature experiments were carried out for the slag systems of“FeO”−SiO_(2)−CaO−Al_(2)O_(3)and“FeO”−SiO_(2)−CaO−MgO at 1200℃and p(O_(2))of 10^(−7)*** equilibrated samples were quenched,and the phase compositions were measured by electron probe microanalysis(ePMA).A series of pseudo-ternary and pseudo-binary phase diagrams are constructed to demonstrate their applications in copper smelting process and evaluation of the thermodynamic *** and tridymite are identified to be the major primary phases in the composition range related to the copper smelting *** is found that the operating window of the smelting slag is primarily determined by w_(Fe)/w_(SiO_(2))ratio in the *** MgO and Al_(2)O_(3)in the slag reduce the operating window which requires extra fluxing agent to keep the slag to be fully *** spinel solid solutions cause inaccurate predictions of the current thermodynamic database.

关键词： phase equilibrium “FeO”−SiO_(2)−CaO−Al_(2)O_(3)slag system “FeO”−SiO_(2)−CaO−MgO slag system oxygen partial pressure copper smelting slag FactSage

Impact of dietary nutrition regimens based on body composition analysis on bone metabolism in Alzheimer’s disease patients

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World Journal of Psychiatry 2025年第2期15卷 59-68页

作者： xue-Lian Wang Yi-Ran zhao Ying Yu Zhi-Fang Mao Su-Xian Tan Shan-Shan Yu Department of Clinical Nutrition The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Rehabilitation Treatment Group The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Geriatrics The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Rehabilitation Medicine The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Psychiatry The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Geriatric Psychiatry The Third Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Body composition analysis(BCA)is primarily used in the management of conditions such as obesity and endocrine ***,its potential in providing nutritional guidance for patients with Alzheimer’s disease(AD)remains relatively *** To explore the clinical efficacy of BCA-based dietary nutrition scheme on bone metabolism in AD *** This retrospective study included 96 patients with AD complicated by osteoporosis who were admitted to The Third Hospital of Quzhou between January 2023 and December *** on data from previous similar studies,the patients were randomly assigned to either a routine diet(RD)group(n=48)or a personalized nutrition(PN)group(n=48).The RD group received conventional dietary guidance,while the PN group received individualized diet intervention measures based on human *** intervention period lasted for 12 *** mineral density(BMD),body mass index(BMI),muscle mass,mineral content,osteocalcin,25-hydroxyvitamin D,procollagen type I N-terminal propeptide(PINP),beta C-terminal telopeptide of type I collagen(β-CTX),and serum calcium were measured and compared between the two groups before and 12 weeks after the *** No significant differences were observed between groups in terms of age,sex,height,BMI,or other baseline data(P>0.05).In both groups,BMI did not show significant changes after the intervention(P>0.05),whereas muscle mass and mineral content were significantly increased(Per the intervention,BMI in the PN group did not differ significantly from that of the RD group,but muscle mass and mineral content were significantly higher in the PN group(Per the intervention,a higher proportion of patients in the PN group had a T score>-1 compared to the RD group(Pe mini-mental state examination(MMSe)score was similar in both groups before the ***,12 weeks after the intervention,the MMSe score in the PN group was significantly higher than

关键词： Alzheimer’s disease Bone metabolism disorders Human body composition analysis Dietary nutrition Bone homeostasis Dietary management

Conjunctival microbiota variations in a subset of middleaged and elderly individuals from Beijing,China

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International Journal of Ophthalmology(english edition) 2025年第2期18卷 237-243页

作者： Tian-Yao zhao Yu-Chen Wang Ying-Juan Sun Jun-Yue Wang Xiao-Dan Jiang xue-Min Li Ai-Hua Deng Department of Ophthalmology Peking University Third HospitalBeijing Key Laboratory of Restoration of Damaged Ocular NerveBeijing 100191China Fangshan Hospital Beijing University of Chinese Medicine Beijing 102400China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Animal Nutrition and Feeding Ministry of Agriculture and Rural Affairs Feed Industry CentreAgricultural UniversityBeijing 100193China

AIM:To isolate and identify the conjunctival microbiota of cataract patients and analyze the associated influencing ***:This study recruited 216 participants(216 eyes)from April 2022 to July *** the condition of no antibiotic use prior to cataract surgery,sterile swabs were used to collect samples from the lower conjunctival *** cultures were then conducted,followed by species identification through 16S rDNA gene *** factors associated with positive or negative bacterial isolation rates were analyzed,including age,gender,meibomian gland dysfunction(MGD),history of hypertension,history of diabetes,history of cancer,history of infectious diseases and the habit of wearing ***:Among the 216 eyes,78 eyes yielded isolates,with an isolation rate of 36.11%,detecting a total of 122 ***-positive rods accounted for 49.18%(60 strains),gram-positive cocci accounted for 45.08%(55 strains),gram-negative bacteria accounted for 4.92%(6 strains),and fungi accounted for 0.82%(1 strain).This study found that the most abundant genera in the conjunctival sac were Corynebacterium(42.62%),Staphylococcus(31.15%),Micrococcus(9.84%),Acinetobacter(4.10%),and Bacillus(3.28%).Furthermore,age(P=0.006),gender(P=0.039),diabetes(P=0.003),history of infectious diseases(P=0.02),and duration of mask replacement(Pere important factors influencing the positive bacterial culture of the conjunctival *** hypertensive patients exhibited a higher isolation rate of conjunctival bacteria,it did not reach statistical significance,and the history of cancer did not affect the isolation rate of the conjunctival microbial community in cataract patients before ***:Potential changes are observed in the conjunctival microbiota among a sample of middleaged and elderly individuals from Beijing,***,an increased isolation rate of Corynebacterium and Micrococcus is detected,suggesting a possible change in the mic

关键词： conjunctival microbiota 16S rDNA middle-aged and elderly population mask cataract surgery

PriChain: efficient Privacy-Preserving Fine-Grained Redactable Blockchains in Decentralized Settings

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Chinese Journal of electronics 2025年第1期34卷 82-97页

作者： Hongchen Guo Weilin Gan Mingyang zhao Chuan Zhang Tong Wu Liehuang Zhu Jingfeng xue School of Computer Science and Technology Beijing Institute of Technology School of Cyberspace Science and Technology Beijing Institute of Technology School of Computer and Communication engineering University of Science and Technology Beijing

Recently, redactable blockchain has been proposed and leveraged in a wide range of real systems for its unique properties of decentralization, traceability, and transparency while ensuring controllable on-chain data redaction. However, the development of redactable blockchain is now obstructed by three limitations, which are data privacy breaches, high communication overhead, and low searching efficiency, respectively. In this paper, we propose PriChain, the first efficient privacy-preserving fine-grained redactable blockchain in decentralized settings. PriChain provides data owners with rights to control who can read and redact on-chain data while maintaining downward compatibility, ensuring the one who can redact will be able to read. Specifically, inspired by the concept of multi-authority attribute-based encryption, we utilize the isomorphism of the access control tree, realizing fine-grained redaction mechanism, downward compatibility, and collusion resistance. With the newly designed structure, PriChain can realize O（n） communication and storage overhead compared to prior O（n2） schemes. Furthermore, we integrate multiple access trees into a tree-based dictionary, optimizing searching efficiency. Theoretical analysis proves that PriChain is secure against the chosen-plaintext attack and has competitive complexity. The experimental evaluations show that PriChain realizes 10× efficiency improvement of searching and 100× lower communication and storage overhead on average compared with existing schemes.

关键词： Resistance Access control Data privacy Dictionaries Blockchains encryption Complexity theory Usability Protection

Review of rare earth oxide doping-modified laser cladding of Fe-based alloy coatings

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China Foundry 2025年第1期22卷 12-22页

作者： Han-yu Zhou Li-yao Li Yang zhao Ming-xue Shen Huo-ping zhao Ye-long Xiao Shao-peng Liu School of Materials Science and engineering East China Jiaotong UniversityNanchang 330013China

Conventional Fe-C alloy parts used in mechanical transmission and braking systems exposed to the external environment often suffer from wear and corrosion *** coating strengthening technologies have been explored to improve the surface performance and prolong service life of these *** these technologies,laser cladding has shown promise in producing Fe-based alloy coatings with superior interfacial bonding properties to the Fe-C alloy ***,the microstructure of the Fe-based alloy coating is more uniform and the grain size is finer than that of surfacing welding,thermal spraying,and plasma cladding,and the oxide film of alloying elements on the coating surface can improve the coating ***,Fe-based alloy coatings produced by laser cladding typically exhibit lower hardness,lower wear resistance,corrosion resistance,and oxidation resistance compared to coatings based on Co and Ni ***,these coatings are susceptible to defects such as pores and *** address these limitations,the incorporation of rare-earth oxides through doping in the laser cladding process has garnered significant *** approach has demonstrated substantial improvements in the microstructure and properties of Fe-based alloy *** paper reviewed recent research on the structure and properties of laser-cladded Fe-based alloy coatings doped with various rare earth oxides,including La_(2)O_(3),CeO_(2),and Y_(2)O_(3).Specifically,it discussed the effects of rare earth oxides and their concentrations on the structure,hardness,friction,wear,corrosion,and oxidation characteristics of these ***,the mechanisms by which rare earth oxides influence the coating’s structure and properties were *** review aimed to serve as a valuable reference for the application and advancement of laser cladding technology for rare earth modified Fe-based alloy coatings.

关键词： Fe-based alloys laser cladding rare-earth oxides microstructure tribological properties

Cisplatin-appended BODIPY for near infraredⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy of cancer

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Chinese Chemical Letters 2024年第3期35卷 352-357页

作者： xue.ian xing.e.pang.shaojing.zhao Tangna Pan Qiuxia Tan Benhua Wang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic ***,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were *** cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPe-PeG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,***^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,***,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of *** vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic ***,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.

关键词： Phototherapy Chemotherapy Cisplatin Bodipy NIRⅡfluorescent imaging