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MiRNA-145-5p inhibits gastric cancer progression via the serpin family e member 1-extracellular signal-regulated kinase-1/2 axis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： Hong-Xia Bai xue-Mei Qiu Chun-Hong Xu Jian-Qiang Guo Department of Gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(eMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family e member 1(SeRPINe1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SeRPINe1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SeRPINe1 and GC progression was also tested.A rescue experiment of SeRPINe1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SeRPINe1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and eMT,and these effects were reversed by forcing SeRPINe1 ***-Meier plot analysis revealed that patients with higher SeRPINe1 expression had a shorter survival rate than those with lower SeRPINe1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family e member 1 epithelial-mesenchymal transition Proliferation extracellular signal-regulated kinase-1/2

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efficient desorption and reuse of collector from the flotation concentrate:A case study of scheelite

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International Journal of Minerals,Metallurgy and Materials 2024年第11期31卷 2435-2444页

作者： Liming Tao Jianjun Wang Dejin Liao Wenkai Jia Zihan Zhao Wenfang che Zhongxu Qi Wei Sun Zhiyong Gao School of Minerals Processing and Bioengineering Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral ResourcesEngineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and UtilizationCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing BGRIMM Technology GroupBeijing 102628China Mining Technology Research Center China Tungsten and Hightech Materials Co.Ltd.Chenzhou 423000China Luoyang Luanchuan molybdenum Group Co. Ltd.Luoyang 471500China Changsha Institute of Mining Research Co. Ltd.Changsha 410012China

Flotation is the most common method to obtain concentrate through the selective adsorption of collectors on target minerals to make them hydrophobic and *** the hydrometallurgy of concentrate,collectors adsorbed on concentrate can damage ion-exchange resin and increase the chemical oxygen demand(COD)value of *** this work,we proposed a new scheme,i.e.,desorbing the collectors from concentrate in ore dressing plant and reusing them in flotation *** nitrate and benzohydroxamic acid(Pb-BHA)complex is a common collector in scheelite *** this study,different physical(stirring or ultrasonic waves)and chemical(strong acid or alkali environment)methods for facilitating the desorption of Pb-BHA collector from scheelite concentrate were ***-mineral desorption tests showed that under the condition of pulp pH 13 and ultrasonic treatment for 15 min,the highest desorption rates of Pb and BHA from the scheelite concentrate were 90.48%and 63.75%,***-of-mine ore flotation tests revealed that the reuse of desorbed Pb and BHA reduced the collector dosage by 30%for BHA and 25%for *** strong alkali environment broke the chemical bonds between Pb and *** cavitation effect of ultrasonic waves effectively reduced the interaction intensity between Pb-BHA collector and scheelite *** method combining ultrasonic waves and strong alkali environment can effectively desorb the collectors from concentrate and provide“clean”scheelite concentrate for metallurgic plants;the reuse of desorbed collector in flotation flowsheet can reduce reagent cost for ore dressing plants.

关键词： scheelite concentrate collector desorption reuse flotation

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山地旅游目的地“三生”系统耦合协调时空演化分析——以贵州省为例

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生态经济 2024年第1期40卷 111-118页

作者：李锦宏曾雪车旭航贵州大学旅游与文化产业学院贵州贵阳550025

以贵州省9个市(州)为例,构建“生产—生活—生态”系统耦合协调评价指标体系,运用加权TOPSIS法对该区三大系统的综合发展水平进行评价,再基于重心模型和耦合协调模型分析“三生”系统的时空耦合态势。结果表明:(1)研究期内,贵州省各市(... 详细信息

以贵州省9个市(州)为例,构建“生产—生活—生态”系统耦合协调评价指标体系,运用加权TOPSIS法对该区三大系统的综合发展水平进行评价,再基于重心模型和耦合协调模型分析“三生”系统的时空耦合态势。结果表明:(1)研究期内,贵州省各市(州)“三生”系统的发展水平不一致,其综合评价指数差异显著。(2)“三生”系统的重心一直位于贵阳市境内,但偏移方向有所不同;“三生”系统两两之间空间耦合性从高到低依次为“生产—生活”系统、“生活—生态”系统、“生产—生态”系统。(3)从时间上看,“三生”系统耦合协调度以波动上升和保持稳定为主,空间上呈现出以贵阳、遵义为核心的“核心—边缘”式结构特征。

关键词：山地旅游 “三生”系统重心模型时空耦合贵州省

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Machine learning for predicting fatigue properties of additively manufactured materials

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Chinese Journal of Aeronautics 2024年第4期37卷 1-22页

作者： Min YI Ming xue Peihong CONG Yang SONG Haiyang ZHANG Lingfeng WANG Liucheng ZHOU Yinghong LI Wanlin GUO State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China Institute for Frontier Science Nanjing University of Aeronautics and AstronauticsNanjing 210016China College of Aerospace engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Shenyang engine Research Institute Shenyang 110015China Liaoning Key Laboratory of Impact Dynamics on Aero engine Shenyang 110015China Science and Technology on Plasma Dynamics Laboratory Air Force Engineering UniversityXi’an 710038China

Fatigue properties of materials by Additive Manufacturing(AM) depend on many factors such as AM processing parameter, microstructure, residual stress, surface roughness, porosities, post-treatments, etc. Their evaluation inevitably requires these factors combined as many as possible, thus resulting in low efficiency and high cost. In recent years, their assessment by leveraging the power of Machine Learning(ML) has gained increasing attentions. A comprehensive overview on the state-of-the-art progress of applying ML strategies to predict fatigue properties of AM materials, as well as their dependence on AM processing and post-processing parameters such as laser power, scanning speed, layer height, hatch distance, built direction, post-heat temperature,etc., were presented. A few attempts in employing Feedforward Neural Network(FNN), Convolutional Neural Network(CNN), Adaptive Network-Based Fuzzy Inference System(ANFIS), Support Vector Machine(SVM) and Random Forest(RF) to predict fatigue life and RF to predict fatigue crack growth rate are summarized. The ML models for predicting AM materials' fatigue properties are found intrinsically similar to the commonly used ones, but are modified to involve AM features. Finally, an outlook for challenges(i.e., small dataset, multifarious features,overfitting, low interpretability, and unable extension from AM material data to structure life) and potential solutions for the ML prediction of AM materials' fatigue properties is provided.

关键词： Additive manufacturing Machine learning Fatigue life Fatigue crack growth rate Prediction

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SUB1 promotes colorectal cancer metastasis by activating NF-κB signaling via UBR5-mediated ubiquitination of UBXN1

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Science China(Life Sciences) 2024年第6期67卷 1199-1211页

作者： Hao Wang Wenwen chen Yanting Wang Yuzhen Gao Zizhen Zhang Shuyi Mi Liangjing Wang Meng xue Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Institution of Gastroenterology Zhejiang UniversityHangzhou 310058China Department of Clinical Laboratory Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

Metastasis accounts for the major cause of colorectal cancer(CRC)related mortality due to the lack of effective *** this study,we integrated the single-cell RNA-seq(sc RNA-seq)and bulk RNA-seq data and identified the transcriptional coactivator SUB1 homolog(SacSaccharomyces cerevisiae)/PC4(positive cofactor 4)associated with CRC *** SUB1 expression was correlated with advanced tumor stage and poor survival in *** vivo and vitro assays showed that SUB1 depletion could inhibit the invasive and metastatic abilities of CRC ***1 activated NF-κB signaling and its transcriptional target genes CXCL1 and CXCL3 to drive CRC ***,SUB1 integrated with the e3 ubiquitin-protein ligase UBR5 and increased its protein level in CRC ***,the increased UBR5mainly mediated Lys11-linked polyubiquitination and degradation of NF-κB negative regulator UBXN1,thus to activate the NF-κB ***,our study demonstrated that SUB1 promoted CRC progression by modulating UBR5/UBXN1 and activating NF-κB signaling,providing a new therapeutic strategy for treating metastatic CRC through targeting SUB1.

关键词： colorectal cancer Metastasis SUB1 UBR5 NF-κB signaling

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Recent advances in intermediate-temperature CO_(2) capture: Materials,technologies and applications

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Journal of energy chemistry 2024年第3期90卷 435-452,I0010页

作者： chengbo Zhao Leiming Wang Liang Huang Nicholas M.Musyoka Tianshan xue Jabor Rabeah Qiang Wang engineering Research Center for Water Pollution Source Control&eco-remediation College of Environmental Science and EngineeringBeijing Forestry UniversityBeijing 100083China State Key Laboratory of efficient Production of Forest Resources Beijing Forestry UniversityBeijing 100083China China Machinery Huanyu Certification and Inspection Co. Ltd.Beijing 102609China Nottingham Ningbo China Beacons of excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315100ZhejiangChina Institute of Atmospheric environment Chinese Research Academy of Environmental SciencesBeijing 100012China Leibniz-Institut für Katalyse e.V. Albert-Einstein-Str.29aRostock D-18059Germany

Carbon capture,utilization and storage(CCUS) is widely recognized as a vital strategy for mitigating the impact of human induced climate *** various CO_(2) adsorbents,intermediate-temperature solid adsorbents have garnered significant attention due to their potential applications in hydrogen utilization,specifically in the water gas shift,steam reforming and gasification *** processes are crucial for achieving carbon *** laboratory-level studies have showcased the high adsorption capacity of these materials via various synthesis and modification methods,their practical application in complex industrial environments remains challenging,impeding the commercialization *** review aims to critically summarize the recent research progress made in intermediatetemperature(200-400℃) solid CO_(2) adsorbents,particularly focusing on indicators such as cyclability,gas selectivity,and formability,which play vital roles in industrial application ***,we provide an overview of laboratory-level advanced technologies specifically tailored for industrial ***,we highlight several industrial-ready advanced technologies that can pave the way for overcoming the challenges associated with large-scale *** insights provided by this review aim to assist researchers in identifying the most relevant research directions for industrial *** promoting advances in the application of solid adsorbents,we strive to facilitate the ultimate goal of achieving carbon neutrality.

关键词： Intermediate-temperature CO_(2) capture MgO LDHs Industrialization

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Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan:Antibody Recruiting at engineered Bacterial Surface with Peptidoglycan Analogs

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CCS chemistry 2024年第6期6卷 1448-1457页

作者： Yuan Xu Shihao Song Hongwei Duan Yinyue Deng xue-Wei Liu School of chemistry Chemical Engineering and BiotechnologyNanyang Technological UniversitySingapore 637371 Key Laboratory of Tropical Biological Resources of Ministry of education School of Pharmaceutical SciencesHainan UniversityHaikou 570228 School of Pharmaceutical Sciences(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversitySun Yat-sen UniversityShenzhen 518107

The emergence of microbial drug resistance,coupled with the paucity of new antibiotics poses an impending threat to public *** this work,we drew inspiration from synthetic peptidoglycan oligomers and successfully constructed antibody-recruiting peptidoglycan analogs,2a-d,with excellent safety profiles and high efficiencies in recruiting antibodies across different ***,we demonstrated that these peptidoglycan analogs could be readily incorporated into bacteria cell walls,whereby both simple monoclonal and pooled human serum antibodies effectively congregated to the surfaceengineered bacteria,leading to the complete extermination of the engineered bacterial cells both in vitro and in *** peptidoglycan analog agents for recruiting endogenous antibodies to combat pathogenic bacteria enable further development of promising broad-spectrum immunotherapeutics.

关键词： chitosan bacterial infection endogenous antibodies bacterial surface engineering peptidoglycan analogs

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effect of Plastic Deformation on Microstructure and Properties of Cu-(1 wt%-6 wt%) Ag Alloy

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Journal of Wuhan University of Technology(Materials Science) 2024年第3期39卷 747-753页

作者：茹亚东 ZHANG Zhongyuan 高召顺 ZHANG Ling ZUO Tingting xue Jiangli TANG Zhixiang DA Bo LIU Yongsheng XIAO Liye Institute of electrical engineering Chinese Academy of SciencesBeijing 100190China Department of Physics Shanghai University of Electric PowerShanghai 201306China University of Chinese Academy of Sciences Beijing 100190China International Joint Labora-tory for Light Alloys(MOe) College of Materials Science and EngineeringChongqing UniversityChongqing 400044China Research and Services Division of Materials Data and Integrated System National Institute for Materials ScienceTsukuba 305-0047Japan

In the present study,the Cu-(1 wt%-6 wt%)Ag alloys were prepared by melting,forging and wire *** effects of plastic deformation on microstructure evolution and properties of the alloys were *** results show that non-equilibrium eutectic colonies exist in the Cu-(3 wt%-6 wt%)Ag alloy and no eutectic colonies in the 1 wt%-2 wt%Ag containing *** eutectic colonies are aligned along the drawing direction and refined with the increase of draw *** to the refinement of eutectic colonies,the Cu-Ag alloy exhibits higher strength with the increase of draw *** Cu-6Ag alloy exhibits excellent comprehensive properties with a strength of 930 MPa and a conductivity of 82%IACS when the draw ratio reaches 5.7.

关键词： Cu-Ag alloy high strength and high conductivity microstructure eutectic structure strengthening mechanism

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Nano polystyrene microplastics could accumulate in Nile tilapia(Oreochromis niloticus):Negatively impacts on the intestinal and liver health through water exposure

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Journal of environmental Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-xue Dong Juan Tian Jin Deng Lei Wei Hua Wen Shan Zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&e staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

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Simultaneously achieving high energy density and responsivity in submicron BaTiO_(3) film capacitors integrated on Si

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Journal of Advanced Ceramics 2024年第2期13卷 198-206页

作者： Jun Ouyang Yinxiu xue Chuanqi Song Meiling Yuan Kun Wang Yuyao Zhao Hongbo cheng Hanfei Zhu Chao Liu Institute of Advanced energy Materials and chemistry School of Chemistry and Chemical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Key Laboratory of Key Film Materials&Application for equipment School of Material Sciences and EngineeringXiangtan UniversityXiangtan 411105China School of Materials Science and engineering Shandong UniversityJinan 250061China Academic Affairs Office Civil Aviation University of ChinaTianjin 300300China China Tobacco Shandong Industrial Co. Ltd.Jinan 250014China

In the research field of energy storage dielectrics,the“responsivity”parameter,defined as the recyclable/recoverable energy density per unit electric field,has become critically important for a comprehensive evaluation of the energy storage capability of a *** this work,high recyclable energy density and responsivity,i.e.,W_(rec)=161.1 J·cm^(-3) and ξ=373.8 J·(kV·m^(2))^(-1),have been simultaneously achieved in a prototype perovskite dielectric,BaTiO_(3),which is integrated on Si at 500℃ in the form of a submicron thick *** ferroelectric film features a multi-scale polar structure consisting of ferroelectric grains with different orientations and inner-grain ferroelastic domains.A LaNiO_(3) buffer layer is used to induce a{001}textured,columnar nanograin microstructure,while an elevated deposition temperature promotes lateral growth of the nanograins(in-plane diameter increases from~10-20 nm at lower temperatures to~30 nm).These preferably oriented and periodically regulated nanograins have resulted in a small remnant polarization and a delayed polarization saturation in the film’s P-e behavior,leading to a high recyclable energy ***,an improved polarizability/dielectric constant of the BaTiO_(3) film has produced a much larger maximum polarization than those deposited at lower temperatures at the same electric field,leading to a record-breaking responsivity for this simple perovskite.

关键词： energy storage energy density responsivity BaTiO_(3) dielectric capacitor Si

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