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Neural Regeneration Research 2021年第3期16卷 405-413页

作者： Xu-Chang Hu Yu-Bao Lu Yong-Na Yang xue-wen kang Yong-Gang Wang Bing Ma Shuai Xing Key Laboratory of Bone and Joint Diseases Research of Gansu Province Department of OrthopedicsLanzhou University Second HospitalLanzhouGansu ProvinceChina Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurology The First People’s Hospital of Lanzhou CityLanzhouGansu ProvinceChina

Spinal cord injury can lead to severe motor,sensory and autonomic nervous ***,there is currently no effective treatment for spinal cord *** stem cells and progenitor cells,bone marrow mesenchymal stem cells,olfactory ensheathing cells,umbilical cord blood stem cells,adipose stem cells,hematopoietic stem cells,oligodendrocyte precursor cells,macrophages and Schwann cells have been studied as potential treatments for spinal cord *** treatments were mainly performed in ***,subtle changes in sensory function,nerve root movement and pain cannot be fully investigated with animal *** these cell types have shown excellent safety and effectiveness in various animal models,sufficient evidence of efficacy for clinical translation is still *** transplantation should be combined with tissue engineering scaffolds,local drug delivery systems,postoperative adjuvant therapy and physical rehabilitation training as part of a comprehensive treatment plan to provide the possibility for patients with SCI to return to normal *** review summarizes and analyzes the clinical trials of cell transplantation therapy in spinal cord injury,with the aim of providing a rational foundation for the development of clinical treatments for spinal cord injury.

关键词： central nervous system clinical trials injury plasticity protection regeneration repair spinal cord stem cells

基于Biot方程的纵波波场高阶有限差分法模拟及波场分析

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矿物岩石 2010年第1期30卷 116-120页

作者：肖思和许多文雪康孔选林成都理工大学材料与化学化工学院四川成都610000 中国石油化工西南分公司研究院德阳分院四川德阳618000 中国石油化工西南分公司监理中心四川德阳618000

地球物理勘探中的含油气储层通常被认为是一种典型的双相介质,这种介质模型能更精确的描述含气性储层的特征,开展双相介质波场传播特性的研究具有十分重要意义。研究以Biot理论为基础,从双相介质中的纵波方程出发,导出求解双相各向同性... 详细信息

地球物理勘探中的含油气储层通常被认为是一种典型的双相介质,这种介质模型能更精确的描述含气性储层的特征,开展双相介质波场传播特性的研究具有十分重要意义。研究以Biot理论为基础,从双相介质中的纵波方程出发,导出求解双相各向同性介质中纵波方程的高阶差分格式,在此基础上实现双相各向同性介质中纵波方程的高阶有限差分法正演模拟,数值模拟结果表明:这种算法能在少量增加计算量的前提下大大提高精度,同时波场模拟结果与理论相吻合,波场快照快慢纵波的波场反映出不同速度、相位相反等特征差异,对将该理论应用于实际有重要的指导意义。

关键词：双相介质波动方程 Biot理论波场模拟高阶差分

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多子波分解与重构技术应用研究

成都理工大学学报（自然科学版） 2010年第6期37卷 660-665页

作者：徐天吉沈忠民文雪康 "油气藏地质及开发工程"国家重点实验室(成都理工大学) 成都610059 中国石化西南油气分公司勘探开发研究院德阳分院四川德阳618000 中国石化西南油气分公司工程监督中心四川德阳618000

探讨地震信号的多子波分解与重构方法,为地质解释与油气藏描述提供技术支撑。该方法在对地震信号进行分解时,利用匹配追踪算法,将原始地震信号分解成由一系列频率成分不同的Morlet子波函数组成的原子函数库;在重构地震信号时,根据油气... 详细信息

探讨地震信号的多子波分解与重构方法,为地质解释与油气藏描述提供技术支撑。该方法在对地震信号进行分解时,利用匹配追踪算法,将原始地震信号分解成由一系列频率成分不同的Morlet子波函数组成的原子函数库;在重构地震信号时,根据油气响应特征、地质现象描述的需求,先对原子函数库进行筛选、优化,再按照频率属性对Morlet子波函数进行线性求和。在对地震信号进行分解与重构的过程中,实现了将地震信号在时间域内、时间-频率域内进行联合解释,挖掘出了单域内难以发现的地质现象、油气响应特征。将该技术应用到四川新场地区沙溪庙组的储层预测与含气性识别中,获得了与钻井实测结果相吻合的良好效果。

关键词：地震信号多子波分解筛选重构气藏预测

速度、加速度检波器在超深层地震勘探中应用效果分析——以川南赤水地区为例

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地球物理学进展 2020年第4期35卷 1489-1496页

作者：文雪康袁莹唐建明刘胜陈明春中国石化西南油气分公司成都610016 中石化石油工程地球物理有限公司南方分公司成都610016

川南地区重要产气层之一的震旦系灯影组埋深约9000 m,以往多期地震勘探未能取得高品质资料,原因之一就是灯影组反射信息频率较低,而常规检波器(六串两并20DX-10 Hz速度型检波器)在低频段衰减严重,未能完整接收到地震反射信息.为得到深... 详细信息

川南地区重要产气层之一的震旦系灯影组埋深约9000 m,以往多期地震勘探未能取得高品质资料,原因之一就是灯影组反射信息频率较低,而常规检波器(六串两并20DX-10 Hz速度型检波器)在低频段衰减严重,未能完整接收到地震反射信息.为得到深层高品质的资料,在川南赤水地区开展了不同类型检波器试验研究工作,首先研究了3种检波器(20 DX-10 Hz速度型检波器、自然频率5 Hz速度型检波器、单点陆用压电加速度检波器)的幅频特征,分析了不同检波器对低频信号接收能力的差异;对比测试了3种检波器对主频为25 Hz的雷克子波的波形、频率响应;结合实际地震资料,分析了加速度型检波器的实际地震资料在加速度域和速度域的频率特征;最后将加速度检波器地震资料转换至速度域,与其他两种速度型检波器地震资料对比分析得到以下认识:(1)加速度检波器具有宽频带特性,对提高分辨率较为有利,适用于勘探目的层相对较浅地区的高分辨率勘探.(2)加速度检波器地震资料在加速度域、速度域两种不同域的资料差别较大,前者积分转换虽然提高了低频段响应但频带变窄,不利于提高分辨率,生产中使用原始域数据更为合适.(3)野外实际资料表明,低频速度型检波器在保持常规20DX-10 Hz的勘探效果的基础上提高了低频段的响应,与加速度检波器转域后的低频效果接近,频带比加速度检波器转域后要宽,更加适合超深层地震勘探.

关键词：川南赤水超深层低频信号幅频特征检波器震旦系灯影组

Porous Organic Cage‑Based Quasi‑Solid‑State Electrolyte with Cavity‑Induced Anion‑Trapping Effect for Long‑Life Lithium Metal Batteries

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Nano-Micro Letters 2025年第2期17卷 376-386页

作者： Wei-Min Qin Zhongliang Li wen‑Xia Su Jia‑Min Hu Hanqin Zou Zhixuan Wu Zhiqin Ruan Yue‑Peng Cai kang Li Qifeng Zheng School of Chemistry South China Normal UniversityGuangzhou 510006People’s Republic of China Key Laboratory of Functional Metal‑Organic Compounds of Hunan Province College of Chemistry and Material ScienceHengyang Normal UniversityHengyang 421008People’s Republic of China Guangzhou Key Laboratory of Energy Conversion and Energy Storage Materials Guangzhou 510006People’s Republic of China

Porous organic cages(POCs)with permanent porosity and excellent host–guest property hold great potentials in regulating ion transport behavior,yet their feasibility as solid-state electrolytes has never been testified in a practical ***,we design and fabricate a quasi-solid-state electrolyte(QSSE)based on a POC to enable the stable operation of Li-metal batteries(LMBs).Benefiting from the ordered channels and cavity-induced anion-trapping effect of POC,the resulting POC-based QSSE exhibits a high Li+transference number of 0.67 and a high ionic conductivity of 1.25×10^(−4) S cm^(−1) with a low activation energy of 0.17 *** allow for homogeneous Li deposition and highly reversible Li plating/stripping for over 2000 *** a proof of concept,the LMB assembled with POC-based QSSE demonstrates extremely stable cycling performance with 85%capacity retention after 1000 ***,our work demonstrates the practical applicability of POC as SSEs for LMBs and could be extended to other energy-storage systems,such as Na and K batteries.

关键词： Porous organic cage Cavity-induced anion-trapping Quasi-solid-state electrolyte Homogeneous Li+flux Lithium metal battery

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动态时窗多参数油气预测技术在柏垭的应用

物探化探计算技术 2000年第2期22卷 179-183页

作者：王斌李显贵文雪康成都理工学院四川成都610059 西南石油局第二物探大队四川德阳618000

在地震勘探中快速有效地进行油气预测的方法研究已成为我们目前十分重要的研究课题。作者研究了利用地震资料沿层按动态时窗提取多种特征参数进行综合处理的办法对油气进行预测的油气预测实用技术。经柏垭地区的实际资料预测验证 ,效果... 详细信息

在地震勘探中快速有效地进行油气预测的方法研究已成为我们目前十分重要的研究课题。作者研究了利用地震资料沿层按动态时窗提取多种特征参数进行综合处理的办法对油气进行预测的油气预测实用技术。经柏垭地区的实际资料预测验证 ,效果良好。此方法具有预测精度高。

关键词：地震资料动态时窗特征参数油气预测油气勘探

A novel approach to extract Nb,Y and Ce from a niobium-bearing ore of low grade by roasting KHSO_(4)-H_(2)SO_(4) system

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Rare Metals 2021年第7期40卷 1979-1986页

作者： wen-Cheng Gao Jian-kang wen Biao Wu He Shang xue Liu National Engineering Laboratory of Biohydrometallurgy GRIMAT Engineering Institute Co.LtdBeijing 101407China GRINM Resources and Environment Tech.Co. LtdBeijing 101407China

In this work,a novel approach of leaching valuable metals,such as niobium,yttrium and cerium,from a niobium-bearing ore of low grade by roasting KHSO_(4)-H_(2)SO_(4)system was experimentally *** the work,the effects of roasting temperature,roasting time,mass ratio of agents to ore and the types of leaching agents on the extraction of Nb,Y and Ce were investigated,and the roasting KHSO_(4)-H_(2)SO_(4)-ore system was thought as an effective method to extract these valuable *** was found that the recovery of Nb,Y and Ce can,respectively,reach 90.20%,97.22%and 98.41%in condition of roasting temperature of 300℃,roasting time of 2 h,mass ratio of KHSO_(4)-to-H_(2)SO_(4)to ore of 0.5:1:1,particle size of-74 lm(~95%),leaching solution of oxalic acid(30 g·L^(-1)),leaching temperature of 90℃and leaching liquid-to-solid ratio of 5:*** leaching kinetics of the calcined Nb-bearing ore in oxalic acid solution was successfully modeled by chemical reaction model,and the apparent activity energy was obtained to be14.16 kJ·mol^(-1).The results generated from this work will provide the fundamentals for extracting Nb,Y and Ce from a niobium-bearing ore of low grade and have potential applications value in future.

关键词： Roasting Extraction Niobium Yttrium Cerium Low grade

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan Meng kang Du xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein

Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang Jia-Zhu wen Li-kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report