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Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

Prediction of flow field and thermal environment in the gap is crucial to the design of hypersonic vehicle thermal protection system. The compressible Navier-Stokes equation is solved to study the flow field and aerodynamic heating in the gap. The effect of inflow parameter on the aerodynamic heating is analyzed. The results show that there are vortex motions in the gap. The heat transfer in the gap mainly depends on the convection in the top region. The heat flux along the gap wall distributes in U-shape, and at the outlet of the gap is highest, which is the key point in the thermal protection design. As the angle of attack increases, the number of vortices will decrease gradually, and wall heat flux will increase, especially at the gap exit. The research results provide references for the design and optimization of thermal protection system.

关键词： Hypersonic Gap flow Aerodynamic heating Numerical simulation

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li wenbo Yu Zhenyu sun Weichen Zheng Liangwei Zhang Yanling xue wenning Liu Shoumei Xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

Regulation of graphdiyne-based nanozymes with enhanced oxidaselike activity by cobalt and nitrogen codoping

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Nano Research 2025年第1期18卷 21-29页

作者： Jiali Liu Xiaoli Wang Yongfu Lian xue Wang Xiuxiu Wang Xingfa Gao Baoyun sun Xihong Guo CAS Key Laboratory for Biomedical Effects of Nanomaterial&Nanosafety Institute of High Energy PhysicsChinese Academy of ScienceBeijing 100049China Key Laboratory of Functional Inorganic Material Chemistry Ministry of EducationSchool of Chemistry and Materials ScienceHeilongjiang UniversityHarbin 150080China Laboratory of Theoretical and Computational Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The development of nanozymes with excellent intrinsic oxidase-like activity and specificity has received increasing ***(GDY)could be a promising choice for designing nanozymes with enhanced oxidase(OXD)-like activity due to its unique structure and ***,Co-N-GDY with high OXD activity but no peroxidase(POD)activity was synthesized by codoping of cobalt(Co)and nitrogen(N)into GDY and compared with other GDY-based nanozymes(including GDY,Co-GDY,and N-GDY).Upon analyzing the doping effect of Co and N on the OXD-like and POD-like activities,we found that the combination of Co and N in GDY played a significant role in enhancing the OXD-like activity,and even reversed the POD-like activity of N-GDY to OXD-like activity of *** electrochemical experiment and the theoretical calculations provided an explanation for the mechanism and showed that the activity was closely linked to the reduction ability of O_(2) or H_(2)O_(2) on the nanozyme substrates,which was determined by the ratedetermining step of the catalytic reaction.

关键词： nanozymes oxidase-like activity graphdiyne heteroatom doping regulation

自含式压力蒸汽灭菌生物指示剂D值测定的影响因素

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中国消毒学杂志 2017年第7期34卷 612-615页

作者：崔学文刘华孙雪奇黄瑛伍丹四川省食品药品检验检测院四川成都610097 四川科伦药业股份有限公司

目的研究自含式压力蒸汽灭菌生物指示剂D值测定的影响因素,提高D值测定的准确性。方法使用生物指示剂抗力测定仪,对不同生产企业的自含式压力蒸汽灭菌生物指示剂进行D值测定,比较透气孔、培养基、放置方式、载样器材对D值测定的影响。... 详细信息

目的研究自含式压力蒸汽灭菌生物指示剂D值测定的影响因素,提高D值测定的准确性。方法使用生物指示剂抗力测定仪,对不同生产企业的自含式压力蒸汽灭菌生物指示剂进行D值测定,比较透气孔、培养基、放置方式、载样器材对D值测定的影响。结果透气孔、培养基、放置方式、载样器材对D值的最大影响率分别为6.9%、17.3%、29.9%、38.2%。结论放置方式和载样器材是影响自含式压力蒸汽灭菌生物指示剂D值测定的主要因素,建议用带孔支架以水平方式进行测定。

关键词：自含式生物指示剂嗜热脂肪芽孢杆菌压力蒸汽灭菌 D值

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu wen-Chang Jia Jing wen xue-Lin Cheng Yan Han Ming-Hui Peng Jing Zhou Yao Liu sun-Fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors

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Design and characterization of α-lipoic acyl shikonin ester...

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

江苏省遗传学会2017年学术研讨会——“技术创新与遗传学发展”

作者：林红燕 Hong-Wei Han wen-xue sun Yu-Shun Yang Cheng-Yi Tang Gui-Hua Lu Jin-Liang Qi Xiao-Ming Wang 杨永华 Nanjing University 南京大学

Shikonin exhibits powerful anticancer activities for various cancer cells, but its poor solubility and strong toxicity hinder its development as clinical anticancer agent. We previously confirmed that shikonin and its derivatives could disturb mitosis through targeting tubulin. In this study, α-lipoic acid, the naturally-occurring co-factor of pyruvate dehydrogenase(PDH), was introduced into shikonin to design the twin drugs against both mitosis(tubulin) and glycolysis(PDK). Through three rounds of screening process performed by computer assistant drug design method, 18 kinds of α-lipoic acid shikonin ester derivatives were achieved as the outstanding compounds. Among them, 1 c displayed the most potent cytotoxicity towards cervical cancer cells(HeLa) with an IC50 value of 3.14 ± 0.58 μM and inhibited xenotransplanted tumor growth in a dose-dependent manner. Further pharmacologic study demonstrated that 1 c could cause cell cycle arrest in G2/M phase as tubulin polymerization inhibitor. Moreover, it also showed good PDK1 inhibitory activity, promoting PDH activity and forced HeLa cells to process more aerobic metabolism to undergo cell apoptosis. We reported here the first dual inhibitors of tubulin and PDK1 based on shikonin. It may form a basis for shikonin optimization through twin drug design framework for the discovery of new and potent shikonin derivatives in the study of targeted cancer therapy.

关键词： Design α-lipoic acyl shikonin ester Twin drugs Tubulin PDK1 Inhibitors

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang xue Fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

用RAPD技术对鲶和褐首鲶遗传多样性的研究

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武汉大学学报（理学版） 2001年第6期47卷 782-784页

作者：赵文学孙玉华邵雪玲成竹蒋超殷文莉刘思阳武汉大学生命科学学院湖北武汉430072 湖北师范学院生物系湖北黄石435002

用 RAPD技术对鲶天然群体和褐首鲶养殖群体进行了遗传多样性分析 .结果表明 ,鲶的遗传相似度S=0 .6 192 ,褐首鲶 S=0 .92 6 9.作为天然群体的鲶在 RAPD图谱具有比作为养殖群体的褐首鲶更为丰富的 DNA多态 ,同时也表明 ,长期的人工养殖... 详细信息

用 RAPD技术对鲶天然群体和褐首鲶养殖群体进行了遗传多样性分析 .结果表明 ,鲶的遗传相似度S=0 .6 192 ,褐首鲶 S=0 .92 6 9.作为天然群体的鲶在 RAPD图谱具有比作为养殖群体的褐首鲶更为丰富的 DNA多态 ,同时也表明 ,长期的人工养殖导致遗传多样性的下降 ,自然种群个体间基因的随机交流会使遗传多样性增加 .

关键词：鲶褐首鲶 RAPD技术遗传多样性鲶形目遗传相似度 DNA多态遗传距离

Zoledronate-loaded aluminum salt nanovaccines amplify cellular immune response by enhancing cross-presentation

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Nano Research 2025年第1期18卷 559-571页

作者： Chunting He Penghui He xue Tang Shuting Bai Ming Qin Yunting Zhang Zhaofei Guo Guangsheng Du Xun sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China

Being a Th2 stimulator,classic aluminum salt-based adjuvants only stimulate weak cellular immune responses that are required for vaccination against intracellular viruses or cancerous *** a thirdgeneration bisphosphonate,zoledronate(ZOL)can enhance antigen crosspresentation by inhibiting key enzymes of the mevalonate ***,we developed the subunit antigen ovalbumin(OVA)and ZOL co-loaded aluminum hydroxide nanoparticles(APN-OVA-ZOL)and investigated their capacity for inducing cellular immune responses against the *** results showed that the developed nanovaccines could successfully encapsulate OVA and ZOL,and enabled efficient lymph node *** by the mevalonate pathway inhibition effect of ZOL,APN-OVA-ZOL significantly promoted *** a result,APN-OVA-ZOL induced robust cellular immunity,including the activation of T and B *** a EG7-OVA tumor-bearing murine model,APN-OVA-ZOL significantly inhibited the tumor growth and prolonged mice *** work provided a strong empirical foundation indicating that zoledronate-loaded aluminum salt nanovaccines had a strong potency for cancer immunotherapy.

关键词： zoledronate(ZOL) mevalonate pathway antigen cross-presentation cellular immune responses