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Chinese Journal of Cancer Research 2011年第3期23卷 208-213页

作者： xue-song fu Ping-ping Li Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Integrated Traditional Chinese and Western MedicinePeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：Estradiol （E2） plays an important role in the development of breast *** postmenopausal women,the estrogen can be synthesized via aromatase （CYP19） pathway and steroid-sulfatase （STS） pathway in peripheral tissues,when the production in ovary has *** objective of our study was to explore the effects of Shu-Gan-Liang-xue Decoction （SGLXD） on the expressions of CYP19 and STS in estrogen receptor positive breast cancer MCF-7 and T47D ***：The effects of SGLXD on the cell viability of MCF-7 and T47D were analyzed by MTT *** quantitative real-time RT-PCR and Western blot,we evaluated the mRNA and protein expressions of CYP19 and STS in MCF-7 and T47D cells after SGLXD ***：By MTT assay,the cell viability rates of MCF-7 and T47D were significantly inhibited by SGLXD in a dose-dependent manner,the IC50 values were 40.07 mg/ml for MCF-7 cells and 25.62 mg/ml for T47D cells,*** evidenced by real-time PCR and Western blot,the high concentrations of SGLXD significantly down-regulated the expressions of CYP19 and STS both in the transcript level and the protein ***：The results suggest that SGLXD is a potential dual aromatase-sulfatase inhibitor by simultaneously down-regulating the expressions of CYP19 and STS in MCF-7 and T47D cells.

关键词： Shu-Gan-Liang-xue Decoction (SGLXD) Aromatase (CYP19) Steroid-sulfatase (STS) Breast cancer

Effects of Welding Speed and Post-weld Hot Rolling on Microstructure and Mechanical Properties of Friction Stir-Welded AZ31 Magnesium Alloy

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Acta Metallurgica Sinica(English Letters) 2018年第8期31卷 853-864页

作者： Gang Liu Li-Na Ma Zhen-Duo Ma xue-song fu Guo-Bing Wei Yan Yang Tian-Cai Xu Wei-Dong Xie Xiao-Dong Peng College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing 400044China

The as-rolled AZ31 Mg alloy sheets are welded by friction stir welding（FSW） in this study, followed by annealing and hot rolling with different reductions. The effects of welding speed and the rolling reduction on the microstructure, tensile properties, microhardness and fracture surfaces of the specimens are investigated. The results show that the microstructures of the FSW joint in different regions become more and more consistent as the hot rolling reduction increases. The mechanical properties of the FSW joints and the joint coefficient are improved with increasing rolling reduction; however,the hardness value in the stirred zone decreases firstly and then increases. When the rolling reduction is 50%, the tensile strength of FSW joint is close to that of base metal. The sample L_3 achieves the best comprehensive properties, with the yield strength, ultimate tensile strength and elongation of 162, 287.9 MPa, and 17.9%, respectively.

关键词： Magnesium alloy FSW Post-weld hot rolling Microstructure Mechanical properties

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耐碱玻璃纤维混凝土的配合比设计

哈尔滨工业大学学报 2005年第6期37卷 766-768页

作者：赵晶李晓民宋学富哈尔滨工业大学材料科学与工程学院黑龙江哈尔滨150001 哈尔滨工业大学交通科学与工程学院黑龙江哈尔滨150001

为解决耐碱玻璃纤维防腐蚀问题,基于最紧密堆积理论,提出了混凝土配合比设计的新方法:在保证粗、细集料处于最紧密堆积的状态下,减少混凝土中的水泥用量.粉煤灰作为细集料早期填充混凝土的空隙,后期发挥胶凝材料的作用,其掺量可达30%以... 详细信息

为解决耐碱玻璃纤维防腐蚀问题,基于最紧密堆积理论,提出了混凝土配合比设计的新方法:在保证粗、细集料处于最紧密堆积的状态下,减少混凝土中的水泥用量.粉煤灰作为细集料早期填充混凝土的空隙,后期发挥胶凝材料的作用,其掺量可达30%以上,并且同时可以保证混凝土的早期强度不降低.耐碱玻璃纤维应用在这种富含活性混合材料的混凝土中既可以提高混凝土的抗拉强度又能够保证纤维不被腐蚀.

关键词：耐碱玻璃纤维最紧密堆积理论配合比设计腐蚀

Separation of the ionospheric and thermospheric contributions in the data from the Triple Ionosophere Photo Meter onboard the Feng-Yun 3E satellite

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Science China Earth Sciences 2025年第1期68卷 172-184页

作者： Fang JIANG Tian MAO Jin-song WANG Xiu-Qing HU Xiao-Xin ZHANG Liping fu Nan JIA Tianfang WANG National Space Science Center Chinese Academy of Sciences Beijing Key Laboratory of Space Environment Exploration Key Laboratory of Environmental Space Situation Awareness Technology National Satellite Meteorological Center China Meteorological Administration

The Triple Ionosphere Photo Meter （TRIPM） is a far ultraviolet nadir-view photometer that is onboard the secondgeneration,polar-orbiting Chinese meteorological satellite Feng-Yun 3E （FY-3E）,which was launched on July 5,*** has three channels,and each is used to measure different types of emissions:（1） 135.6 nm airglow produced by the recombination of the O+ions and electrons in the absence of sunlight （nighttime channel）;（2） 135.6 nm airglow from the OI when sunlight is present （daytime/dusk-dawn 135.6 nm channel）;and （3） Airglow in the N2LBH of the TRIPM （daytime/dusk-dawn N2LBH channel）.FY-3E is a satellite operating in the early morning ***,the data are mostly distributed on the dawndusk side or at times when the solar zenith angle is relatively *** this study,combined with simulation calculations,the data are *** further explore the application value of the data products,a model is used to separate the ionospheric radiative recombination contribution from the thermosphere photoelectron impact excitation contribution in the data from the daytime/dusk-dawn 135.6 nm *** approach not only improves the accuracy of O/N2derived from the 135.6 nm channel and N2LBH channel but also provides the ionospheric 135.6 nm radiance at the same time as the *** results show that the 135.6 nm radiance originating from the combination of O+and electrons extracted from the measurement data exhibits similar equatorial anomaly peak structure characteristics and seasonal variations as the corresponding GPS total electron content （TEC） *** the other hand,the separated 135.6 nm radiance generated from the thermosphere photoelectron collision excitation does not contain radiative recombination contributions;thus,the ionosphere influence is greatly avoided when the O/N2is obtained.

关键词： Far ultraviolet 135.6 nm emission intensity Photoelectron impact excitation Radiative recombination excitation

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang xue Fang Hongmei Luo Chuanhai fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

Effect of electropulsing on deformation behavior of Ti-6Al-4V alloy during cold drawing

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Transactions of Nonferrous Metals Society of China 2014年第4期24卷 1012-1021页

作者：周岩陈国清付雪松周文龙大连理工大学材料科学与工程学院大连116085

Electron backscattered diffraction （EBSD） and transmission electron microscopy （TEM） were used to investigate effect of electropulsing on microstructure and texture evolution of Ti-6Al-4V during cold drawing. Research results demonstrate that the electropulsing treatment （EPT） can enhance the deformability of the grains with unfavorable orientations, which makes the compatibility of deformation among grains much better. A comparison in texture evolution between conventional cold drawing and EPT cold drawing indicates that the EPT promotes prismatic 〈a〉 slip moving, restricts pyramidal 〈c＋a〉 slip occurring and accommodates the deformation with c-component by grain boundary sliding. The fraction decrease of low-angle grain boundaries for samples deformed with EPT reveals that the application of electropulsing restricts the formation of the incidental dislocation boundaries and the geometrically necessary boundaries.

关键词： Ti-6Al-4V alloy electropulsing cold drawing texture evolution

De novo synthesis of atropisomeric benzofurans via Cu/SPDO complex catalyzed asymmetric formal [3 + 2] annulation

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Science China Chemistry 2025年第1期68卷 174-180页

作者： Fan-Xiao Meng Xing-Yu Wang Ka Lu Ju-song Yang fu-Min Zhang Ai-Jun Ma Bao Du Yong-Qiang Tu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University School of Chemistry and Chemical Engineering Shanghai Jiao Tong University School of Biotechnology and Health Sciences Wuyi University

Herein, the de novo synthesis of atropisomeric benzofurans through the Cu/spirocyclic-pyrrolidine-oxazoline(SPDO) complex catalyze asymmetric formal [3 + 2] cycloaddition between quinones and ynamides is explored, producing a range of structurally diverse axially chiral benzofurans in satisfactory yields with good to excellent enantioselectivities. furthermore, density functional theory calculations were applied to explain the possible reaction mechanism.

关键词： benzofuran atropisomers novel de novo synthetic strategy asymmetric formal [3 + 2] cycladdition Cu/SPDO complex DFT calculations

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常压高频等离子体电子温度的光谱法诊断

光谱学与光谱分析 2017年第2期37卷 368-373页

作者：孙元成宋学富杜秀蓉张晓强王慧中国建筑材料科学研究总院北京100024

常压高频等离子体由于其无电极污染、能量密度大、温度高及气氛可控的特点而得到了广泛应用,电子温度是影响其使用性能的关键参数,根据发射光谱使用玻尔兹曼图解法计算是最常用且最可行的诊断方法,但由于跃迁几率数据可靠性、环境背景... 详细信息

常压高频等离子体由于其无电极污染、能量密度大、温度高及气氛可控的特点而得到了广泛应用,电子温度是影响其使用性能的关键参数,根据发射光谱使用玻尔兹曼图解法计算是最常用且最可行的诊断方法,但由于跃迁几率数据可靠性、环境背景、仪器误差、数据处理误差等原因,不同研究者根据不同谱线计算的结果通常不具有可比性。为了得到可靠性高的电子温度计算结果,针对存在SiO_2颗粒的常压高频空气等离子体,以光谱范围为200~1 077nm的7通道高分辨光纤光谱仪为测量工具,该研究讨论了元素、光谱段选择对计算结果可靠性的影响。结果表明,由于N_2占电离气体的主要部分且不参与化学反应,NⅠ发射谱线是最佳选择,使用738~940nm内NⅠ的谱线计算的拟合度为0.95,计算的电子温度最为可靠;由于Si和O极易结合成SiO_2颗粒,此二元素的能量不再满足玻尔兹曼分布,计算结果的可靠性较差,因此不能使用Si和O元素的发射谱线计算电子温度;使用掺入Ar的谱线同样不能得到可靠的电子温度计算结果。因此,为了有效诊断等离子体电子温度,在不同应用场合中,应当根据实际情况,合理选择测量光谱范围及光谱仪,选取合适的粒子及其发射谱线。

关键词：高频等离子体发射光谱电子温度

Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-fu Xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

单核苷酸多态性位点rs6983267与溃疡性结肠炎及大肠癌的相关性

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北京大学学报（医学版） 2016年第6期48卷 994-999页

作者：刘艳霞杨雪松付卫姚宏伟北京大学第三医院消化科北京100191 北京大学第三医院普外科北京100191

目的:探讨rs6983267多态性与散发性大肠癌发病风险的相关性,初步比较rs6983267多态性在溃疡性结肠炎患者和普通人群中的分布差异。方法:该病例对照研究共纳入186例散发性大肠癌患者、129例溃疡性结肠炎患者和189例对照者,采集外周静脉... 详细信息

目的:探讨rs6983267多态性与散发性大肠癌发病风险的相关性,初步比较rs6983267多态性在溃疡性结肠炎患者和普通人群中的分布差异。方法:该病例对照研究共纳入186例散发性大肠癌患者、129例溃疡性结肠炎患者和189例对照者,采集外周静脉血并提取基因组DNA,采用基质辅助激光解吸电离-飞行时间质谱平台进行基因型分型,采用非条件Logistic回归方法校正年龄、性别,并比较各组间的等位基因和基因型频率分布差异。结果:大肠癌组的G等位基因频率及GG、GT基因型频率均高于对照组,差异具有统计学意义(P<0.001)。溃疡性结肠炎组的G等位基因频率及GG、GT基因型频率均高于对照组,差异具有统计学意义(P=0.041,P=0.006和P<0.001)。结论:rs6983267多态性与散发性大肠癌的发病风险相关,rs6983267多态性在溃疡性结肠炎患者和普通人群中的分布可能存在差异,且溃疡性结肠炎患者中的G风险等位基因频率可能高于普通人群。

关键词：多态性,单核苷酸结肠炎,溃疡性结直肠肿瘤