检索结果-南通市图书馆

IL-10 Gene Modified Dendritic Cells Inhibit T helper Type 1-Mediated Alloimmune Responses and Promote Immunological Tolerance in Diabetes

引用

Cellular & Molecular Immunology 2008年第1期5卷 41-46页

作者： Huifen Zhu Wenhong qiu Ping Lei Wei Zhou xue Wen Fengrong he Li Li Hong Dai Guanxin Shen Feili Gong Department of Immunology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Medicine and Life Science College of Jianghan University Wuhan 430056 China These authors contributed equally to this work

Dendritic cells （DCs） have the potency to regulate the outcome of autoimmunity through the modulation of immune responses. The induction of antigen specific tolerance is critical for prevention and treatment of allograft rejection. In the present Study, we transfected IL-10 gene into DCs and investigated their effect on inhibition of lymphocyte activity in vitro and induction of immune tolerance on islet allograft in mice. An IDDM C57BL/6 mouse model was induced by streptozotocin. The islet cells isolated from the BALB/c mice were transplanted into the kidney capules of the model mice followed by injection of IL-10 modified DCs （mDCs）. The results showed that mDCs could significantly inhibit T lymphocyte proliferation mediated by allotype cells and induce its apoptosis, whereas, unmodified DCs （umDCs） could promote the murine lymphocyte proliferation markedly. The injection of mDCs could prolong the survival of allotype islet transplanted IDDM mice. The average plasma glucose （PG） level in mDCs treated mice returned to normal within 3 days and lasted for about 2 weeks. The rejection response in control mice occurred for 5 days after transplantation. The level of IFN-γ was lower while IL-4 was higher in mDCs treated mice than that in umDCs treated mice, which indicated that Thl/Th2 deviation occurred. Our studies suggest that IL-10 gene modified DCs can induce the immune tolerance to islet graft and prolong survival of the recipients by the inhibiting of T cell proliferation in allotype mice. Cellular ＆ Molecular Immunology.

关键词： IL-10 dendritic cell IDDM islet transplantation immune tolerance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Synthesis and anti-integrase evaluation of novel calix[4]arene derivatives containing the triazolyl 1,3-diketo moiety

引用

Chinese Chemical Letters 2014年第5期25卷 737-740页

作者： Zai-Gang Luo Yu Zhao Chao Ma xue-Mei Xu Xiao-Mei Zhang Nian-Yu Huang Hong-qiu he College of Chemical Engineering Anhui University of Science & Technology College of Chemistry and Life Sciences China Three Gorges University Chongqing Center for Biomedicines and Medical Equipment Chongqing Academy of Science and Technology

A series of novel calix[4]arene derivatives incorporating two triazolyl 1 3-diketo subunits in alternate positions at the lower rim were synthesized and screened for HⅣ integrase inhibition *** chemical structures of these compounds were confirmed by means of1H NMR 13C NMR,and *** bioassays indicated that calix[4]arene derivatives proved to be more active than p-tertbutylcalix[4]arene *** particular,compound 4g presented the most potent integrase strand transfer inhibitory activity with an IC50value of 6.1 mmol/L.

关键词： HIV-1 integrase inhibitor Calixarene derivative 1 2 3-Triazole 1 3-Diketo Strand transfer

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Functionalized Hierarchical ZSM-5 Zeolites for the Viscosity Reduction of heavy Oil at Low Temperature

引用

Chemical Research in Chinese Universities 2022年第4期38卷 1083-1088页

作者： XIAO Peiwen LI Hui WANG Pingmei LIU Bolun JING Wendan he Lipeng WANG Runwei HAN xue ZHANG Zongtao qiu Shilun LUO Jianhui Research Institute of Petroleum Exploration&Development PetroChinaBeijing100083P.R.China Key Laboratory of Nano Chemistry(KLNC) CNPCBeijing100083P.R.China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin UniversityChangchun130012P.R.China

herein,we propose a novel approach to reduce the viscosity of heavy oil by functional hierarchical CTMS-ZSM-5-PTMS ***-ZSM-5-PTMS zeolites synthesized by asymmetric modification and selective alkali etching can reduce the viscosity of heavy oil through adsorbing *** method can reduce the viscosity of heavy oil from hundreds of thousands mPa·s to about ten thousand mPa·*** work provides an economical and environmentally friendly candidate for heavy oil viscosity reduction under low-temperature conditions.

关键词： heavy oil Viscosity Hierarchical ZSM-5 zeolite

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

heat treatment effect on electrochemical properties of spinel Li_4Ti_5O_(12)

引用

Rare Metals 2008年第2期27卷 165-169页

作者： LI Yue ZHAO Hailei TIAN Zhihong qiu Weihua LI xue School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Anode material Li4Ti5O12 was prepared at 800℃ by a solid-state reaction, followed by heat-treatment at 600℃ for different times （0, 2, 8, and 12 h）. The effects of heat-treatment time on the particle morphology, rate-capability, and electrode kinetic process of the Li4Ti5O12 electrode, and on the lithium ion diffusion coefficient inside the Li4Ti5O12 electrode were investigated. Proper heat treatment could smoothen the particle surface of Li4Ti5O12 particles and increase the rate-capability of the electrode. Overlong heat treatment might cause particle aggregation and hence result in a poor electrode kinetic process. A sample with 8 h of heat treatment showed the best rate-capability and the lowest electrode reaction resistance. heat treatment for 2-8 h does not significantly change the lithium ion diffusion coefficient inside the Li4Ti5O12 electrode, whereas, 12-h treatment results in a lower lithium ion diffusion coefficient.

关键词： lithium titanate heat treatment electrochemical property lithium ion battery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Isothermal reduction of titanomagnetite concentrates containing coal

引用

International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 131-137页

作者： Tu Hu xue-wei Lü Chen-guang Bai Gui-bao qiu College of Materials Science and Engineering Chongqing University Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology

The isothermal reduction of the Panzhihua titanomagnetite concentrates （PTC） briquette containing coal under argon atmosphere was investigated by thermogravimetry in an electric resistance furnace within the temperature range of 1250-1350°C. The samples reduced in argon at 1350°C for different time were examined by X-ray diffraction （XRD） analysis. Model-fitting and model-free methods were used to evaluate the apparent activation energy of the reduction reaction. It is found that the reduction rate is very fast at the early stage, and then, at a later stage, the reduction rate becomes slow and decreases gradually to the end of the reduction. It is also observed that the reduction of PTC by coal depends greatly on the temperature. At high temperatures, the reduction degree reaches high values faster and the final value achieved is higher than at low temperatures. The final phase composition of the reduced PTC-coal briquette consists in iron and fer-rous-pseudobrookite （FeTi2O5）, while Fe2.75Ti0.25O4, Fe2.5Ti0.5O4, Fe2.25Ti0.75O4, ilmenite （FeTiO3） and wustite （FeO） are intermediate products. The reaction rate is controlled by the phase boundary reaction for reduction degree less than 0.2 with an apparent activation energy of about 68 kJ·mol-1 and by three-dimensional diffusion for reduction degree greater than 0.75 with an apparent activation energy of about 134 kJ·mol-1. For the reduction degree in the range of 0.2-0.75, the reaction rate is under mixed control, and the activation energy increases with the increase of the reduction degree.

关键词： titanomagnetite carbothermal reduction thermogravimetric analysis kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Stability analysis and optimization of excavation method of double-arch tunnel with an extra-large span based on numerical investigation

引用

Frontiers of Structural and Civil Engineering 2021年第1期15卷 136-146页

作者： Yiguo xue Huimin GONG Fanmeng KONG Weimin YANG Daohong qiu Binghua ZHOU Geotechnical and Structural Engineering Research Center Shandong UniversityJinan 250061China

The Xiamen Haicang double-arch tunnel has a maximum span of 45.73 m and a minimum burial depth of 5.8 m.A larger deformation or collapse of the tunnel is readily encountered during tunnel *** is therefore necessary to select a construction approach that is suitable for double-arch tunnel projects with an extra-large *** this study,three construction methods for double-arch tunnels with extra-large spans were numerically ***,the deformation behavior and stress characteristics of the surrounding rock were obtained and *** results showed that the double-side-drift method with temporary vertical support achieves better adaptability in the construction of such tunnels,which can be observed from both the numerical results and in situ monitoring *** addition,the improved temporary support plays a critical role in controlling the surrounding rock *** addition,the disturbance resulting from the excavation of adjacent drifts was obvious,particularly the disturbance of the surrounding rock caused by the excavation of the middle *** present findings can serve as the initial guidelines for the construction of ultra-shallowly buried double-arch tunnels with extra-large spans.

关键词： double-arch tunnel triple-layer composite liner system numerical modeling stress analysis settlement

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Observation of dark edge states in parity-time-symmetric quantum dynamics

引用

National Science Review 2023年第8期10卷 156-165页

作者： Peng xue Xingze qiu Kunkun Wang Barry C. Sanders Wei Yi Beijing Computational Science Research Center Key Laboratory of Quantum Information University of Science and Technology of China Chinese Academy of Sciences Synergetic Innovation Center in Quantum Information and Quantum Physics University of Science and Technology of China Chinese Academy of Sciences 4. School of Physics and Optoelectronic Engineering Anhui University Shanghai Branch National Laboratory for Physical Sciences at MicroscaleUniversity of Science and Technology of China Institute for Quantum Science and Technology University of Calgary Program in Quantum Information Science Canadian Institute for Advanced Research

Topological edge states arise in non-hermitian parity-time(PT)-symmetric systems, and manifest themselves as bright or dark edge states, depending on the imaginary components of their eigenenergies. As the spatial probabilities of dark edge states are suppressed during the non-unitary dynamics, it is a challenge to observe them experimentally. here we report the experimental detection of dark edge states in photonic quantum walks with spontaneously broken PT symmetry, thus providing a complete description of the topological phenomena therein. We experimentally confirm that the global Berry phase in PT-symmetric quantum-walk dynamics unambiguously defines topological invariants of the system in both the PT-symmetry-unbroken and-broken regimes. Our results establish a unified framework for characterizing topology in PT-symmetric quantum-walk dynamics, and provide a useful method to observe topological phenomena in PT-symmetric non-hermitian systems in general.

关键词： parity-time symmetry photonic quantum walks dark edge states topological invariants

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Sb nanoparticles encapsulated in N-doped carbon nanotubes as freestanding anodes for high-performance lithium and potassium ion batteries

引用

Rare Metals 2023年第2期42卷 449-458页

作者： Xiao-Ping Lin Fang-Fang xue Zhi-Gang Zhang qiu-Hong Li Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen361005China

Sb-based materials with high specific capacity have targeted as an alternative anode material for alkali metal ion ***,Sb nanoparticles embedded in hollow porous N-doped carbon nanotubes(Sb@N-C nanotubes)are used as freestanding anode for Li-ion batteries(LIBs)and K-ion batteries(PIBs).The Sb@N-C nanotubes demonstrate exceptional reversible capacity of643 mAh·g^(-1)at 0.1 A·g^(-1)with long cycle stability,as well as outstanding rate performance(219.6 mAh·g^(-1)at10 A·g^(-1))in *** the anode material of PIBs,they reveal impressive capacity of 325.4 mAh·g^(-1)at 0.1 A·g^(-1).The superior electrochemical properties mainly originate from the novel *** be specific,the obtained 3D connected network allows for quick ion and electron migration,and prevents the aggregation of Sb *** hollow porous nanotubes can not only accommodate the volume expansion of Sb nanoparticles during cycling,but also facilitate the infiltration of the electrolyte and reduce the ion diffusion *** work provides a new insight for designing advanced Sb-based anodes for alkali metal ion batteries.

关键词： Alkali metal ion batteries Freestanding electrode Hollow porous nanotube Sb@N-C nanotubes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tailoring polymeric composite gel beads-encapsulated microorganism for efficient degradation of phenolic compounds

引用

Chinese Journal of Chemical Engineering 2021年第4期34卷 301-306页

作者： xueping Liu Ping xue Feng Jia Dongya qiu Keren Shi Weiwei Zhang State Key Laboratory of High-efficiency Coal Utilization and Green Chemical Engineering College of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021China

Phenol and its derivatives are highly toxic pollutants in industrial wastewater for the ecological environments,so there is essential attention to develop effective means of removing these harmful substances from *** this work,the microorganism was immobilized into polymeric composite gel beads prepared by the effective recombination of natural abundant chitosan(CS)and industrial polyvinyl alcohol(PVA)for treating phenolic *** degradation rate of 99.5%can be achieved to treat 100 mg·L^(1)of phenol at 30℃using the fresh resultant immobilized microorganism,where only 21.1%degradation rate was obtained by the free microorganism under the identical *** recycling experiments of repeated 90 times to treat 100 mg·L^(1)of phenol displayed that the degradation rate of phenol was stable to 99%with the appearance of beads unchanged significantly,indicating the immobilized microorganism possessed excellent operating ***,while the phenol derivatives of 100 mg·L^(1)were treated catalytically including pmethylphenol,catechol,and oaminophenol for 24 h by the immobilized microorganism,the degradation rates were all above 95%.The immobilized microorganism into PVACS polymeric composite with excellent operating stability and degradation activity would provide a feasible solution for treating phenolic compounds in water in industrial applications.

关键词： Polymeric composite Immobilization Biocatalysis Phenolic compounds Degradation Reusability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of electrode change on solidification of slag and metal pool profile in electroslag remelting process

引用

Journal of Iron and Steel Research International 2021年第12期28卷 1582-1590页

作者： Yi-ru Duan Bao-kuan Li xue-chi Huang Zhong-qiu Liu School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina

A two-dimensional axisymmetric model is established to study the effect of electrode change on the solidification of slag and metal pool profile during electroslag remelting *** basic considerations of flow and heat transfer are included in the model,and the growth of ingot is described by the dynamic mesh *** electrode melting rate is predicted based on the transient thermal conductivity model between slag and *** results indicate that in the electrode change stage,the slag temperature drops from 1847 to 1763 K gradually and the“hot heart”phenomenon is *** the metal pool profile is slightly changed with a depth decrease from 0.3984 to 0.3688 *** the heating and melting stage of new electrode,the maximum slag temperature firstly increases from 1763 to 1892 K,then decreases to 1845 K,and finally at 3558 s,the maximum slag temperature is stable at 1884 *** slag shell with a maximum volume of 7.31×10^(-3) m^(3) is formed at the electrode tip,and then,the solidified slag melts *** depth of metal pool firstly rises to 0.3700 m and then drops to 0.3565 *** the preheating temperature of the new electrode increases from 473 to 973 K,the maximum volume of solidified slag decreases from 0.00748 to 0.00592 m^(3),and the time from heating to melting of the new electrode decreases from 996 to 887 s.

关键词： Electroslag remelting Electrode change Metal pool profile Solidified slag Numerical simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：