检索结果-南通市图书馆

A systematic evaluation of computational methods for predicting translated non-canonical ORFs from ribosome profiling data

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第1期51卷 105-108页

作者： Tianyu Lei Yue Chang Chao Yao Hong zhang College of Ecology Lanzhou UniversityLanzhouGansu 730000China Cuiying Honors College Lanzhou UniversityLanzhouGansu 730000China

Ribosome profiling(Ribo-Seg)enables genome-wide survey of translational activities at nucleotide resolution by enriching and sequencing ribosome-protected fragments(RPFs)in the cell(Ingolia et al.,2009).Based on the characteristic distribution of RPFs in Ribo-Seq,such as enrichment in open reading frames(ORFs)and three-nucleotide periodicity,many computational methods have been developed to detect translated ORFs from Ribo-Seq data(Wang et al.,2020a).

关键词： translated enable canonical

LncRNA HOTTIP facilitated tumor growth via stimulating the hnRNPA2B1/DKK1/Wnt/β-catenin regulatory axis in hepatocellular carcinoma

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 53-56页

作者： Weiqiang Zeng Chuanjian Shi Liqiang Deng Weiming Fu Jinfang zhang Cancer Center Shenzhen Hospital(Futian)of Guangzhou University of Chinese MedicineShenzhenGuangdong 518000China Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China

Hepatocellular carcinoma(HcC)has become the fifth leading cause of cancer mortality worldwide in the past decade.1 Dysregulated long noncoding RNAs(lncRNAs)are closely associated with its occurrence and *** identified IncRNA named"HOXA transcript at the distal tip"(HOTTIP)has been considered as an oncogene in multiple ***,the mechanism underlying HOTTiP-mediated hepatocarcinogenesis remains mostly unknown.

关键词： DKK1 mortality stimulating

Experimental Investigation on Vertical Hydraulic Transport of Ores in Deepsea Mining

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第1期38卷 42-53页

作者： LIU Lei LIU Jian-cheng LI Xin XU Li-xin zhang Xiu-zhan State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Sanya Yazhou Bay Institution of Deep-sea Sci-Tech Shanghai Jiao Tong UniversitySanya 572000China China Merchants Marine And Offshore Research Institute Co. Ltd.Shenzhen 518067China China Merchants Deepsea Research Institute(Sanya)Co. Ltd.Sanya 572000China School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212100China

Deepsea mining has been proposed since the 1960s to alleviate the lack of resources on *** hydraulic transport of collected ores from the seabed to the sea surface is considered the most promising method for industrial *** the present study,an indoor model test of the vertical hydraulic transport of particles was conducted.A noncontact optical method has been proposed to measure the local characteristics of the particles inside a vertical pipe,including the local concentration and particle *** hydraulic gradient of ore transport was evaluated with various particle size distributions,particle densities,feeding concentrations and mixture flow *** transport,the local concentration is larger than the feeding concentration,whereas the particle velocity is less than the mixture *** qualitative effects of the local concentration and local fluid velocity on the particle velocity and slip velocity were *** local fluid velocity contributes significantly to particle velocity and slip velocity,whereas the effect of the local concentration is marginal.A higher feeding concentration and mixture flow velocity result in an increased hydraulic *** effect of the particle size gradation is slight,whereas the particle density plays a crucial role in the transport.

关键词： deepsea mining vertical hydraulic transport experiment flow characteristics

An integrated strategy of UPLC-Q-TOF/MS and HPTLC/PAD-DESI-MSI for the analysis of chemical variations:A case study of Tibetan medicine Tiebangchui

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2024年第4期14卷 615-618页

作者： Yue Liu Mengjia Li Xing Fu Yi zhang Ce Tang State Key Laboratory of Southwestern Chinese Medicine Resources School of Ethnic MedicineChengdu University of Traditional Chinese MedicineChengdu611137China meishan Hospital of Chengdu University of Traditional Chinese Medicine MeishanSichuan620010China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu611137China

The dried roots of Aconitum pendulum Busch are the major source of a commonly used Tibetan medicine,namely Tiebangchui(TBC)(Fig.S1).However,raw TBC contains a large amount of high toxic diester-diterpenoid alkaloids(DDAs),and the improper use would cause arrhythmia,irreversible cardiovascular damages,and even death.“Paozhi”,an appropriate processing method,is the essential prerequisite for the safe clinical application of ***-decocting and sand-frying are commonly used processing methods for toxicity attenuation and efficacy preservation for TBC.

关键词： dried irreversible roots

Cucurbit[n]uril-based nanostructure construction and modification

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第8期35卷 138-148页

作者： Lijun Mao Shuo Li Xin zhang Zhan-Ting Li Da Ma School of Pharmaceutical Engineering&Institute for Advanced Studies Taizhou UniversityJiaojiang 318000China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

New fabrication method of nanostructures is of great importance for the applications of nanoscience and *** review summarizes cucurbit[n]uril(CB[n])-based nanostructure fabrication and modification *** strategies include the use of CB[n]s as building blocks and supramolecular crosslinkers to fabricate nanostructures,to surface modify nanostructures,and as gatekeepers to control the release of encapsulated *** nanostructures are used for drug delivery,bioimaging,chemical sensing,catalysis and other ***[n]s often play a vital role in the fabrication of these nanos-tructures,and the realization of the applications.

关键词： Cucurbit[n]uril Nanostructure Host-guest interaction Nanofabrication

在线全文

学校读者我要写书评

暂无评论

Radon变换频变自适应多次波压制方法

地球物理学报 2024年第6期67卷 2402-2414页

作者：冯璐瑜薛亚茹张程苏军利梁琪乔佳瑜中国石油大学(北京)信息科学与工程学院/人工智能学院北京102249 中国石油大学(北京)油气资源与探测国家重点实验室北京102249

Radon变换是常用多次波压制方法之一,然而有限、离散的采样空间导致一次波和多次波在Radon域混叠,并且混叠程度随频率降低愈加严重.高分辨率Radon变换可以改善一次波和多次波分离效果,但分辨率的提高会降低保幅性,导致多次波残留或一次... 详细信息

Radon变换是常用多次波压制方法之一,然而有限、离散的采样空间导致一次波和多次波在Radon域混叠,并且混叠程度随频率降低愈加严重.高分辨率Radon变换可以改善一次波和多次波分离效果,但分辨率的提高会降低保幅性,导致多次波残留或一次波损伤.为此,本文在最小二乘反演基础上,提出一种随混叠程度自适应分离多次波的频变滤波方法.根据Radon变换褶积模型,分析一次波和多次波频变混叠机制;建立随频率调整的修正柯西函数混叠模型;依据一次波和多次波的混叠比例设计多次波滤波器,该滤波器能够根据一次波和多次波的混叠程度自适应调整滤波函数,提高多次波估计精度.合成数据和实际数据的多次波压制实验表明,这种频变滤波方法既可以改善多次波压制效果,又可避免高分辨率反演方法计算量大的问题.

关键词： Radon变换多次波压制混叠机制频变滤波

在线全文

学校读者我要写书评

暂无评论

多示例学习的簇频繁性分析及双角度融合嵌入

南京大学学报（自然科学版） 2024年第4期60卷 531-541页

作者：杨梅张靖宇闵帆方宇西南石油大学计算机与软件学院成都610500 西南石油大学人工智能研究院成都610500 西南石油大学机器学习研究中心成都610500

多示例学习(Multi-Instance Learning,MIL)的训练数据是由若干个未带标记的示例组成的带标记的包,基于嵌入的方法,通过将包嵌入成单向量来解决包表示问题,然而大部分现有方法忽略了示例与包的联系,难以保证所选示例的代表性.同时,单角... 详细信息

多示例学习(Multi-Instance Learning,MIL)的训练数据是由若干个未带标记的示例组成的带标记的包,基于嵌入的方法,通过将包嵌入成单向量来解决包表示问题,然而大部分现有方法忽略了示例与包的联系,难以保证所选示例的代表性.同时,单角度的嵌入方法无法有效地提取正、负包的差异信息,使嵌入向量的质量较差.提出一种多示例学习的簇频繁性分析及双角度融合嵌入(FADE).簇频繁性分析技术从正、负子空间中分别筛选部分示例作为子空间的簇心,依据簇心将子空间聚类成簇,再计算簇频繁性指标,选择频繁性较高的簇的簇心组成子空间代表示例集.双角度融合嵌入技术基于正、负子空间代表示例集和差值嵌入函数,分别从正、负角度挖掘信息,融合两个角度信息获得最终的嵌入向量.在29个数据集上与七个MIL算法进行了对比实验,结果表明,FADE的分类准确率总体上优于七个对比算法,在图像数据集上有显著优势,在文本和网页数据集上也表现良好.

关键词：多示例学习嵌入方法簇频繁性示例来源双角度融合

在线全文

学校读者我要写书评

暂无评论

双膦酸盐抗三种顶复门原虫研究进展

中国人兽共患病学报 2024年第2期40卷 185-190,196页

作者：侯文燕张营营张龙现张素梅河南农业大学动物医学院郑州450046 河南省人兽共患病国际联合实验室郑州450046

顶复门原虫可引起严重疾病威胁人类健康,如每年导致近100万人死亡的疟原虫,感染全球约1/3人口的弓形虫以及导致新生儿腹泻的隐孢子虫等。这3种顶复门原虫对全球的生物安全和公共卫生构成巨大隐患,且目前在临床上有效治疗药物有限。双膦... 详细信息

顶复门原虫可引起严重疾病威胁人类健康,如每年导致近100万人死亡的疟原虫,感染全球约1/3人口的弓形虫以及导致新生儿腹泻的隐孢子虫等。这3种顶复门原虫对全球的生物安全和公共卫生构成巨大隐患,且目前在临床上有效治疗药物有限。双膦酸盐临床上广泛用于治疗骨代谢疾病,但其化合物可有效抑制顶复门原虫生长,作用机制为竞争性抑制寄生虫类异戊二烯分子生物合成的2C-甲基-D-赤藓糖醇-4-磷酸途径(MEP途径)中的法尼基焦磷酸合酶,干扰类异戊二烯化合物的合成而发挥作用。本文综述了双膦酸盐化合物在疟原虫、弓形虫和隐孢子虫方面的相关研究,以期为临床治疗相关疾病提供理论基础。

关键词：疟原虫弓形虫隐孢子虫双膦酸盐类异戊二烯 MEP途径

Numerical Simulation on Radon Retardation Behavior of Covering Floats in Radon-Containing Water

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第4期37卷 406-417页

作者： LIU Shu Yuan zhang Li YE Yong Jun DING Ku Ke National Institute for Radiological Protection Chinese Center for Disease Control and PreventionBeijing 100088China Office for Public Health Management Chinese Center for Disease Control and PreventionBeijing 102206China Key Discipline Laboratory for National Defense for Biotechnology in Uranium Mining and Hydrometallurgy University of South ChinaHengyang 421001HunanChina

Objective This study aimed to efficiently reduce the release of radon from water bodies to protect the *** Based on the sizes of the experimental setup and modular float,computational fluid dynamics(CFD)was used to assess the impact of the area coverage rate,immersion depth,diffusion coefficient,and radon transfer velocity at the gas–liquid interface on radon migration and exhalation of radon-containing *** on the numerical simulation results,an estimation model for the radon retardation rate was *** effectiveness of the CFD simulation was evaluated by comparing the experimental and simulated variation values of the radon retardation rate with the coverage area *** The effect of radon transfer velocity on radon retardation in water bodies was minor and insignificant according to the appropriate value;therefore,an estimation model of the radon retardation rate of the coverage of a radon-containing water body was constructed using the synergistic impacts of three factors:area coverage rate,immersion depth,and diffusion *** deviation between the experimental and simulated results was<4.3%.Conclusion Based on the numerical simulation conditions,an estimation model of the radon retardation rate of covering floats in water bodies under the synergistic effect of multiple factors was obtained,which provides a reference for designing covering floats for radon retardation in radoncontaining water.

关键词： Radon-containing water Radon retardation rate CFD Coverage experiment Optimized design