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Synthesis,Structure and Biological Activities of 2-(1H- 1,2,3-Benzotriazol-1-yl)-1-(4-methylphenyl)-2- (1H-1,2,4-triazol-1-yl)-1-ethanone

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Chemical Research in Chinese Universities 2006年第4期22卷 465-467页

作者： WAN Jun LI Chun-li LI xue-mei zhang Shu-sheng College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China

The title compound was synthesized and characterized by IR, ^1H NMR, elemental analysis and single crystal X-ray diffraction analysis. Its biological activities were also tested. The results show that the title compound reveals inhibiting activities towards wheat gibberellin, apple ringspot, tomato early blight, peanut cercospora arachidicola and stem wilt of asparagus.

关键词： Triazole derivative Biological activity Crystal structure

Aβ28-Induced Specific and Effective Serum Antibodies Against Aβ42

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Chemical Research in Chinese Universities 2010年第6期26卷 974-980页

作者： WANG Jia-peng CUI Li-li HUANG xue-mei zhang Ying-jiu Key Laboratory for Molecular Enzymology ＆ Engineering Ministry of Education Jilin University Changchun 130021 P. R. China

Though phase I clinical trial of immunotherapy for Alzheimer＇s disease（AD） with inoculated Aβ42 in humans had been proven to be effective,phase II immunotherapy trial was discontinued in 2002 because a few patients developed significant inflammatory reactions caused by C-terminal domain of Aβ*** aim of the study was to investigate the levels and the abilities of antibodies induced by C-terminal truncated Aβ species to inhibit Aβ42 aggregation and cytotoxity in vitro.46-week-old male BALB/c mice,Aβ42 and Aβ28/Aβ35/Aβ42 with a C-terminal eight-histidine tag（Aβ28H8,Aβ35H8,and Aβ42H8） were applied in the present *** mice were randomly divided into 5 groups（n=8）,control mice immunized with the normal saline,Aβ42-immunized mice and Aβ42H-/Aβ35H-/Aβ28H-immunized *** the serum antibodies were evaluated by measuring their abilities to inhibit Aβ42 aggregation and cytotoxity in *** mouse was vaccinated with purified Aβ peptide emulsified with Freund＇s adjuvant（volume ratio 1：1）.Titers,concentrations and isotypes of serum antibodies against Aβ42 were measured by indirect *** of serum antibodies on Aβ42 aggregation and disassembly of Aβ42 fibrils in vitro were observed by electron *** of serum antibodies on Aβ42 cytotoxicity were determined by MTT assay.Aβ42 or Aβ28 could induce higher anti-Aβ42 antibody titer（1：6400） than Aβ35（1：3200）.Significantly,Aβ28 induced more IgG1 and IgG2b isotype antibodies and less IgG2b isotype antibody than other Aβ species though all the induced serum antibodies could inhibit Aβ42 aggregation or fibrillogenesis,could induce the disassembly of Aβ42 aggregates,and neutralized or inhibited the cytotoxicity of Aβ42 in vitro.C-Terminal truncated Aβ28 could induce the same effective but safer serum antibodies against Aβ42 than full length Aβ42 by eliciting more Th2-type immune responses.

关键词： Alzheimer's disease Amyloid peptide Antibody Epitope Immunization

Chemistry and Process Optimization of V-Microalloyed N80-Class Seamless Casing Tube

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Journal of Iron and Steel Research International 2010年第3期17卷 72-78页

作者： PAN Tao YANG Cai-fu MA Yue xue Dong-mei zhang Yong-quan Division for Structural Materials Central Iron and Steel Research Institute Beijing 100081 China

The complex effects of different nitrogen （N） contents and thermal routines on the microstructure and mechanical properties of 33Mn2V steels for N80-Class seamless casing tube application were investigated using Gleeble simulation technique. The results showed that the N additions of 0. 014 %- 0. 021 % in the steels for the in-line normalization process （ILNP） increased the strength while the toughngss remained at a high level as compared with the steel with N content of 0. 005 %. It was also revealed that the N addition of 0. 021%could enhance the performance combination of strength and toughness in the steels by using 700 ℃ as the cooling interrupted temperature （CIT） for the non in-line normalizing process （NILNP）. It was further evidenced that the toughness was improved at expense of strength to some degree in all the steels by decreasing reheating temperature for the ILNP, while an increase of CIT for NILNP severely impaired the toughness and slightly improve the strength in the high-N steel with N content of 0. 021%. This can be attributed to the dissolution and precipitation behavior of V（C,N）. The optimization of V （C,N） precipitation could be achieved by enhancing N. The precipitation of V（C, N） in austenite was promoted by cooling to a certain temperature lower than the A,1 for the ILNP. The V（C,N） particles formed in austenite contrib- uted to grain refinement by the VN-induced nucleation of intragranular ferrite, but as a result the effect of precipitation on strengthening would become weaker due to a decrease of the precipitation of V in ferrite.

关键词： seamless tube in-line normalizing V-N microalloying reheating mechanical properties Gleeble simulation

Expression Characterization and Preparation of Human Amyloid Precursor Protein in Escherichia coli

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Chemical Research in Chinese Universities 2009年第1期25卷 64-68页

作者： XU Guang-wei WANG Jia-peng HUANG xue-mei zhang Ying-jiu Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education Jilin University Changehun 130021 P R. China

To analyze whether expressed amyloid precursor protein（APP） existed in hydrophilic（cytoplasmid） or hydrophobic（lipid bilayer） environment in E. coli and to obtain intact APP for study on its function, we investigated the expression characterization and preparation of the three intact isoforms APP770, APP751, and APP695 in E. coll. The results show that these expressed APPs existed both in hydrophilic cytoplasm region as inclusion bodies and hydrophobic membrane region as membrane-bound state in E. coll. APPs in inclusion bodies were purified on an NTA-Ni^2＋ agarose column after dissolving in the urea buffer and APPs in membrane-bound state were obtained by ultracentrifugation. The activity analysis indicates that APP770 and APP751 exhibited strong trypsin-inhibitory activity like the natural ones. These results indicate that E. coli cells can be used as host cells for the expression of human integral membrane protein like APP in either soluble or membrane-bound state unless the interest protein undergone post-translational modification is required.

关键词： Amyloid precursor protein Expression characterization Preparation Membrane Inclusion body

A preliminary report of the Yangbi, Yunnan, M_(S)6.4 earthquake of May 21, 2021

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Earth and Planetary Physics 2021年第4期5卷 362-364页

作者： ZhiGao Yang Jie Liu xue-mei zhang WenZe Deng GuangBao Du XiYan Wu China Earthquake Networks Center Beijing 100045China Institute of Geology Chinese Earthquake AdministrationBeijing 100029China

According to the reports of China Earthquake Networks Center,an Ms6.4 earthquake occurred in Yangbi City,Dali Prefecture,Yun-nan Province,on May 21,2021;the epicenter was located at 25.67°N and 99.87°E with a focal ... 详细信息

关键词： Yangbi M_(s)6.4 earthquake focal mechanism earthquake sequence

A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 32-39页

作者： xue-ling HE Hai-lin YIN Jiang WU Ke zhang Yan LIU Tao YUAN Hai-lin RAO Liang LI Guang YANG xue-mei zhang Institute of Biomedical Engineering West China Center of Medical Sciences Sichuan University Chengdu 610041 China Laboratory Animal Center of Sichuan University Chengdu 610041 China Chengdu Institute of Biological Products China National Biotic Group (CNBG) Chengdu 610023 China

Radiation therapy has been widely applied in cancer ***,it often causes thrombocytopenia (deficiency of white blood cells) as an adverse *** human interleukin-6 (rhIL-6) has been found to be a very effective way against this thrombocytopenia,but IL-6 has low stability in blood,which reduces its *** increases the stability and half-life of rhIL-6,it was modified by polyethylene glycol (PEG).The pharmacokinetics and the tissue distribution of PEG-rhIL-6 labeled with 125I were examined after subcutaneous injection in *** pharmacokinetic pattern of PEG-rhIL-6 was defined with linear-kinetics,and we fitted a one-compartment model with half-lives of 10.44–11.37 h (absorption,t1/2Ka) and 19.77–21.53 h (elimination,t1/2Ke),and peak concentrations at 20.51–21.96 h (tpeak) in ***-lives and tpeak of PEG-rhIL-6 were longer than those of rhIL-6 previously *** the present study,for deposition of PEG-rhIL-6 in rats,the tissue distribution examination showed that blood was the major organ involved,rather than ***,as to the elimination of PEG-rhIL-6,the major organ was the *** excretion fraction of the injection dose recovered from urine was 23.32% at 192 h after subcutaneous *** than 6% of PEG-rhIL-6 was eliminated via the feces at 192 *** results indicate that PEG-rhIL-6 is a good candidate drug formulation for patients with cancer.

关键词： Polyethylene glycol Recombinant human interleukin-6 Pharmacokinetics Rat

Relationship between the Stratospheric Arctic Vortex and Surface Air Temperature in the Midlatitudes of the Northern Hemisphere

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Journal of Meteorological Research 2024年第1期38卷 39-52页

作者： xue RAN Dingzhu HU Yang zhang mei-Chen LIU Key Laboratory of Meteorological Disaster Ministry of Education(KLME)/Joint International Research Laboratory of Climate and Environmental Change(ILCEC)/Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science&TechnologyNanjing 210044 School of Atmospheric Sciences Nanjing UniversityNanjing 210023

It is known that different relationships exist between the strength and displacement of the stratospheric polar vortex(SPV),and the surface air temperature(SAT)patterns in Eurasia and North America,but the mechanisms behind these relationships remain unclear,especially on an interannual *** on empirical orthogonal function(EOF)analysis using NCEP reanalysis data over 1958–2018,this study attempts to ascertain the relationship between the SPV intensity and displacement over the Arctic and the SATs in the midlatitudes of the Northern *** results indicate that a strengthened SPV corresponds to an SAT increase in Eurasia and a decrease in eastern North America and *** the SPV is shifted towards Eurasia,however,a corresponding SAT increase occurs in both North America and Eurasia,with a larger increase in North America than in ***,a strengthened SPV tends to correspond to a positive North Atlantic Oscillation-like circulation in the troposphere with negative geopotential height(GH)anomalies in Greenland and eastern North American continent and positive GH anomalies to the north of 45°N in Eurasia,which corresponds to lower SATs in North America than in ***,when the SPV shifted towards Eurasia,it was accompanied by a positive Pacific/North American-like pattern with a deepened Aleutian low,which corresponds to the increasing SATs in North *** tropospheric circulation changes are related to the response of tropospheric planetary wave activity to the SPV.A strengthened SPV corresponds to the weakening of tropospheric planetary wave-1 waves,which is accompanied by a negative GH in North America but a positive GH in *** the SPV shifted towards Eurasia,the tropospheric planetary wave-1(-2)waves strengthened(weakened),and the combined effects of the planetary wave-1 and wave-2 waves would cause positive GH anomalies in both Eurasia and North America.

关键词： stratospheric polar vortex surface air temperature teleconnection patterns planetary waves

Self-Powered Flexible Multicolor Electrochromic Devices for Information Displays

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Research 2024年第2期2023卷 529-540页

作者： Wenzhao xue Yun zhang Feng Liu Yao Dou mei Yan Wenshou Wang School of Chemistry and Chemical Engineering University of JinanJinan 250022P.R.China

The development of self-powered flexible multicolor electrochromic(EC)systems that could switch different color without an external power supply has remained extremely ***,a new trilayer film structure for achieving self-powered flexible multicolor EC displays based on self-charging/discharging mechanism is proposed,which is simply assembled by sandwiching an ionic gel film between 2 cathodic nickel hexacyanoferrate(NiHCF)and Prussian blue(PB)nanoparticle films on indium tin oxide *** display exhibits independent self-powered color switching of NiHCF and PB films with fast responsive time and high reversibility by selectively connecting the Al wire as anodes with the 2 EC *** switching is thus achieved through a color overlay effect by superimposing the 2 EC films,including green,blue,yellow,and *** bleaching/coloration process of the displays is driven by the discharging/self-charging mechanism for NiHCF and PB films,respectively,ensuring the self-powered color switching of the displays reversibly without an external power *** is further demonstrated that patterns can be easily created in the self-powered EC displays by the spray-coating method,allowing multicolor changing to convey specific ***,a self-powered ionic writing board is demonstrated based on the self-powered EC displays that can be repeatedly written freehand without the need of an external power *** believe that the design concept may provide new insights into the development of self-powered flexible multicolor EC displays with self-recovered energy for widespread applications.

关键词： connecting repeatedly powered

Tsaokols A and B,unusual flavanol-monoterpenoid hybrids asα-glucosidase inhibitors from Amomum tsao-ko

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Chinese Chemical Letters 2021年第3期32卷 1202-1205页

作者： Xiao-Feng He Ji-Jun Chen Tian-Ze Li Jing Hu Xu-Ke zhang Yuan-Qiang Guo xue-mei zhang Chang-An Geng State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesYunnan Key Laboratory of Natural Medicinal ChemistryKunming 650201China College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai UniversityTianjin 300071China University of Chinese Academy of Sciences Beijing 100049China

Tsaokols A(1)and B(2),two complicated flavanol-monoterpenoid hybrids,were isolated from the dried fruits of Amomum tsao-ko under the guidance of LCMS and *** structures were determined by extensive spectroscopic analyses and electronic circular dichroism(ECD)*** 1 and2 shared a flavanol backbone fused with 5/7 and 5/6 bicyclic monoterpenoid scaffolds,which were biogenetically condensed by Michael addition and *** 1 and 2 exhibited significantα-glucosidase inhibitory activity with IC_(50)values of 18.8 and 38.6μmol/L(acarbose,IC_(50)=213μmol/L).Docking study supported the strong interactions of 1 and 2 bonding with enzyme by mainly hydrophobic and hydrogen-bond *** 1 and 2 could be fast distinguished by the diagnostic ions at m/z 289 and 313 in negative MS^(2)experiments.

关键词： Amomum tsao-ko Zingiberaceae Flavanol-monoterpenoid hybrids α-Glucosidase inhibitors