检索结果-南通市图书馆

Echinacoside and Cistanche tubulosa(Schenk) R. wight have male reproductive protection effect by targeting hypothalamic and rogen receptor

引用

中国药理学与毒理学杂志 2018年第4期32卷 257-258页

作者： Xiao-ying ZHANG Zhi-hui JIANG xue-mei chang Rui-min CAO College of Veterinary Medicine Northwest A&F University Research Center of Modern Biotechnology School of Biotechnology and Food EngineeringAnyang Institute of Technology College of Veterinary Medicine Xinjiang Agricultural University

OBJECTIVE Cistanche deserticola *** is an official plant that grows in arid or semi-arid *** early work demonstrated that Cistanche extracts protect against sperm damage in mice under bisphenol A induced reproductive ***(ECH) is one of the major active *** present study investigated the mechanisms behind the possible protective effects of ECH against oligoasthenospermia in rat and identified the interaction between ECH and *** The distribution of ECH was assayed by HPLC,the quantity and quality of sperm was evaluated and hormone levels were determined by radioimmunosorbent *** levels of androgen receptor(AR) and key steroidogenic-related genes were reduced as determined by Western blotting and qPCR *** interaction between ECH and AR were evaluated by fluorescence localization assay,indirect ELISA and molecular *** ECH significantly increased the quantity of sperm and secretions of luteinizing hormone and *** was distributed to the hypothalamus but not in the *** combined with hypothalamic AR in the pocket of Met-894 and Val-713 to inhibit transfer of AR from the cytoplasm to nuclei in the *** negative feedback of sex hormone *** was inhibited,positive feedback was stimulated to increase the secretion of luteinizing hormone and testosterone subsequently enhancing the quantity of *** significantly alleviated the BPA-induced reproductive damage by increasing testicular superoxide dismutase(SOD),glutathione peroxidase(GSH-PX) and glutathione(GSH);as well as by reducing serum malondialdehyde(MDA).*** not only obviously enhanced the levels of serumLH and T,but it also improved the sperm count and motility compared to the BPA-treated *** *** and ECH protect the BPA induced reproductive *** blocks AR activity in the hypothalamus to increase the quantity of sperm and protect against oligoasthenospermia in rats.

关键词：肉苁蓉植物类固醇药物分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Human Leukocyte Antigen-A Allele Distribution in Nasopharyngeal Carcinoma Patients Showing Anti-Melanoma-Associated Antigen A or Synovial Sarcoma X-2 T Cell Response in Blood

引用

Chinese Medical Journal 2018年第11期131卷 1289-1295页

作者： Pei-Wen Fan Li Huang xue-mei chang Ya-Ning Feng Xuan Yao Yan-Chun Peng Tao Dong Ruo-Zheng Wang Xinjiang Key Laboratory of Oncology The Affiliated Tumor Hospital of Xinjiang Medical University Urumqi Xinjiang 830000 China Department of Radiation Oncology The Affiliated Tumor Hospital of Xinjiang Medical University Urumqi Xinjiang 830000 China CAMS Oxford Center for Translation Immunology Chinese Academy of Medical Science Oxford Institute Nuffield Department of Medicine Oxford University Oxford OX3 9DS UK MRC Human Immunology Unit Weatherall Institute of Molecular Medicine Oxford University Oxford OX3 9DS UK

Background： Development of innovative immunotherapy is imperative to improve the poor survival of the nasopharyngeal carcinoma （NPC） patients. In this study, we evaluated the T cell response to melanoma-associated antigen （MAGE）-A1, MAGE-A3, or synovial sarcoma X-2 （SSX-2） in the peripheral blood of treatment-naive NPC patients. The relationship of responses among the three proteins and the human leukocyte antigen （HLA）-A types were analyzed to provide evidence of designing novel therapy. Methods： Sixty-one NPC patients admitted into the Tumor Hospital affiliated to the Xinjiang Medical University between March 2015 and July 2016 were enrolled. Mononuclear cells were isolated from the peripheral blood before any treatment. HLA-A alleles were typed with Sanger sequence-based typing technique. The T cell response to the MAGE-A1, MAGE-A3, or SSX-2 was evaluated with the Enzyme-Linked ImmunoSpot assay. Mann-Whitney U-test was used to compare the T cell responses from different groups. Spearman＇s rank correlation was used to analyze the relationship of T cell responses. Results： HLA-A＊02：01, A＊02：07, and A＊24：02 were the three most frequent alleles （18.9%, 12.3%, and 11.5%, respectively） among the 22 detected alleles. 31.1%, 19.7%, and 16.4% of the patients displayed MAGE-A1, MAGE-A3, or SSX-2-specific T cell response, respectively. The magnitudes of response to the three proteins were 32.5, 38.0, and 28.7 SFC/106 peripheral blood mononuclear cells, respectively. The T cell response against the three proteins correlated with each other to different extent. The percentage of A＊02：01 and A＊24：02 carriers were significantly higher in patients responding to any of the three proteins compared to the nonresponders. Conclusion： MAGE-A1, MAGE-A3, or SSX-2-specific T cell responses were detectable in a subgroup of NPC patients, the frequency and magnitude of which were correlated.

关键词： Human Leukocyte Antigen-A Melanoma-Associated Antigen-A Nasopharyngeal Carcinoma Synovial Sarcoma X-2 T Cell Response

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

响应面法优化亚临界流体萃取牡蛎中持久性有机污染物工艺

引用

食品科技 2017年第9期42卷 309-314页

作者：石念荣韩玉谦冯晓梅薛长湖中国海洋大学食品科学与工程学院青岛266003

利用响应面法对亚临界1,1,1,2-四氟乙烷(R134a)同时萃取牡蛎中多种持久性有机污染物(POPs)的工艺条件进行优化。实验结果表明,萃取温度、萃取压力、共溶剂用量对萃取效果的影响均极显著,萃取温度和萃取压力交互影响极显著;研究确定的最... 详细信息

利用响应面法对亚临界1,1,1,2-四氟乙烷(R134a)同时萃取牡蛎中多种持久性有机污染物(POPs)的工艺条件进行优化。实验结果表明,萃取温度、萃取压力、共溶剂用量对萃取效果的影响均极显著,萃取温度和萃取压力交互影响极显著;研究确定的最佳工艺条件为萃取温度38℃、萃取压力11.6 MPa、共溶剂二氯甲烷用量4.37 m L;此条件下多环芳烃(PAHs)、多氯联苯(PCBs)和多溴联苯醚(PBDEs)的平均回收率为81.2%。该方法是一种简单、快速、环保,适用于多种POPs同时萃取的新型前处理技术,应用前景广阔。

关键词：亚临界流体萃取多环芳烃多氯联苯多溴联苯醚响应面

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

喉鳞状细胞癌微血管密度和层粘连蛋白表达与颈淋巴结转移的关系

引用

复旦学报（医学版） 2003年第6期30卷 585-587页

作者：谢晓凤王建中吴钦苏周旭罗雪梅常荣先复旦大学附属中山医院耳鼻喉科上海200032

目的探讨喉鳞癌中微血管密度(microvessel density,MVD)和层粘连蛋白(laminin,LN)表达与颈淋巴结转移的关系。方法应用CD34和LN抗体,采用免疫组织化学(Envision)染色方法对54例喉鳞癌组织中微血管密度及LN表达进行了检测。结果 (1)喉... 详细信息

目的探讨喉鳞癌中微血管密度(microvessel density,MVD)和层粘连蛋白(laminin,LN)表达与颈淋巴结转移的关系。方法应用CD34和LN抗体,采用免疫组织化学(Envision)染色方法对54例喉鳞癌组织中微血管密度及LN表达进行了检测。结果 (1)喉鳞癌组织中MVD与颈淋巴结转移相关,淋巴结转移组的MVD高于非转移组(P0.05)。(2)LN表达与喉鳞癌颈淋巴结转移相关,有淋巴结转移组LN表达率高于无淋巴结转移组(P0.05)。(3)喉鳞癌组织中MVD与LN表达无关(P>0.05)。结论喉鳞癌中MVD和LN表达可作为预测颈淋巴结转移的指标。

关键词：喉鳞状细胞癌微血管密度层粘连蛋白颈淋巴结转移免疫组织化学检测

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

引用

Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li Jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo xue xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

开放性前列腺手术治疗68例良性前列腺增生的临床疗效

引用

系统医学 2018年第12期3卷 97-99页

作者：贺德龙薛长梅杨录青海省湟中县第二人民医院外科青海西宁811601

目的探讨开放性前列腺手术治疗良性前列腺增生的临床效果。方法选取该院2017年3月—2018年3月收治的68例良性前列腺增生的患者,按入院顺序编号后随机分成两组,对照组34例患者接受常规的开放性耻骨上列腺切除手术,34例观察组患者接受经... 详细信息

目的探讨开放性前列腺手术治疗良性前列腺增生的临床效果。方法选取该院2017年3月—2018年3月收治的68例良性前列腺增生的患者,按入院顺序编号后随机分成两组,对照组34例患者接受常规的开放性耻骨上列腺切除手术,34例观察组患者接受经尿道等离子电切手术,对比两组患者手术过程中的出血量,手术时间,手术后导尿管的滞留时间、住院时间以及手术后两者患者的临床满意度情况,并对比两组患者术后的并发症发生率。结果观察组患者并发症的发生率为2.94%,对照组并发症的发生率为29.41%,对照组患者的术后并发症发生率明显高于观察组,数据对比差异有统计学意义(χ2=4.62,P<0.05)。观察组患者手术过程中的出血量,手术时间,手术后导尿管的滞留时间、住院时间数据均小于对照组,观察组患者的临床满意度高于对照组,两组患者的临床数据对比均有统计学意义(P<0.05)。结论开放性前列腺手术治疗良性前列腺增生能够显著缩短患者的手术时间与住院时间,降低患者的手术过程中出血量,同时降低术后并发症的发生率,有效提高临床患者的临床满意度,值得临床推广。

关键词：良性前列腺增生开放性前列腺手术临床效果

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

引用

Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

铬(Ⅲ)络合物作为光敏剂的光还原水放氢体系的研究

引用

太阳能学报 1985年第2期 156-162页

作者：王绵绍张玉美王雪梅顾长立中国科学院大连化学物理研究所

对Cr（bpy）33+-EDTA-Pt、Cr（phen）33+-EDTA-Pt和CrCl3-bpy-EDTA-Pt等光还原水放氢体系进行了实验研究。Cr（bpy）33+有较好的放氢效果,用CrCl3和bpy替代Cr（bpy）33+也能得到氢气,添加过量的bpy能促进放氢。通过对体系吸收光谱和荧... 详细信息

对Cr（bpy）33+-EDTA-Pt、Cr（phen）33+-EDTA-Pt和CrCl3-bpy-EDTA-Pt等光还原水放氢体系进行了实验研究。Cr（bpy）33+有较好的放氢效果,用CrCl3和bpy替代Cr（bpy）33+也能得到氢气,添加过量的bpy能促进放氢。通过对体系吸收光谱和荧光发射光谱的分析,讨论了上述放氢体系的反应过程,并测得EDTA对*Cr（bpy）33+的双分子淬灭常数Kα=5.9×108M-1S-1。

关键词：放氢 Cr 放氢反应 EDTA 络合试剂光敏剂络合物配位化合物光还原

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Recent Advances in Asymmetric Structural Composites for Excellent Electromagnetic Interference Shielding: A Review

引用

Chinese Journal of Polymer Science 2024年第6期42卷 693-710页

作者： Ying Zhou Bai xue Lan Xie chang-mei Wu Qiang Zheng Department of Polymer Materials and Engineering College of Materials and Metallurgy Guizhou University National Engineering Research Center for Compounding and Modification of Polymer Materials National and Local Joint Engineering Research Center for Functional Polymer Membrane Materials and Membrane Processes State Key Laboratory of Public Big Data Guizhou University Department of Polymer Science and Engineering Zhejiang University

Since electromagnetic pollution is detrimental to human health and the environment, numerous efforts have been successively made to achieve excellent electromagnetic interference shielding effectiveness(EMI SE) via designing the hierarchical structures for electromagnetic interference(EMI) shielding polymer composites. Among the plentiful structures, the asymmetric structures are currently a hot spot, principally categorizing into multi-layered, porous, fibrous, and segregated asymmetric structures, which endows the high EMI shielding performance for polymer composites incorporated with magnetic, conductive, and/or dielectric micro/nano-fillers, due to the “absorption-reflection-reabsorption” shielding mechanism. Therefore, this review provides the retrospection and summary of the efforts with respect to abundant asymmetric structures and multifunctional micro/nano-fillers for enhancing EMI shielding properties, which is conducive to the booming development of polymeric EMI shielding materials for the promising prospect in modern electronics and 5-generation(5G) technology.

关键词： Asymmetric structure Micro/nano functional filler Polymer composite Electromagnetic interference shielding

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Mitochondrial dysfunction and cellularmetabolic deficiency in Alzheimer's disease

引用

Neuroscience Bulletin 2012年第5期28卷 631-640页

作者： xue-mei Gu Han-chang Huang Zhao-Feng Jiang Beijing Military General Hospital Beijing 100700 China Beijing Key Laboratory of Bioactive Substances and Functional Foods Beijing Union University Beijing 100191 China College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 China

Alzheimer＇s disease （AD） is an age-related neurodegenerative disorder. The pathology of AD includes amyloid-β （Aβ） deposits in neuritic plaques and neurofibrillary tangles composed of hyperphosphorylated tau, as well as neuronal loss in specific brain regions. Increasing epidemiological and functional neuroimaging evidence indicates that global and regional disruptions in brain metabolism are involved in the pathogenesis of this disease. Aβ precursor protein is cleaved to produce both extracellular and intracellular Aβ, accumulation of which might interfere with the homeostasis of cellular metabolism. Mitochondria are highly dynamic organelles that not only supply the main energy to the cell but also regulate apoptosis. Mitochondrial dysfunction might contribute to Aβ neurotoxicity. In this review, we summarize the pathways ofAβ generation and its potential neurotoxic effects on cellular metabolism and mitochondrial dysfunction.

关键词： Alzheimer’s disease amyloid-β metabolic deficiency mitochondrial dysfunction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：