检索结果-南通市图书馆

CYP17A1基因突变致先天性肾上腺皮质增生症一例报道并文献复习

在线全文

学校读者我要写书评

暂无评论

中国全科医学 2025年第6期28卷 771-776页

作者：戴遥薛丽萍章诗琪许敏章秋胡红琳安徽医科大学第一附属医院内分泌代谢科安徽省合肥市2320000

17α-羟化酶缺乏症(17-OHD)是先天性肾上腺皮质增生症(CAH)中的一种罕见类型,约占CAH的1%,其患病率为1∶50000。本文报道了1例疑似17-OHD患者,通过外显子测序鉴定了1个类固醇生成酶基因CYP17A1的基因突变,结合临床表现、体格检查、肾上... 详细信息

17α-羟化酶缺乏症(17-OHD)是先天性肾上腺皮质增生症(CAH)中的一种罕见类型,约占CAH的1%,其患病率为1∶50000。本文报道了1例疑似17-OHD患者,通过外显子测序鉴定了1个类固醇生成酶基因CYP17A1的基因突变,结合临床表现、体格检查、肾上腺和性腺功能检查等,最终将其明确诊断为CAH并给予规范治疗。故结合该病例,本文回顾总结了17-OHD的鉴别和诊断,以期提高临床对该病的认识,促进临床对17-OHD的规范诊治,为17-OHD的诊断和治疗提供更多的参考资料。

关键词：肾上腺皮质疾病先天性肾上腺皮质增生症 17α-羟化酶缺陷症基因诊断 CYP17A1基因

Three-Dimensional Climatological Structures of the Arabian Sea Eddies and Eddy-Induced Flux

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2023年第4期22卷 874-885页

作者： lin Xinyu qiu Yun NI Xutao lin Wenshu AUNG Cherry Third Institute of Oceanography Ministry of Natural ResourcesXiamen 361005China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQingdao 266061China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China Fujian Provincial Key Laboratory of Marine Physical and Geological Processes Xiamen 361005China Marine Science Department Myeik UniversityTanintharyi 14052Myanmar

This study explores the spatial structure and transport characteristics of eddies in the Arabian Sea(AS)using Argo profiles and satellite *** majority of eddies occur in the northern AS,especially along its northeastern *** contrast,the western AS had a relatively higher eddy kinetic energy compared to the eastern ***,the strongest energetic eddies were present in the Somali Current *** composite results revealed the evident thermohaline anomalies caused by cyclonic eddies(CEs)and anticyclonic eddies(AEs)in the upper 300m *** anomalous temperature structure within CEs and AEs showed a dominant dipole structure in the near-surface layer and a monopole structure below,with maximum temperature anomalies of approximately−0.8℃and+1.0℃located at depths of 100–150m,*** composited salinity structures for CEs and AEs exhibited monopole vertical structures and sandwich-like *** AEs,large positive salinity anomalies occurred at subsurface layers of 60–180 m with a peak value of about 0.07,and weak negative values were observed above 60m and below 180 m.A similar vertical structure but with an opposite sign operates for *** composited CE and AE caused an equatorward salt flux with values of−8.1×10^(4)and−2.2×10^(4)kg s^(−1),*** caused an equatorward heat flux of−7.7×10^(11)W,and AEs induced a poleward flux of 1.5×1011 W.

关键词： Arabian Sea mesoscale eddy thermohaline structure heat and salt flux

Suppression of leakage current in carbon nanotube field-effect transistors

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Nano Research 2021年第4期14卷 976-981页

作者： lin Xu Chenguang qiu Lian-mao Peng Zhiyong Zhang Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics Peking UniversityBeijing 100871China

Carbon nanotube field-effect transistor(CNT FET)has been considered as a promising candidate for future high-performance and low-power integrated circuits(ICs)applications owing to its ballistic transport and excellent immunity to short channel effects(SCEs).Still,it easily suffers from the ambipolar property,and severe leakage current at off-state originated from gate-induced drain leakage(GIDL)in CNT FETs with small *** some modifications on device structure have been experimentally demonstrated to suppress the leakage current in CNT FETs,there is still a lack of the structure with excellent scalability,which will hamper the development of CNT FETs toward a competitive technology ***,we explore how the device geometry design affects the leakage current in CNT FETs,and then propose the possible device structures to suppress off-state current and check their availability through the two-dimensional(2D)TCAD *** all the proposed structures,the L-shaped-spacer CNT FET exhibits significantly suppressed leakage current and excellent scalability down to sub-50 nm with a simple self-aligned gate *** to the simulation results,the 50 nm gate-length L-shaped-spacer CNT FET exhibits an off-state current as low as approximately 1 nA/μm and an on-current as high as about 2.1 mA/μm at a supply voltage of-1 V and then can be extended as a universal device structure to suppress leakage current for all the narrow-bandgap semiconductors based FETs.

关键词： carbon nanotube field-effect transistor leakage current TCAD simulation narrow-bandgap semiconductor

Ultra-compact tunable graphene-based plasmonic multimode interference power splitter in mid infrared frequencies

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2017年第8期60卷 211-216页

作者： Pingping qiu Weibin qiu Zhili lin Houbo CHEN Yixin TANG Jiaxian WANG Qiang KAN Jiaoqing PAN College of Information Science and Engineering Huaqiao University Institute of Semiconductors Chinese Academy of Sciences

In this paper, we propose graphene-based plasmonic multimode interference power splitters with ultra-compact size working in mid infrared range. Further, the arbitrary-ratio 1×2 power splitter with a size of 140 nm×232 nm, where the splitting ratio can be tuned continuously from 1:1 to 100:0, is numerically demonstrated. Meanwhile, the graphene-based arbitrary-ratio 1×2 power splitters with different frequencies and chemical potentials are also investigated. The proposed multimode interference structure with a deep nanoscale footprint might be a fundamental component of the future high density integrated plasmonic circuit or on-chip plasmonic interconnect techniques.

关键词： graphene multimode interference surface plasmon polaritons power splitter plasmonic integrated circuits

Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2018年第9期9卷 820-825页

作者： Tian-lin Cheng Zilong qiu Institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and IntelligenceTechnology Chinese Academy of Sciences Shanghai 200031China

Dear Editor, Long non-coding RNAs （IncRNAs）, defined as RNA transcripts longer than 200 nucleotides without the protein-coding ability （Carninci et al., 2005）, share many features with protein-coding messenger RNAs （mRNAs） such as polyadenylated 5＇ ends and multi-exonic structures （Guttman et al., 2010）. Though expression levels are less abundant, IncRNAs outnumber mRNAs with more diverse regulatory functions （Quinn and Chang, 2016）. They may serve as decoys, sponges, signals or scaffolds in regulating chromatin conformation, nuclear organization, gene expression, and protein activity in cis or trans manner （Ulitsky and Bartel, 2013; Quinn and Chang, 2016）. LncRNAs are involved in various physiological processes and their lossor gain-offunction mutations have been implicated in the pathogenesis of human diseases （Wapinski and Chang, 2011）.

关键词：

The effects of long-term administration of tadalafil on STZ-induced diabetic rats with erectile dysfunction via a local antioxidative mechanism

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第4期14卷 616-620页

作者： Yun Chen Xiao-Xin Li Hao-Cheng lin xue-Feng qiu Jing Gao Yu-Tian Dai Run Wang Department of Urology the Affiliated Drum Tower HospitalNanjing University Medical SchoolNanjing 210008China School of Pharmacy Jiangsu UniversityZhenjiang 212013China Department of Urology University of Texas Health Science Center and MD Anderson Cancer CenterHoustonTX 77030USA

Type 5 phosphodiesterase inhibitors （PDE51s） are well known being effective via the nitric oxide and cyclic guanosine monophosphate （NO-cGMP） pathway and are widely used in the treatment of diabetic erectile dysfunction （ED）. However, it is unclear whether other pathways may be involved in the treatment of diabetic ED with PDE51s. The purpose of this study was to clarify the role of antioxidants in diabetic ED treatment through the long-term administration of PDE51s. Three groups of Sprague-Dawley rats were utilized： Group N, the normal control; Group D, streptozotocin （STZ）-induced diabetic rats as a control; and Group D＋T, STZ-induced diabetic rats who received oral administration of tadalafil for 8 weeks. Erectile function was assessed by intracavernous pressure （ICP） and mean arterial pressure （MAP） during electrical stimulation of the cavernous nerve before euthanasia. The levels of malondialdehyde （MDA）, superoxide dismutase （SOD） and mitochondrial membrane potential （MMP） of cavernous tissue were assessed by biochemical analysis. The morphology of mitochondria was observed by electron microscopy. The ICP/MAP ratio was higher in Group D＋T than in Group D （P〈O.05）. The levels of MDA decreased and the activities of SOD increased in Group D＋T in comparison with Group D （P〈O.05）. The mitochondrial membrane potential level of cavernous tissue in diabetic rats was partially recovered by tadalafil treatment for 8 weeks. The morphology changes of mitochondria were also remarkably ameliorated in Group D＋T. Collectively, the long-term administration of tadalafil in diabetic rats partially reduced oxidative stress lesions of the penis via a local antioxidative stress pathway. Long-term dosages of tadalafil given once daily beginning soon after the onset of diabetes may aid in preventing rats from developing diabetic ED.

关键词： diabetes erectile dysfunction mitochondria oxidative stress PDE5 inhibitor

Heat treatment effect on electrochemical properties of spinel Li_4Ti_5O_(12)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2008年第2期27卷 165-169页

作者： LI Yue ZHAO Hailei TIAN Zhihong qiu Weihua LI xue School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Anode material Li4Ti5O12 was prepared at 800℃ by a solid-state reaction, followed by heat-treatment at 600℃ for different times （0, 2, 8, and 12 h）. The effects of heat-treatment time on the particle morphology, rate-capability, and electrode kinetic process of the Li4Ti5O12 electrode, and on the lithium ion diffusion coefficient inside the Li4Ti5O12 electrode were investigated. Proper heat treatment could smoothen the particle surface of Li4Ti5O12 particles and increase the rate-capability of the electrode. Overlong heat treatment might cause particle aggregation and hence result in a poor electrode kinetic process. A sample with 8 h of heat treatment showed the best rate-capability and the lowest electrode reaction resistance. Heat treatment for 2-8 h does not significantly change the lithium ion diffusion coefficient inside the Li4Ti5O12 electrode, whereas, 12-h treatment results in a lower lithium ion diffusion coefficient.

关键词： lithium titanate heat treatment electrochemical property lithium ion battery

Isothermal reduction of titanomagnetite concentrates containing coal

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2014年第2期21卷 131-137页

作者： Tu Hu xue-wei Lü Chen-guang Bai Gui-bao qiu College of Materials Science and Engineering Chongqing University Faculty of Metallurgical and Energy Engineering Kunming University of Science and Technology

The isothermal reduction of the Panzhihua titanomagnetite concentrates （PTC） briquette containing coal under argon atmosphere was investigated by thermogravimetry in an electric resistance furnace within the temperature range of 1250-1350°C. The samples reduced in argon at 1350°C for different time were examined by X-ray diffraction （XRD） analysis. Model-fitting and model-free methods were used to evaluate the apparent activation energy of the reduction reaction. It is found that the reduction rate is very fast at the early stage, and then, at a later stage, the reduction rate becomes slow and decreases gradually to the end of the reduction. It is also observed that the reduction of PTC by coal depends greatly on the temperature. At high temperatures, the reduction degree reaches high values faster and the final value achieved is higher than at low temperatures. The final phase composition of the reduced PTC-coal briquette consists in iron and fer-rous-pseudobrookite （FeTi2O5）, while Fe2.75Ti0.25O4, Fe2.5Ti0.5O4, Fe2.25Ti0.75O4, ilmenite （FeTiO3） and wustite （FeO） are intermediate products. The reaction rate is controlled by the phase boundary reaction for reduction degree less than 0.2 with an apparent activation energy of about 68 kJ·mol-1 and by three-dimensional diffusion for reduction degree greater than 0.75 with an apparent activation energy of about 134 kJ·mol-1. For the reduction degree in the range of 0.2-0.75, the reaction rate is under mixed control, and the activation energy increases with the increase of the reduction degree.

关键词： titanomagnetite carbothermal reduction thermogravimetric analysis kinetics

Anti-inflammatory effects of astaxanthin against fungal keratitis

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2020年第11期13卷 1681-1688页

作者： Yu Huan Xu-Dong Peng Jing lin Ying-xue Zhang Lu Zhan Han Gao Gui-qiu Zhao Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Depatment of Biochemistry Microbiology and ImmunologyWayne State University School of MedicineMI 48201USA

AIM:To characterize effect of astaxanthin(ASX)in Aspergillus fumigatus(***)induced keratitis in mouse ***:In vivo,fungal keratitis mouse model was established in C57BL/6 mice using ***,followed by ASX or dimethyl sulfoxide(DMSO)*** responses were evaluated by clinical score and myeloperoxidase(MPO)*** cytokines were assessed by reverse-transcription polymerase chain reaction(RT-PCR),Western blot,immunofluorescence,and enzyme-linked immuno sorbent assay(ELISA).RESULTS:In animal model,ASX improved corneal transparency and clinical response,suppressed the expression of inflammatory cytokine like IL-1β,TNF-α,and *** levels have been shown to decrease in ASX-treated cornea by immunofluorescence and ***2 and TLR4 levels were lower in ASX-treated group than ***:ASX can suppress inflammatory response and reduce inflammatory cytokine production in mice model with *** keratitis.

关键词： astaxanthin fungal keratitis Aspergillus fumigatus anti-inflammation neutrophil