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Synthetic Control of Thorium Metal-Organic Frameworks for Sequencing and Sensing of Radioiodine Species

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Chinese Journal of Chemistry 2024年第1期42卷 20-28,I0004页

作者： Yu Ju Zi-Jian Li xue Wang Jie qiu Yiuhon Chan Zhi-Hui Zhang Mingyang He Jian lin Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology Changzhou UniversityNo.21Gehu Middle RoadChangzhouJiangsu 213164China Schoolof Nuclear Science and Technology Xi'an Jiaotong UniversityNo.28West Xianning RoadXianShaanxi 710049China Key Laboratoryof Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of Sciences2019JiaLuoRoadShanghai 201800China

Exploring the physiochemical properties and expanding the applications of actinide-containing materials is paramount to address the escalating challenge of radioactive waste ***,unlocking the full potential of these materials is largely crippled by the radiotoxicity of the *** report here two porous and luminescent thorium-based metal-organic frameworks(Th-BITD-1 and Th-BITD-2)that serve as a bifunctional platform for sequencing and sensing of radioiodine,a much more radioactive fission product discharged during the nuclear fuel *** particular,Th-BITD-1 displays better iodine uptake performance than Th-BITD-2 via the solution-based process and vapor diffusion with the maximum adsorption capacities of 831 and 1099 mg/g,*** thermore,Th-BITD-1 can function as a highly sensitive luminescence sensor for iodate with a quenching constant(Ksv)of 6.6(5)×10^(3) M^(-1)and a detection limit of 2.02μM,respectively,outperforming 2.96(6)×10^(3)M^(-1)and 10.5μM of ***,a positive correlation between the sensing efficacy and the iodate adsorption capacity has been *** work highlights the opportunity in designing novel actinide-based MOFs for their potential applications in radiological fields,e.g.,radionuclide separation and detection.

关键词： Thorium Metal-organic frameworks Adsorption Detection lodine Actinides Radiochemistry Luminescence

Spreading-rate dependence of hydroacoustic and teleseismic seismicity of ridge-transform systems:East Pacific Rise,Galapagos Ridge,and Mid-Atlantic Ridge

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Acta Oceanologica Sinica 2022年第5期41卷 124-135页

作者： Tingting Zheng Jian lin qiu Zhong Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyInnovation Academy of South China Sea Ecology and Environmental EngineeringChinese Academy of SciencesGuangzhou510301China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458China China-Pakistan Joint Research Center on Earth Sciences Chinese Academy of Science-Higher Education Commission(Pakistan)Islamabad45320Pakistan Department of Ocean Science and Engineering Southern University of Science and TechnologyShenzhen518055China Department of Geology and Geophysics Woods Hole Oceanographic InstitutionFalmouthWoods HoleMA02543USA

Seismicity in ocean ridge-transform systems reveals fundamental processes of mid-ocean ridges,while comparisons of seismicity in different oceans remain rare due to a lack of detection of small *** 1996 to 2003,the Pacific Marine Environmental Laboratory of the National Oceanic and Atmospheric Administration(NOAA/PMEL)deployed several hydrophones in the eastern Pacific Ocean and the northern Atlantic *** hydrophones recorded earthquakes with small magnitudes,providing us with opportunities to study the seismic characteristics of ridge-transform systems at different spreading rates and make further comparisons of their *** study comparatively analyzed hydroacoustic and teleseismic data recorded on the fast-spreading East Pacific Rise(EPR,10°S to 12°N),intermediate-spreading Galapagos Ridge(103°W to 80°W),and slow-spreading Mid-Atlantic Ridge(MAR,15°N to 37°N).We present a systematic study of the spatial and temporal distribution of events,aftershock seismicity,and possible triggering mechanisms of aftershock *** analysis yields the following conclusions.(1)From the hydroacoustic data,the EPR transform faults had the highest average seismicity rate among the three regions.(2)Along-ridge event distributions show that a high number of earthquakes were concentrated on the EPR,while they became dispersed on the GR and fewer and more scattered on the MAR,reflecting that the different tectonic origins were closely correlated with the spreading rate.(3)Analysis from mainshock-aftershock sequences shows no significant differences in the aftershock decay rate among the three regions.(4)Multiple types of aftershock triggering models were inferred from Coulomb stress changes:strike-slip mainshocks triggered strike-slip aftershocks and normal faulting aftershocks,and normal faulting mainshocks triggered normal faulting *** these results are case studies,they may be applicable to other ocean ridge-transform systems in future

关键词： East Pacific Rise Galapagos Ridge Mid-Atlantic Ridge hydroacoustic and teleseismic seismicity ridge-transform system

Efficient Humoral and Cellular Immune Responses Induced by a Chimeric Virus-like Particle Displaying the Epitope of EV71 without Adjuvant

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Biomedical and Environmental Sciences 2018年第5期31卷 343-350页

作者： LIANG Pu YI Yao SU qiu Dong qiu Feng FAN xue Ting LU xue Xin BI Sheng Li National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing Key Laboratory of Emerging Infectious DiseasesBeijing 100015China

Objective To eliminate the side effects of aluminum adjuvant and His-tag,we constructed chimeric VLPs displaying the epitope of EV71（SP70） without *** evaluating whether the VLPs could efficiently evoke not only humoral but also cellular immune responses against EV71 without *** The fusion protein was constructed by inserting SP70 into the MIR of truncated HBc Ag sequence,expressed in ***,and purified through ion exchange chromatography and density gradient *** were immunized with the VLPs and sera were collected *** specific antibody titers,Ig G subtypes and neutralizing efficacy were detected by ELISA,neutralization assay,and EV71 lethal ***-γ and IL-4 secreted by splenocytes were tested by ELISPOT *** HBc-SP70 proteins can self-assemble into empty *** immunization with HBc-SP70 VLPs,the detectable anti-EV71 antibodies were effective in neutralizing EV71 and protected newborn mice from EV71 lethal *** was no significant difference for the immune efficacy whether the aluminum adjuvant was added or *** specific Ig G subtypes were mainly IgG1 and IgG2 b and splenocytes from the mice immunized produced high levels of IFN-γ and *** The fusion proteins without His-tagged was expressed and purified as soluble chimeric HBc-SP70 VLPs without *** the absence of adjuvant,they were efficient to elicit high levels of Th1/Th2 mixed immune response as well as assisted by aluminum ***,the chimeric VLPs have potential to prevent HBV and EV71 infection simultaneously.

关键词： Virus-like particles Enterovirus 71 Neutralizing antibody Humoral and cellular immunity Adjuvant Vaccine

Dectin-1 agonist curdlan modulates innate immunity to Aspergillus fumigatus in human corneal epithelial cells

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International Journal of Ophthalmology(English edition) 2015年第4期8卷 690-696页

作者： Cheng-Cheng Zhu Gui-qiu Zhao Jing lin Li-Ting Hu Qiang Xu Xu-Dong Peng xue Wang Sheng qiu Department of Ophthalmology the Affiliated Hospital of Qingdao University

· AIM: To explore the immunomodulatory effects of curdlan on innate immune responses against Aspergillus fumigatus(A. fumigatus) in cultured human corneal epithelial cells(HCECs), and whether C-type lectin receptor Dectin-1 mediates the immunomodulatory effects of curdlan.·METHODS: The HCECs were stimulated by curdlan in different concentrations(50, 100, 200, 400 μg/m L) for various time. Then HCECs pretreated with or without laminarin(Dectin-1 blocker, 0.3 mg/m L) and curdlan were stimulated by A. fumigatus hyphae. The m RNA and protein production of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6) were determined by real-time quantitative polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. The protein level of Dectin-1 was measured by Western blot.· RESULTS: Curdlan stimulated m RNA expression of TNF-α and IL-6 in a dose and time dependent manner in HCECs. Curdlan pretreatment before A. fumigatus hyphae stimulation significantly enhanced the expression of TNF-α and IL-6 at m RNA and protein levels compared with A. fumigatus hyphae stimulation group(P linical application values in fungal keratitis treatment.

关键词： curdlan Dectin-1 innate immunity Aspergillus fumigatus corneal epithelium

Analysis of plant remains at the Neolithic Yangjia Site, Wuxi City, Jiangsu Province (East China)

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Science China Earth Sciences 2016年第9期59卷 1803-1816页

作者： qiu ZhenWei LIU BaoShan LI YiQuan SHANG xue JIANG HongEn Department of Archaeology and Anthropology University of Chinese Academy of Sciences Beijing 100049 China Research Center of Field Archaeology National Museum of China Beijing 100006 China Wuxi Institute of Cultural Heritage Conservation and Archaeological Research Wuxi 214001 China

According to archaeological investigation and preliminary excavation, the Yangjia Site, located in the northern Taihu Lake region, at Wuxi City, Jiangsu Province, is a Neolithic archaeological site dominated by cultural remains attributed to the late Majiabang Culture(6270–5920 cal. a BP). Here a systematic archaeobotanical study was conducted to investigate vegetation landscape, environmental characteristics and rice agriculture in the prehistoric northern Taihu Lake area. The abundance, frequency and standard density of charred rice were the highest of all of the remains of the seed plants unearthed. In addition, a variety of wetland weeds, such as Haloragaceae, Cyperaceae, Carex sp., and Oxalis corniculata, were found. Pollen and phytoliths recorded that the evergreen-deciduous broadleaf mixed forest(represented by Quercus and Castanopsis) tends to decrease, while Poaceae was the most significant of the terrestrial herbs, water area expanded and water activities strengthened, indicating generally warm and humid conditions at the Yangjia Site during the late Majiabang Culture. All indicators of pollen, phytolith and macro-plant remains suggest that wild rice should be once distributed at or around the site before human occupation, after which rice agriculture progressed rapidly during the late Majiabang Culture.

关键词： Floatation Pollen Phytolith Vegetation landscape Rice agriculture

A comparison of static and rotordynamic characteristics for two types of liquid annular seals with and without helical grooved stator

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Chinese Journal of Aeronautics 2024年第11期37卷 94-106页

作者： Wensong xue Hailong qiu Tianhao WANG Zhigang LI Jun LI Institute of Turbomachinery Xi’an Jiaotong UniversityXi’an 710049China

Less leakage is a benefit of parallel grooved liquid seals(labyrinth seals).But researches show that the liquid seal with parallel grooves on the rotor harms the rotor *** seal with helical grooves on stator performs well in terms of rotordynamics,and its leakage is sensitive to the rotating *** make use of the advantages of both seals and improve seal stability,based on the Smooth-stator/Parallel Grooved-rotor(SPG)liquid seal,a Helical Grooved-stator/Parallel Grooved-rotor(HGPG)liquid seal is *** evaluate two liquid seals'leakage,rotordynamic characteristics and drag power loss,a transient computational fluid dynamics-based method is *** method is based on the multi-frequency elliptical-orbit rotor whirling model and the mesh deformation *** published experimental data of the leakage and rotordynamic force coefficients for an SPG liquid seal are used to validate the accuracy and dependability of the current *** leakage and force coefficients are presented and compared for the SPG liquid seal and the HGPG liquid seal at various pressure *** influences of parallel groove depth on the leakage and rotordynamic properties for the HGPG liquid seals at two rotational speeds(2000,6000 r/min)are *** numerical findings demonstrate that the novel HGPG liquid seal has a lower leakage flow rate(by$22.3%)than the traditional SPG liquid *** is an optimal parallel groove depth that minimizes *** presented novel HGPG liquid seal significantly improves rotordynamic stability,due to the similar effective stiffness and the obviously larger positive effective *** parallel groove depth can increase the positive effective *** terms of leakage and rotordynamic characteristics,the novel HGPG liquid seal is a better seal design for liquid turbomachinery.

关键词： Liquid seal Leakage flow Rotor dynamics Drag power loss Flow induced vibration

Early expression of PTX3 in Aspergillus fumigatus infected rat cornea

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International Journal of Ophthalmology(English edition) 2018年第7期11卷 1084-1089页

作者： Jie Zhang Gui-qiu Zhao Jing Qu Jing lin Cheng-Ye Che xue-Jiao Yang Department of Ophthalmology the Affiliated Hospital of Qingdao University Department of Administrative Office the Affiliated Hospital of Qingdao University

AIM： To investigate the expression of pentraxin 3（PTX3） in rat corneal epithelium at the early stage of Aspergillus fumigatus（A. fumigatus） infection. METHODS： A total of 50 Wistar rats were randomly divided into control group, Sham group and experimental group（fungal keratitis group, FK group）. The right eye was chosen as the experiment one and infected by A. fumigatus. Rats were executed at 8, 16 and 24 h after the experimental models being established. Corneal epithelia were collected to assess the expression of PTX3 by quantitative reverse transcription polymerase chain reaction（q RT-PCR） and Western blot analysis. RESULTS： Corneal inflammation scores increased as infection prolonged（P〈0.05, P〈0.001）. PTX3 m RNA expression was low in normal and Sham group rats＇ corneas. Level of PTX3 m RNA in infected rat cornea was elevated at 8 h and peaked at 16 h. The difference was significant compared with control group（P〈0.001）. Western blot analysis also showed a significant increase of PTX3 protein in experimental group at 8 h and peaked at 16 h（P〈0.001）. The synchronous expression of control group and experimental group were also in significant difference（P〈0.001）. CONCLUSION： PTX3 exists in cornea epithelium and is significantly increased after A. fumigatus infection. PTX3 plays an important role in the early stage of cornea innate immunity against A. fumigatus.

关键词： fungal keratitis AspergiIlus fumigates pentraxin 3 innate immunity

Marine renewable energy in China: Current status and perspectives

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Water Science and Engineering 2014年第3期7卷 288-305页

作者： Yong-liang ZHANG Zheng lin qiu-lin LIU State Key Laboratory of Hydro-Science and Engineering Tsinghua University

Based on a general review of marine renewable energy in China, an assessment of the development status and amount of various marine renewable energy resources, including tidal energy, tidal current energy, wave energy, ocean thermal energy, and salinity gradient energy in China＇s coastal seas, such as the Bohai Sea, the Yellow Sea, the East China Sea, and the South China Sea, is presented. We have found that these kinds of marine renewable energy resources will play an important role in meeting China＇s future energy needs. Additionally, considering the uneven distribution of China＇s marine renewable energy and the influences of its exploitation on the environment, we have suggested several sites with great potential for each kind of marine energy. Furthermore, perspectives on and challenges related with marine renewable energy in China are addressed.

关键词： renewable energy tidal energy tidal current energy wave energy ocean thermalenergy salinity gradient energy

Natamycin in the treatment of fungal keratitis : a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2015年第3期8卷 597-602页

作者： Sheng qiu Gui-qiu Zhao Jing lin xue Wang Li-Ting Hu Zhao-Dong Du Qian Wang Cheng-Cheng Zhu Department of Ophthalmology Medical College Qingdao University Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To review published clinical studies examining the effect of natamycin in the treatment of fungal ***: We selected the publications in CENTRAL,MEDlinE, EMBASE, CNKI, and CBM. This study systematically reviewed published randomized controlled trials(RCTs) that compared natamycin to other antifungal agents, and conducted feasible Meta-analysis of efficacy results using Revman 5.2 ***: We included seven trials which were mainly carried out in developing countries of Asia, with five trials conducted in India, one each in China and Bangladesh. A total of 804 participants were randomized to following comparisons: 2% econazole versus 5%natamycin showed little difference in the effects of treatment of fungal keratitis [RR =0.99, 95% confidence interval(CI), 0.8 to 1.21]; chlorhexidine gluconate versus5% natamycin indicated that the results on healing of the ulcer at 21 d was less conclusive(RR=0.77, 95% CI, 0.55 to 1.08; I2=0%); 1% voriconazole versus 5% natamycin suggested that natamycin treatment appeared to be significantly better outcomes than voriconazole(regression coefficient =-0.18 log MAR; 95% CI,-0.30 to-0.05; P =0.006), especially in Fusarium cases(regression coefficient=-0.41 log MAR; 95% CI,-0.61 to-0.20; P <0.001);natamycin versus fluconazole showed a significant difference in cure rate(χ2=5.048, P <0.05) and natamycin group was more effective than fluconazole in average period of therapy(t =7.94, P <0.01).CONCLUSION: Natamycin was a preferable choice in the treatment of fungal keratitis, especially in the early period of Fusarium cases.

关键词： eye infection fungal natamycin Metaanalysis