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Hydrogen sulfide attenuates gastric mucosal injury induced by restraint water-immersion stress via activation of KATPchannel and NF-κB dependent pathway

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World Journal of Gastroenterology 2017年第1期23卷 87-92页

作者： Hong-Zhao Sun Shan Zheng Kai Lu Feng-Tian Hou Jie-xue Bi xue-lian Liu Shan-Shan Wang College of Life Science Qi Lu Normal UniversityZhangqiu 250200JinanShandong ProvinceChina

AIMTo explore the effect of hydrogen sulfide (H2S) on restraint water-immersion stress (RWIS)-induced gastric lesions in rats and the influence of adenosine triphosphate (ATP)-sensitive potassium (KATP) channels and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway on such an *** Wistar rats were randomly divided into a control group, a physiological saline (PS) group, a sodium hydrosulfide (NaHS) group, a glibenclamide (Gl) group, Gl plus NaHS group, a pyrrolidine dithiocarbamate (PDTC) group, and a PDTC plus NaHS group. Gastric mucosal injury was induced by RWIS for 3 h in rats, and gastric mucosal damage was analyzed after that. The PS, NaHS (100 μmol/kg body weight), Gl (100 μmol/kg body weight), Gl (100 μmol/kg or 150 μmol/kg body weight) plus NaHS (100 μmol/kg body weight), PDTC (100 μmol/kg body weight), and PDTC (100 μmol/kg body weight) plus NaHS (100 μmol/kg body weight) were respectively injected intravenously before *** induced serious gastric lesions in the rats in the PS pretreatment group. The pretreatment of NaHS (a H2S donor) significantly reduced the damage induced by RWIS. The gastric protective effect of the NaHS during RWIS was attenuated by PDTC, an NF-κB inhibitor, and also by glibenclamide, an ATP-sensitive potassium channel blocker, in a dose-dependent *** results suggest that exogenous H2S plays a protective role against RWIS injury in rats, possibly through modulation of KATP channel opening and the NF-κB dependent pathway.

关键词： Hydrogen sulfide Nuclear factor kappa B Gastric mucosal injury Restraint water-immersion stress Adenosine triphosphate-sensitive potassium

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青岛市雾日PM_(1)中金属元素来源及健康风险评估

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中国环境科学 2024年第4期44卷 1945-1956页

作者：陶文鑫杜金花杨建立谭玉冉王超龙薛莲隋浩新张厚勇刘晓环张宜升青岛理工大学环境与市政工程学院山东青岛266520 山东省青岛生态环境监测中心山东青岛266003 山东省济南生态环境监测中心山东济南250102 中国海洋大学环境科学与工程学院山东青岛266100

为了解青岛市雾日PM_(1)中金属元素的污染程度及其来源,并评估其对人类健康的危害,依据能见度及湿度数据对雾日进行划分,结合正定矩阵因子分解法(PMF)源解析模型和健康风险评价模型研究青岛市雾日亚微米颗粒物(PM_(1))中金属元素的来源... 详细信息

为了解青岛市雾日PM_(1)中金属元素的污染程度及其来源,并评估其对人类健康的危害,依据能见度及湿度数据对雾日进行划分,结合正定矩阵因子分解法(PMF)源解析模型和健康风险评价模型研究青岛市雾日亚微米颗粒物(PM_(1))中金属元素的来源和健康风险.结果表明,清洁雾日PM_(1)浓度略高于清洁日,而污染雾日PM_(1)浓度是霾日PM_(1)的1.11倍,清洁日的3.07倍.秋冬季雾日金属元素受人为源影响,K元素含量最高;夏季雾日的主要贡献元素是典型的地壳元素Ca、Fe、Al及海盐Na元素.PMF结果表明秋冬季雾日PM_(1)中金属元素主要来自煤/生物质燃烧、机动车源、地壳源、海盐源、船舶源和工业源;夏季雾日PM_(1)中金属元素主要来自煤/生物质燃烧、机动车源、地壳源、海盐源、船舶源和工业源.夏季采样点位临海,海雾频发,海盐源为夏季雾日金属元素的重要贡献.健康风险评估结果表明,成年人与儿童暴露于青岛秋冬季雾日PM_(1)的非致癌风险均低于阈值.成人和儿童呼吸途径Mn的非致癌风险最高,儿童手口摄食As的非致癌风险(HQAS=0.50)最高.As(3.1×10^(-6))和Cr(1.9×10^(-6))的致癌风险均已超过致癌风险阈值,建议加强含Mn、As、Cr排放源的管控.

关键词： PM_(1) 金属元素雾日来源健康风险

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Intensified haze formation and meteorological feedback by complex terrain in the North China Plain region

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Atmospheric and Oceanic Science Letters 2023年第2期16卷 1-8页

作者： Jingyi Liu lian xue Xin Huang Zilin Wang Sijia Lou Aijun Ding School of Atmospheric Sciences Nanjing UniversityNanjingChina Jiangsu Provincial Collaborative Innovation Center for Climate Change NanjingChina Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjingChina

华北平原地区冬季雾霾污染频发,本研究结合地面观测,卫星反演和大气动力-化学耦合模拟发现,该地区复杂地形加剧了细颗粒物污染及其与大气边界层之间的相互作用.一方面,复杂地形导致污染在山麓平原积聚,加强迎风坡上升气流.在污染事件中... 详细信息

华北平原地区冬季雾霾污染频发,本研究结合地面观测,卫星反演和大气动力-化学耦合模拟发现,该地区复杂地形加剧了细颗粒物污染及其与大气边界层之间的相互作用.一方面,复杂地形导致污染在山麓平原积聚,加强迎风坡上升气流.在污染事件中,污染层易被抬升至1-2公里高度,高空较强的氧化能力利于二次气溶胶生成;另一方面,地形导致的污染层抬升和二次生成进一步加强气溶胶-边界层相互作用,削弱垂直扩散并加剧近地面大气污染.

关键词： PM_(2.5) 复杂地形二次污染气溶胶-边界层相互作用

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Soil Nematode Response to Biochar Addition in a Chinese Wheat Field

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Pedosphere 2013年第1期23卷 98-103页

作者： ZHANG Xiao-Ke LI Qi lianG Wen-Ju ZHANG Min BAO xue-lian XIE Zu-Bin State Key Laboratory of Forest and Soil Ecology Institute of Applied Ecology Chinese Academy of Sciences University of Chinese Academy of Sciences Jiangsu Biochar Engineering Center State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil Science Chinese Academy of Sciences

While studies have focused on the use of biochar as soil amendment, little attention has been paid to its effect on soil fauna. The biochar was produced from slow pyrolysis of wheat straw in the present study. Four treatments, no addition (CK) and three rates of biochar addition at 2 400 (B1), 12 000 (B5) and 48 000 kg ha-1 (B20), were investigated to assess the effect of biochar addition to soil on nematode abundance and diversity in a microcosm trial in China. The B5 and B20 application significantly increased the total organic carbon and the C/N ratio. No significant difference in total nematode abundance was found among the treatments. The biochar addition to the soil significantly increased the abundance of fungivores, and decreased that of plant parasites. The diversity of soil nematodes was significantly increased by B1 compared to CK. Nematode trophic groups were more effectively indicative to biochar addition than total abundance.

关键词： diversity ecological indices microcosm trial nematode community trophic groups

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Electrocatalytic Oxidation of NADH Based on Self-assembled Colloidal Gold and Nafion Matrixes and Co Complex Mediator

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Chinese Chemical Letters 2006年第5期17卷 683-686页

作者： Na WANG Ruo YUAN Ya Qin CHAI Dian Ping TANG Qiang ZHU xue lian LI Chongqing Key Laboratory of Analytical Chemistry College of Chemistry and Chemical Engineering Southwest University Chongqing 400715

A novel approach based on self-assembled colloidal gold and Nation matrixes and Co complex mediator to construct Co（bpy）3^3＋/nano-Au/Co（bpy）3^3＋/nafion/GC electrode, on which formed stable redox-active films. This electrode can decrease the overpotential about 330 mV for the oxidation of NADH with high stability, wide linear range and low detection limit.

关键词： Electrocatalysis NADH gold nanoparticles Co(bpy)3^3+ Nation. coenzymes

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Predictors of pain response after endoscopic ultrasound-guided celiac plexus neurolysis for abdominal pain caused by pancreatic malignancy

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World Journal of Gastroenterology 2021年第1期27卷 69-79页

作者： Chao-Qun Han xue-lian Tang Qin Zhang Chi Nie Jun Liu Zhen Ding Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Endoscopic ultrasound-guided celiac plexus neurolysis(EUS-CPN)has gained popularity as a minimally invasive approach and is currently widely used to treat pancreatic cancer-associated ***,response to treatment is *** To identify the efficacy of EUS-CPN and explore determinants of pain response in EUS-CPN for pancreatic cancer-associated *** A retrospective study of 58 patients with abdominal pain due to inoperable pancreatic cancer who underwent EUS-CPN were *** efficacy for palliation of pain was evaluated based on the visual analog scale pain score at 1 wk and 4 wk after *** and multivariable logistic regression analyses were performed to explore predictors of pain *** A good pain response was obtained in 74.1%and 67.2%of patients at 1 wk and 4 wk,*** located in the body/tail of the pancreas and patients receiving bilateral treatment were weakly associated with a good *** analysis revealed patients with invisible ganglia and metastatic disease were significant factors for a negative response to EUS-CPN at 1 wk and 4 wk,respectively,particularly for invasion of the celiac plexus(odds ratio(OR)=13.20,P=0.003 for 1 wk and OR=15.11,P=0.001 for 4 wk).No severe adverse events were *** EUS-CPN is a safe and effective form of treatment for intractable pancreatic cancer-associated *** ganglia,distant metastasis,and invasion of the celiac plexus were predictors of less effective response in EUS-CPN for pancreatic cancer-related *** these patients,efficacy warrants attention.

关键词： Endoscopic ultrasound Celiac plexus neurolysis Pancreatic cancer Pain Predictor

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A condition-based maintenance policy for reconfigurable multi-device systems

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Advances in Manufacturing 2024年第2期12卷 252-269页

作者： Shu-lian Xie Feng xue Wei-Min Zhang Jia-Wei Zhu School of Mechanical Engineering Tongji UniversityShanghai201804People’s Republic of China

The exploration of component states for optimizing maintenance schedules in complex systems has garnered significant interest from ***,current literature usually overlooks the critical aspects of system flexibility and *** implementation of system reconfiguration can effectively mitigate system downtime and enhance production *** study proposes a dynamic condition-based maintenance policy considering reconfiguration for reconfigurable systems.A double-layer decision rule was constructed for the devices and *** achieve the best overall maintenance effect of the system,the remaining useful life probability distribution and recommended maintenance time of each device were used to optimize the concurrent maintenance time window of the devices and determine whether to reconfigure them.A comprehensive maintenance efficiency index was introduced that simultaneously considered the maintenance cost rate,reliability,and availability of the system to characterize the overall maintenance *** reconfiguration cost was included in the maintenance *** proposed policy was tested through numerical experiments and compared with different-level *** results show that the proposed policy can significantly reduce the downtime and maintenance costs and improve the overall system reliability and availability.

关键词： Condition-based maintenance(CBM) Reconfigurable system Remaining useful life Maintenance cost System reliability

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Trend and causes of neonatal mortality in a level Ⅲ children's hospital in Shanghai: a 15-year retrospective study

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World Journal of Pediatrics 2018年第1期14卷 44-51页

作者： xue-lian Wang Jin Wang Lin Yuan Wen-Jing Shi Yun Cao Chao Chen Department of Neonatology Children’s Hospital of FudanUniversity399Wanyuan StreetMinhang DistrictShanghaiChina Present Address:Department ofN eonatology GuangdongGeneral HospitalGuangzhouChina

Background To determine the trend and causes of neonatal mortality in a large level Ⅲ neonatal intensive care unit in Shanghai during a 15-year period. Methods This is a retrospective, single-centered study. All neonates who died during the period from January 1, 1999 to December 31, 2013 at Children's Hospital of Fudan University were included. We extracted relevant clinical information from their medical records, analyzed neonatal mortality rate and the characteristics of these patients, and compared neonatal deaths between different periods and populations. Results Among a total of 50,957 admissions during the study period, there were 929 neonatal deaths. The neonatal mortality rate was 1.82%. Trends in neonatal mortality rate showed an increase in the period from 1.0% in 2003 to 2.2% in 2013. The main causes of neonatal mortality were complications of preterm birth (33.6%), congenital anomalies (21.3%), infections (12.6%), and birth asphyxia (9.1%). The proportions of complications of preterm birth (P < 0.001) and congenital anomalies (P = 0.018) increased yearly, while the proportions of birth asphyxia (P < 0.001) and infections (P < 0.001) decreased. Proportions of deaths caused by birth asphyxia (P = 0.005) and infections (P < 0.001) were both higher in the migrating population than in the permanent residents. Conclusions Neonatal mortality rate increased from 2003 to 2013 in our study. The proportion of preterm infants in neonatal deaths also increased within the same period. Complications of preterm birth were the main cause of neonatal mortality and the percentage increased year by year. Neonates in the migrating population appeared to be at a higher risk of death during the neonatal period compared to those in the permanent residents, and efforts should be made towards improving perinatal care to prevent infections and birth asphyxia in this vulnerable population.

关键词： Birth asphyxia Cause of death Neonatal infection Neonatal mortality Preterm birth

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超灵敏高特异性巢式PCR检测方法的建立及其在大黄鱼(Larimichthys crocea)弧菌病早期预警中的应用

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海洋与湖沼 2024年第4期55卷 1008-1018页

作者：魏雪莲包红玉李继姬施慧陶震段鑫冰叶莹莹郭宝英浙江海洋大学国家海洋设施养殖工程技术研究中心浙江舟山316022 浙江省舟山市定海区经济和信息化局浙江舟山316041 浙江省海洋水产研究所浙江省海水增养殖重点实验室浙江舟山316021 浙江海洋大学水产学院浙江舟山316022 浙江海洋大学海洋科学与技术学院浙江舟山316022

由哈维氏弧菌(Vibrio harveyi)、副溶血弧菌(***)及溶藻弧菌(***)等病菌感染导致的弧菌病是大黄鱼养殖中最常见、最具危害性的疾病之一,然而目前针对发病后的遏制手段有限,因此亟待建立高灵敏度、高特异性的病原检测技术以实现病害早期... 详细信息

由哈维氏弧菌(Vibrio harveyi)、副溶血弧菌(***)及溶藻弧菌(***)等病菌感染导致的弧菌病是大黄鱼养殖中最常见、最具危害性的疾病之一,然而目前针对发病后的遏制手段有限,因此亟待建立高灵敏度、高特异性的病原检测技术以实现病害早期预警。在普通两轮巢式PCR引物的基础上,对这3种弧菌分别设计一套三轮巢式PCR引物,通过扩增条件优化、特异性检验及灵敏度测定,确定了能精准检测3种弧菌的方法,达到了扩增产物单一、参考菌假阳性检出率为0、靶序列最低检出灵敏度分别为2.50 copies/μL(哈维氏弧菌)、3.12 copies/μL(副溶血弧菌)、2.53 copies/μL(溶藻弧菌)等效果。利用开发的检测方法,检测了2021~2023年度浙江、福建一带大黄鱼养殖样本,所有样本均检测出哈维氏弧菌和溶藻弧菌,副溶血弧菌未检出。结果显示浙江、福建一带大黄鱼弧菌病主要是由哈维氏弧菌和溶藻弧菌引起。开发的检测方法有望应用于大黄鱼等养殖物种弧菌病的早期预警和常规检测。

关键词：巢式PCR 大黄鱼弧菌病病原检测

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聚丙烯酰胺热分解与脱硝性能研究

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应用化工 2024年第5期53卷 1104-1108页

作者：刘俊张彬彬闫珍许战峰张昭军吴雪莲王琪合肥工业大学资源与环境工程学院安徽合肥230009 安徽中环环保科技股份有限公司、工业园区污染治理与资源化利用安徽省联合共建学科重点实验室安徽合肥230001 合肥工业大学化学与化工学院安徽合肥230009

选择三种不同类型聚丙烯酰胺作为高分子脱硝剂,通过热重分析、程序升温-质谱分析了三种不同类型的聚丙烯酰胺升温分解过程,同时考察其高温烟气脱硝性能。结果表明,三种不同的聚丙烯酰胺最终失重率大小为:阳离子型CPAM>非离子型NPAM>阴... 详细信息

选择三种不同类型聚丙烯酰胺作为高分子脱硝剂,通过热重分析、程序升温-质谱分析了三种不同类型的聚丙烯酰胺升温分解过程,同时考察其高温烟气脱硝性能。结果表明,三种不同的聚丙烯酰胺最终失重率大小为:阳离子型CPAM>非离子型NPAM>阴离子型APAM。通过程序升温-质谱检测显示,三种聚丙烯酰胺在升温分解过程中均首先发生端基酰胺基分解产生氨气,然后发生主链断裂。三种聚丙烯酰胺的热分解生成氨的表观活化能分别为CPAM 169.72 kJ/mol,APAM 246.58 kJ/mol和NPAM 210.18 kJ/mol。三种聚丙烯酰胺脱硝性能为NPAM>CPAM>APAM。脱硝活性与PAM分解产氨的速率和产氨量有关,产氨速率较慢、产氨量较高的NPAM脱硝活性较高,产氨量较低的APAM活性较差。优良的高分子脱硝剂需要较好的热稳定性以及更多分解氨的量。

关键词：聚丙烯酰胺热分解脱硝

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