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Will the 2022 compound heatwaveedrought extreme over the Yangtze River Basin become Grey Rhino in the future?

Advances in Climate Change Research 2024年第3期15卷 547-556页

作者： Ai-Qing FENG Qing-Chen CHAO Lu-Lu LIU Ge GAO Guo-Fu WANG xue-jun zhang Qi-Guang WANG China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China China Institute of Water Resources and Hydropower Research Beijing 100038China China Meteorological Administration Training Centre China Meteorological AdministrationBeijing 100081China

The increasingly frequent and severe regional-scale compound heatwave-drought extreme events(CHDEs),driven by global warming,present formidable challenges to ecosystems,residential livelihoods,and economic ***,uncertainty persists regarding the future trend of CHDEs and their insights into regional spatiotemporal *** integrating daily meteorological data from observations in 1961-2022 and global climate models(GCMs)based on the Shared Socioeconomic Pathways,the evolution patterns of CHDEs were compared and examined among three sub-catchments of the Yangtze River Basin,and the return periods of CHDE in 2050s and 210Os were *** findings indicate that the climate during the 2022 CHDE period was the warmest and driest recorded in 1961-2022,with precipitation less than 154.5 mm and a mean daily maximum temperature 3.4°C higher than the average of 1981-2010,whereas the char-acteristics in the sub-catchments exhibited temporal and spatial *** July-August 2022,the most notable feature of CHDE was its extremeness since 1961,with return periods of~200-year in upstream,80-year in midstream,and 40-year in downstream,*** 2050,the return periods witnessed 2022 CHDE would likely be reduced by *** towards 2100,under the highest emission scenario of SSP585,it was projected to substantially increase the frequency of CHDEs,with return periods reduced to one-third in the upstream and downstream,as well as halved in the *** findings provide valuable insights into the changing risks associated with forthcoming climate extremes,emphasizing the urgency of addressing these challenges in regional management and sustainable development.

关键词： Compound extreme event Joint return period Drought Heatwave Climate change Yangtze River Basin

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Modeling droplet vaporization and combustion with the volume of fluid method at a small Reynolds number

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第5期13卷 361-374页

作者： Xiao-bin zhang Wei zhang xue-jun zhang Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China

The volume of fluid(VOF) formulation is applied to model the combustion process of a single droplet in a hightemperature convective air free stream *** calculations solve the flow field for both phases,and consider the droplet deformation based on an axisymmetrical *** chemical reaction is modeled with one-step finite-rate mechanism and the thermo-physical properties for the gas mixture are species and temperature dependence.A mass transfer model applicable to the VOF calculations due to vaporization of the liquid phases is developed in consideration with the fluctuation of the liquid *** model is validated by examining the burning rate constants at different convective air temperatures,which accord well with experimental data of previous *** phenomena from the simulations,such as the transient history of droplet deformation and flame structure,are also qualitatively accordant with the descriptions of other numerical ***,a different droplet deformation mechanism for the low Reynolds number is explained compared with that for the high Reynolds *** calculations verified the feasibility of the VOF computational fluid dynamics(CFD) formulation as well as the mass transfer model due to vaporization.

关键词： Droplet Vaporization Combustion process Volume of fluid(VOF) Numerical simulation

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GWAS 2011:Opportunities and challenges

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Journal of Genetics and Genomics 2011年第9期38卷 425-427页

作者： Jian-jun Liu xue-jun zhang State Key Laboratory Incubation Base of Dermatology Ministry of National Science and Technology Hefei 230032 China Institute of Dermatology and Department of Dermatolog3 No. 1 Hospital Anhui Medical University Hefei 230032 China

The wide adoption of genome-wide association study （GWAS） has dramatically changed the landscape of the genetic studies of human *** on the study design that employs large and multiple-independent samples,linkage disequilibrium（LD） -based systematic genome-wide interrogation, and vigorous statistical standard for declaring genetic

关键词： GWAS 2011 Opportunities and challenges

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Reprogrammed CRISPR-Cas9 targeting the conserved regions of HPV6/11 E7 genes inhibits proliferation and induces apoptosis in E7-transformed keratinocytes

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Asian Journal of Andrology 2016年第3期18卷 475-479,I0011,I0012页

作者： Yu-Chen Liu Zhi-Ming Cai xue-jun zhang Institute of Dermatology Department of Dermatology The First Affiliated Hospital Anhui Medical University Hefei China Key Laboratory of Dermatology Ministry of Education State Key-Laboratory of Dermatology Incubation Center Department of Dermatology Anhui Medical University Hefei China Key Laboratory of Medical Reprogramming Technology Department of Urology The Genitourinary Institution of Shenzhen University Shenzhen Second People's Hospital The First Affiliated Hospitalof Shenzhen University Shenzhen China.

The persistence infection of low-risk type （type 6 or type 11） of human papillomavirus （HPV） is the main cause of genital warts. Given the high rate of recurrence after treatment, the use of a new molecular agent is certain to be of value. The aim of this study was to achieve targeted inactivation of viral E7 gene in keratinocytes using the reprogrammed clustered regularly interspaced short palindromic repeats （CRISPR）/CRISPR-associated （Cas） 9 system. To accomplish this, a universal CRISPR-Cas9 system for targeting both HPV6/11 E7 genes was constructed by using a dual guide RNA vector. After transfection of the vector into E7-transfromed keratinocytes, the expression level of E7 protein was measured using western-blot analysis and the sequence of the E7 gene was determined using Sanger sequencing. Cell proliferation was analyzed by CCK-8 assay, and cell apoptosis was evaluated by Hoechst 33258 staining, flow cytometry analysis and ELISA assay. The results indicated that both HPV6/11 E7 genes can be inactivated by the single CRISPR-Cas9 system. Furthermore, silencing of E7 led to inhibition of cell proliferation and induction of apoptosis in E7-transfromed keratinocytes but not in normal keratinocytes. Our data suggested that the reprogrammed CRISPR-Cas9 system has the potential for the development of an adjuvant therapy for genital warts.

关键词： apoptosis CRISPR-Cas9 HPV E7 proliferation

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Compact Ceshro Operators from Spaces H（p,q,u） to H（p, q, v）

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Acta Mathematicae Applicatae Sinica 2006年第3期22卷 437-442页

作者： xue-jun zhang Yu-ming Chu College of Mathematics and Computer Science Hunan Normal University Changsha 410006 China Department of Mathematics Huzhou Teachers College Huzhou 313000 China

Let μ and v be normal functions and let Tg be the extended Ceshso operator in terms of the symbol g. In this paper, we will characterize those g so that Tg is bounded （or compact） from mixed norm spaces H（p, q, μ） to H（p, q, v） in the unit ball of C^n, Furthermore, as applications, some analogous results are also given on weighted Bergman spaces and Dirichlet type spaces.

关键词： Cesàro operator boundedness compactness mixed norm space

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Expert Consensus on the Treat-to-Target Strategy for Psoriasis With Biological Agents in China(Simplified Edition)

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International Journal of Dermatology and Venereology 2024年第2期7卷 61-69页

作者： Ai-jun Chen Da-Xing Cai Xiang Chen Yong Cui Yan Ding Heng Gu Xing-Hua Gao Chao Ji Xiao-Jing Kang Ye-Hong Kuang Cheng-Zhi Lyu Min Li Wei Li Xia Li Yu-Zhen Li Xiao-Yong Man Jian-jun Qiao Juan Su Liang-Dan Sun Yu-Ling Shi Juan Tao Jian-Xin Xia Rong Xiao Bin Yang Wu Zhu xue-jun zhang Committee on Psoriasis Dermatology and Venereology Branch of the Chinese Medical Association Department of Dermatology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Dermatology Qilu HospitalShandong UniversityJinanShandong 250100China Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology China-Japan Friendship HospitalBeijing 100192China Department of Dermatology Hainan Provincial Hospital of Skin DiseaseHaikouHainan 570311China Department of Dermatology Hospital for Skin DiseasesChinese Academy of Medical SciencesNanjingJiangsu 210042China Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110002China Department of Dermatology The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350004China Department of Dermatology People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang Uyghur Autonomous Region 830001China Department of Dermatology Dalian Dermatosis HospitalDalianLiaoning 116021China Department of Dermatology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhouJiangsu 215127China Department of Dermatology West China Hospital of Sichuan UniversityChengduSichuan 610044China Department of Dermatology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Dermatology The Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang 150086China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200093China Department of Dermatology The Union Hospital of Tongji Medical CollegeHuazhong University of Science and Te

Psoriasis is a chronic,recurrent,inflammatory systemic disease that is not only characterized by skin manifestations but may also be accompanied by various comorbidities,imposing a heavy burden on patients’physical and mental health and affecting their quality of *** the continuous approval of various biological agents for clinical use has provided more effective treatment options to patients with psoriasis,no consensus on the evaluation of comprehensive treatment goals has yet been *** treat-to-target(T2T)strategy requires consideration of multiple dimensions of treatment outcomes,the development of long-term management goals,and regular assessments of treatment conditions,which are often used in the management of chronic ***,based on the latest consensuses and guidelines,research data,and clinical experience as well as the combination of survey results and expert group discussions,the present consensus focuses on 4 dimensions of short-and long-term integrated management goals for biological agents:alleviating skin lesions,improving quality of life,screening and managing psoriasis comorbidities,and ensuring drug *** implementation methods,evaluation time,treatment monitoring,and program adjustments are also herein described to achieve comprehensive management of psoriasis to the maximum *** consensus provides a reference for clinical practice.

关键词： psoriasis biological agents treat-to-target comorbidity consensus

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Control of different occurrence types of organic matter on hydrocarbon generation in mudstones

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Petroleum Science 2022年第4期19卷 1483-1493页

作者： Peng-Yan Du Jin-Gong Cai Qing Liu xue-jun zhang Juan Wang State Key Laboratory of Marine Geology Tongji UniversityShanghai200092China Exploration and Development Research Institute of Shengli Oilfield Company SINOPECDongyingShandong 257001China

Organic matter(OM) is preserved as different occurrences in mudstones, which can affect the hydrocarbon generation process. However, little research has focused on hydrocarbon generation as a function of different occurrences of OM. This study collected a suite of mudstones in the Dongying Sag, Bohai Bay Basin, and conducted Rock-Eval Ⅵ pyrolysis after Soxhlet extraction and Na_(2)S_(2)O_(8) oxidation, aiming to quantify the OM with different occurrences and figure out the contributions of each occurrence of OM to the hydrocarbon generation. There are three types of occurrences of OM: soluble organic matter(SOM),mineral-bound organic matter(MOM), and particulate organic matter(POM). MOM is the most abundant among the three occurrence types of OM. SOM and MOM are the main hydrocarbon precursors, and their hydrocarbon contributions alternate with different kerogen types and layers. Additionally, MOMcontributed hydrocarbons are numerous at shallow depths;SOM-contributed hydrocarbons mainly occur at deep depths;and POM-contributed hydrocarbons change little with depth. These results demonstrate that MOM should be the main hydrocarbon precursor in shallow formations and that SOM is the main hydrocarbon contributor at deep depths.

关键词： Soluble organic matter Mineral-bound organic matter Particulate organic matter Hydrocarbon precursor Rock-EvalⅥpyrolysis

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Optimized deployment of a radar network based on an improved firefly algorithm

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Frontiers of Information Technology & Electronic Engineering 2019年第3期20卷 425-437页

作者： xue-jun zhang Wei JIA Xiang-min GUAN Guo-qiang XU jun CHEN Yan-bo ZHU National Key Laboratory of CNS/ATM School of Electronic and Information EngineeringBeihang University Department of General Aviation Civil Aviation Management Institute of China Lincoln School of Engineering University of LincolnBrayford Pool Campus

The threats and challenges of unmanned aerial vehicle(UAV) invasion defense due to rapid UAV development have attracted increased attention recently. One of the important UAV invasion defense methods is radar network detection. To form a tight and reliable radar surveillance network with limited resources, it is essential to investigate optimized radar network deployment. This optimization problem is difficult to solve due to its nonlinear features and strong coupling of multiple constraints. To address these issues, we propose an improved firefly algorithm that employs a neighborhood learning strategy with a feedback mechanism and chaotic local search by elite fireflies to obtain a trade-off between exploration and exploitation abilities. Moreover, a chaotic sequence is used to generate initial firefly positions to improve population diversity. Experiments have been conducted on 12 famous benchmark functions and in a classical radar deployment scenario. Results indicate that our approach achieves much better performance than the classical firefly algorithm(FA) and four recently proposed FA variants.

关键词： Improved firefly algorithm Radar surveillance network Deployment optimization Unmanned aerial vehicle (UAV) invasion defense

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Microstructure and properties of AlSi7Mg alloy fabricated by selective laser melting

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China Foundry 2021年第4期18卷 416-423页

作者： Shuai Huang Shao-qing Guo Biao Zhou Guo-hui zhang xue-jun zhang 3D Printing Research and Engineering Technology Center Beijing Institute of Aeronautical MaterialsBeijing 100095China

The AlSi7Mg alloy was fabricated by selective laser melting(SLM),and its microstructure and properties at different building directions after heat treatment were *** show that the microstructure of SLM AlSi7Mg samples containes three zones:fine grain zone,coarse grain zone,and heat affected *** fine-grain regions locate inside the molten pool,and the grains are *** coarse-grain regions locate in the overlap of molten *** T6 treatment,the microstructure at the molten pool boundary is still the network eutectic Si,but the network structure becomes discrete,and is composed of intermittent,chain-like eutectic Si *** yield strength at three directions(xy,45°,z direction)of the AlSi7Mg alloy samples fabricated by SLM is improved after T6 heat *** fracture mechanism of the samples is a mixed ductile and brittle fracture before heat treatment and ductile fracture after heat treatment.

关键词： selective laser melting AlSi7Mg alloy microstructure mechanical property

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Impact response and energy absorption of metallic buffer with entangled wire mesh damper

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Defence Technology（防务技术） 2024年第5期35卷 137-150页

作者： Chao Zheng jun Wu Mangong zhang Xin xue Institute of Metal Rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou 350116China Wuhan Second Ship Design and Research Institute Wuhan 430205China

An innovative metallic buffer consisting of series-connected hat-shaped entangled wire mesh damper(EWMD)and parallel springs are proposed in this work to enhance the reliability of engineering *** impact response and the energy dissipation mechanism of hat-shaped EWMD under different quasi-static compression deformations(2-7 mm)and impact heights(100-200 mm)are investigated using experimental and numerical *** results demonstrate distinct stages in the quasi-static mechanical characteristics of hat-shaped EWMD,including stiffness softening,negative stiffness,and stiffness *** loss factor gradually increases with increasing compression deformation before entering the stiffness hardening *** impact loads,the hat-shaped EWMD exhibits optimal impact energy absorption when it enters the negative stiffness stage(150 mm),resulting in the best impact isolation effect of metallic ***,the impact energy absorption significantly decreases when hat-shaped EWMD enters the stiffness hardening ***,quasi-static compression analysis after experiencing different impact loads reveals the disappearance of the negative stiffness ***,with increasing impact loads,the stiffness hardening point progressively shifts to an earlier stage.

关键词： Metallic buffer Hat-shaped EWMD Drop impact Energy absorption characteristics Mechanical behavior

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