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Construction of fault diagnosis system for control rod drive mechanism based on knowledge graph and Bayesian inference

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Nuclear Science and Techniques 2023年第2期34卷 58-75页

作者： xue‑jun jiang Wen Zhou Jie Hou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Knowledge graph technology has distinct advantages in terms of fault *** this study,the control rod drive mechanism(CRDM)of the liquid fuel thorium molten salt reactor(TMSR-LF1)was taken as the research object,and a fault diagnosis system was proposed based on knowledge *** subject–relation–object triples are defined based on CRDM unstructured data,including design specification,operation and maintenance manual,alarm list,and other forms of expert *** this study,we constructed a fault event ontology model to label the entity and relationship involved in the corpus of CRDM fault events.A three-layer robustly optimized bidirectional encoder representation from transformers(RBT3)pre-training approach combined with a text convolutional neural network(TextCNN)was introduced to facilitate the application of the constructed CRDM fault diagnosis graph database for fault *** RBT3-TextCNN model along with the Jieba tool is proposed for extracting entities and recognizing the fault query intent *** on the dataset collected from TMSR-LF1 CRDM fault diagnosis unstructured data demonstrate that this model has the potential to improve the effect of intent recognition and entity ***,a fault alarm monitoring module was developed based on WebSocket protocol to deliver detailed information about the appeared fault to the operator ***,the Bayesian inference method combined with the variable elimination algorithm was proposed to enable the development of a relatively intelligent and reliable fault diagnosis ***,a CRDM fault diagnosis Web interface integrated with graph data visualization was constructed,making the CRDM fault diagnosis process intuitive and effective.

关键词： CRDM Knowledge graph Fault diagnosis Bayesian inference RBT3-TextCNN Web interface

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A BIOREDUCIBLE POLYPEPTIDE FOR EFFICIENT GENE TRANSFECTION BOTH IN VITRO AND IN VIVO

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Chinese Journal of Polymer Science 2013年第5期31卷 713-713,714-718页

作者： Wei Qu Si Chen Shan Ren xue-jun jiang Ren-xi Zhuo 张先正 Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry Wuhan University Department of Cardiology Renmin Hospital of Wuhan University

A disulfide bond containing polypeptide, PolyK6-R8, was designed and prepared by oxidative polymerization between terminal cysteinyl thiol groups of CHK6HC and CR8C. The molar ratio between CHK6HC and CR8C within obtained PolyK6-Rs was 9：1, and PolyK6-R8 could combine DNA compactly when weight ratio reached 5. Through in vitro investigation, it was found that PolyK6-R8 was an efficient gene vector with low cytotoxicity for delivering DNA in both COS-7 and HeLa cells. Cellular uptake of DNA mediated by PolyK6-R8/DNA complexes was promoted after incubation for 4 h. Moreover, by examining the histological sections of hindlimb ischemia rats through immunohistochemistry, PolyK6- R8/VEGF complexes were proved to be effective in both VEGF protein expression and succeeding vessel formation. The results indicated that polypeptide-based PolyK6-R8 is a promising gene vector for the limb ischemia treatment.

关键词： Gene vector Polypeptide Angiogenesis Limb ischemia.

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Autologous transplantation of bone marrow mononuclear cells improved heart function after myocardial infarction

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Acta Pharmacologica Sinica 2004年第7期25卷 30-40页

作者： Guo-sheng LIN1, Jing-jun Lü, xue-jun jiang, Xiao-yan LI, Geng-shan LI Department of Cardiology, Renmin Hospitalof Wuhan University, Wuhan 430060, China Department of Cardiology Renmin Hospital of Wuhan University Wuhan 430060

AIM: To investigate whether autologous transplantation of adult stem cells could improve post-infarcted heart function. METHODS: Bone marrow mononuclear cells (MNCs) were isolated from adult rabbits’ tibias after coronary ligation. These cells were exposed to 5-azacytidine 10 μmol/L for 24 h on the third day of culture. After being labeled with bromodeoxyuridine (BrdU), the cells were auto-transplanted into bordering zone of the infarcted area at 2 weeks after injury. The animals were killed at 3 days, 2 weeks, 1 month, and 2 months after transplantation, respectively. The left ventricular functions, capillary density, and cardiac nerve density were measured and the differentiation of the engrafted cells was determined by immunostaining. RESULTS: BrdU-labeled MNCs were well aligned with the host cardiomyocytes. Parts of them were incorporated into capillary and arteriolar vessel walls. In addition to inducing angiogenic ligands (basic fibroblast growth factor, vascular endothelial growth factor) and imflammation cytokines (interleukin 1-β) during the early period of MNCs implantation, MNCs induced 2.0-fold increase in capillary density as well. Moreover, GAP43-positive and TH-positive nerve density were markedly higher in the MNCs-treated groups than that in the non-treated hearts. Left ventricular ejection fraction, LV+dp/dtmax, and LV-dp/dtmax were 47 %, 67 %, and 55 % in MNCs-treated heart respectively, which was higher than that of the control heart, whereas left ventricular end-diastolic volume, left ventricular end-diastolic diameter, and left ventricular end-diastolic pressure were 45 %, 22 %, and 50 % respectively in MNCs-treated heart, which was lower than that of the control heart at 2 months after cell transplantation. CONCLUSION: Autologous transplantation of MNCs induced angiogenesis and nerve sprouting and improved left ventricular diastolic function.

关键词： autologous transplantation bone marrow cells stem cell left ventricular function angiogenesis nerve regeneration myocardial infarction

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Cox7a2 mediates steroidogenesis in TM3 mouse Leydig cells

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Asian Journal of Andrology 2006年第5期8卷 589-594页

作者： Liang Chen Zhong-Cheng Xin Xin Li Long Tian Yi-Ming Yuan Gang Liu xue-jun jiang Ying-Lu Guo Andrology Center of Peking University First Hospital Beijing 100009 China Department of Surgery People＇s Hospital of Zhangqiu Zhangqiu 250200 China Institute of Microbiology Chinese Academy of Sciences Beijing 100080 China

Aim： To investigate the regulatory function of Cox7a2 on steroidogenesis and the mechanism involved in TM3 mouse Leydig cells. Methods： The cDNA of Cox7a2 was cloned from TM3 mouse Leydig cells. It was subcloned to pDsRed- Express-N 1 and transfected back into TM3 mouse Leydig cells for Cox7a2 overexpression by transient gene transfection. Steroidogenesis affected by overexpressed Cox7a2 was studied by ELISA. To elicit the mechanism of this effect, expression of steroidogenic acute regulatory （STAR） protein and reactive oxygen species （ROS） were examined by Western blot and fluorometer, respectively. Results： The cDNA of Cox7a2 （249 bp） was cloned from Leydig cells and confirmed by DNA sequencing. After constructed pDsRed-Express-N1-Cox7a2 was transfected back into TM3 mouse Leydig cells, Cox7a2 inhibited not only luteinizing hormone （LH）-induced secretion of testosterone but also the expression of StAR protein. At the same time, Cox7a2 increased the activity of ROS in TM3 mouse Leydig cells. Conclusion： Cox7a2 inhibited LH-induced StAR protein expression, and consequent testosterone production, at least in part, by increasing ROS activity in TM3 mouse Leydig cells.

关键词： Cox7a2 fusion protein steroidogenesis steroidogenic acute regulatory protein reactive oxygen species Leydig cell

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Origin of natural sulfur-metal chimney in the Tangyin hydrothermal field,Okinawa Trough:constraints from rare earth element and sulfur isotopic compositions

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China Geology 2018年第2期1卷 225-235页

作者： Hong Cao Zhi-lei Sun Chang-ling Liu En-tao Liu xue-jun jiang Wei Huang The Key Laboratory of Gas Hydrate Ministry of Land and ResourcesQingdao Institute of Marine GeologyQingdao 266071China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Manne Science and TechnologyQingdao 266071China College of Marine Science and Technology China University ofGeosciences (Wuhan)Wuhan 430074China

For the first time,we present the rare earth element (REE)and sulfur isotopic composition of hydrothermal precipitates recovered from the Tangyin hydrothermal field (THF),Okinawa Trough at a water depth of 1206 *** natural sulfur samples exhibit the lowest ∑REE concentrations (∑REE= 0.65×10^-6-4.580×10^-6)followed by metal sulfides (∑REE=1.71×10^-6-11.63×10^-6).By contrast,the natural sulfur-sediment samples have maximum ∑REE concentrations (∑REE=1 1.54×10^-6-33.06×10^-6), significantly lower than those of the volcanic and sediment ***,the δEu,δCe,(La/Yb)N, La/Sm,(Gd/Yb)N and normalized patterns of the natural sulfur and metal sulfide show the most similarity to the *** hydrothermal precipitate samples are characterized by enrichments of LREE (LREE/HREE=10.09-24.53)arid slightly negative Eu anomalies or no anomaly (δEu=0.48-0.99),which are different from the hydrothermal fluid from sediment-free mid-oceanic ridges and back-are basins,but identical to the sulfides from the Jade hydrothermal *** lower temperature and more oxidizing conditions produced by the mixing between seawater and hydrothermal fluids further attenuate the leaching ability of hydrothermal fluid,inducing lower REE concentrations for natural sulfur compared with metal sulfide;meanwhile,the negative Eu anomaly is also weakened or almost *** sulfur isotopic compositions of the natural sulfur (δ^34S=3.20‰-5.01‰,mean 4.23 ‰)and metal sulfide samples (δ34S=0.82‰-0.89‰,mean 0.85‰)reveal that the sulfur of the chimney is sourced from magmatic degassing.

关键词： Hydrothormal processes Natural sulfur Isotopic compositions REE Tangyin field Okinawa Trough China

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Expression and localization of CKLFSF2 in human spermatogenesis

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Asian Journal of Andrology 2007年第2期9卷 189-198页

作者： Gang Liu Zhong-Cheng Xin Liang Chen Long Tian Yi-Ming Yuan Wei-Dong Song xue-jun jiang Ying-Lu Guo Andrology Center of Peking University First Hospital Beijing 100009 China Institute of Microbiology Chinese Academy of Sciences Beijing 100080 China

Aim： To investigate the expression and subcellular localization of chemokine-like factor superfamily 2 （CKLFSF2） in human testis and its potential role in spermatogenesis. Methods： A specific polyclonal antibody against CKLFSF2 was raised. The expression and cellular localization of CKLFSF2 in the seminiferous tubules was checked by immunohistochemistry method. Also, in situ hybridization was applied to localize the mRNA distribution. The EGFP- CKLFSF2 fusion protein was expressed in COS-7 cells to localize its subcellular location in vitro. In addition, the abnormal expression of CKLFSF2 in testes of patients with male infertility was assayed by reverse transcription polymerase chain reaction （RT-PCR） and immunohistochemistry methods. Results： Having a close correlation with spermatogenesis defects, CKLFSF2 was specifically expressed in meiotic and post-meiotic germ cells, which were localized to the endoplasmic reticulum （ER） near the Golgi apparatus. Conclusion： CKLFSF2 could play important roles in the process of meiosis and spermiogenesis, and might be involved in the vesicular transport or membrane apposition events in the endoplasmic reticulum.

关键词： spermatogenesis testis chemokine-like factor superfamily infertility endoplasmic reticulum

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Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen xue-jun Li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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Staged dendrite suppression for high safe and stable lithium-sulfur batteries

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Journal of Energy Chemistry 2025年第1期100卷 674-683页

作者： jun jiang Zhenjie Lu Yanwen Ding Shujun Liu Zhijie Qi Tian Tang Yunfan Zhang Zhiyuan Ma Jingwen Sun Liang xue Wenyao Zhang Pan Xiong Xin Wang junwu Zhu Yongsheng Fu Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology jiangsu Pylon Battery Co.Ltd

The unavoidable dendrite growth and shuttle effect have long been stranglehold challenges limiting the safety and practicality of lithium-sulfur ***,we propose a dual-action strategy to address the lithium dendrite issue in stages by constructing a multifunctional surface-negatively-charged nanodiamond layer with high ductility and robust puncture resistance on polypropylene （PP） *** uniformly loaded compact negative layer can not only significantly enhance electron transmission efficiency and promote uniform lithium deposition,but also reduce the formation of dendrite during early deposition *** importantly,under the strong puncture stress encountered during the deterioration of lithium dendrite growth under limiting current,the high ductility and robust puncture resistance（145.88 MPa） of as-obtained nanodiamond layer can effectively prevent short circuits caused by unavoidable lithium *** Li||Li symmetrical cells assembled with nanodiamond layer modified PP demonstrated a stable cycle of over 1000 h at 2 mA cm-2with a polarization voltage of only 29.3 ***,the negative charged layer serves as a physical barrier blocking lithium polysulfide ions,effectively mitigating capacity *** improved cells achieved a capacity decay of only 0.042%per cycle after 700 cycles at 3 C,demonstrating effective suppression of dendrite growth and capacity attenuation,showing promising prospect.

关键词： Lithium-sulfur batteries Staged dendrite suppression Shuttle effect Surface-negatively-charged nanodiamond

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基于PSO-SVM的咪唑类离子液体捕集CO_2性能预测

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安全与环境学报 2016年第6期16卷 265-269页

作者：薛妮蒋军成倪磊南京工业大学安全科学与工程学院江苏省危险化学品本质安全与控制技术重点实验室南京210009

CO_2是主要的温室气体,大量CO_2的存在严重影响着环境,而咪唑类离子液体具有独特的气体选择溶解性,在CO_2的捕集分离中有非常好的应用前景。基于支持向量机方法,结合粒子群优化算法(PSO-SVM)建立了咪唑类离子液体捕集CO_2性能的理论预... 详细信息

CO_2是主要的温室气体,大量CO_2的存在严重影响着环境,而咪唑类离子液体具有独特的气体选择溶解性,在CO_2的捕集分离中有非常好的应用前景。基于支持向量机方法,结合粒子群优化算法(PSO-SVM)建立了咪唑类离子液体捕集CO_2性能的理论预测模型,该模型包含温度、压力、密度、黏度和表面张力5个主要参数。根据PSO算法,得到模型的最优参数为惩罚参数C=100,不敏感损失参数ε=11.699 7,核函数的宽度γ=0.279 2;SVM算法得出训练集的相关系数r=0.993,均方根误差RMSE=12.012,平均绝对误差AAE=4.117,测试集r=0.999,RMSE=4.766,AAE=3.028。对预测模型进行了评价验证以及稳定性分析,明确了咪唑类离子液体捕集CO_2性能的主要影响因素及其重要程度。

关键词：环境工程学离子液体捕集 CO2 支持向量机方法粒子群优化算法预测模型

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Multi-model ensemble learning for battery state-of-health estimation:Recent advances and perspectives

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Journal of Energy Chemistry 2025年第1期100卷 739-759页

作者： Chuanping Lin jun Xu Delong jiang Jiayang Hou Ying Liang Zhongyue Zou xuesong Mei State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Shaanxi Key Laboratory of Intelligent Robots School of Mechanical Engineering Xi'an Jiaotong University Department of Electrical Engineering and Automation Luoyang Institute of Science and Technology School of Mechanical Engineering Hangzhou Dianzi University

The burgeoning market for lithium-ion batteries has stimulated a growing need for more reliable battery performance monitoring. Accurate state-of-health(SOH) estimation is critical for ensuring battery operational performance. Despite numerous data-driven methods reported in existing research for battery SOH estimation, these methods often exhibit inconsistent performance across different application scenarios. To address this issue and overcome the performance limitations of individual data-driven models,integrating multiple models for SOH estimation has received considerable attention. Ensemble learning(EL) typically leverages the strengths of multiple base models to achieve more robust and accurate outputs. However, the lack of a clear review of current research hinders the further development of ensemble methods in SOH estimation. Therefore, this paper comprehensively reviews multi-model ensemble learning methods for battery SOH estimation. First, existing ensemble methods are systematically categorized into 6 classes based on their combination strategies. Different realizations and underlying connections are meticulously analyzed for each category of EL methods, highlighting distinctions, innovations, and typical applications. Subsequently, these ensemble methods are comprehensively compared in terms of base models, combination strategies, and publication trends. Evaluations across 6 dimensions underscore the outstanding performance of stacking-based ensemble methods. Following this, these ensemble methods are further inspected from the perspectives of weighted ensemble and diversity, aiming to inspire potential approaches for enhancing ensemble performance. Moreover, addressing challenges such as base model selection, measuring model robustness and uncertainty, and interpretability of ensemble models in practical applications is emphasized. Finally, future research prospects are outlined, specifically noting that deep learning ensemble is poised to advance ens

关键词： Lithium-ion battery State-of-health estimation Data-driven Machine learning Ensemble learning Ensemble diversity

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