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About 300 days Optical Quasi-periodic Oscillations in the Long-term Light Curves of the Blazar PKS 2155-304

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Research in Astronomy and Astrophysics 2022年第8期22卷 284-293页

作者： Qi Zheng xue-guang zhang Qi-Rong Yuan School of Physics and Technology Nanjing Normal UniversityNanjing 210023China

Based on the long-term light curves collected from the Catalina Sky Survey(CSS)(from 2005 to 2013)and the All-Sky Automated Survey for Supernovae(ASAS-SN)(from 2014 to 2018),optical quasi-periodic oscillations(QPOs)about 300 days can be well determined in the well-known blazar PKS 2155-304 through four different methods:the generalized Lomb-Scargle periodogram(GLSP)method,the weighted wavelet Z-transform technique,the epoch-folded method and the redfit *** GLSP determined significance level for the periodicity is higher than 99.9999%based on a false alarm *** redfit provided confidence level for the periodicity is higher than 99%in the ASAS-SN light curve,after considering the effects of red *** on continuous autoregressive process created artificial light curves,the probability of detecting fake QPOs is lower than 0.8%.The determined optical periodicity of 300 days from the CSS and ASAS-SN light curves is well consistent with the reported optical periodicity in the ***,three possible models are discussed to explain the optical QPOs in PKS 2155-304:the relativistic frame-dragging effect,the binary black hole model and the jet precession model.

关键词： (galaxies:)BL Lacertae objects:individual(PKS 2155-304) galaxies:active (galaxies:)quasars:supermassive black holes

Antibody Therapies Targeting Complex Membrane Proteins

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Engineering 2021年第11期7卷 1541-1551页

作者： Georgina To’a Salazar Ziyi Huang Ningyan zhang xue-guang zhang Zhiqiang An Texas Therapeutics Institute Brown Foundation Institute of Molecular MedicineThe University of Texas Health Science Center at HoustonHoustonTX 77030USA Jiangsu Institute of Clinical Immunology The First Affiliated Hospital of Soochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Clinical Immunology Soochow UniversitySuzhou 215123China Jiangsu Key Laboratory of Gastrointestinal Tumor Immunology The First Affiliation Hospital of Soochow UniversitySuzhou 215123China State Key Laboratory of Radiation Medicine and Protection Soochow UniversitySuzhou 215123China

In analyses of protein families that may serve as drug targets,membrane-associated G-protein-coupled receptors(GPCRs)dominate,followed by ion channels,transporters,and—to a lesser extent—membrane-bound ***,various challenges put such membrane proteins among key groups of underutilized opportunities for the application of therapeutic *** hold the promise of exquisite specificity,as they are able to target even specific conformations of a particular membrane protein,as well as adaptability through engineering into various antibody ***,the ease of raising and isolating specific,effective antibodies targeting membrane proteins depends on many *** particular,the generation of specific antibodies is easier when targeting larger,simpler,extracellular domains with greater uniqueness of amino acid *** rareness of such ideal conditions is illustrated by the limited number of approved biologics for targeting GPCRs and other complex membrane *** in developing antibodies to complex membrane proteins such as GPCRs,ion channels,transporters,and membrane-bound enzymes can be addressed by the design of the antigen,antibody-generation strategies,lead optimization technologies,and antibody modalities.A better understanding of the membrane proteins being targeted would facilitate mechanism-based drug *** review describes the advantages and challenges of targeting complex membrane proteins with antibodies and discusses the preparation of membrane protein antigens and antibody generation,illustrated by select examples of success.

关键词： Antibody therapy Complex membrane protein Ion channels Transporters Membrane-bound enzymes GPCRs Drug discovery

Inhibited experimental corneal neovascularization by neutralizing anti-SDF-1α antibody

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International Journal of Ophthalmology(English edition) 2012年第1期5卷 7-12页

作者： Gao-Qin Liu, xue-guang zhang Department of Ophthalmology the First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu Province China Jiangsu Institute of Clinic Immunology the First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu Province China

AIM: To explore the effect of SDF-1α on the development of experimental corneal neovascularization (CRNV).METHODS: CRNV was induced by alkali injury in mice. The expression of SDF-1α and CXCR4 in burned corneas was examined by Flow Cytometry. Neutralizing anti-mouse SDF-1α antibody was locally administrated after alkali injury and the formation of CRNV 2 weeks after injury was assessed by Immunohistochemistry. The expression of VEGF and C-Kit in burned corneas was detected by ***: The number of CRNV peaks at 2 weeks after alkali injury. Compared to control group, SDF-1α neutralizing antibody treatment significantly decreased the number of CRNV. RT-PCR confirmed that SDF-1α neutralizing antibody treatment resulted in decreased intracorneal VEGF and C-Kit ***: SDF-1α neutralizing antibody treated mice exhibited impaired experimental CRNV through down regulated VEGF and C-Kit expression.

关键词： corneal neovascularization alkali injury chemokine

Development of setal patterns in embryonic and adult aphids of the Hormaphidinae （Hemiptera： Aphididae）

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Insect Science 2007年第4期14卷 339-350页

作者： LI-YUN JIANG GE-XIA QIA0 guang-xue zhang Institute of Zoology Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences BeijingChina

The elementary traits and diversity of embryonic setal patterns of 31 species of 22 genera, in three tribes of Hormaphidinae are studied. The embryonic setal patterns to every species are provided. Based on the parsimony principle and the developmental principle, these patterns are analyzed in each tribe following the terminology of Richards （1965）. It is suggested that the setal patterns of abdominal tergites are the most important characters in embryonic and adult setal patterns. In conclusion, neoteny is a phylogenetic trend in the Hormaphidinae. Nipponaphidini and Hormaphidini have more typical neoteny in each genus and more diversity in different types of adult viviparous females than Cerataphidini, by showing more frequent and various protopatterns or mesopatterns.

关键词： Hemiptera Hormaphidinae embryo adult setal pattern development neo-teny

Minimally invasive thalamic hematoma drainage can improve the six-month outcome of thalamic hemorrhage

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Journal of Geriatric Cardiology 2017年第4期14卷 266-273页

作者： Wen-Ming LIU xue-guang zhang Ze-Li zhang Gang LI Qi-Bing HUANG Department of Emergency Surgery Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University Jinan ShandongChina Department of Neurosurgery Liaocheng People's Hospital Liaocheng Shandong China Department of Neurosurgery Qilu Hospital of Shandong University and Brain Science Research Institute of Shandong University Jinan Shandong China

Objective To explore predictors of the 6-month clinical outcome ofthalamic hemorrhage, and evaluate if minimally invasive thalamic hematoma drainage （THD） could improve its prognosis. Methods A total of 54 patients with spontaneous thalamic hemorrhage were evaluated retrospectively. Clinical data, including demographics, stroke risk factors, neuroimaging variables, Glasgow Coma Score （GCS） on admission, surgical strategy, and outcome, were collected. Clinical outcome was assessed using a modified Rankin Scale, six months after onset. Univariate analysis and multivariate logistic regression analysis were performed to determine predictors of a poor outcome. Results Conservative treatnaent was performed for five patients （9.3%）, external ventricular drainage （EVD） for 20 patients （37.0%）, THD for four patients （7.4%）, and EVD combined with THD for 25 patients （46.3%）. At six months after onset, 21 （38.9%） patients achieved a favorable outcome, while 33 （61.1%） had a poor outcome. In the univariate analysis, predictors of poor 6-month outcome were lower GCS on admis- sion （P = 0.001）, larger hematoma volume （P 〈 0.001）, midline shift （P = 0.035）, acute hydrocephalus （P = 0.039）, and no THD （P = 0.037）. The independent predictors of poor outcome, according to the multivariate logistic regression analysis, were no THD and larger hematoma volume. Conclusions Minimally invasive THD, which removes most of the hematoma within a few days, with limited damage to perihematomal brain tissue, improved the 6-month outcome of thalamic hemorrhage. Thus, THD can be widely applied to treat patients with thalamic hemorrhage.

关键词： Hematoma volume Minimally invasive Outcome Predictor Thalamic hematoma drainage Thalamic hemorrhage

B7-H1 expression is associated with expansion of regulatory T cells in colorectal carcinoma

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World Journal of Gastroenterology 2012年第9期18卷 971-978页

作者： Dong Hua Jing Sun Yong Mao Lu-Jun Chen Yu-Yu Wu xue-guang zhang Department of Oncology the FourthAffiliated Hospital of Suzhou University Wuxi 214062 JiangsuProvince China Institute of MedicalBiotechnology Soochow University Suzhou 215007 Jiangsu Pro-vince China Clinical central Laboratory The Third AffiliatedHospital of Soochow University Changzhou 213003 JiangsuProvince China Department of Pathology The Fourth Affiliated Hos-pital of Soochow University Wuxi 214062 Jiangsu ProvinceChina

AIM： To investigate the expression of B7-H1 in human colorectal carcinoma （CRC） to define its regulating ef- fects on T cells in tumor microenvironment.

关键词： Costimulatory molecule B7-H1 PD-1 Regu-latory T cell Colorectal carcinoma

Study of overthrust nappe structure and its geodynamic mechanism along the southeastern margin of Nansha Trough

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China Geology 2018年第4期1卷 459-465页

作者： guang-xue zhang Zhen Yang Li zhang Wei Yan Kun-sheng Qiang MLR Key Laboratory of Marine Mineral Resources Guangzhou Marine Geological SurveyGuangzhou 510075China Marine Petroleum and Gas geological Research Center (China Geological Survey) Guangzhou Marine Geological SurveyGuangzhou 510075China

On the basis of interpretation of comprehensive geophysical data and foreign data analysis,there existed a lot of overburden detachment shear thrust faults along the southeastern margin of Nansha Trough,which composed imbricated overthrust nappe ***-faulted nappe structure pattern is determined in this area,which consists of frontal fault zone,thrust fault-folded zone and root zone structures,and presents regularly zonation on *** detail description of the structural geometrical characteristics is given in shallow thrust fault zone,and the kinematical mechanism of thrust fault nappe structure is furtherly *** nappe structure in this area is resulted from island arc-continent collision and orogenic activities.

关键词： Overthrust Structure Geodynamic Mechanism Nansha Trough

SDSS J1042-0018:a Broad Line AGN but Misclassified as an HⅡGalaxy in the BPT Diagram by Flux Ratios of Narrow Emission Lines

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Research in Astronomy and Astrophysics 2022年第4期22卷 114-122页

作者： Yi Cao Si-Dan Zhao Xing-Yu Zhu Hai-Chao Yu Yi-Wei Wang xue-guang zhang School of Physics and Technology Nanjing Normal UniversityNanjing 210023China

In this paper,we discuss properties of SDSS J1042-0018 which is a broad line active galactic nucleus(AGN)but misclassified as an H II galaxy in the BPT diagram(SDSS J1042-0018 is called a misclassified broad line AGN).The emission lines around Hαand around Hβare well described by different model functions,considering broad Balmer lines to be described by Gaussian or Lorentz *** model functions lead to different determined narrow emission line fiuxes,but the different narrow emission line fiux ratios lead SDSS J1042-0018 as an H II galaxy in the BPT *** order to explain the unique properties of the misclassified broad line AGN SDSS J1042-0018,two methods are proposed,the star-forming contributions and the compressed narrow emission line regions with high electron densities near to critical densities of forbidden emission ***,the strong star-forming contributions can be preferred in SDSS *** misclassified broad line AGN SDSS J1042-0018,well explained by star-forming contributions,could provide further clues on the applications of BPT diagrams to the normal broad line AGNs.

关键词： active galaxies active galactic nuclei emission line galaxies Quasars

Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis

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World Journal of Gastroenterology 2006年第3期12卷 457-459页

作者： Chang-Ping Wu Jing-Ting Jiang Min Tan Yi-Bei Zhu Mei Ji Kuan-Feng Xu Jie-Min Zhao guang-Bo zhang xue-guang zhang The Third Affiliated Hospital of Suzhou University Changzhou213003 Jiangsu Province China Institute of Biotechnology Suzhou University KeyLaboratory of Clinical Immunology of Jiangsu Province Suzhou215007 Jiangsu Province China 不详

AIM:To investigate the expression of co-stimulatorymolecule B7-H3 in gastric carcinoma and adenomatissue as well as normal gastric tissue and to explore therelationship between B7-H3 expression and pathologicalfeatures and prognosis of gastric ***:B7-H3 expression was detected in 102samples of human gastric carcinoma and 10 samples ofgastric adenoma and 10 samples of normal gastric tissueby immunohistochemical *** betweenthe expression of B7-H3 and the patients'age,sex,gastric carcinoma locus,tumor size,tissue type,tumorinfiltration depth,differentiation degree,lymph nodemetastasis,and survival time was ***:B7-H3 was expressed in all gastric adenomasamples and in 58.8% samples of gastric carcinoma.B7-H3 expression in gastric carcinoma samples wasnot related with the patients'age,sex,lymph nodemetastasis,and tumor size(P>0.05),but with thesurvival time,infiltration depth of tumor and tissue ***:Detection of B7-H3 expression in gastriccarcinoma tissue is beneficial to the judgment of theprognosis of gastric carcinoma patients and the choice oftreatment.

关键词： B7-H3 expression Gastric carcinoma Gastricadenoma Prognosis