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Inactivated Sendai Virus Suppresses Murine Melanoma Growth by Inducing Host Immune Responses and Down-regulating β-catenin Expression

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Biomedical and Environmental Sciences 2012年第5期25卷 509-516页

作者： ZHANG Quan YUAN Wei feng ZHAI Guo Qin xue zheng feng ZHU Hong Fei XU Xiang Ming College of Veterinary Medicine Yangzhou UniversRyYangzhou 225009JiangsuChina Institute of Animal Science and Veterinary Medicine Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Animal-used High-tech Biopharmaceutical of Jiangsu Province Taizhou 225300JiangsuChina

Abstract Objective This paper aims to investigate the anti-tumor mechanism of inactivated Sendai virus （Hemagglutinating virus of Japan envelope, HVJ-E） for murine melanoma （B16F10）. Methods The murine dendritic cells （DCs） were treated with HVJ-E, and then the cytokines secreted from DCs and costimulation-related molecules on DCs were measured. Meanwhile, the expression of 13-catenin in HVJ-E treated murine melanoma cells was detected. In addition, HVJ-E was intratumorally injected into the melanoma on C57BL/6 mice, and the immune cells, CTL response and tumor volume were analyzed. Results HVJ-E injected into B16F10 melanoma obviously inhibited the growth of the tumor and prolonged the survival time of the tumor-bearing mice. Profiles of cytokines secreted by dendritic cells （DCs） after HVJ-E stimulation showed that the number of cytokines released was significantly higher than that elicited by PBS （P〈O.05）. The co-stimulation-related molecules on DCs were comparable to those stimulated by LPS. Immunohistochemical examinations demonstrated the repression of 13-catenin in B16F10 melanoma cells after HVJ-E treatment. Meanwhile, real-time reverse transcription PCR revealed that HVJ-E induced a remarkable infiltration of CDllc positive cells, chemokine ligand 10 （CXCL10） molecules, interleukin-2 （IL-2） molecule, CD4^＋ and CD8^＋ T cells into HVJ-E injected tumors. Furthermore, the mRNA expression level of 13-catenin in the HVJ-E injected tumors was also down-regulated. In addition, B16F10-specific CTLs were induced significantly after HVJ-E was injected into the tumor-bearing mice. Conclusion This is the first report to show the effective inhibition of melanoma tumors by HVJ-E alone and the mechanism through which it induces antitumor immune responses and regulates important signal pathways for melanoma invasion. Therefore, HVJ-E shows its prospect as a novel therapeutic for melanoma therapy.

关键词： HVJ-E Dendritic cell Melanoma β-catenin

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S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells

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World Journal of Gastroenterology 2012年第9期18卷 915-922页

作者： Dong Chen xue-feng zheng Ze-You Yang Dong-Xiao Liu Guo-You Zhang xue-Long Jiao Hui Zhao Department of Surgery the Affiliated Hospital of Qingdao Medi-cal CollegeQingdao UniversityQingdao 266003ShandongProvinceChina Department ofSurgery Tianjin Union Medicine CenterTianjin 300121China

AIM： To investigate a potential role of S100A4 in esoph- agus squamous cell carcinoma metastasis （ESCCs）.METHODS： Expression of $100A4 and E-cadherin were analyzed in frozen sections from ESCCs （metastasis, n = 28; non-metastasis, n = 20） by reverse transcrip- tion-polymerase chain reaction, quantitative polymerase chain reaction and immunohistochemistry. To explore the influence of $100A4 on esophageal cancer invasion and metastasis, $100A4 was overexpressed or silenced by $100A4 siRNA in TE-13 or Eca-109 cells/n vitro and /n vivo.

关键词： Esophagus squamous cell carcinoma Metas-tasis Gene treatment $100A4 E-cadherin

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Characteristic response of striatal astrocytes to dopamine depletion

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Neural Regeneration Research 2020年第4期15卷 724-730页

作者： Yao-feng Zhu Wei-Ping Wang xue-feng zheng Zhi Chen Tao Chen Zi-Yun Huang Lin-Ju Jia Wan-Long Lei Department of Anatomy Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Institute of Medicine College of MedicineJishou UniversityJishouHunan ProvinceChina Periodical Center the Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Astrocytes and astrocyte-related proteins play important roles in maintaining normal brain function,and also regulate pathological processes in brain diseases and ***,the role of astrocytes in the dopamine-depleted striatum remains unclear.A rat model of Parkinson’s disease was therefore established by injecting 10μL 6-hydroxydopamine(2.5μg/μL)into the right medial forebrain *** staining was used to detect the immunoreactivity of glial fibrillary acidic protein(GFAP),calcium-binding protein B(S100B),and signal transducer and activator of transcription 3(STAT3)in the striatum,and to investigate the co-expression of GFAP with S100B and *** blot assay was used to measure the protein expression of GFAP,S100B,and STAT3 in the *** demonstrated that striatal GFAP-immunoreactive cells had an astrocytic appearance under normal conditions,but that dopamine depletion induced a reactive phenotype with obvious morphological *** normal striatum also contained S100B and STAT3 expression.S100B-immunoreactive cells were uniform in the striatum,with round bodies and sparse,thin ***3-immunoreactive cells presented round cell bodies with sparse processes,or were darkly stained with a large cell *** deprivation induced by 6-hydroxydopamine significantly enhanced the immunohistochemical positive reaction of S100B and *** striatal astrocytes expressed both S100B and *** dopamine deprivation increased the number of GFAP/S100B and GFAP/STAT3 double-labeled cells,and increased the protein levels of GFAP,S100B,and *** present results suggest that morphological changes in astrocytes and changes in expression levels of astrocyte-related proteins are involved in the pathological process of striatal dopamine *** study was approved by Animal Care and Use Committee of Sun Yat-sen University,China(Zhongshan Medical Ethics 2014 No.23)on September 22,2014.

关键词： 6-hydroxydopamine astrocyte dopamine depletion dopaminergic neurons Parkinson’s disease SIOOB STAT3 striatum

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Effect of heavy ion irradiation on the interface traps of AlGaN/GaN high electron mobility transistors

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Chinese Physics B 2022年第3期31卷 428-433页

作者： zheng-Zhao Lin Ling Lü xue-feng zheng Yan-Rong Cao Pei-Pei Hu Xin Fang Xiao-Hua Ma School of Microelectronics Xidian UniversityXi'an 710071China School of Mechano-Electronic Engineering Xidian UniversityXi'an 710071China Institute of Modern Physics Chinese Academy of Sciences (CAS)Lanzhou 730000China

AlGaN/GaN high electron mobility transistors(HEMTs)were irradiated with heavy ions at various *** irradiation by 2.1 GeV^(181) Ta^(32+) ions,the electrical characteristics of the devices significantly *** threshold voltage shifted positively by approximately 25%and the saturation currents decreased by approximately 14%.Defects were induced in the band gap and the interface between the gate and barrier acted as tunneling sites,which increased the gate current tunneling *** to the pulsed output characteristics,the amount of current collapse significantly increased and more surface state traps were introduced after heavy ion *** time constants of the induced surface traps were mainly less than 10μs.

关键词： gallium nitride radiation effects defects pulse testing

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Novel CMOS image sensor pixel to improve charge transfer speed and efficiency by overlapping gate and temporary storage diffusing node

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Chinese Physics B 2021年第1期30卷 593-599页

作者： Cui Yang Guo-Liang Peng Wei Mao xue-feng zheng Chong Wang Jin-Cheng Zhang Yue Hao School of Physics and Optoelectronic Engineering Xidian UniversityXi’an 710071China Key Laboratory of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi’an 710071China

A novel CMOS image sensor(CIS) pinned photodiode(PPD) pixel, named as O-T pixel, is proposed and investigated by TCAD simulations. Compared with the conventional PPD pixel, the proposed pixel features the overlapping gate(OG)and the temporary storage diffusing(TSD) region, based on which the several-nanosecond-level charge transfer could be achieved and the complete charge transfer from the PPD to the floating node(FD) could be realized. And systematic analyses of the influence of the doping conditions of the proposed processes, the OG length, and the photodiode length on the transfer performances of the proposed pixel are conducted. Optimized simulation results show that the total charge transfer time could reach about 5.862 ns from the photodiode to the sensed node and the corresponding charge transfer efficiency could reach as high as 99.995% in the proposed pixel with 10 μm long photodiode and 2.22 μm long OG. These results demonstrate a great potential of the proposed pixel in high-speed applications.

关键词： CMOS image sensor charge transfer efficiency high-speed charge transfer pinned photodiode

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Recent Progress in Fabrication and Structural Design of Thermal Conductive Polymer Composites

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Chinese Journal of Polymer Science 2024年第3期42卷 277-291,I0004页

作者： Yuan-Kai Du zheng-xue Shi Shan Dong Hui Jin xue Ke Pei Zhao Bing-Bing Jiang feng You Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Material Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Preparation and Application of Functional Materials Ministry of EducationHubei UniversityWuhan 430062China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China

In recent years, the demand direction for electronic equipment has expanded into embedded and miniaturized devices. The heat radiation problem has become one of the most significant factors for hindering the development of electronic devices. Since heat radiation material is one of the important components in electronic devices, the demand for enhancing thermal conductivity is also increasingly urgent. Research on thermal conductive polymer composites has become a major direction for developing functional composites. This work reviewed the recent progress in the fabrication of thermal conductive polymer composites. Five different structures are presented, including the using of single fillers,hybrid fillers, double threshold percolation structure, segregated structure and other complex multiphase structures. Specifically, the preparation of high-performance thermal conductive polymer composites was introduced through the combination of various thermal conductive ***, the development direction of high thermal conductive polymer composites was briefly explored.

关键词： Thermal conductive polymer Hybrid fillers Polymer composite Thermal resistance

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Mechanical property of cylindrical sandwich shell with gradient core of entangled wire mesh

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Defence Technology（防务技术） 2024年第1期31卷 510-522页

作者： Xin xue Chao zheng Fu-qiang Lai xue-qian Wu Institute of Metal-rubber&Vibration Noise School of Mechanical Engineering and AutomationFuzhou UniversityFuzhou350116China Fujian Metallurgical Industry Design Institute Fuzhou350116China

To explore the wide-frequency damping and vibration-attenuation performances in the application of aerospace components,the cylindrical sandwich shell structure with a gradient core of entangled wire mesh was proposed in this ***,the gradient cores of entangled wire mesh in the axial and radial directions were prepared by using an in-house Numerical Control weaving machine,and the metallurgical connection between skin sheets and the gradient core was performed using vacuum ***,to investigate the mechanical properties of cylindrical sandwich shells with axial or radial gradient cores,quasi-static and dynamic mechanical experiments were carried *** primary evaluations of mechanical properties include secant stiffness,natural frequency,Specific Energy Absorption(SEA),vibration acceleration level,and so *** results suggest that the vibration-attenuation performance of the sandwich shell is remarkable when the high-density core layer is at the end of the shell or abuts the inner *** axial gradient material has almost no influence on the vibration frequencies of the shell,whereas the vibration frequencies increase dramatically when the high-density core layer approaches the ***,compared to the conventional sandwich shells,the proposed functional grading cylindrical sandwich shell exhibits more potential in mass reduction,stiffness designing,and energy dissipation.

关键词： Entangled wire mesh Gradient cylindrical sandwich shell Vacuum brazing Secant stiffness Damping

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Comparative study on characteristics of Si-based AlGaN/GaN recessed MIS-HEMTs with HfO2 and Al2O3 gate insulators

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Chinese Physics B 2020年第8期29卷 445-450页

作者： Yao-Peng Zhao Chong Wang xue-feng zheng Xiao-Hua Ma Kai Liu Ang Li Yun-Long He Yue Hao Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi'an 710071China

Two types of enhancement-mode(E-mode)AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistors(MIS-HEMTs)with different gate insulators are fabricated on Si *** HfO2 gate insulator and the Al2O3 gate insulator each with a thickness of 30 nm are grown by the plasma-enhanced atomic layer deposition(PEALD).The energy band diagrams of two types of dielectric MIS-HEMTs are *** breakdown voltage(VBR)of HfO2 dielectric layer and Al2O3 dielectric layer are 9.4 V and 15.9 V,*** the same barrier thickness,the transconductance of MIS-HEMT with HfO2 is *** threshold voltage(Vth)of the HfO2 and Al2O3 MIS-HEMT are 2.0 V and 2.4 V,respectively,when the barrier layer thickness is 0 *** C-V characteristics are in good agreement with the Vth's transfer *** the barrier layer becomes thinner,the drain current density decreases *** to the dielectric/AlGaN interface is very close to the channel,the scattering of interface states will lead the electron mobility to *** current collapse and the Ron of Al2O3 MIS-HEMT are smaller at the maximum gate *** Al2O3 has excellent thermal stability and chemical stability,the interface state density of Al2O3/AlGaN is less than that of HfO2/AlGaN.

关键词： AlGaN/GaN enhancement-mode MIS-HEMT HfO2 Al2O3

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Simulation design of normally-off AlGaN/GaN high-electron-mobility transistors with p-GaN Schottky hybrid gate

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Chinese Physics B 2022年第6期31卷 712-716页

作者： Yun-Long He Fang Zhang Kai Liu Yue-Hua Hong xue-feng zheng Chong Wang Xiao-Hua Ma Yue Hao Key Laboratory of Wide Band Gap Semiconductor Materials and Devices School of MicroelectronicsXidian UniversityXi’an 710071China

A novel normally-off AlGaN/GaN high-electron-mobility transistor(HEMT)with a p-GaN Schottky hybrid gate(PSHG)is proposed,and compared with the conventional p-GaN normally-off AlGaN/GaN *** structure can be realized by selective etching of p-GaN layer,which enables the Schottky junction and PN junction to control the channel charge at the same *** direct current(DC)and switching characteristics of the PSHG HEMTs are simulated by Slivaco TCAD,and the p-GaN HEMTs and conventional normally-on HEMTs are also simulated for *** simulation results show that the PSHG HEMTs have a higher current density and a lower on-resistance than p-GaN HEMTs,which is more obvious with the decrease of p-GaN ratios of the PSHG *** breakdown voltage and threshold voltage of the PSHG HEMTs are very close to those of the p-GaN *** addition,the PSHG HEMTs have a higher switching speed than the conventional normally-on HEMTs,and the p-GaN layer ratio has no obvious effect on the switching speed.

关键词： normally-off high-electron-mobility transistor AlGaN/GaN p-GaN

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Spontaneous anchoring Cl intoα-Co(OH)_(2) as efficient and stable oxygen reduction electrocatalysts for seawater battery

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Rare Metals 2024年第7期43卷 3074-3083页

作者： Wang zheng xue-Rong zheng Qi Lu Yan-Hui Cao Yang Wang Hai-Peng Fu Jin-feng Zhang Yi-Da Deng Wen-Bin Hu School of Materials Science and Engineering Key Laboratory of Advanced Ceramics and Machining Technology of Ministry of EducationTianjin UniversityTianjin 300072China State Key Laboratory of Marine Resource Utilization in South China Sea School of Materials Science and EngineeringHainan UniversityHaikou 570228China Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang 110819China

Seawater battery is an advanced energy storage system that enables conversion of chemical energy to electricity by consuming metals,dissolved oxygen and seawater in anode,cathode and electrolyte,***,the oxygen reduction reaction(ORR)activity and stability of electrocatalysts can be easily deactivated due to the severe Cl~-permeation and corrosion in seawater ***,we developed a structural buffer engineering strategy by spontaneously anchoring Cl~-intoα-Co(OH)_(2) as efficient and stable ORR electrocatalysts,in which the ultrathinα-Co(OH)_(2) nanosheets were synthesized using an ultrafast solution high-temperature shock(SHTS)*** large lattice space(~0.8 nm)of layeredα-Co(OH)_(2) ensured the spontaneously penetration of Cl~-into the lattice structure and replaced part of OH~-to formα-Co(OH)_(2-x)Cl_*** continuous leaching and compensating of saturated Cl inα-Co(OH)_(2-x)Cl_x could enhance the Cl~-corrosion resistance and modulate electronic structure of Co metallic sites,thus improving the ORR electrocatalytic activity and stability in seawater ***α-Co(OH)_(2-x)Cl_x seawater batteries display superior onset and half-wave potentials of 0.71 and 0.66 V,respectively,which are much better than the counterparts ofα-Co(OH)_(2) and ofβ-Co(OH)_(2) with no Cl~-penetrating and no buffer ***α-Co(OH)_(2-x)Cl_x-based seawater batteries display stable open-circuit potential of 1.69 V and outstanding specific capacity of 1345 mAh·g^(-1).

关键词： Seawater battery Oxygen reduction electrocatalyst Solution high-temperature shock Structural buffer engineering

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