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Advances in the Development of Gradient Scaffolds Made of Nano‑Micromaterials for Musculoskeletal Tissue Regeneration

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Nano-Micro Letters 2025年第3期17卷 455-500页

作者： Lei Fang Xiaoqi Lin Ruian Xu Lu Liu Yu Zhang feng tian Jiao Jiao Li Jiajia xue Beijing Laboratory of Biomedical Materials Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China State Key Laboratory of Organic‑Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029People’s Republic of China School of Biomedical Engineering Faculty of Engineering and ITUniversity of Technology SydneySydneyNSW 2007Australia

The intricate hierarchical structure of musculoskeletal tissues,including bone and interface tissues,necessitates the use of complex scaffold designs and material structures to serve as tissue-engineered *** has led to growing interest in the development of gradient bone scaffolds with hierarchical structures mimicking the extracellular matrix of native tissues to achieve improved therapeutic *** on the anatomical characteristics of bone and interfacial tissues,this review provides a summary of current strategies used to design and fabricate biomimetic gradient scaffolds for repairing musculoskeletal tissues,specifically focusing on methods used to construct compositional and structural gradients within the *** latest applications of gradient scaffolds for the regeneration of bone,osteochondral,and tendon-to-bone interfaces are ***,the current progress of testing gradient scaffolds in physiologically relevant animal models of skeletal repair is discussed,as well as the challenges and prospects of moving these scaffolds into clinical application for treating musculoskeletal injuries.

关键词： Gradient scaffolds Musculoskeletal tissues Advanced manufacturing Biomaterials Tissue regeneration

Detection of T lymphocyte subsets and mIL-2R on surface of PBMC in patients with hepatitis B

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World Journal of Gastroenterology 2003年第9期9卷 2017-2020页

作者： Ke-Xia Wang Jiang-Long Peng xue-feng Wang Ye tian Jian Wang Chao-Pin Li School of Medicine,Anhui University of Science and Technology,Huainan 232001,Anhui Province,China School of Medicine Anhui University of Science and Technology Huainan 232001 Anhui Province China.

AIM: To study the levels of T lymphocyte subsets andmembrane interleukin-2 receptor (mIL-2R) on surface ofperipheral blood mononuclear cells (PBMCs) of patients withhepatitis B and its role in the pathogenesis of hepatitis ***: The levels of T lymphocyte subsets and mIL-2R in PBMC before and after being stimulated with PHAwere detected by biotin-streptavidin (BSA) technique in 196cases of hepatitis ***: In patients with hepatitis B, the levels of CD3+,CD4+ cells, and the ratio of CD4+ cells/CD8+ cells were lower,but the level of CD8+ cells was higher than those in normalcontrols (42.20±6.01 vs65.96±6.54, 38.17±5.93 vs41.73±6.40,0.91±0.28 vs 1.44±0.31, 39.86±6.36 vs30.02±-4.54, P＜0.01).The total expression level of mIL-2R in PBMC before andafter being stimulated with PHA was also lower than thosein normal controls (3.47±1.55 vs4.52±1.49, 34.03±2.94 vs37.95±3.00, P＜0.01). In all the patients with hepatitis B, thelevels of T lymphocyte subsets and mIL-2R in PBMC withHBV-DNA (+) were lower than those with HBV-DNA (-),which were significantly different (39.57±7.11 vs44.36±5.43,34.36±7.16 vs 40.75±5.87, 37.82±6.54 vs 41.72±6.21,0.88±0.33 vs0.99±0.27, 2.82±1.62 vs3.85±1.47, 31.56±3.00vs35.84±2.83, P＜0.01). In addition, the levels of CD3+, CD4+,CD8+ cells, the ratio of CD4+ cells/CD8+ cells and mIL-2R amongdifferent courses of hepatitis B were all significantly different(F=3 723.18, P＜0.01. F=130.43, P＜0.01. F=54.01, P＜0.01.F=2.99, P＜0.05. F=7.16, P＜0.01).CONCLUSION: Both cellular and humoral immune functionsare obviously in disorder in patients with hepatitis B, whichmight be closely associated with the chronicity in patients.

关键词： T淋巴细胞乙型肝炎外周血单核细胞白细胞介素-2 受体

Optimizing battery deployment: Aging trajectory prediction enabling homogenous performance grouping

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Journal of Energy Chemistry 2025年第1期100卷 565-577页

作者： Shuquan Wang feng Gao Zhan Ma Hao tian Yusen Zhang School of Control Science and Engineering Shandong University Key Lab of Power System Intelligent Dispatch and Control of Ministry of Education Shandong University

As battery deployments in electric vehicles and energy storage systems grow, ensuring homogeneous performance across units is crucial. We propose a multi-derivative imaging fusion(MDIF) model, employing advanced imaging and machine learning to predict battery aging trajectories from minimal initial data, thus facilitating effective performance grouping before deployment. Utilizing a derivative strategy and Gramian Angular Difference Field for dimensional enhancement, the MDIF model uncovers subtle predictive features from discharge curve data after only ten cycles. The architecture includes a parallel convolutional neural network with lateral connections to enhance feature integration and *** on a self-developed dataset, the model achieves an average root-mean-square error of 0.047 Ah and an average mean absolute percentage error of 1.60%, demonstrating high precision and *** robustness is further validated through transfer learning on two publicly available datasets, adapting with minimal retraining. This approach significantly reduces the testing cycles required, lowering both time and costs associated with battery testing. By enabling precise battery behavior predictions with limited data, the MDIF model optimizes battery utilization and deployment strategies, enhancing system efficiency and sustainability.

关键词： Lithium-ion battery Battery prognostics Fusion model Convolutional neural network Transfer learning

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第1期68卷 329-336页

作者： Yuzhu Li Yumeng Gao feng tian Yu Wang Yuan Yao Shaoliang Lin Xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

关键词： self-assembly conformation ordering alternating copolymer phosphorescence emission

Distribution and mapping of temperate savanna in the sandy lands of eastern China

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Science China Earth Sciences 2025年第1期68卷 128-141页

作者： Xiaoya LI feng WANG Tao DUAN Kaijie YANG Bin YANG Chunmei WANG Xin tian Qi LU Institute of Ecological Conservation and Restoration Institute of Desertification Studies Chinese Academy of Forestry Institute of Desertification Institute of Desertification Studies Chinese Academy of Forestry Institute of Great Green Wall Satellite Application Centre for Ecology and Environment MEE Institute of Microelectronics Chinese Academy of Sciences Aerospace Information Research Institute Chinese Academy of Sciences Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Savannas are distributed globally across various *** perform a significant socioeconomic role in regulating net primary productivity and the terrestrial carbon *** to the high spatial heterogeneity induced by the mixed distribution of trees and grasses,current global land-cover classification maps often classify savannas as forests or grasslands Temperate savannas in China cover a vast area,yet their spatial patterns and extent remain poorly *** study developed a novel remote sensing temperate savannas mapping method by integrating very high-resolution （VHR） unmanned aerial vehicle （UAV） and GF-6 satellite imagery based on the vegetation structure characteristics of temperate savannas using the FAO definition of *** and validation datasets were collected from VHR UAV imagery covering the main temperate savannah types with a ground area of 1818 *** fractional woody vegetation cover （FWVC） and fractional herbaceous vegetation cover （FHVC） in temperate savannas were estimated by integrating Classification and Regression Tree and Random Forest *** current distribution of temperate savannas in the Horqin and Otindag Sandy Lands of Eastern China was mapped to a unit area of 0.5 *** root-mean-square error （RMSE） values for the FWVC and FHVC models were 10.69% and 11.67%,and the R2values were 0.66 and 0.63,*** assessment indicated that the new temperate savanna map had high identification accuracy,with a Kappa coefficient of 0.70,overall accuracy of 0.88,and average accuracy of *** savannas in the sandy lands of eastern China were primarily distributed in the northern Horqin Sandy Land the central and eastern regions of the Otindag Sandy Land,and the transition zone from the southern slopes of the Greater Khingan Mountains to the plains,covering a total area of 3.27×10～6 *** main savannah types were elm,oak/maple,and shrub *** savannas were widely distributed in the Otindag Sandy

关键词： Temperate savanna UAV imagery GF-6 Fractional woody vegetation cover Fractional herbaceous vegetation cover Machine learning

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我国食品企业的选择:“一体化”还是“外包”——基于消费者食品质量关注视角

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经济理论与经济管理 2017年第3期37卷 37-47页

作者：曹冰雪郑风田中国人民大学农业与农村发展学院

本文构建了一个包含消费者、食品终端企业、食品加工企业的不完全契约模型,以分析消费者食品质量关注对我国食品终端企业组织结构选择的影响。研究结果表明:消费者对食品质量越关注,终端企业越可能选择一体化生产。此外,终端企业与加工... 详细信息

本文构建了一个包含消费者、食品终端企业、食品加工企业的不完全契约模型,以分析消费者食品质量关注对我国食品终端企业组织结构选择的影响。研究结果表明:消费者对食品质量越关注,终端企业越可能选择一体化生产。此外,终端企业与加工企业的技术、终端企业一体化生产所需的固定资本、终端企业对中间投入品的质量认知以及加工企业在交易中的收益比例,均会影响终端企业的组织结构选择。

关键词：食品企业一体化外包型食品质量

A Bayesian expectation maximization algorithm for state estimation of intelligent vehicles considering data loss and noise uncertainty

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Science China Technological Sciences 2025年

作者： Yan WANG feng tian Jianqiang WANG Keqiang LI Department of Industrial and Systems Engineering The Hong Kong Polytechnic University School of Vehicle and Mobility Tsinghua University

Sideslip angle, yaw rate, and vehicle velocity are essential for intelligent vehicle control. Since these vehicle states are not measured directly, some Kalman-based approaches have been developed to estimate these states using in-vehicle sensors. However, the existing studies seldom account for the influence of sensor data loss on estimation accuracy. In addition,the process and measurement noise change during the estimation process because of the various driving conditions. To address these problems, an expectation-maximization robust extended Kalman filter (EMREKF) is proposed. Firstly, a robust extended Kalman filter (REKF) is developed to deal with the impact of missing measurements. Then, an improved expectation maximization (EM) algorithm that considers data loss is presented to update the noise parameter of the REKF dynamically. Finally,the improved EM is fused with the REKF to form the EMREKF to estimate vehicle state. The experimental results demonstrate that the EMREKF outperforms EKF, REKF, and maximum correntropy criterion EKF for various degrees of data loss and the proposed algorithm has a strong adaptive ability to different driving conditions.

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Nanocarrier-mediated siRNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying Lu Linqiang tian Sanqiao Yao feng Lai Yangfan Liang Chuanchuan Liu Yujia Lu Sijia tian Yanmei Zhao Wenjie Ren Institute of Disaster and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Disaster Medicine Technology TianjinChina Henan Medical Key Laboratory for Research of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tissue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Institutes of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's disease share pathological similarities,including neuronal loss,amyloid-βdeposition,tau hyperphosphorylation,blood-brain barrier dysfunction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's disease-like pathologies,potentially leading to the development of Alzheimer's *** offer a potential solution by facilitating the delive ry of small interfering RNAs across the blood-brain barrier for the targeted silencing of key pathological genes implicated in traumatic brain injury and Alzheimer's disease.U nlike traditional approaches to neuro regeneration,this is a molecula r-targeted strategy,thus avoiding non-specific drug *** review focuses on the use of nanocarrier systems for the efficient and precise delive ry of siRNAs,discussing the advantages,challenges,and future *** principle,siRNAs have the potential to target all genes and non-targetable protein s,holding significant promise for treating various *** the various therapeutic approaches currently available for neurological diseases,siRNA gene silencing can precisely"turn off"the expression of any gene at the genetic level,thus radically inhibiting disease progression;however,a significant challenge lies in delivering siRNAs across the blood-brain *** have received increasing attention as an innovative drug delive ry tool fo r the treatment of brain *** are considered a potential therapeutic strategy with the advantages of being able to cross the blood-brain barrier,targeted drug delivery,enhanced drug stability,and multifunctional *** use of nanoparticles to deliver specific modified siRNAs to the injured brain is gradually being recognized as a feasible and effective *** this strategy is still in the preclinical exploration stage,it is expected to achieve clinical translation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dysfunction exosomes gene silencing immunotherapy inorganic nanomaterials liposome nanoparticles neuroinflammation polymer nanoparticles stem cells

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延龙图地区城市土地生态适宜性评价

自然资源学报 2017年第5期32卷 778-787页

作者：赵小娜宫雪田丰昊李明玉延边大学理学院地理系吉林延吉133002

土地是人类生存、发展的物质基础,但是快速的城市化和城镇化每年使得很多生态用地转化为建设用地,结果导致一系列严峻的生态环境问题。在生态文明建设背景下,城市发展需合理规划以减少城市发展对生态环境造成的影响,而城市合理规划的前... 详细信息

土地是人类生存、发展的物质基础,但是快速的城市化和城镇化每年使得很多生态用地转化为建设用地,结果导致一系列严峻的生态环境问题。在生态文明建设背景下,城市发展需合理规划以减少城市发展对生态环境造成的影响,而城市合理规划的前提是认清土地生态适宜性及其等级。鉴于此,论文从自然地理、社会经济、生态限制三方面选取了12个评价因子构建阻力评价体系,运用"阻力模型"和"最小累积阻力模型"相结合的方法,并借助GIS空间分析技术对延龙图地区城市土地生态适宜性及其等级进行了评价。结果表明:延龙图地区城市土地生态适宜性可分为重点建设区(538.55 km^2)、优化建设区(743.53 km^2)、限制建设区(1 887.46 km^2)和禁止建设区(1 919.16 km^2)。论文明确各区空间分布并提出相对应的发展建议,以期为延龙图地区城市土地规划布局提供理论、技术、决策支撑与参考。

关键词：土地生态适宜性最小累积阻力模型延龙图地区